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  1. AU="Molokhia, Ashraf"
  2. AU="Zirone, Eleonora"
  3. AU="Tong, Wenxia"
  4. AU="Chalira, Davie"
  5. AU="Hodane Yonis"
  6. AU="Boggiano, César"
  7. AU="Gainor, Justin F"
  8. AU="Scurr, David J"
  9. AU="Mahuran, Don J"
  10. AU="Dominguez, Dana A"
  11. AU=Mota Gustavo R
  12. AU="Pandey, Gayathri"
  13. AU=Kiesslich Ralf
  14. AU="Wiskar, Katie"
  15. AU=Bennett Kaila M.
  16. AU=Bacci Jennifer L
  17. AU="Wildman, Ricky D."
  18. AU="Alshibani, Nouf"
  19. AU="Loens, Christopher"
  20. AU="Friedman, Lawrence M."
  21. AU="Johnstone, Damian"
  22. AU="Maleki, Shayan"
  23. AU="G. E-S. Batiha"
  24. AU=Johnson Guyla G
  25. AU="Patel, Parth H"
  26. AU="Manassero, Carlo"
  27. AU="Kirk, Tom"
  28. AU="Bezabih, Yihienew Mequanint"
  29. AU="Hirsinger, Estelle"
  30. AU="Robles-Musso Castillo, Emilio"
  31. AU="Vahdatihassani, Faezeh"
  32. AU="Maria Pala"
  33. AU=Singh Indra
  34. AU="Gallacher, Nicola"
  35. AU="Chen, Pei-Min"
  36. AU=Andre L
  37. AU="Aleksandra I. Pivovarova"
  38. AU="Cruz, Thainá Gabriele Camargo da"
  39. AU="Atkins, Peter"

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  1. Artikel ; Online: Need for guidance and training for physicians when communicating with under 18-year-old relative in critical care.

    Molokhia, Ashraf / Richmond, Georgia / Rochester, Alana / Breeze, Richard

    Intensive care medicine

    2023  Band 49, Heft 8, Seite(n) 1021–1022

    Mesh-Begriff(e) Humans ; Adolescent ; Physicians ; Critical Care
    Sprache Englisch
    Erscheinungsdatum 2023-07-04
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07139-z
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  2. Artikel ; Online: Death in the ICU from COVID-19: more research on its effects on families needed.

    Molokhia, Ashraf / Khaliq, Waqas

    British journal of anaesthesia

    2020  Band 125, Heft 3, Seite(n) e338–e339

    Mesh-Begriff(e) Betacoronavirus ; COVID-19 ; Coronavirus Infections/mortality ; Family ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/mortality ; SARS-CoV-2
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-06-17
    Erscheinungsland England
    Dokumenttyp Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2020.06.018
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  4. Artikel ; Online: Death in the ICU from COVID-19

    Molokhia, Ashraf / Khaliq, Waqas

    British Journal of Anaesthesia

    more research on its effects on families needed

    2020  Band 125, Heft 3, Seite(n) e338–e339

    Schlagwörter Anesthesiology and Pain Medicine ; covid19
    Sprache Englisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2020.06.018
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Cardiac arrest secondary to Covid19 pneumonia post full vaccination.

    Mohamed, Eslam / Coyle, Peter / Kumar, T Suresh / Molokhia, Ashraf / Harris, Tim

    The American journal of emergency medicine

    2021  Band 49, Seite(n) 257–258

    Mesh-Begriff(e) COVID-19/complications ; COVID-19/prevention & control ; Heart Arrest/epidemiology ; Heart Arrest/etiology ; Humans ; Pneumonia/epidemiology ; Pneumonia/etiology ; Vaccination/methods ; Vaccination/standards ; Vaccination/statistics & numerical data ; COVID-19 Drug Treatment
    Sprache Englisch
    Erscheinungsdatum 2021-06-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2021.06.027
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Flow controlled ventilation in Acute Respiratory Distress Syndrome associated with COVID-19: A structured summary of a study protocol for a randomised controlled trial.

    Roehrig, Stefan / Ait Hssain, Ali / Shallik, Nabil Al Hamid / Elsaid, Ingi Mohamed A / Mustafa, Salma Faisal / Smain, Osama A M / Molokhia, Ashraf Abdulla / Lance, Marcus D

    Trials

    2020  Band 21, Heft 1, Seite(n) 781

    Abstract: Objectives: This study aims to demonstrate the positive effects on oxygenation of flow-controlled ventilation compared to conventionally ventilated patients in patients suffering from Acute respiratory distress syndrome (ARDS) associated with COVID-19 ... ...

