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  1. Article: Microvascular Diabetes Complications in Wolfram Syndrome (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness [DIDMOAD]): An age- and duration-matched comparison with common type 1 diabetes

    Cano, Aline / Molines, Laurent / Valéro, René / Simonin, Gilbert / Paquis-Flucklinger, Véronique / Vialettes, Bernard

    Diabetes care. 2007 Sept., v. 30, no. 9

    2007  

    Abstract: OBJECTIVE:--Some previous studies suggested that patients suffering from Wolfram syndrome or DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness) might be relatively preserved from diabetic retinopathy and nephropathy. However, ... ...

    Abstract OBJECTIVE:--Some previous studies suggested that patients suffering from Wolfram syndrome or DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness) might be relatively preserved from diabetic retinopathy and nephropathy. However, these data were not conclusive because either observations were only anecdotic or did not match with control type 1 diabetic populations. RESEARCH DESIGN AND METHODS--A group of 26 French diabetic patients with DIDMOAD was compared with a population of 52 patients with common type 1 diabetes matched for age at diabetes diagnosis (8.62 ± 1.84 vs. 8.27 ± 1.30 years; P = NS) and diabetes duration (12.88 ± 1.58 vs. 12.87 ± 1.13 years; P = NS) to study the quality of glycemic control and the incidence of microvascular complications. RESULTS:--Glycemic control was significantly better in the DIDMOAD group than in the type 1 diabetic group (A1C: 7.72 ± 0.21 vs. 8.99 ± 0.25%, respectively; P = 0.002), with significant lower daily insulin requirements (0.71 ± 0.07 vs. 0.88 ± 0.04 UI · kg⁻¹ · day⁻¹, respectively; P = 0.0325). The prevalence of microvascular complications in the DIDMOAD group was half that observed in the type 1 diabetic group, but the difference was not significant. CONCLUSIONS:--Diabetes in DIDMOAD patients is more easily controlled despite the presence of other handicaps. This better glycemic control could explain the trend to decreased microvascular diabetes complications observed in previous studies.
    Keywords atrophy ; deafness ; diabetes insipidus ; diabetic retinopathy ; glycemic control ; insulin ; insulin-dependent diabetes mellitus ; kidney diseases ; patients
    Language English
    Size p. 2327-2330.
    Publishing place American Diabetes Association
    Document type Article
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 1434: Show issues Location:
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  2. Article ; Online: Microvascular diabetes complications in Wolfram syndrome (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness [DIDMOAD]): an age- and duration-matched comparison with common type 1 diabetes.

    Cano, Aline / Molines, Laurent / Valéro, René / Simonin, Gilbert / Paquis-Flucklinger, Véronique / Vialettes, Bernard

    Diabetes care

    2007  Volume 30, Issue 9, Page(s) 2327–2330

    Abstract: Objective: Some previous studies suggested that patients suffering from Wolfram syndrome or DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness) might be relatively preserved from diabetic retinopathy and nephropathy. However, ... ...

    Abstract Objective: Some previous studies suggested that patients suffering from Wolfram syndrome or DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness) might be relatively preserved from diabetic retinopathy and nephropathy. However, these data were not conclusive because either observations were only anecdotic or did not match with control type 1 diabetic populations.
    Research design and methods: A group of 26 French diabetic patients with DIDMOAD was compared with a population of 52 patients with common type 1 diabetes matched for age at diabetes diagnosis (8.62 +/- 1.84 vs. 8.27 +/- 1.30 years; P = NS) and diabetes duration (12.88 +/- 1.58 vs. 12.87 +/- 1.13 years; P = NS) to study the quality of glycemic control and the incidence of microvascular complications.
    Results: Glycemic control was significantly better in the DIDMOAD group than in the type 1 diabetic group (A1C: 7.72 +/- 0.21 vs. 8.99 +/- 0.25%, respectively; P = 0.002), with significant lower daily insulin requirements (0.71 +/- 0.07 vs. 0.88 +/- 0.04 UI x kg(-1) x day(-1), respectively; P = 0.0325). The prevalence of microvascular complications in the DIDMOAD group was half that observed in the type 1 diabetic group, but the difference was not significant.
    Conclusions: Diabetes in DIDMOAD patients is more easily controlled despite the presence of other handicaps. This better glycemic control could explain the trend to decreased microvascular diabetes complications observed in previous studies.
    MeSH term(s) Age Factors ; Blood Glucose/analysis ; Child ; Diabetic Angiopathies/etiology ; Female ; Humans ; Male ; Microcirculation/physiopathology ; Time Factors ; Wolfram Syndrome/complications
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2007-09
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc07-0380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pseudomalabsorption de L-thyroxine: une forme de pathomimie.

