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Article ; Online: Reply to: Flaws in the meta-analysis of comparison between different types of exercise training in patients with type 2 diabetes mellitus: A letter to the editor.

Mannucci, Edoardo / Monami, Matteo

Nutrition, metabolism, and cardiovascular diseases : NMCD

2022 Volume 32, Issue 7, Page(s) 1810

MeSH term(s)	Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/therapy ; Exercise ; Humans ; Meta-Analysis as Topic
Language	English
Publishing date	2022-04-22
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	1067704-5
ISSN	1590-3729 ; 0939-4753
ISSN (online)	1590-3729
ISSN	0939-4753
DOI	10.1016/j.numecd.2022.04.012
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Article: Autologous Peripheral Blood Mononuclear Cells in Patients with Small Artery Disease and Diabetic Foot Ulcers: Efficacy, Safety, and Economic Evaluation.

Ragghianti, Benedetta / Berardi, Bianca Maria / Mannucci, Edoardo / Monami, Matteo

Journal of clinical medicine

2023 Volume 12, Issue 12

Abstract: Background: diabetic foot ulcers (DFU) represent the main cause of major amputations and hospitalisations in diabetic patients. The aim of this study was to assess the safety and cost-efficacy of intramuscular injection of peripheral blood mononuclear ... ...

Abstract	Background: diabetic foot ulcers (DFU) represent the main cause of major amputations and hospitalisations in diabetic patients. The aim of this study was to assess the safety and cost-efficacy of intramuscular injection of peripheral blood mononuclear cells (PBMNCs) in diabetic patients with no-option chronic limb-threatening ischemia (CLTI) and small artery disease (SAD). Methods: a retrospective study was carried out on a series of type 2 diabetic patients with DFU grade Texas 3 and no-option CLTI and SAD. All patients had undergone at least a previous revascularization and were allocated to a surgery waiting list for major amputation. The principal endpoint evaluated at 90 days was a composite of TcPO Results: the composite endpoint was achieved in nine patients (60.0%); one patient (6.7%) healed within ninety days and 26.7% and 46.7% showed TcPO Conclusions: the use of PBMNCs implants in no-option CLTI diabetic patients with SAD seems to be of help in reducing the risk of major amputation.
Language	English
Publishing date	2023-06-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12124148
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Article ; Online: Metformin may not reduce cardiovascular risk or all-cause mortality.

Monami, Matteo

Evidence-based medicine

2013 Volume 18, Issue 2, Page(s) e13

MeSH term(s)	Diabetes Mellitus, Type 2/drug therapy ; Diabetic Angiopathies/mortality ; Humans ; Metformin/therapeutic use ; Outcome Assessment (Health Care)
Chemical Substances	Metformin (9100L32L2N)
Language	English
Publishing date	2013-04
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	1324346-9
ISSN	1473-6810 ; 1356-5524
ISSN (online)	1473-6810
ISSN	1356-5524
DOI	10.1136/eb-2012-100836
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Zs.A 4793: Show issues

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Article ; Online: Comparison between different types of exercise training in patients with type 2 diabetes mellitus: A systematic review and network metanalysis of randomized controlled trials.

Mannucci, Edoardo / Bonifazi, Allegra / Monami, Matteo

Nutrition, metabolism, and cardiovascular diseases : NMCD

2021 Volume 31, Issue 7, Page(s) 1985–1992

Abstract: Aim: Aim of the present meta-analysis and network metanalysis (NMA) is the assessment of the effects of physical exercise on glucose control and cardiovascular risk factors in type 2 diabetes.: Data synthesis: This metanalysis includes all available ... ...

