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  1. Article: Cooling-Induced ER Stress is Good for Your Brain.

    Mollereau, Bertrand

    EBioMedicine

    2015  Volume 2, Issue 6, Page(s) 482–483

    MeSH term(s) Cerebral Cortex/cytology ; Cold-Shock Response/physiology ; Endoplasmic Reticulum Stress/physiology ; Humans ; Hypothermia, Induced/methods ; Neurons/cytology
    Language English
    Publishing date 2015-06
    Publishing country Netherlands
    Document type Comment ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2851331-9
    ISSN 2352-3964 ; 2352-3964
    ISSN (online) 2352-3964
    ISSN 2352-3964
    DOI 10.1016/j.ebiom.2015.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
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  2. Article ; Online: Establishing links between endoplasmic reticulum-mediated hormesis and cancer.

    Mollereau, Bertrand

    Molecular and cellular biology

    2013  Volume 33, Issue 12, Page(s) 2372–2374

    MeSH term(s) Animals ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Endoplasmic Reticulum/physiology ; Endoplasmic Reticulum Stress/drug effects ; Hedgehog Proteins/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction ; Smoothened Receptor ; Unfolded Protein Response/physiology
    Chemical Substances Drosophila Proteins ; Hedgehog Proteins ; Receptors, G-Protein-Coupled ; Smoothened Receptor ; smo protein, Drosophila
    Language English
    Publishing date 2013-04-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/MCB.00315-13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Is WDR45 the missing link for ER stress-induced autophagy in beta-propeller associated neurodegeneration?

    Mollereau, Bertrand / Walter, Ludivine

    Autophagy

    2019  Volume 15, Issue 12, Page(s) 2163–2164

    Abstract: Beta-propeller protein-associated neurodegeneration (BPAN) is caused by mutations in the autophagy ... ...

    Abstract Beta-propeller protein-associated neurodegeneration (BPAN) is caused by mutations in the autophagy gene
    MeSH term(s) Adult ; Animals ; Autophagy/genetics ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Child ; Endoplasmic Reticulum Stress/genetics ; Humans ; Mice ; Mice, Knockout ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism
    Chemical Substances Carrier Proteins ; WDR45 protein, human ; Wdr45 protein, mouse
    Language English
    Publishing date 2019-09-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2019.1668229
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  4. Article ; Online: Cell death: what can we learn from flies? Editorial for the special review issue on Drosophila apoptosis.

    Mollereau, Bertrand

    Apoptosis : an international journal on programmed cell death

    2009  Volume 14, Issue 8, Page(s) 929–934

    MeSH term(s) Animals ; Apoptosis ; Apoptosis Regulatory Proteins/metabolism ; Caspases/metabolism ; Drosophila/cytology ; Drosophila/embryology ; Drosophila/genetics ; Endoplasmic Reticulum/metabolism ; Humans ; Mitochondria/metabolism
    Chemical Substances Apoptosis Regulatory Proteins ; Caspases (EC 3.4.22.-)
    Language English
    Publishing date 2009-08
    Publishing country Netherlands
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1452360-7
    ISSN 1573-675X ; 1360-8185
    ISSN (online) 1573-675X
    ISSN 1360-8185
    DOI 10.1007/s10495-009-0383-1
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    Zs.A 5178: Show issues Location:
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  5. Article ; Online: Rb-mediated apoptosis or proliferation: It's up to JNK.

    Mollereau, Bertrand / Ma, Dali

    Cell cycle (Georgetown, Tex.)

    2015  Volume 15, Issue 1, Page(s) 11–12

    MeSH term(s) Animals ; Apoptosis/physiology ; Cell Proliferation/physiology ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; Retinoblastoma Protein/metabolism
    Chemical Substances Retinoblastoma Protein ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2015-11-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15384101.2015.1119492
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    Zs.A 5881: Show issues Location:
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  6. Article ; Online: Intersections between Regulated Cell Death and Autophagy.

    Napoletano, Francesco / Baron, Olga / Vandenabeele, Peter / Mollereau, Bertrand / Fanto, Manolis

    Trends in cell biology

    2019  Volume 29, Issue 4, Page(s) 323–338

    Abstract: In multicellular organisms, cell death is an essential aspect of life. Over the past decade, the spectrum of different forms of regulated cell death (RCD) has expanded dramatically with relevance in several pathologies such as inflammatory and ... ...

    Abstract In multicellular organisms, cell death is an essential aspect of life. Over the past decade, the spectrum of different forms of regulated cell death (RCD) has expanded dramatically with relevance in several pathologies such as inflammatory and neurodegenerative diseases. This has been paralleled by the growing awareness of the central importance of autophagy as a stress response that influences decisions of cell life and cell death. Here, we first introduce criteria and methodologies for correct identification of the different RCD forms. We then discuss how the autophagy machinery is directly associated with specific cell death forms and dissect the complex interactions between autophagy and apoptotic and necrotic cell death. This highlights how the balance of the relationship between other cell death pathways and autophagy presides over life and death in specific cellular contexts.
    MeSH term(s) Animals ; Autophagy ; Humans ; Neurodegenerative Diseases/pathology ; Regulated Cell Death
    Language English
    Publishing date 2019-01-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2018.12.007
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    Zs.MG 25: Show issues
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    Zs.A 3410: Show issues Location:
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  7. Article ; Online: A burning question from the first international BPAN symposium: is restoration of autophagy a promising therapeutic strategy for BPAN?