    Abstract Objectives: This study aims to demonstrate the positive effects on oxygenation of flow-controlled ventilation compared to conventionally ventilated patients in patients suffering from Acute respiratory distress syndrome (ARDS) associated with COVID-19.We define ARDS according to the "Berlin" definition integrating the oxygenation index (P/F ratio), the level of Positive End Expiratory Pressure (PEEP), radiological and clinical findings.
    Trial design: This is a prospective, randomized (1:1 ratio), parallel group feasibility study in adult patients with proven COVID-19 associated ARDS.
    Participants: All adult patients admitted to the ICU of Hamad Medical Corporation facilities in Qatar because of COVID-19 infection who develop moderate to severe ARDS are eligible. The inclusion criteria are above 18 years of age, proven COVID-19 infection, respiratory failure necessitating intubation and mechanical ventilation, ARDS with a P/F ratio of at least 200mmHg or less and a minimum PEEP 5cmH2O, BMI less 30 kg/ m2. The following exclusion criteria: no written consent, chronic respiratory disease, acute or chronic cardiovascular disease, pregnancy or need for special therapy (prone position and/or Extracorporeal membrane oxygenation).
    Intervention and comparator: After randomisation, the group A patients will be ventilated with the test-device for 48 hours. The settings will be started with the pre-existing-PEEP. The upper pressure will be determined to achieve a tidal volume of 6 ml/kg lean body mass, while the respiratory rate will be set to maintain an arterial pH above 7.2. In group B, the ventilator settings will be adjusted by the attending ICU team in accordance with lung-protective ventilation strategy. All other treatment will be unchanged and according to our local policies/guidelines.
    Main outcomes: The primary end point is PaO2. As this is a dynamic parameter, we will record it every 6-8 hours and analyse it sequentially.
    Randomisation: The study team screens the ventilated patients who fulfil the inclusion criteria and randomise using a 1:1 allocation ratio after consenting using a closed envelope method. The latter were prepared and sealed in advance by an independent person.
    Blinding (masking): Due to the technical nature of the study (use of a specific ventilator) blinding is only possible for the data-analysts and the patients.
    Numbers to be randomised (sample size): The sample size calculation based on the assumption of an effect size (change in PaO2) of 1.5 SDS in the primary endpoint (PaO2), an intended power of 80%, an alpha error of 5% and an equal sample ratio results in n=7 patients needed to treat. However, to compensate for dropouts we will include 10 patients in each group, which means in total 20 patients.
    Trial status: The local registration number is MRC-05-018 with the protocol version number 3. The date of approval is 14
    Trial registration: The protocol was registered before starting subject recruitment under the title: "Flow controlled ventilation in ARDS associated with COVID-19" in ClinicalTrials.org with the registration number: NCT04399317 . Registered on 22 May 2020.
    Full protocol: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.
    Mesh-Begriff(e) Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/physiopathology ; Coronavirus Infections/therapy ; Coronavirus Infections/virology ; Feasibility Studies ; Host-Pathogen Interactions ; Humans ; Lung/physiopathology ; Lung/virology ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; Prospective Studies ; Qatar ; Randomized Controlled Trials as Topic ; Respiration, Artificial/adverse effects ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/physiopathology ; Respiratory Distress Syndrome/therapy ; Respiratory Distress Syndrome/virology ; SARS-CoV-2 ; Time Factors ; Treatment Outcome
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-09-11
    Erscheinungsland England
    Dokumenttyp Clinical Trial Protocol ; Letter
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-020-04708-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Flow controlled ventilation in Acute Respiratory Distress Syndrome associated with COVID-19

    Roehrig, Stefan / Ait Hssain, Ali / Shallik, Nabil Al Hamid / Elsaid, Ingi Mohamed A. / Mustafa, Salma Faisal / Smain, Osama A. M. / Molokhia, Ashraf Abdulla / Lance, Marcus D.

    Trials

    A structured summary of a study protocol for a randomised controlled trial

    2020  Band 21, Heft 1

    Abstract: Abstract Objectives This study aims to demonstrate the positive effects on oxygenation of flow-controlled ventilation compared to conventionally ventilated patients in patients suffering from Acute respiratory distress syndrome (ARDS) associated with ... ...