Abstract	Aim: Aim of the present meta-analysis and network metanalysis (NMA) is the assessment of the effects of physical exercise on glucose control and cardiovascular risk factors in type 2 diabetes. Data synthesis: This metanalysis includes all available trials exploring the effects of different exercise modalities in type 2 diabetes, with a duration of ≥3 months. The standardized difference in means (SDM) with 95% Confidence Intervals were calculated. Data were analyzed using MetaXL and Rev Man 5.0. Primary endpoint was the effect of exercise versus no exercise on HbA1c and fasting plasma glucose (FPG) at endpoint. Secondary endpoints were body weight and fat, waist circumference, and blood pressure. A comparison of different exercise training modalities (aerobic, resistance and combined) for the same endpoints was also performed, choosing 'no exercise' as the reference for indirect comparisons. We included 25 trials fulfilling all inclusion criteria. Physical exercise versus no exercise produced a small, but significant, improvement of HbA1c, body fat, and systolic blood pressure at endpoint (-0.3 [-0.1;-0.4]%, -1.44 [-2.22, -0.66]%, and -5.6 [-9.5, -1.6] mmHg, respectively). Combined, supervised aerobic and resistance exercise were associated with a significantly greater reduction of HbA1c (SDM, -0.4 [-0.6;-0.3], -0.2 [-0.4;-0.1], and -0.2 [-0.3;-0.1]%, respectively), but not of FPG, in comparison with no exercise. Conclusions: Physical exercise produces small, but detectable, advantages on glycemic control and cardiovascular risk factors and should be suggested in type 2 diabetes. Combined aerobic/resistance training seems to be superior to aerobic training alone, but differences are small and the reliability of supporting evidence limited.
MeSH term(s)	Biomarkers/blood ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/physiopathology ; Diabetes Mellitus, Type 2/therapy ; Exercise Therapy/methods ; Female ; Glycated Hemoglobin A/metabolism ; Glycemic Control/methods ; Humans ; Male ; Middle Aged ; Network Meta-Analysis ; Randomized Controlled Trials as Topic ; Resistance Training ; Treatment Outcome
Chemical Substances	Biomarkers ; Blood Glucose ; Glycated Hemoglobin A ; hemoglobin A1c protein, human
Language	English
Publishing date	2021-03-20
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	1067704-5
ISSN	1590-3729 ; 0939-4753
ISSN (online)	1590-3729
ISSN	0939-4753
DOI	10.1016/j.numecd.2021.02.030
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Zs.A 3149: Show issues

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Article: Effects of pioglitazone on cardiovascular events and all-cause mortality in patients with type 2 diabetes: A meta-analysis of randomized controlled trials

Mannucci, Edoardo / Giaccari, Andrea / Gallo, Marco / Targher, Giovanni / Pintaudi, Basilio / Candido, Riccardo / Monami, Matteo

The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University Nutrition, metabolism, and cardiovascular diseases. 2022 Mar., v. 32, no. 3

2022

Abstract: In 2019, the Italian Society of Diabetology and the Italian Association of Clinical Diabetologists nominated an expert panel to develop guidelines for drug treatment of type 2 diabetes. After identifying the effects of glucose-lowering agents on major ... ...

Institution	SID-AMD joint panel for Italian Guidelines on Treatment of Type 2 Diabetes
Abstract	In 2019, the Italian Society of Diabetology and the Italian Association of Clinical Diabetologists nominated an expert panel to develop guidelines for drug treatment of type 2 diabetes. After identifying the effects of glucose-lowering agents on major adverse cardiovascular events (MACEs), all-cause mortality, and hospitalization for heart failure (HHF) as critical outcomes, the experts decided to perform a systematic review and meta-analysis on the effect of pioglitazone with this respect. A MEDLINE database search was performed to identify RCTs, up to June 1st, 2021, with duration≥52 weeks, in which pioglitazone was compared with either placebo or active comparators. The principal endpoints were MACE and HHF (restricted for RCT reporting MACEs within their outcomes), all-cause mortality (irrespective of the inclusion of MACEs among the pre-specified outcomes). Mantel-Haenszel odds ratio (MH–OR) with 95% Confidence Interval (95% CI) was calculated for all the endpoints considered. Eight RCTs were included in the analysis for MACEs and HF (5048 and 5117 patients in the pioglitazone and control group, respectively), and 24 in that for all-cause mortality (10,682 and 9674 patients). Pioglitazone neither significantly increased nor reduced the risk of MACE, all-cause mortality, and HHF in comparison with placebo/active comparators (MH–OR: 0.90, 95% CI 0.78–1.03, 0.91, 95% CI 0.77, 1.09, and 1.16, 95% CI 0.73, 1.83, respectively). Pioglitazone was associated with a significant reduction of MACE in patients with prior cardiovascular events (MH–OR 0.84, 95% CI 0.72–0.99). This meta-analysis showed no significant effects of pioglitazone on incident MACE, all-cause mortality, and HHF.
Keywords	confidence interval ; databases ; drug therapy ; heart failure ; meta-analysis ; metabolism ; mortality ; noninsulin-dependent diabetes mellitus ; nutrition ; odds ratio ; placebos ; risk ; systematic review
Language	English
Dates of publication	2022-03
Size	p. 529-536.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1067704-5
ISSN	0939-4753
ISSN	0939-4753
DOI	10.1016/j.numecd.2021.12.006
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 3149: Show issues

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Article ; Online: Glucagon-like peptide-1 and diabetes.

