LIVIVO - Search results -

Search results

Result 1 - 10 of total 269

Search options

Article ; Online: Suppression of B7-H7 Enhanced MCF-7 Cancer Cell Line's Chemosensitivity to Paclitaxel.

Taghavi, Bita Amir / Salehi, Mitra / Mokhtarzadeh, Ahad / Baradaran, Behzad

2024

Abstract: The B7-H7 is the newest addition to the B7 family of proteins that is present in the majority of malignancies. In this respect, the goal of the work was to investigate the impact of B7-H7 inhibition on breast cancer cells when paclitaxel and small ... ...

Abstract	The B7-H7 is the newest addition to the B7 family of proteins that is present in the majority of malignancies. In this respect, the goal of the work was to investigate the impact of B7-H7 inhibition on breast cancer cells when paclitaxel and small interference RNA (siRNA) were combined. B7-H7 siRNA was used with Paclitaxel to treat MCF-7 cells. The IC50 of Paclitaxel and the cell survival was then assessed through using MTT assay. Investigation was conducted using flow cytometry to both the induction of apoptosis and the cell cycle. In addition, the clonogenic capacity of MCF-7 cells was investigated. Furthermore, qRT-PCR, was used to evaluate expression of genes. Our results demonstrated that suppressing B7-H7 sensitizes MCF-7 cells to Paclitaxel by triggering apoptosis and altering the expression of critical apoptosis mediator genes. In addition, the cell cycle was stopped in the sub-G1 and also G2-M phases as a result of the combination therapy leading prevention of developing colonies by MCF-7 cells. B7-H7 silencing improved the chemosensitivity of MCF-7 cells to Paclitaxel and demonstrated antiproliferative effects. After the adequate study has been conducted, this strategy may be regarded as a possible alternative treatment option for this cancer.
Language	English
Publishing date	2024-04-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1193057-3
ISSN	1559-0305 ; 1073-6085
ISSN (online)	1559-0305
ISSN	1073-6085
DOI	10.1007/s12033-024-01145-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4031: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Pore-forming Peptides: A New Treatment Option for Cancer.

Jahanafrooz, Zohreh / Mokhtarzadeh, Ahad

Current medicinal chemistry

2021 Volume 29, Issue 23, Page(s) 4078–4096

Abstract: Cancer, a challenging medical problem, affects millions of people around the world. Cancer cell resistance is one of the main drawbacks in the complete prosperity of even more sophisticated therapies. Pore-forming peptides (PFPs), a group of natural ... ...

Abstract	Cancer, a challenging medical problem, affects millions of people around the world. Cancer cell resistance is one of the main drawbacks in the complete prosperity of even more sophisticated therapies. Pore-forming peptides (PFPs), a group of natural defense system proteins are used by nearly all living organisms as anti-bacterial and anti-- fungal agents, and could also be regarded as novel tumoricidal peptides. PFPs approach entails using soluble peptides by assembling them mainly on the target cell membrane and forming potential death-causing pores. Physical damage induction by natural PFPs or their synthetic derivatives could conquer the resistance mechanisms of tumor cells. Given that peptide drugs involve a significant proportion of the pharmaceutical market primarily because of easy synthesis and safety, evaluating this nature provided a model system as a group of anticancer peptides seems a valuable approach. Here, the mode of action of PFPs and their anticancer mechanism are highlighted, followed by addressing the anticancer studies using PFPs from different sources along with various strategies applied to obtain selective action of PFPs against cancer cells. Challenges and future perspectives of these promising bioactive molecules in cancer treatment are also provided.
MeSH term(s)	Cell Membrane/metabolism ; Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Peptides/analysis ; Peptides/pharmacology ; Peptides/therapeutic use
Chemical Substances	Peptides
Language	English
Publishing date	2021-11-26
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867328666211126150055
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4432: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Downregulation of long noncoding RNA B4GALT1-AS1 is associated with breast cancer development.

Ahvaz, Samaneh / Amini, Mohammad / Yari, Amirhossein / Baradaran, Behzad / Jebelli, Asiyeh / Mokhtarzadeh, Ahad

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3114

Abstract: The misregulation of long non-coding RNAs (lncRNAs) is related to the progressive evolution of various human cancers, such as Breast cancer (BC). The role of lncRNA B4GALT1-AS1 has been investigated in some human cancers. Therefore, studying B4GALT1-AS1 ... ...