    Molines, Laurent / Fromont, Isabelle / Morlet-Barla, Nathalie / Nogueira, Juan-Patricio / Valéro, René / Vialettes, Bernard

    Presse medicale (Paris, France : 1983)

    2007  Volume 36, Issue 10 Pt 1, Page(s) 1390–1394

    Abstract: Introduction: Thyroxine supplementation of patients with hypothyroidism is usually simple. A few patients, however, continue to present elevated TSH levels despite large doses of L-thyroxine.: Case: We report the case of a 71-year-old women who had ... ...

    Title translation L-thyroxine pseudomalabsorption: a factitious disease.
    Abstract Introduction: Thyroxine supplementation of patients with hypothyroidism is usually simple. A few patients, however, continue to present elevated TSH levels despite large doses of L-thyroxine.
    Case: We report the case of a 71-year-old women who had had a thyroidectomy 10 years earlier and had since been hospitalized repeatedly for profound hypothyroidism. Despite her consistent claims of good adherence to her treatment regimen, we considered the diagnosis of L-thyroxine pseudomalabsorption and confirmed it by thyroid hormone absorption tests.
    Discussion: L-thyroxine pseudomalabsorption due to concealed poor treatment adherence should be considered after ruling out drug or dietary interference and true organic malabsorption. Diagnosis of this factitious disease can be confirmed by L-thyroxine absorption tests.
    MeSH term(s) Aged ; Diagnosis, Differential ; Factitious Disorders/diagnosis ; Female ; Goiter, Nodular/surgery ; Humans ; Hypothyroidism/drug therapy ; Intestinal Absorption ; Malabsorption Syndromes/diagnosis ; Patient Compliance ; Thyroidectomy ; Thyroxine/administration & dosage ; Thyroxine/metabolism ; Thyroxine/therapeutic use ; Time Factors
    Chemical Substances Thyroxine (Q51BO43MG4)
    Language French
    Publishing date 2007-10
    Publishing country France
    Document type Case Reports ; Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0755-4982 ; 0032-7867 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0755-4982 ; 0032-7867 ; 0301-1518
    DOI 10.1016/j.lpm.2006.09.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comparison of platelet reactivity and clopidogrel response in patients ≤ 75 Years Versus > 75 years undergoing percutaneous coronary intervention for non-ST-segment elevation acute coronary syndrome.

    Cuisset, Thomas / Quilici, Jacques / Grosdidier, Charlotte / Fourcade, Laurent / Gaborit, Bénédicte / Pankert, Mathieu / Molines, Laurent / Morange, Pierre-Emmanuel / Bonnet, Jean Louis / Alessi, Marie-Christine

    The American journal of cardiology

    2011  Volume 108, Issue 10, Page(s) 1411–1416

    Abstract: Specific data about the clopidogrel response in elderly patients are lacking. The present study was performed to compare the platelet reactivity and clopidogrel response between patients aged > 75 years and < 75 years undergoing percutaneous coronary ... ...

