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  1. Book: Haemostasis

    Monagle, Paul T.

    methods and protocols

    (Methods in molecular biology ; 992 ; Springer protocols)

    2013  

    Author's details ed. by Paul Monagle
    Series title Methods in molecular biology ; 992
    Springer protocols
    Collection
    Language English
    Size XII, 431 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017612603
    ISBN 978-1-62703-338-1 ; 9781627033398 ; 1-62703-338-6 ; 1627033394
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2013 A 636 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Slow progress. How do we shift the paradigm of thinking in pediatric thrombosis and anticoagulation?

    Monagle, Paul

    Thrombosis research

    2018  Volume 173, Page(s) 186–190

    Abstract: Since Maureen Andrew began systematically describing thrombosis in children in 1994, there has been surprisingly slow process in advancing our knowledge in terms of diagnosis, prevention and treatment of thrombosis in children. There are a variety of ... ...

    Abstract Since Maureen Andrew began systematically describing thrombosis in children in 1994, there has been surprisingly slow process in advancing our knowledge in terms of diagnosis, prevention and treatment of thrombosis in children. There are a variety of reasons for this slow progress. Overwhelmingly the low incidence of thrombosis in children has been a major barrier. Second, the developmental, age related, changes in haemostasis mean that the physiology of haemostasis in children, and the interaction of the haemostatic system with anticoagulant drugs is constantly changing. This presents further challenges in identifying the risk benefit ratio of therapies. In addition, the failure to adequately understand the subtleties of pathogenesis of the variety of thrombotic syndromes, and the failure to know the natural history of many types of thrombosis are also significant problems. We continue to try and solve these problems by extrapolation, not just of adult based data, but of methodologies for research founded in the adult paradigm. If we are truly going to improve our understanding of thrombosis in children and improve our ability to prevent and adequately treat thrombosis in this population, then we need multiple paradigm shifts; First, in the way we think about thrombosis and anticoagulation in children. Second in the way we design and conduct research studies to provide evidence on which to base the care of children suffering from thrombosis in the future.
    MeSH term(s) Anticoagulants/therapeutic use ; Blood Coagulation/drug effects ; Child ; Humans ; Incidence ; Infant ; Thrombosis/diagnosis ; Thrombosis/drug therapy ; Thrombosis/epidemiology ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/epidemiology
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2018-07-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2018.07.016
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  3. Article ; Online: Baby steps in managing CVAD-related thrombosis.

    Monagle, Paul / Newall, Fiona

    Blood

    2022  Volume 139, Issue 3, Page(s) 321–322

    MeSH term(s) Central Venous Catheters ; Humans ; Thrombosis/etiology
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021014615
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  4. Article ; Online: The value of the old and the new.

    Monagle, Paul / Male, Christoph / Raffini, Leslie

    Blood advances

    2023  Volume 7, Issue 14, Page(s) 3683–3685

    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023009723
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  5. Article ; Online: At last: evidence rather than emotion.

    Monagle, Paul

    Blood

    2017  Volume 129, Issue 20, Page(s) 2714–2715

    MeSH term(s) Humans ; Stroke ; Thrombophilia
    Language English
    Publishing date 2017-05-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-03-772095
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  6. Article ; Online: Surgeons' perspectives on operation report documentation.

    Fink, Teagan / Holmes, Tony / Monagle, Paul / Penington, Tony

    ANZ journal of surgery

    2023  Volume 93, Issue 11, Page(s) 2626–2630

    Abstract: Background: Operation report documentation is essential for safe patient care and team communication, yet it is often imperfect. This qualitative study aims to understand surgeons' perspectives on operation report documentation, with surgeons reviewing ... ...

    Abstract Background: Operation report documentation is essential for safe patient care and team communication, yet it is often imperfect. This qualitative study aims to understand surgeons' perspectives on operation report documentation, with surgeons reviewing cleft palate repair operation reports. It aims to determine how surgeons write an operation report (in narrative and synoptic report formats) and explore the consequences of incomplete documentation on patient care.
    Methods: A qualitative semi-structured interview was conducted with cleft surgeons who were asked to consider operation reports and hypothetical clinical cases. Eight operation reports performed at one centre for cleft palate repair were randomly selected for review.
    Results: An operation report's purpose-patient care, complication documentation, future surgery, and research-will influence the detail documented. All cleft palate repair operation reports had important information missing. Synoptic report writing provides clearer documentation; however, narrative report writing may be a more robust communication and education tool. Surgeons described a bell-curve response in the level of training required to document an operation report-residents knew too little, fellows documented clearly, and Consultants documented briefer reports to highlight salient points.
    Conclusions: An understanding of surgeons' perspectives on operation report documentation is richer after this study. Surgeons know that clear documentation is essential for patient care and a skill that must be taught to trainees; barriers may be the documentation method. The flexibility of a hybrid operation report format is necessary for surgical care.
    MeSH term(s) Humans ; Cleft Palate/surgery ; Surgeons ; Documentation
    Language English
    Publishing date 2023-07-26
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.18619
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  7. Article ; Online: Technical report: The clinically useful selection of proteins protocol: An approach to identify clinically useful proteins for validation.