Abstract	The misregulation of long non-coding RNAs (lncRNAs) is related to the progressive evolution of various human cancers, such as Breast cancer (BC). The role of lncRNA B4GALT1-AS1 has been investigated in some human cancers. Therefore, studying B4GALT1-AS1 expression was aimed for the first time in the tumor and marginal tissues of BC in this study. The cancer genome atlas (TCGA) database was utilized to evaluate the relative expression of B4GALT1-AS1 in BC and other cancers. RNA was extracted from twenty-eight paired BC and marginal tissues, and cDNA was synthesized. The quantitative expression level of B4GALT1-AS1 was evaluated using real-time PCR. The bioinformatics analyses were performed to identify co-expression genes and related pathways. B4GALT1-AS1 was significantly downregulated in BC specimens compared to tumor marginal samples. The TCGA data analysis confirmed the downregulation of B4GALT1-AS1 in BC. The bioinformatics analysis discovered the correlation between 700 genes and B4GALT1-AS1 and identified GNAI1 as the high degree gene which was positively correlated with B4GALT1-AS1 expression. It seems B4GALT1-AS1 provides its function, at least partly, in association with one of the hippo pathway components, YAP, in other cancers. This protein has the opposite role in BC and its loss of function can result in poor survival in BC. Further research is needed to investigate the interaction between B4GALT1-AS1 and YAP in various subtypes of BC.
MeSH term(s)	Humans ; Female ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Down-Regulation/genetics ; MicroRNAs/genetics ; Hippo Signaling Pathway ; Neoplasms/genetics ; Breast Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; Cell Proliferation/genetics ; Cell Line, Tumor
Chemical Substances	RNA, Long Noncoding ; MicroRNAs
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-51124-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Microbial L-asparaginase as a promising enzyme for treatment of various cancers

Darvishi, Farshad / Jahanafrooz, Zohreh / Mokhtarzadeh, Ahad

Applied microbiology and biotechnology. 2022 Sept., v. 106, no. 17

2022

Abstract: Metabolic differences between normal and cancerous cells have been used as a point of view for developing anticancer drugs. Some degrading enzymes of certain amino acids have been regarded to kill cancerous cells. L-Asparaginase (ASNase) has shown an ... ...

Abstract	Metabolic differences between normal and cancerous cells have been used as a point of view for developing anticancer drugs. Some degrading enzymes of certain amino acids have been regarded to kill cancerous cells. L-Asparaginase (ASNase) has shown an excellent therapeutic response to asparagine-auxotrophic cancers such as acute lymphoblastic leukemia (ALL). Some bacteria, yeasts, molds, plants, and animals produce ASNase. Bacterial ASNases from Escherichia coli and Erwinia chrysanthemi are the FDA-approved drugs for ALL treatment. Here, we review new natural prokaryotic and eukaryotic sources of ASNases, recent advances to introduce improvement strategies for the production of recombinant ASNases as well as their chemical modifications, immobilization, nanoencapsulation, and in silico studies to increase efficiency and decrease side effects. Recent studies for application of ASNases to treatment of asparagine-auxotrophic cancers, especially solid cancers, have been reviewed. Furthermore, challenges and future perspectives are discussed for this promising therapeutic enzyme. KEY POINTS: • Review recent advances to introduce new sources of microbial L-asparaginases. • Review improvement strategies for the development of stable and non-toxic L-asparaginases. • Review microbial L-asparaginase application in various cancers’ treatment.
Keywords	Erwinia chrysanthemi ; Escherichia coli ; asparaginase ; biotechnology ; computer simulation ; lymphocytic leukemia ; microbiology ; nanocapsules ; therapeutics
Language	English
Dates of publication	2022-09
Size	p. 5335-5347.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	Review
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-022-12086-8
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 79/727: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Anticancer properties of curcumin-treated Lactobacillus plantarum against the HT-29 colorectal adenocarcinoma cells.

Gholipour, Faranak / Amini, Mohammad / Baradaran, Behzad / Mokhtarzadeh, Ahad / Eskandani, Morteza

Scientific reports

2023 Volume 13, Issue 1, Page(s) 2860

Abstract: Probiotic bacteria with functions of importance to the health and well-being of the host exhibit various medicinal properties including anti-proliferative properties against cancer cells. There are observations demonstrating probiotic bacteria and their ... ...