    Abstract Abstract Objectives This study aims to demonstrate the positive effects on oxygenation of flow-controlled ventilation compared to conventionally ventilated patients in patients suffering from Acute respiratory distress syndrome (ARDS) associated with COVID-19.We define ARDS according to the “Berlin” definition integrating the oxygenation index (P/F ratio), the level of Positive End Expiratory Pressure (PEEP), radiological and clinical findings. Trial design This is a prospective, randomized (1:1 ratio), parallel group feasibility study in adult patients with proven COVID-19 associated ARDS. Participants All adult patients admitted to the ICU of Hamad Medical Corporation facilities in Qatar because of COVID-19 infection who develop moderate to severe ARDS are eligible. The inclusion criteria are above 18 years of age, proven COVID-19 infection, respiratory failure necessitating intubation and mechanical ventilation, ARDS with a P/F ratio of at least 200mmHg or less and a minimum PEEP 5cmH2O, BMI less 30 kg/ m2. The following exclusion criteria: no written consent, chronic respiratory disease, acute or chronic cardiovascular disease, pregnancy or need for special therapy (prone position and/or Extracorporeal membrane oxygenation). Intervention and comparator After randomisation, the group A patients will be ventilated with the test-device for 48 hours. The settings will be started with the pre-existing-PEEP. The upper pressure will be determined to achieve a tidal volume of 6 ml/kg lean body mass, while the respiratory rate will be set to maintain an arterial pH above 7.2. In group B, the ventilator settings will be adjusted by the attending ICU team in accordance with lung-protective ventilation strategy. All other treatment will be unchanged and according to our local policies/guidelines. Main outcomes The primary end point is PaO2. As this is a dynamic parameter, we will record it every 6-8 hours and analyse it sequentially. Randomisation The study team screens the ventilated patients who fulfil the inclusion criteria and randomise using a 1:1 allocation ratio after consenting using a closed envelope method. The latter were prepared and sealed in advance by an independent person. Blinding (masking) Due to the technical nature of the study (use of a specific ventilator) blinding is only possible for the data-analysts and the patients. Numbers to be randomised (sample size) The sample size calculation based on the assumption of an effect size (change in PaO2) of 1.5 SDS in the primary endpoint (PaO2), an intended power of 80%, an alpha error of 5% and an equal sample ratio results in n=7 patients needed to treat. However, to compensate for dropouts we will include 10 patients in each group, which means in total 20 patients. Trial Status The local registration number is MRC-05-018 with the protocol version number 3. The date of approval is 14 th April 2020. Recruitment began 28th May 2020 and is expected to end in September 2020. Trial registration The protocol was registered before starting subject recruitment under the title: “Flow controlled ventilation in ARDS associated with COVID-19” in ClinicalTrials.org with the registration number: NCT04399317 . Registered on 22 May 2020. Full protocol The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.
    Schlagwörter Medicine (miscellaneous) ; Pharmacology (medical) ; covid19
    Sprache Englisch
    Verlag Springer Science and Business Media LLC
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 2040523-6
    ISSN 1468-6694 ; 1745-6215 ; 1468-6708
    ISSN (online) 1468-6694 ; 1745-6215
    ISSN 1468-6708
    DOI 10.1186/s13063-020-04708-1
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel: Flow controlled ventilation in Acute Respiratory Distress Syndrome associated with COVID-19: A structured summary of a study protocol for a randomised controlled trial

    Roehrig, Stefan / Ait Hssain, Ali / Shallik, Nabil Al Hamid / Elsaid, Ingi Mohamed A / Mustafa, Salma Faisal / Smain, Osama A M / Molokhia, Ashraf Abdulla / Lance, Marcus D

    Trials

    Abstract: OBJECTIVES: This study aims to demonstrate the positive effects on oxygenation of flow-controlled ventilation compared to conventionally ventilated patients in patients suffering from Acute respiratory distress syndrome (ARDS) associated with COVID-19.We ...

