Article ; Online: lncRNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiation.
Life science alliance
2024 Volume 7, Issue 7
Abstract: Numerous long non-coding RNAs (lncRNAs) were shown to have a functional impact on cellular processes such as human epidermal homeostasis. However, the mechanism of action for many lncRNAs remains unclear to date. Here, we report that lncRNA LINC00941 ... ...
| Abstract | Numerous long non-coding RNAs (lncRNAs) were shown to have a functional impact on cellular processes such as human epidermal homeostasis. However, the mechanism of action for many lncRNAs remains unclear to date. Here, we report that lncRNA LINC00941 regulates keratinocyte differentiation on an epigenetic level through association with the NuRD complex, one of the major chromatin remodelers in cells. We find that LINC00941 interacts with NuRD-associated MTA2 and CHD4 in human primary keratinocytes. LINC00941 perturbation changes MTA2/NuRD occupancy at bivalent chromatin domains in close proximity to transcriptional regulator genes, including the |
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| MeSH term(s) | Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Cell Differentiation/genetics ; Keratinocytes/metabolism ; Keratinocytes/cytology ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/metabolism ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/genetics ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Epidermis/metabolism ; Histone Deacetylases/metabolism ; Histone Deacetylases/genetics ; Early Growth Response Protein 3/genetics ; Early Growth Response Protein 3/metabolism ; Epigenesis, Genetic ; Epidermal Cells/metabolism ; Epidermal Cells/cytology ; Chromatin/metabolism ; Chromatin/genetics ; Gene Expression Regulation ; Cells, Cultured |
| Chemical Substances | RNA, Long Noncoding ; Mi-2 Nucleosome Remodeling and Deacetylase Complex (EC 3.5.1.98) ; Repressor Proteins ; MTA2 protein, human (EC 3.5.1.-) ; Histone Deacetylases (EC 3.5.1.98) ; Early Growth Response Protein 3 (144516-98-3) ; EGR3 protein, human ; Chromatin |
| Language | English |
| Publishing date | 2024-04-22 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 2575-1077 |
| ISSN (online) | 2575-1077 |
| DOI | 10.26508/lsa.202302475 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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