    Abstract Specific data about the clopidogrel response in elderly patients are lacking. The present study was performed to compare the platelet reactivity and clopidogrel response between patients aged > 75 years and < 75 years undergoing percutaneous coronary intervention for non-ST-segment elevation acute coronary syndrome. A total of 689 patients were enrolled, including 162 patients aged > 75 years and 527 younger patients. All patients received a loading dose of 600 mg clopidogrel followed by 150 mg/day. Post-treatment platelet reactivity was assessed by adenosine diphosphate 10 μmol/L-induced platelet aggregation and the specific pharmacologic response to clopidogrel by the platelet reactivity index vasoactive stimulated phosphoprotein. High post-treatment platelet reactivity was defined as adenosine diphosphate 10 μmol/L-induced platelet aggregation >70%. Clinical events were recorded during 1 month of follow-up. The patients > 75 years old had a greater rate of both ischemic and bleeding complications (p = 0.04 and p = 0.03, respectively). The post-treatment platelet reactivity in response to both the loading and the maintenance clopidogrel dose was greater in patients > 75 years old than in the younger patients: 50 ± 17% versus 45 ± 17% (p = 0.002) and 57 ± 15% versus 53 ± 16% (p = 0.0005), respectively. The rate of high post-treatment platelet reactivity was significantly greater in patients aged > 75 years after 600 mg and 150 mg clopidogrel: 14% versus 9% (p = 0.04) and 23% versus 15% (p = 0.02), respectively. In contrast, the pharmacologic response to clopidogrel was not impaired in patients > 75 years after loading and maintenance doses: 43 ± 21% versus 46 ± 21% (p = 0.17) and 38 ± 18% versus 39 ± 18% (p = 0.55), respectively. In conclusion, patients aged > 75 years have an impaired prognosis after acute coronary syndrome. They display greater post-treatment platelet reactivity. However, this greater platelet reactivity does not seem to be related to an impaired specific response to clopidogrel.
    MeSH term(s) Acute Coronary Syndrome/epidemiology ; Acute Coronary Syndrome/therapy ; Adenosine Diphosphate ; Age Factors ; Aged ; Aged, 80 and over ; Angioplasty, Balloon, Coronary ; Aspirin/administration & dosage ; Drug Resistance ; Follow-Up Studies ; Hemorrhage/epidemiology ; Humans ; Middle Aged ; Myocardial Ischemia/epidemiology ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/administration & dosage ; Prospective Studies ; Recurrence ; Stents ; Ticlopidine/administration & dosage ; Ticlopidine/analogs & derivatives
    Chemical Substances Platelet Aggregation Inhibitors ; Adenosine Diphosphate (61D2G4IYVH) ; clopidogrel (A74586SNO7) ; Ticlopidine (OM90ZUW7M1) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2011-11-15
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2011.06.060
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  5. Article ; Online: Non-adherence to aspirin in patients undergoing coronary stenting: negative impact of comorbid conditions and implications for clinical management.

    Cuisset, Thomas / Quilici, Jacques / Fugon, Lionel / Cohen, William / Roux, Perrine / Gaborit, Bénédicte / Molines, Laurent / Fourcade, Laurent / Bonnet, Jean-Louis / Carrieri, Patrizia

    Archives of cardiovascular diseases

    2011  Volume 104, Issue 5, Page(s) 306–312

    Abstract: Background: Premature discontinuation of and reduced adherence to antiplatelet therapy have been identified as major risk factors for stent thrombosis and poor prognosis after acute coronary syndrome.: Aim: We aimed to identify correlates of non- ... ...

    Abstract Background: Premature discontinuation of and reduced adherence to antiplatelet therapy have been identified as major risk factors for stent thrombosis and poor prognosis after acute coronary syndrome.
    Aim: We aimed to identify correlates of non-adherence to aspirin among patients who had undergone coronary stenting.
    Methods: We prospectively included all patients who had undergone coronary stenting in our institution. Response to aspirin was assessed during the hospital phase with arachidonic acid-induced platelet aggregation (AA-Ag) and only good responders to aspirin (AA-Ag<30%) were included in the study for longitudinal assessment (n=308). Response to aspirin was reassessed 1 month after hospital discharge and non-responders received a directly observed intake of aspirin to exclude any biological non-response due to bioavailability problems. After excluding patients with such problems, response to aspirin based on platelet function testing was used to estimate non-adherence to aspirin after coronary stenting. A logistic regression model was used to identify predictors of non-adherence.
    Results: Non-adherence to aspirin concerned 14% of the study sample (n=43). After adjustment for age, those who reported the highest risk of non-adherence to aspirin were migrants (odds ratio [95% confidence interval], 8.3 [3.5-19.8], followed by patients receiving treatment for diabetes (4.5 [1.9-10.9]). Smokers had a threefold risk of non-adherence (3.1 [1.4-6.9]).
    Conclusions: Non-adherence to aspirin is relatively frequent in populations at high risk of cardiovascular events. Appropriate case management and special interventions targeting these groups need to be implemented to avoid fatal events and assure long-term adherence to treatment.
    MeSH term(s) Aged ; Angioplasty, Balloon, Coronary/adverse effects ; Angioplasty, Balloon, Coronary/instrumentation ; Aspirin/therapeutic use ; Comorbidity ; Coronary Artery Disease/blood ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/therapy ; Female ; France/epidemiology ; Humans ; Logistic Models ; Male ; Medication Adherence ; Middle Aged ; Odds Ratio ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/therapeutic use ; Platelet Function Tests ; Prospective Studies ; Risk Assessment ; Risk Factors ; Stents ; Thrombosis/blood ; Thrombosis/etiology ; Thrombosis/prevention & control ; Time Factors ; Treatment Outcome
    Chemical Substances Platelet Aggregation Inhibitors ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2011-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2408778-6
    ISSN 1875-2128 ; 1875-2136
    ISSN (online) 1875-2128
    ISSN 1875-2136
    DOI 10.1016/j.acvd.2011.03.091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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