    Abstract OBJECTIVES: This study aims to demonstrate the positive effects on oxygenation of flow-controlled ventilation compared to conventionally ventilated patients in patients suffering from Acute respiratory distress syndrome (ARDS) associated with COVID-19.We define ARDS according to the "Berlin" definition integrating the oxygenation index (P/F ratio), the level of Positive End Expiratory Pressure (PEEP), radiological and clinical findings. TRIAL DESIGN: This is a prospective, randomized (1:1 ratio), parallel group feasibility study in adult patients with proven COVID-19 associated ARDS. PARTICIPANTS: All adult patients admitted to the ICU of Hamad Medical Corporation facilities in Qatar because of COVID-19 infection who develop moderate to severe ARDS are eligible. The inclusion criteria are above 18 years of age, proven COVID-19 infection, respiratory failure necessitating intubation and mechanical ventilation, ARDS with a P/F ratio of at least 200mmHg or less and a minimum PEEP 5cmH2O, BMI less 30 kg/ m2. The following exclusion criteria: no written consent, chronic respiratory disease, acute or chronic cardiovascular disease, pregnancy or need for special therapy (prone position and/or Extracorporeal membrane oxygenation). INTERVENTION AND COMPARATOR: After randomisation, the group A patients will be ventilated with the test-device for 48 hours. The settings will be started with the pre-existing-PEEP. The upper pressure will be determined to achieve a tidal volume of 6 ml/kg lean body mass, while the respiratory rate will be set to maintain an arterial pH above 7.2. In group B, the ventilator settings will be adjusted by the attending ICU team in accordance with lung-protective ventilation strategy. All other treatment will be unchanged and according to our local policies/guidelines. MAIN OUTCOMES: The primary end point is PaO2. As this is a dynamic parameter, we will record it every 6-8 hours and analyse it sequentially. RANDOMISATION: The study team screens the ventilated patients who fulfil the inclusion criteria and randomise using a 1:1 allocation ratio after consenting using a closed envelope method. The latter were prepared and sealed in advance by an independent person. BLINDING (MASKING): Due to the technical nature of the study (use of a specific ventilator) blinding is only possible for the data-analysts and the patients. NUMBERS TO BE RANDOMISED (SAMPLE SIZE): The sample size calculation based on the assumption of an effect size (change in PaO2) of 1.5 SDS in the primary endpoint (PaO2), an intended power of 80%, an alpha error of 5% and an equal sample ratio results in n=7 patients needed to treat. However, to compensate for dropouts we will include 10 patients in each group, which means in total 20 patients. TRIAL STATUS: The local registration number is MRC-05-018 with the protocol version number 3. The date of approval is 14th April 2020. Recruitment began 28th May 2020 and is expected to end in September 2020. TRIAL REGISTRATION: The protocol was registered before starting subject recruitment under the title: "Flow controlled ventilation in ARDS associated with COVID-19" in ClinicalTrials.org with the registration number: NCT04399317 . Registered on 22 May 2020. FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #751154
    Datenquelle COVID19

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  9. Artikel ; Online: AVPR1A and SLC6A4 polymorphisms in choral singers and non-musicians: a gene association study.

    Morley, Andrew P / Narayanan, Madan / Mines, Rebecca / Molokhia, Ashraf / Baxter, Sebastian / Craig, Gavin / Lewis, Cathryn M / Craig, Ian

    PloS one

    2012  Band 7, Heft 2, Seite(n) e31763

    Abstract: Amateur choral singing is a common pastime and worthy of study, possibly conferring benefits to health and social behaviour. Participants might be expected to possess musical ability and share some behavioural characteristics. Polymorphisms in genes ... ...

    Abstract Amateur choral singing is a common pastime and worthy of study, possibly conferring benefits to health and social behaviour. Participants might be expected to possess musical ability and share some behavioural characteristics. Polymorphisms in genes concerned with serotonergic neurotransmission are associated with both behaviour and musical aptitude. Those investigated previously include the variable number tandem repeats RS1, RS3 and AVR in the AVPR1A (arginine vasopressin receptor 1a) gene and STin2 in the SLC6A4 (solute carrier family 6 [neurotransmitter transporter, serotonin], member 4) gene, as well as the SLC6A4 promoter region polymorphism, 5-HTTLPR. We conducted a genetic association study on 523 participants to establish whether alleles at these polymorphisms occur more commonly in choral singers than in those not regularly participating in organised musical activity (non-musicians). We also analysed tagging single nucleotide polymorphisms (SNPs) for AVPR1A and SLC6A4 to determine whether other variants in these genes were associated with singer/non-musician status. At the STin2 polymorphism, overall association with singer/non-musician status was evident at P = 0.006. The 9-repeat (P = 0.04) and 12-repeat (P = 0.04) alleles were more common in singers and the 10-repeat allele less so (P = 0.009). Odds ratios were 0.73 (95% CI 0.57-0.94) for the 10-repeat allele and 2.47 (95% CI 0.88-6.94) for the rarer 9-repeat allele. No overall association was detected at P<0.05 between any other polymorphism and singer/non-musician status. Our null findings with respect to RS3, RS1 and AVR, polymorphisms associated with musical ability by other authors, suggest that choir membership may depend partly on factors other than musical ability. In a related musical project involving one participating choir, a new 40-part unaccompanied choral work, "Allele", was composed and broadcast on national radio. In the piece, each singer's part incorporated their personal RS3 genotype.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alleles ; Female ; Genotype ; Haplotypes ; Homozygote ; Humans ; Male ; Middle Aged ; Minisatellite Repeats ; Models, Genetic ; Music ; Odds Ratio ; Phenotype ; Polymorphism, Genetic ; Receptors, Vasopressin/genetics ; Serotonin Plasma Membrane Transport Proteins/genetics
    Chemische Substanzen Receptors, Vasopressin ; SLC6A4 protein, human ; Serotonin Plasma Membrane Transport Proteins
    Sprache Englisch
    Erscheinungsdatum 2012-02-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0031763
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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