    Swaney, Ella E K / Hearps, Stephen / Monagle, Paul / Roehrl, Michael H A / Ignjatovic, Vera

    Journal of proteomics

    2024  Volume 296, Page(s) 105110

    Abstract: Clinical proteomics studies aiming to develop markers of clinical outcome or disease typically involve distinct discovery and validation stages, neither of which focus on the clinical applicability of the candidate markers studied. Our clinically useful ... ...

    Abstract Clinical proteomics studies aiming to develop markers of clinical outcome or disease typically involve distinct discovery and validation stages, neither of which focus on the clinical applicability of the candidate markers studied. Our clinically useful selection of proteins (CUSP) protocol proposes a rational approach, with statistical and non-statistical components, to identify proteins for the validation phase of studies that could be most effective markers of disease or clinical outcome. Additionally, this protocol considers commercially available analysis methods for each selected protein to ensure that use of this prospective marker is easily translated into clinical practice. SIGNIFICANCE: When developing proteomic markers of clinical outcomes, there is currently no consideration at the validation stage of how to implement such markers into a clinical setting. This has been identified by several studies as a limitation to the progression of research findings from proteomics studies. When integrated into a proteomic workflow, the CUSP protocol allows for a strategically designed validation study that improves researchers' abilities to translate research findings from discovery-based proteomics into clinical practice.
    MeSH term(s) Proteomics/methods ; Biomarkers/metabolism ; Prospective Studies ; Proteins
    Chemical Substances Biomarkers ; Proteins
    Language English
    Publishing date 2024-02-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2400835-7
    ISSN 1876-7737 ; 1874-3919
    ISSN (online) 1876-7737
    ISSN 1874-3919
    DOI 10.1016/j.jprot.2024.105110
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  8. Article ; Online: What did we learn (and did not learn) from the pediatric direct oral anticoagulant trials, and how might we better design pediatric anticoagulant trials in the future?

    Betensky, Marisol / Monagle, Paul / Male, Christoph / Goldenberg, Neil A

    Research and practice in thrombosis and haemostasis

    2023  Volume 7, Issue 3, Page(s) 100140

    Abstract: A State of the Art lecture titled "What the direct oral anticoagulants (DOACs) trials did and didn't tell us" was presented at the International Society on Thrombosis and Haemostasis (ISTH) Congress in 2022. The use of DOACs in children is of particular ... ...

    Abstract A State of the Art lecture titled "What the direct oral anticoagulants (DOACs) trials did and didn't tell us" was presented at the International Society on Thrombosis and Haemostasis (ISTH) Congress in 2022. The use of DOACs in children is of particular interest as they exhibit several advantages over conventional anticoagulation agents most commonly used in pediatrics. To date, several DOAC pediatric investigational programs (PIPs) have been completed, and although they have provided some of the best quality of evidence in pediatric anticoagulation therapy, the data generated by these trials remain limited. Here, we review and summarize the currently available data provided by the DOAC PIPs, provide perspectives on what we have and have not learned from these trials, and how we might leverage this knowledge to optimize the design of future anticoagulant PIPs. Finally, we summarize relevant new data on this topic presented during the 2022 ISTH Congress.
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1016/j.rpth.2023.100140
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  9. Article ; Online: Newborn and Pediatric Reference Intervals for Coagulation Assays Using Novel Reagents.

    Letunica, Natasha / Karlaftis, Vasiliki / Monagle, Paul / Ignjatovic, Vera

    Thrombosis and haemostasis

    2022  Volume 122, Issue 12, Page(s) 2042–2044

    MeSH term(s) Infant, Newborn ; Child ; Humans ; Indicators and Reagents ; Blood Coagulation Tests ; Reference Values
    Chemical Substances Indicators and Reagents
    Language English
    Publishing date 2022-11-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0042-1756437
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  10. Article: Platelet Transfusion During Extracorporeal Membrane Oxygenation: Possible Harm, Ongoing Uncertainty.

    MacLaren, Graeme / Monagle, Paul

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2020  Volume 21, Issue 2, Page(s) 208–209

    MeSH term(s) Child ; Erythrocyte Transfusion ; Extracorporeal Membrane Oxygenation ; Humans ; Longitudinal Studies ; Platelet Transfusion ; Uncertainty
    Language English
    Publishing date 2020-02-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000002111
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