Abstract	Probiotic bacteria with functions of importance to the health and well-being of the host exhibit various medicinal properties including anti-proliferative properties against cancer cells. There are observations demonstrating probiotic bacteria and their metabolomics can be different in various populations with different eating habits. Here, Lactobacillus plantarum was treated with curcumin (the major compound of turmeric), and its resistance to the curcumin was determined. After then the cell-free supernatants of untreated bacteria (CFS) and bacteria treated with curcumin (cur-CFS) were isolated and their anti-proliferative properties against HT-29 colon cancer cells were compared. The ability of L. plantarum treated with curcumin to combat a variety of pathogenic bacterial species and its ability to survive in acidic conditions were evidence that the probiotic properties of the bacterium were unaffected by the curcumin treatment. L. plantarum treated with curcumin and intact L. plantarum were both able to live in acidic conditions, according to the results of the resistance to low pH test. The MTT result showed that CFS and cur-CFS dose-dependently decreased the growth of HT29 cells with a half-maximal inhibitory concentration of 181.7 and 116.3 µL/mL at 48 h, respectively. Morphological alteration of DAPI-stained cells also exhibited significant fragmentation in the chromatin within the nucleus of cur-CFS-treated cells compared to CFS-treated HT29 cells. Moreover, flow cytometry analyses of apoptosis and cell cycle confirmed DAPI staining and MTT assay results and stipulated the increased occurrence of programmed cell death (apoptosis) in cur-CFS-treated cells (~ 57.65%) compared to CFS-treated cells (~ 47%). These results were more confirmed with qPCR and exhibited the upregulation of Caspase 9-3 and BAX genes, and downregulation of the BCL-2 gene in cur-CFS- and CFS-treated cells. In conclusion, turmeric spice and curcumin may affect the metabolomics of probiotics in intestinal flora which could subsequently influence their anticancer properties.
MeSH term(s)	Humans ; HT29 Cells ; Curcumin/pharmacology ; Curcumin/chemistry ; Lactobacillus plantarum ; Apoptosis ; Colonic Neoplasms/drug therapy ; Adenocarcinoma
Chemical Substances	Curcumin (IT942ZTH98)
Language	English
Publishing date	2023-02-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-29462-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Microbial L-asparaginase as a promising enzyme for treatment of various cancers.

Darvishi, Farshad / Jahanafrooz, Zohreh / Mokhtarzadeh, Ahad

Applied microbiology and biotechnology

2022 Volume 106, Issue 17, Page(s) 5335–5347

Abstract	Metabolic differences between normal and cancerous cells have been used as a point of view for developing anticancer drugs. Some degrading enzymes of certain amino acids have been regarded to kill cancerous cells. L-Asparaginase (ASNase) has shown an excellent therapeutic response to asparagine-auxotrophic cancers such as acute lymphoblastic leukemia (ALL). Some bacteria, yeasts, molds, plants, and animals produce ASNase. Bacterial ASNases from Escherichia coli and Erwinia chrysanthemi are the FDA-approved drugs for ALL treatment. Here, we review new natural prokaryotic and eukaryotic sources of ASNases, recent advances to introduce improvement strategies for the production of recombinant ASNases as well as their chemical modifications, immobilization, nanoencapsulation, and in silico studies to increase efficiency and decrease side effects. Recent studies for application of ASNases to treatment of asparagine-auxotrophic cancers, especially solid cancers, have been reviewed. Furthermore, challenges and future perspectives are discussed for this promising therapeutic enzyme. KEY POINTS: • Review recent advances to introduce new sources of microbial L-asparaginases. • Review improvement strategies for the development of stable and non-toxic L-asparaginases. • Review microbial L-asparaginase application in various cancers' treatment.
MeSH term(s)	Animals ; Antineoplastic Agents ; Asparaginase ; Asparagine ; Bacteria ; Escherichia coli ; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Chemical Substances	Antineoplastic Agents ; Asparagine (7006-34-0) ; Asparaginase (EC 3.5.1.1)
Language	English
Publishing date	2022-07-25
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-022-12086-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2229: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Graphitic carbon nitride/magnetic chitosan composite for rapid electrochemical detection of lactose

Naṣīrī, Ḥasan / Baghban, Hamed / Teimuri-Mofrad, Reza / Mokhtarzadeh, Ahad

International Dairy Journal. 2023 Jan., v. 136 p.105489-

2023

Abstract: Graphitic carbon nitride supported on magnetic chitosan (MNPs/CS/g-C₃N₄) was synthesised via facile route and used as an efficient support for covalent-based immobilisation of cellobiose dehydrogenase (CDH) and also as a modifier for glassy carbon ... ...