Monami, Matteo

Experimental diabetes research

2011 Volume 2011, Page(s) 901954

MeSH term(s)	Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/physiopathology ; Glucagon-Like Peptide 1/physiology ; Humans ; Hyperglycemia/metabolism ; Hyperglycemia/physiopathology ; Incretins/therapeutic use ; Insulin/metabolism ; Signal Transduction/physiology
Chemical Substances	Blood Glucose ; Incretins ; Insulin ; Glucagon-Like Peptide 1 (89750-14-1)
Language	English
Publishing date	2011-12-01
Publishing country	United States
Document type	Editorial ; Introductory Journal Article
ZDB-ID	2465179-5
ISSN	1687-5303 ; 1687-5214
ISSN (online)	1687-5303
ISSN	1687-5214
DOI	10.1155/2011/901954
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Article ; Online: Factors associated with increased all-cause mortality during the COVID-19 pandemic in Italy.

Mannucci, Edoardo / Nreu, Besmir / Monami, Matteo

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2020 Volume 98, Page(s) 121–124

Abstract: Background: The number of excess deaths during February-March 2020 in Italy, in comparison with previous years, was considerably higher than the recorded COVID19-related deaths. The present study aimed to explore the association of excess mortality with ...

Abstract	Background: The number of excess deaths during February-March 2020 in Italy, in comparison with previous years, was considerably higher than the recorded COVID19-related deaths. The present study aimed to explore the association of excess mortality with some indices related to the COVID-19 pandemic and its management. Methods: Data on all-cause mortality from 20 February-31 March in the years 2015-2020, and demographic, socioeconomic and healthcare organisation data of each Italian region were obtained from the Italian Institute of Statistics. Non-COVID-19-Imputed Excess Mortality (NCIEM) was calculated as the difference between the excess 2020 mortality and reported COVID-19 mortality. The association of NCIEM with the rate of COVID-19 cases, COVID-19 mortality and other potential moderators was assessed using linear regression models. Results: The nationwide number of excess deaths and COVID-19 deaths was 26,701 and 13,710, respectively, with a difference of 12,991. The NCIEM in different regions showed a direct correlation with COVID-19 mortality (r Conclusions: The impact of the COVID-19 pandemic on all-cause mortality was considerably greater than that indicated by official counts of victims. Limited testing capacity and causes of death other than COVID-19 could have contributed to the increase in overall mortality rates.
MeSH term(s)	Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/mortality ; Female ; Humans ; Italy/epidemiology ; Linear Models ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/mortality ; Prevalence ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-06-26
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2020.06.077
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Zs.A 4516: Show issues

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Article ; Online: Association between different screening strategies for SARS-CoV-2 and deaths and severe disease in Italy.

Mannucci, Edoardo / Silverii, Antonio / Monami, Matteo

International journal of clinical practice

2020 Volume 75, Issue 4, Page(s) e13867

Abstract: Background: The WHO recommends testing any suspected person with Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2), in order to limit the spread of the epidemic. In Italy, some Regions opted for extensive testing, whereas others limited tests ...

Abstract	Background: The WHO recommends testing any suspected person with Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2), in order to limit the spread of the epidemic. In Italy, some Regions opted for extensive testing, whereas others limited tests to selected subjects. To assess the influence of different strategies, we examined the incidence of death and severe cases in Italy. Methods: Data on new cases of SARS-CoV-2, number of tests, deaths and admissions to Intensive Care Units (ICU) were retrieved in each Italian Region, from 24 February to 18 March 2020. As an index of different screening strategies, the number of tests/positive test results (P/T) ratio as of 7 March 2020, was considered. The cumulative number of deaths and of new severe cases, between March 23 and 25 was recorded. The association of those two outcomes with the number of P/T ratio was assessed using linear regression models. Results: In the interval between March 23 and 25, recorded deaths (million inhabitants) were 14 (3-54), whereas severe cases were 31 (10-112). Both the number of deaths and that of severe cases showed a significant correlation (R Conclusions:* A more aggressive screening strategy for SARS-Cov-2, was associated with lower rates of death and severe disease in Regions of Italy.
MeSH term(s)	COVID-19/diagnosis ; COVID-19/microbiology ; Epidemics ; Humans ; Italy/epidemiology ; Mass Screening ; SARS-CoV-2
Language	English
Publishing date	2020-12-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1111/ijcp.13867
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Article ; Online: Metabolic surgery for the treatment of type 2 diabetes: A network meta-analysis of randomized controlled trials.

Cresci, Barbara / Cosentino, Claudia / Monami, Matteo / Mannucci, Edoardo

Diabetes, obesity & metabolism

2020 Volume 22, Issue 8, Page(s) 1378–1387

Abstract: Aim: To compare different types of metabolic surgery (MS) with medical therapy (MT) for the treatment of type 2 diabetes (T2D).: Materials and methods: We conducted a network-meta-analysis (NMA) including randomized clinical trials comparing ... ...

Abstract	Aim: To compare different types of metabolic surgery (MS) with medical therapy (MT) for the treatment of type 2 diabetes (T2D). Materials and methods: We conducted a network-meta-analysis (NMA) including randomized clinical trials comparing different MS techniques versus MT in people with T2D, with a duration of ≥24 weeks. Primary endpoints were glycated haemoglobin (HbA1c), fasting plasma glucose (FPG) and diabetes remission. Indirect comparisons of different types of surgery were performed by NMA. Mean and 95% confidence intervals for continuous variables, and Mantel-Haenzel odds ratios for categorial variables, were calculated using random effect models. Types of MS included: laparoscopic adjustable gastric banding (LAGB), Roux-en-Y gastric bypass, sleeve gastrectomy (SG), bilio-pancreatic diversion (BPD); greater curvature plication (GCP); one-anastomosis gastric bypass (OAGB); and duodenojejunal bypass. Results: The 24 retrieved trials included 1351 patients (1014 with MS and 337 with MT). The mean baseline BMI was 36.8 kg/m Conclusions: Metabolic surgery is an interesting option for the treatment of T2D, although further data are needed to demonstrate its long-term efficacy and safety. Present data are not sufficient to modify current recommendations, which consider MS a possible treatment for T2D in those with a BMI >35 kg/m
MeSH term(s)	Bariatric Surgery ; Body Mass Index ; Diabetes Mellitus, Type 2/surgery ; Gastrectomy ; Gastric Bypass ; Humans ; Network Meta-Analysis ; Obesity, Morbid/surgery ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Weight Loss
Language	English
Publishing date	2020-05-04
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.14045
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Article ; Online: Sodium-glucose co-transporter-2 inhibitors and all-cause mortality: A meta-analysis of randomized controlled trials.

Silverii, Giovanni Antonio / Monami, Matteo / Mannucci, Edoardo

Diabetes, obesity & metabolism

2020 Volume 23, Issue 4, Page(s) 1052–1056

Abstract: The present meta-analysis is aimed at assessing the effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors on all-cause mortality and differences across different trials and molecules of the class. We included all randomized clinical trials with a ...

Abstract	The present meta-analysis is aimed at assessing the effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors on all-cause mortality and differences across different trials and molecules of the class. We included all randomized clinical trials with a duration of treatment longer than 52 weeks, enrolling at least 100 patients in each arm, and comparing an SGLT2 inhibitor with any comparator or placebo. Out of 139, 235 and 145 items identified, 21 trials were selected, enrolling 39 593 and 30 771 patients in SGLT2 inhibitor and comparator arms, respectively, with a median duration of 104 weeks, and reporting 2474 and 2298 deaths for SGLT2 inhibitors and comparators, respectively. No relevant heterogeneity was found (I
MeSH term(s)	Benzhydryl Compounds ; Diabetes Mellitus, Type 2/drug therapy ; Glucose ; Glucosides ; Humans ; Hypoglycemic Agents/therapeutic use ; Randomized Controlled Trials as Topic ; Sodium ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Symporters
Chemical Substances	Benzhydryl Compounds ; Glucosides ; Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors ; Symporters ; Sodium (9NEZ333N27) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2020-12-23
Publishing country	England
Document type	Journal Article ; Meta-Analysis
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.14286
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