    Mollereau, Bertrand / Hayflick, Susan J / Escalante, Ricardo / Mauthe, Mario / Papandreou, Apostolos / Iuso, Arcangela / Celle, Marion / Aniorte, Sahra / Issa, Abdul Raouf / Lasserre, Jean Paul / Lesca, Gaetan / Thobois, Stéphane / Burger, Pauline / Walter, Ludivine

    Autophagy

    2023  Volume 19, Issue 12, Page(s) 3234–3239

    Abstract: Beta-propeller protein-associated neurodegeneration (BPAN) is a rare neurodegenerative disease associated with severe cognitive and motor deficits. BPAN pathophysiology and phenotypic spectrum are still emerging due to the fact that mutations in ... ...

    Abstract Beta-propeller protein-associated neurodegeneration (BPAN) is a rare neurodegenerative disease associated with severe cognitive and motor deficits. BPAN pathophysiology and phenotypic spectrum are still emerging due to the fact that mutations in the
    MeSH term(s) Animals ; Humans ; Carrier Proteins/genetics ; Neurodegenerative Diseases/genetics ; Autophagy/genetics ; Mutation ; Neurons
    Chemical Substances Carrier Proteins ; WDR45 protein, human
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2023.2247314
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    Zs.A 6741: Show issues Location:
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  8. Article ; Online: The p53 control of apoptosis and proliferation: lessons from Drosophila.

    Mollereau, Bertrand / Ma, Dali

    Apoptosis : an international journal on programmed cell death

    2014  Volume 19, Issue 10, Page(s) 1421–1429

    Abstract: The canonical role of p53 in preserving genome integrity and limiting carcinogenesis has been well established. In the presence of acute DNA-damage, oncogene deregulation and other forms of cellular stress, p53 orchestrates a myriad of pleiotropic ... ...

    Abstract The canonical role of p53 in preserving genome integrity and limiting carcinogenesis has been well established. In the presence of acute DNA-damage, oncogene deregulation and other forms of cellular stress, p53 orchestrates a myriad of pleiotropic processes to repair cellular damages and maintain homeostasis. Beside these well-studied functions of p53, recent studies in Drosophila have unraveled intriguing roles of Dmp53 in promoting cell division in apoptosis-induced proliferation, enhancing fitness and proliferation of the winner cell in cell competition and coordinating growth at the organ and organismal level in the presence of stress. In this review, we describe these new functions of Dmp53 and discuss their relevance in the context of carcinogenesis.
    MeSH term(s) Animals ; Apoptosis ; Cell Division ; Cell Proliferation ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/cytology ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
    Chemical Substances Drosophila Proteins ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2014-08-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1452360-7
    ISSN 1573-675X ; 1360-8185
    ISSN (online) 1573-675X
    ISSN 1360-8185
    DOI 10.1007/s10495-014-1035-7
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  9. Article ; Online: Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.

    Hetz, Claudio / Mollereau, Bertrand

    Nature reviews. Neuroscience

    2014  Volume 15, Issue 4, Page(s) 233–249

    Abstract: The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well characterized in non-neuronal cells, a proliferation of papers over the past few ... ...

    Abstract The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well characterized in non-neuronal cells, a proliferation of papers over the past few years has revealed a key role for the UPR in normal neuronal function and as an important driver of neurodegenerative diseases. A complex scenario is emerging in which distinct UPR signalling modules have specific and even opposite effects on neurodegeneration depending on the disease context. Here, we provide an overview of the most recent findings addressing the biological relevance of ER stress in the nervous system.
    MeSH term(s) Animals ; Endoplasmic Reticulum/physiology ; Homeostasis/physiology ; Humans ; Neurodegenerative Diseases/physiopathology ; Stress, Physiological/physiology ; Unfolded Protein Response/physiology
    Language English
    Publishing date 2014-03-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2034150-7
    ISSN 1471-0048 ; 1471-0048 ; 1471-003X
    ISSN (online) 1471-0048
    ISSN 1471-0048 ; 1471-003X
    DOI 10.1038/nrn3689
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  10. Article ; Online: Chronic Exposure to Paraquat Induces Alpha-Synuclein Pathogenic Modifications in

    Arsac, Jean-Noël / Sedru, Marianne / Dartiguelongue, Mireille / Vulin, Johann / Davoust, Nathalie / Baron, Thierry / Mollereau, Bertrand

    International journal of molecular sciences

    2021  Volume 22, Issue 21

    Abstract: Parkinson's disease (PD) is characterized by the progressive accumulation of neuronal intracellular aggregates largely composed of alpha-Synuclein (αSyn) protein. The process of αSyn aggregation is induced during aging and enhanced by environmental ... ...

    Abstract Parkinson's disease (PD) is characterized by the progressive accumulation of neuronal intracellular aggregates largely composed of alpha-Synuclein (αSyn) protein. The process of αSyn aggregation is induced during aging and enhanced by environmental stresses, such as the exposure to pesticides. Paraquat (PQ) is an herbicide which has been widely used in agriculture and associated with PD. PQ is known to cause an increased oxidative stress in exposed individuals but the consequences of such stress on αSyn conformation remains poorly understood. To study αSyn pathogenic modifications in response to PQ, we exposed
    MeSH term(s) Animals ; Brain/drug effects ; Brain/metabolism ; Disease Models, Animal ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Drosophila/drug effects ; Drosophila/metabolism ; Herbicides/toxicity ; Male ; Neurotoxins/toxicity ; Paraquat/toxicity ; Parkinson Disease/metabolism ; alpha-Synuclein/metabolism
    Chemical Substances Herbicides ; Neurotoxins ; alpha-Synuclein ; Paraquat (PLG39H7695)
    Language English
    Publishing date 2021-10-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222111613
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