Abstract	Graphitic carbon nitride supported on magnetic chitosan (MNPs/CS/g-C₃N₄) was synthesised via facile route and used as an efficient support for covalent-based immobilisation of cellobiose dehydrogenase (CDH) and also as a modifier for glassy carbon electrode (GCE) in the fabrication of an electrochemical lactose sensor. Characterisation techniques, including field-emission scanning electron microscopy, Fourier transform infrared spectroscopy, x-ray powder diffraction, and thermo-gravimetric analysis, were utilised to fully characterise the composite structure. According to the beneficial properties and electrical conductivity of g-C₃N₄, the MNPs/CS/g-C₃N₄ composite displayed excellent electrochemical performance for lactose detection with a low detection limit of 0.3 mm, a broad linear range of 0.9–100 mm, a fast response time of 5 s, and considerably high sensitivity of 40.8 μA mm⁻¹. More importantly, the utility of the developed MNPs/CS/g-C₃N₄/CDH/GCE biosensor was verified in the quantification of lactose in dairy products, indicating its potential application for analysis of real samples.
Keywords	Fourier transform infrared spectroscopy ; X-ray diffraction ; biosensors ; carbon nitride ; cellobiose dehydrogenase ; chitosan ; detection limit ; electrical conductivity ; electrochemistry ; electron microscopy ; glassy carbon electrode ; graphene ; lactose ; magnetism ; thermogravimetry
Language	English
Dates of publication	2023-01
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1076400-8
ISSN	0958-6946
ISSN	0958-6946
DOI	10.1016/j.idairyj.2022.105489
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 5292: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: The triad of nanotechnology, cell signalling, and scaffold implantation for the successful repair of damaged organs: An overview on soft-tissue engineering

Abdollahiyan, Parinaz / Oroojalian, Fatemeh / Mokhtarzadeh, Ahad

Journal of controlled release. 2021 Apr. 10, v. 332

2021

Abstract: As a milestone in therapeutic fields, tissue engineering has offered an alternative strategy to address unmet clinical needs for the repair and replacement of human damaged organs. The premise of regenerative medicine follows an essential triad of cells, ...

Abstract	As a milestone in therapeutic fields, tissue engineering has offered an alternative strategy to address unmet clinical needs for the repair and replacement of human damaged organs. The premise of regenerative medicine follows an essential triad of cells, substrates, and physiologically active biomolecules to generate advanced therapeutic methods for tissue repair. Biomedical usages of nanotechnology in regenerative medicine are considerably growing. Dynamic three-dimensional nano-environments can deliver bioactive molecular substrates to accelerate the recovery of damaged tissues by inducing the preservation, proliferation, and differentiation of healthy cells. Nanotechnology provides the possibility to optimize the characteristics of scaffolds and tune their biological functionality (e.g., cellular attachment, electrical conductivity, biocompatibility, and cell-differentiation inducing effect). In addition, nanoscale substances can supply scaffolds via releasing several loaded drugs and triggering cellular proliferation to deliver efficient repair of various organs such as bone, cornea, cartilage, and the heart. Overall, the nature of damaged tissues, as well as scaffolds' composition, porous structure, degradability, and biocompatibility are determinant factors for successful tissue engineering. This review has addressed the most recent advances in the tissue engineering of various organs with a focus on the applications of nanomaterials in this field.
Keywords	biochemical compounds ; biocompatibility ; cartilage ; cell differentiation ; cell proliferation ; cornea ; electrical conductivity ; heart ; humans ; medicine ; therapeutics ; tissue repair
Language	English
Dates of publication	2021-0410
Size	p. 460-492.
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-light
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2021.02.036
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2055: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Recent Advances in Early Diagnosis of Viruses Associated with Gastroenteritis by Biosensors.

Babaei, Abouzar / Rafiee, Nastaran / Taheri, Behnaz / Sohrabi, Hessamaddin / Mokhtarzadeh, Ahad

Biosensors

2022 Volume 12, Issue 7

Abstract: Gastroenteritis, as one of the main worldwide health challenges, especially in children, leads to 3-6 million deaths annually and causes nearly 20% of the total deaths of children aged ˂5 years, of which ~1.5 million gastroenteritis deaths occur in ... ...

