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  1. Article ; Online: Why does the pUG tail curl?

    Monchaud, David

    Molecular cell

    2023  Volume 83, Issue 3, Page(s) 330–331

    Abstract: Roschdi et al. ...

    Abstract Roschdi et al.
    MeSH term(s) Animals ; Dogs ; RNA ; G-Quadruplexes
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2022.12.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5055: Show issues Location:
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  2. Article ; Online: Template-Assembled Synthetic G-Quartets (TASQs): multiTASQing Molecular Tools for Investigating DNA and RNA G-Quadruplex Biology.

    Monchaud, David

    Accounts of chemical research

    2023  Volume 56, Issue 3, Page(s) 350–362

    Abstract: Biomimetics is defined as a " ...

    Abstract Biomimetics is defined as a "
    MeSH term(s) Humans ; G-Quadruplexes ; Ligands ; RNA/chemistry ; DNA/chemistry ; Biology
    Chemical Substances Ligands ; RNA (63231-63-0) ; DNA (9007-49-2)
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483291-4
    ISSN 1520-4898 ; 0001-4842
    ISSN (online) 1520-4898
    ISSN 0001-4842
    DOI 10.1021/acs.accounts.2c00757
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  3. Article ; Online: Quadruplexes d’ADN : structures, fonctions et détection.

    Monchaud, David

    Medecine sciences : M/S

    2017  Volume 33, Issue 12, Page(s) 1042–1045

    Title translation Quadruplex-DNA: structures, functions and detection.
    MeSH term(s) Animals ; DNA/chemistry ; DNA/isolation & purification ; DNA/physiology ; DNA, Cruciform/chemistry ; DNA, Cruciform/isolation & purification ; DNA, Cruciform/physiology ; G-Quadruplexes ; Humans
    Chemical Substances DNA, Cruciform ; DNA (9007-49-2)
    Language French
    Publishing date 2017-12-20
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/20173312008
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    Zs.B 2872: Show issues Location:
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  4. Book ; Online: Quadruplex detection in human cells

    Monchaud, David

    2019  

    Abstract: DNA and RNA quadruplexes are extensively studied for the key roles they are suspected to play in the cellular regulation networks at both genomic and transcriptomic levels. The reliable detection of quadruplexes in cells was and remains a challenging ... ...

    Abstract DNA and RNA quadruplexes are extensively studied for the key roles they are suspected to play in the cellular regulation networks at both genomic and transcriptomic levels. The reliable detection of quadruplexes in cells was and remains a challenging task. Here, we describe the various strategies that have been implemented over the past years to visualize functionally relevant DNA and RNA quadruplexes in human cells, from immunodetection studies to the design and use of quadruplex-specific turn-on fluorescent probes.

    Comment: Review, 28 pages, 10 figures, 135 references
    Keywords Quantitative Biology - Biomolecules ; Quantitative Biology - Subcellular Processes
    Publishing date 2019-10-08
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Omics studies of DNA G-/C-quadruplexes in plants.

    Li, Mengqi / Tian, Ruiping / Monchaud, David / Zhang, Wenli

    Trends in genetics : TIG

    2022  Volume 38, Issue 10, Page(s) 999–1002

    Abstract: Genome-wide studies of DNA G- and C-quadruplexes (G4s and i-motifs, respectively) can boost the pace of progress towards a comprehensive understanding of their biological implications and practical applications in plants. We summarize the current state ... ...

    Abstract Genome-wide studies of DNA G- and C-quadruplexes (G4s and i-motifs, respectively) can boost the pace of progress towards a comprehensive understanding of their biological implications and practical applications in plants. We summarize the current state of knowledge about omics studies in order to highlight the current challenges and propose future directions to take studies of plant quadruplexes to the next step.
    MeSH term(s) DNA/genetics ; G-Quadruplexes ; Plants/genetics
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2022-07-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2022.06.005
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  6. Article ; Online: Global mapping of RNA G-quadruplexes (G4-RNAs) using G4RP-seq.

    Yang, Sunny Y / Monchaud, David / Wong, Judy M Y

    Nature protocols

    2022  Volume 17, Issue 3, Page(s) 870–889

    Abstract: Guanine-rich RNAs can fold into four-stranded structures, termed G-quadruplexes (G4-RNAs), and participate in a wide range of biological processes. Here we describe in detail a G4-RNA-specific precipitation (G4RP) protocol, which enables the ... ...

    Abstract Guanine-rich RNAs can fold into four-stranded structures, termed G-quadruplexes (G4-RNAs), and participate in a wide range of biological processes. Here we describe in detail a G4-RNA-specific precipitation (G4RP) protocol, which enables the transcriptomic profiling of G4-RNAs. The G4RP protocol consists of a chemical cross-linking step, followed by affinity capture with a G4-specific probe, BioTASQ. G4RP can be coupled with sequencing to capture a comprehensive global snapshot of folded G4-RNAs. This method can also be used to profile induced changes (i.e., through G4 ligand treatments) within the G4-RNA transcriptome. The entire protocol can be completed in 1-2 weeks and can be scaled up or down depending on the specific experimental goals. In addition to the protocol details, we also provide here a guide for optimization in different laboratory setups.
    MeSH term(s) G-Quadruplexes ; Ligands ; RNA/chemistry ; RNA/genetics ; Transcriptome
    Chemical Substances Ligands ; RNA (63231-63-0)
    Language English
    Publishing date 2022-02-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2244966-8
    ISSN 1750-2799 ; 1754-2189
    ISSN (online) 1750-2799
    ISSN 1754-2189
    DOI 10.1038/s41596-021-00671-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: PhpC modulates G-quadruplex-RNA landscapes in human cells.

    Mitteaux, Jérémie / Raevens, Sandy / Wang, Zi / Pirrotta, Marc / Valverde, Ibai E / Hudson, Robert H E / Monchaud, David

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 4, Page(s) 424–427

    Abstract: Stabilizing DNA/RNA G-quadruplexes (G4s) using small molecules (ligands) has proven an efficient strategy to decipher G4 biology. Quite paradoxically, this search has also highlighted the need for finding molecules able to disrupt G4s to tackle G4- ... ...

    Abstract Stabilizing DNA/RNA G-quadruplexes (G4s) using small molecules (ligands) has proven an efficient strategy to decipher G4 biology. Quite paradoxically, this search has also highlighted the need for finding molecules able to disrupt G4s to tackle G4-associated cellular dysfunctions. We report here on both qualitative and quantitative investigations that validate the G4-RNA-destabilizing properties of the leading compound PhpC in human cells.
    MeSH term(s) Humans ; RNA ; G-Quadruplexes ; DNA/genetics ; Ligands
    Chemical Substances RNA (63231-63-0) ; DNA (9007-49-2) ; Ligands
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc05155b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The multivalent G-quadruplex (G4)-ligands MultiTASQs allow for versatile click chemistry-based investigations.

    Rota Sperti, Francesco / Mitteaux, Jérémie / Zell, Joanna / Pipier, Angélique / Valverde, Ibai E / Monchaud, David

    RSC chemical biology

    2023  Volume 4, Issue 7, Page(s) 456–465

    Abstract: Chemical biology hinges on multivalent molecular tools that can specifically interrogate and/or manipulate cellular circuitries from the inside. The success of many of these approaches relies on molecular tools that make it possible to visualize ... ...

    Abstract Chemical biology hinges on multivalent molecular tools that can specifically interrogate and/or manipulate cellular circuitries from the inside. The success of many of these approaches relies on molecular tools that make it possible to visualize biological targets in cells and then isolate them for identification purposes. To this end, click chemistry has become in just a few years a vital tool in offering practically convenient solutions to address highly complicated biological questions. We report here on two clickable molecular tools, the biomimetic G-quadruplex (G4) ligands MultiTASQ and
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Journal Article
    ISSN 2633-0679
    ISSN (online) 2633-0679
    DOI 10.1039/d3cb00009e
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  9. Article ; Online: UV-induced G4 DNA structures recruit ZRF1 which prevents UV-induced senescence.

    De Magis, Alessio / Limmer, Michaela / Mudiyam, Venkat / Monchaud, David / Juranek, Stefan / Paeschke, Katrin

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 6705

    Abstract: Senescence has two roles in oncology: it is known as a potent tumor-suppressive mechanism, which also supports tissue regeneration and repair, it is also known to contribute to reduced patient resilience, which might lead to cancer recurrence and ... ...

    Abstract Senescence has two roles in oncology: it is known as a potent tumor-suppressive mechanism, which also supports tissue regeneration and repair, it is also known to contribute to reduced patient resilience, which might lead to cancer recurrence and resistance after therapy. Senescence can be activated in a DNA damage-dependent and -independent manner. It is not clear which type of genomic lesions induces senescence, but it is known that UV irradiation can activate cellular senescence in photoaged skin. Proteins that support the repair of DNA damage are linked to senescence but how they contribute to senescence after UV irradiation is still unknown. Here, we unraveled a mechanism showing that upon UV irradiation multiple G-quadruplex (G4) DNA structures accumulate in cell nuclei, which leads to the recruitment of ZRF1 to these G4 sites. ZRF1 binding to G4s ensures genome stability. The absence of ZRF1 triggers an accumulation of G4 structures, improper UV lesion repair, and entry into senescence. On the molecular level loss of ZRF1 as well as high G4 levels lead to the upregulation of DDB2, a protein associated with the UV-damage repair pathway, which drives cells into senescence.
    MeSH term(s) Humans ; DNA-Binding Proteins/metabolism ; DNA Damage ; DNA Repair ; Cellular Senescence/genetics ; DNA ; G-Quadruplexes
    Chemical Substances DNA-Binding Proteins ; DNA (9007-49-2)
    Language English
    Publishing date 2023-10-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42494-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Interactions of small molecules with DNA junctions.

    McQuaid, Kane T / Pipier, Angélique / Cardin, Christine J / Monchaud, David

    Nucleic acids research

    2022  Volume 50, Issue 22, Page(s) 12636–12656

    Abstract: The four natural DNA bases (A, T, G and C) associate in base pairs (A=T and G≡C), allowing the attached DNA strands to assemble into the canonical double helix of DNA (or duplex-DNA, also known as B-DNA). The intrinsic supramolecular properties of ... ...

    Abstract The four natural DNA bases (A, T, G and C) associate in base pairs (A=T and G≡C), allowing the attached DNA strands to assemble into the canonical double helix of DNA (or duplex-DNA, also known as B-DNA). The intrinsic supramolecular properties of nucleobases make other associations possible (such as base triplets or quartets), which thus translates into a diversity of DNA structures beyond B-DNA. To date, the alphabet of DNA structures is ripe with approximately 20 letters (from A- to Z-DNA); however, only a few of them are being considered as key players in cell biology and, by extension, valuable targets for chemical biology intervention. In the present review, we summarise what is known about alternative DNA structures (what are they? When, where and how do they fold?) and proceed to discuss further about those considered nowadays as valuable therapeutic targets. We discuss in more detail the molecular tools (ligands) that have been recently developed to target these structures, particularly the three- and four-way DNA junctions, in order to intervene in the biological processes where they are involved. This new and stimulating chemical biology playground allows for devising innovative strategies to fight against genetic diseases.
    MeSH term(s) Base Pairing ; DNA/genetics ; DNA/chemistry ; DNA, B-Form ; Nucleic Acid Conformation ; Molecular Targeted Therapy ; Ligands
    Chemical Substances DNA (9007-49-2) ; DNA, B-Form ; Ligands
    Language English
    Publishing date 2022-11-15
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkac1043
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