Abstract	Gastroenteritis, as one of the main worldwide health challenges, especially in children, leads to 3-6 million deaths annually and causes nearly 20% of the total deaths of children aged ˂5 years, of which ~1.5 million gastroenteritis deaths occur in developing nations. Viruses are the main causative agent (~70%) of gastroenteritis episodes and their specific and early diagnosis via laboratory assays is very helpful for having successful antiviral therapy and reduction in infection burden. Regarding this importance, the present literature is the first review of updated improvements in the employing of different types of biosensors such as electrochemical, optical, and piezoelectric for sensitive, simple, cheap, rapid, and specific diagnosis of human gastroenteritis viruses. The Introduction section is a general discussion about the importance of viral gastroenteritis, types of viruses that cause gastroenteritis, and reasons for the combination of conventional diagnostic tests with biosensors for fast detection of viruses associated with gastroenteritis. Following the current laboratory detection tests for human gastroenteritis viruses and their limitations (with subsections: Electron Microscope (EM), Cell Culture, Immunoassay, and Molecular Techniques), structural features and significant aspects of various biosensing methods are discussed in the Biosensor section. In the next sections, basic information on viruses causing gastroenteritis and recent developments for fabrication and testing of different biosensors for each virus detection are covered, and the prospect of future developments in designing different biosensing platforms for gastroenteritis virus detection is discussed in the Conclusion and Future Directions section as well.
MeSH term(s)	Biosensing Techniques/methods ; Child ; Early Diagnosis ; Gastroenteritis/diagnosis ; Humans ; Immunoassay ; Viruses/chemistry
Language	English
Publishing date	2022-07-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios12070499
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Stem cell membrane, stem cell-derived exosomes and hybrid stem cell camouflaged nanoparticles: A promising biomimetic nanoplatforms for cancer theranostics.

Khosravi, Neda / Pishavar, Elham / Baradaran, Behzad / Oroojalian, Fatemeh / Mokhtarzadeh, Ahad

Journal of controlled release : official journal of the Controlled Release Society

2022 Volume 348, Page(s) 706–722

Abstract: Nanomedicine research has advanced dramatically in recent decades. Nonetheless, traditional nanomedicine faces significant obstacles such as the low concentration of the drug at target sites and accelerated removal of the drug from blood circulation. ... ...

Abstract	Nanomedicine research has advanced dramatically in recent decades. Nonetheless, traditional nanomedicine faces significant obstacles such as the low concentration of the drug at target sites and accelerated removal of the drug from blood circulation. Various techniques of nanotechnology, including cell membrane coating, have been developed to address these challenges and to improve targeted distribution and redcue cell membrane-mediated immunogenicity. Recently, stem cell (SC) membranes, owing to their immunosuppressive and regenerative properties, have grabbed attention as attractive therapeutic carriers for targeting specific tissues or organs. Bioengineering strategies that combine synthetic nanoparticles (NPs) with SC membranes, because of their homing potential and tumor tropism, have recently received a lot of publicity. Several laboratory experiments and clinical trials have indicated that the benefits of SC-based technologies are mostly related to the effects of SC-derived exosomes (SC-Exos). Exosomes are known as nano-sized extracellular vehicles (EVs) that deliver particular bioactive molecules for cell-to-cell communication. In this regard, SC-derived exosome membranes have recently been employed to improve the therapeutic capability of engineered drug delivery vehicles. Most recently, for further enhancing NPs' functionality, a new coating approach has been offered that combines membranes from two separate cells. These hybrid membrane delivery vehicles have paved the way for the development of biocompatible, high-efficiency, biomimetic NPs with varying hybrid capabilities that can overcome the drawbacks of present NP-based treatment techniques. This review explores stem cell membranes, SC-Exos, and hybrid SC-camouflaged NPs preparation methods and their importance in cancer therapy.
MeSH term(s)	Biomimetics ; Cell Membrane ; Drug Delivery Systems/methods ; Exosomes/metabolism ; Humans ; Nanoparticles ; Neoplasms/drug therapy ; Neoplasms/pathology ; Precision Medicine ; Stem Cells
Language	English
Publishing date	2022-06-22
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2022.06.026
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2055: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito