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Artikel ; Online: Predictive parameters of the efficacy of varicocele repair: a review.

Crafa, Andrea / Cannarella, Rossella / Condorelli, Rosita A / Mongioì, Laura M / Vignera, Sandro La / Calogero, Aldo E

2024

Abstract: Abstarct: Varicocele has a prevalence of 15% in the population and represents a primary cause of infertility in 40% of cases and a secondary cause in approximately 80% of cases. It is considered the major correctable cause of male infertility. Despite ... ...

Abstract	Abstarct: Varicocele has a prevalence of 15% in the population and represents a primary cause of infertility in 40% of cases and a secondary cause in approximately 80% of cases. It is considered the major correctable cause of male infertility. Despite its high prevalence in the infertile population, a large number of patients with varicocele do not experience reproductive difficulties. For this reason, it is still highly debated which parameters could be used to predict which patients with varicocele will be most likely to benefit from its repair. The main international and European guidelines state that treatment should only be considered in infertile patients with abnormal sperm quality. However, these guidelines do not help physicians to identify which of these patients may benefit from the treatment. Therefore, this narrative review collects the evidence in the literature on the usefulness of some factors as predictors of improvement, highlighting how some of them may be effective in an initial selection of patients to be treated, while others are promising but further studies are needed. Finally, a brief consideration on the possible role of artificial intelligence is proposed.
Sprache	Englisch
Erscheinungsdatum	2024-05-24
Erscheinungsland	China
Dokumenttyp	Journal Article
ZDB-ID	2075824-8
ISSN	1745-7262 ; 1008-682X
ISSN (online)	1745-7262
ISSN	1008-682X
DOI	10.4103/aja202420
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Examples of Inverse Comorbidity between Cancer and Neurodegenerative Diseases: A Possible Role for Noncoding RNA.

Salemi, Michele / Mogavero, Maria Paola / Lanza, Giuseppe / Mongioì, Laura M / Calogero, Aldo E / Ferri, Raffaele

Cells

2022 Band 11, Heft 12

Abstract: Cancer is one of the most common causes of death; in parallel, the incidence and prevalence of central nervous system diseases are equally high. Among neurodegenerative diseases, Alzheimer's dementia is the most common, while Parkinson's disease (PD) is ... ...

Abstract	Cancer is one of the most common causes of death; in parallel, the incidence and prevalence of central nervous system diseases are equally high. Among neurodegenerative diseases, Alzheimer's dementia is the most common, while Parkinson's disease (PD) is the second most frequent neurodegenerative disease. There is a significant amount of evidence on the complex biological connection between cancer and neurodegeneration. Noncoding RNAs (ncRNAs) are defined as transcribed nucleotides that perform a variety of regulatory functions. The mechanisms by which ncRNAs exert their functions are numerous and involve every aspect of cellular life. The same ncRNA can act in multiple ways, leading to different outcomes; in fact, a single ncRNA can participate in the pathogenesis of more than one disease-even if these seem very different, as cancer and neurodegenerative disorders are. The ncRNA activates specific pathways leading to one or the other clinical phenotype, sometimes with obvious mechanisms of inverse comorbidity. We aimed to collect from the existing literature examples of inverse comorbidity in which ncRNAs seem to play a key role. We also investigated the example of mir-519a-3p, and one of its target genes Poly (ADP-ribose) polymerase 1, for the inverse comorbidity mechanism between some cancers and PD. We believe it is very important to study the inverse comorbidity relationship between cancer and neurodegenerative diseases because it will help us to better assess these two major areas of human disease.
Mesh-Begriff(e)	Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Comorbidity ; Humans ; Neoplasms/epidemiology ; Neoplasms/genetics ; Neoplasms/pathology ; Neurodegenerative Diseases/epidemiology ; Neurodegenerative Diseases/genetics ; Parkinson Disease/pathology ; RNA, Untranslated/genetics
Chemische Substanzen	RNA, Untranslated
Sprache	Englisch
Erscheinungsdatum	2022-06-15
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11121930
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Antioxidants for male infertility: therapeutic scheme and indications. A retrospective single-center real-life study.

Cannarella, Rossella / Crafa, Andrea / Sawaid Kaiyal, Raneen / Kuroda, Shinnosuke / Barbagallo, Federica / Alamo, Angela / Mongioì, Laura M / Sapienza, Sabrina / Condorelli, Rosita A / LA Vignera, Sandro / Calogero, Aldo E

Minerva endocrinology

2024 Band 49, Heft 1, Seite(n) 13–24

Abstract: Background: This single-center real-life study was conducted to evaluate the most effective combination of nutraceuticals and the most appropriate indications for the treatment of male infertile patients.: Methods: Infertile patients aged 20-55 years ...

Abstract	Background: This single-center real-life study was conducted to evaluate the most effective combination of nutraceuticals and the most appropriate indications for the treatment of male infertile patients. Methods: Infertile patients aged 20-55 years were treated with a combination of antioxidants (Androlen Results: Forty-three patients were enrolled. In the overall analysis, only progressive motility significantly improved after therapy. Subgroup analysis showed a significant increase in progressive motility, total motile sperm count (TMSC), and in the percentage of alive spermatozoa after treatment in the group A. Progressive motility improved significantly in patients with varicocele, while the TMSC in patients with varicocele and those with idiopathic infertility. The percentage of alive spermatozoa increased in patients with testicular hypotrophy. Conclusions: Treatment with antioxidants increased progressive sperm motility, especially in patients with varicocele or idiopathic infertility.
Mesh-Begriff(e)	Humans ; Male ; Antioxidants/therapeutic use ; Antioxidants/pharmacology ; Adult ; Infertility, Male/drug therapy ; Retrospective Studies ; Middle Aged ; Varicocele/drug therapy ; Varicocele/complications ; Young Adult ; Sperm Motility/drug effects ; Sperm Count ; Dietary Supplements ; Treatment Outcome
Chemische Substanzen	Antioxidants
Sprache	Englisch
Erscheinungsdatum	2024-01-19
Erscheinungsland	Italy
Dokumenttyp	Journal Article
ZDB-ID	3062786-2
ISSN	2724-6116
ISSN (online)	2724-6116
DOI	10.23736/S2724-6507.23.04080-0
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: The Use of Ellagic Acid and Annona Muricata Improves Semen Quality in Men with High-Risk Papillomavirus Infection.

La Vignera, Sandro / Basile, Livia / Aversa, Antonio / Calogero, Aldo E / Grillo, Agata / Cannarella, Rossella / Mongioì, Laura M / Condorelli, Rosita A

Journal of clinical medicine

2022 Band 11, Heft 16

Abstract: Background: Few data are currently available on the treatment of patients with HPV infection. In particular, there is no agreement on the use of antioxidants in these patients. Ellagic acid and annona muricata appear to improve HPV clearance in infected ... ...

Abstract	Background: Few data are currently available on the treatment of patients with HPV infection. In particular, there is no agreement on the use of antioxidants in these patients. Ellagic acid and annona muricata appear to improve HPV clearance in infected women. However, it is presently unknown whether they could enhance the clearance of HPV infection in infertile male patients. Aim: To evaluate the effects of a commercially available combined compound containing ellagic acid and annona muricata on semen quality in patients with documented papillomavirus (HPV) infection, and on the frequency of HPV DNA detection in seminal fluid after treatment. In addition, anti-sperm antibodies and the percentage of spermatozoa with fragmented DNA were evaluated. Materials and methods: This was a retrospective case-control study including patients attending our center for infertility. Fifty selected patients who were positive for high risk (HR)-HPV with available semen analysis results were consecutively enrolled. Patients were classified into two groups, according to the clinician’s decision to either administer ellagic acid 100 mg and annona muricata 100 mg (combined tablet formulation) for a period of three months (Group A; 25 patients), or to re-evaluate HPV DNA after a period of active surveillance only (protected sexual intercourse) (Group B; 25 patients). Results: Group A patients had a mean age of 31.0 ± 11.0 years, while Group B was 33.0 ± 8.0 years old (p > 0.05). After three months of treatment with ellagic acid and annona muricata, all conventional seminal parameters improved more significantly in Group A than in Group B patients: sperm concentration = 45 mil/mL vs. 20 mil/mL (p < 0.05); sperm progressive motility = 45% vs. 18% (p < 0.05); and normal sperm morphology = 18% vs. 6% (p < 0.05). After the treatment, the frequency of persistence of HPV DNA in the seminal fluid was significantly lower in Group A patients compared to those in Group B (12/25 = 48% vs. 22/25 = 88%; p < 0.05). Finally, after 3 months, Group A showed a significant reduction in anti-sperm antibodies and in the percentage of spermatozoa with fragmented DNA. Conclusion: The results of this study demonstrate, for the first time, the effects of a commercially available combined compound containing ellagic acid and annona muricata on semen quality in patients with HR-HPV infection, and that this therapy is also associated with a significant reduction in the persistence of HPV DNA in the seminal fluid.
Sprache	Englisch
Erscheinungsdatum	2022-08-11
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11164691
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: DNA Methylation in Offspring Conceived after Assisted Reproductive Techniques: A Systematic Review and Meta-Analysis.

Cannarella, Rossella / Crafa, Andrea / Mongioì, Laura M / Leggio, Loredana / Iraci, Nunzio / La Vignera, Sandro / Condorelli, Rosita A / Calogero, Aldo E

Journal of clinical medicine

2022 Band 11, Heft 17

Abstract: ... ...

Abstract	Background
Sprache	Englisch
Erscheinungsdatum	2022-08-28
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11175056
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Beneficial Effects of the Very-Low-Calorie Ketogenic Diet on the Symptoms of Male Accessory Gland Inflammation

Condorelli, Rosita A. / Aversa, Antonio / Basile, Livia / Cannarella, Rossella / Mongioì, Laura M. / Cimino, Laura / Perelli, Sarah / Caprio, Massimiliano / Cimino, Sebastiano / Calogero, Aldo E. / La Vignera, Sandro

Nutrients. 2022 Mar. 04, v. 14, no. 5

2022

Abstract: Introduction. Obesity exposes individuals to the risk of chronic inflammation of the prostate gland. Aim and design of the study. A longitudinal clinical study was conducted on selected overweight/obese patients with male accessory gland inflammation ( ... ...

Abstract	Introduction. Obesity exposes individuals to the risk of chronic inflammation of the prostate gland. Aim and design of the study. A longitudinal clinical study was conducted on selected overweight/obese patients with male accessory gland inflammation (MAGI) to evaluate the effects of body weight loss on their urogenital symptoms. Materials and methods. One hundred patients were selected and assigned to two groups undergoing two different nutritional programs. The first group (n = 50) started a Mediterranean diet (MedDiet) and the second (n = 50) a very-low-calorie ketogenic diet (VLCKD). Before and after three months on the diet, each patient was evaluated for body weight, waist circumference, and MAGI symptoms. The MAGI was assessed using the Structured Interview about MAGI (SI-MAGI), a questionnaire previously designed to assess the symptoms of MAGI. The questionnaire explores four domains, including urinary symptoms, ejaculatory pain or discomfort, sexual dysfunction, and impaired quality of life. Finally, in the two groups, the frequency of an α-blocker used to treat urinary tract symptoms was also evaluated. Results. Patients on MedDiet experienced significant amelioration in urinary symptoms and quality of life. Patients under VLCKD reported not only significant improvement of the same parameters, but also in ejaculatory pain/discomfort and sexual dysfunction. Finally, the percentage of patients on VLCKD taking the α-blocker decreased significantly. Moreover, patients under VLCKD showed a greater loss of body weight than those following the MedDiet. Discussion. The results of this study support the effectiveness of VLCKD in improving the symptoms of patients with MAGI. This improvement involved all of the domains of the SI-MAGI questionnaire and became manifest in a relatively short time. We suggest that a ketogenic nutritional approach can be used in overweight/obese patients with MAGI.
Schlagwörter	Mediterranean diet ; body weight changes ; inflammation ; ketogenic diet ; males ; obesity ; pain ; patients ; prostate gland ; quality of life ; questionnaires ; risk ; urinary tract ; waist circumference
Sprache	Englisch
Erscheinungsverlauf	2022-0304
Erscheinungsort	Multidisciplinary Digital Publishing Institute
Dokumenttyp	Artikel
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14051081
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Molecular Biology of Spermatogenesis: Novel Targets of Apparently Idiopathic Male Infertility.

Cannarella, Rossella / Condorelli, Rosita A / Mongioì, Laura M / La Vignera, Sandro / Calogero, Aldo E

International journal of molecular sciences

2020 Band 21, Heft 5

Abstract: Male infertility affects half of infertile couples and, currently, a relevant percentage of cases of male infertility is considered as idiopathic. Although the male contribution to human fertilization has traditionally been restricted to sperm DNA, ... ...

Abstract	Male infertility affects half of infertile couples and, currently, a relevant percentage of cases of male infertility is considered as idiopathic. Although the male contribution to human fertilization has traditionally been restricted to sperm DNA, current evidence suggest that a relevant number of sperm transcripts and proteins are involved in acrosome reactions, sperm‒oocyte fusion and, once released into the oocyte, embryo growth and development. The aim of this review is to provide updated and comprehensive insight into the molecular biology of spermatogenesis, including evidence on spermatogenetic failure and underlining the role of the sperm-carried molecular factors involved in oocyte fertilization and embryo growth. This represents the first step in the identification of new possible diagnostic and, possibly, therapeutic markers in the field of apparently idiopathic male infertility.
Mesh-Begriff(e)	DNA Fragmentation ; Female ; Humans ; Infertility, Male/genetics ; Infertility, Male/metabolism ; Male ; Oocytes/metabolism ; Oocytes/physiology ; Spermatogenesis/genetics ; Spermatogenesis/physiology ; Spermatozoa/metabolism ; Spermatozoa/physiology
Sprache	Englisch
Erscheinungsdatum	2020-03-03
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21051728
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Lifestyle and sexual habits of students in a Southern Italian region.

Cimino, Laura / Crafa, Andrea / Cannarella, Rossella / Barbagallo, Federica / Mongioì, Laura M / Aversa, Antonio / LA Vignera, Sandro / Condorelli, Rosita A / Calogero, Aldo E

Minerva endocrinology

2023 Band 49, Heft 1, Seite(n) 47–59

Abstract: Background: Incorrect or harmful lifestyle during youth may impact negatively gonadal function later in life. To reduce the development of risky behaviors a series of health prevention and intervention campaigns have been conducted in Italy. The present ...

Abstract	Background: Incorrect or harmful lifestyle during youth may impact negatively gonadal function later in life. To reduce the development of risky behaviors a series of health prevention and intervention campaigns have been conducted in Italy. The present study is part of a Sicily Region (Italy) health surveillance program that was carried out on a sample of late adolescents. Methods: Between March 2022 to December 2022, we enrolled 718 adolescents (15-26 years old) attending the last two years of high school (278 males and 440 females) in the districts of Syracuse, Ragusa, Catania, and Agrigento (Sicily, Italy). All adolescents were invited to complete a questionnaire that explored their lifestyles and the student's knowledge of sexually transmitted diseases (STDs) and the main andrological diseases. Results: Our analysis revealed that 43% of students smoke cigarettes, with a similar gender distribution; one-third of the students use illicit drugs, with a higher prevalence of males than females. More than two-thirds of youngsters reported drinking alcohol with a statistically significant difference between genders. 68.2% of students do not have sexual difficulties and males have a greater tendency to sexual promiscuity than females and only about half of them use condoms. 92% of students surf the Internet every day; boys tend to visit pornographic sites more often than girls. Conclusions: This survey revealed statistically significant differences between the two genders in terms of lifestyle and sexual habits. In particular, the survey shows that the prevalence of risky behaviour is still extremely high among late adolescents and young adults and that much still needs to be done in terms of prevention and information. Adequate prevention campaigns, to be proposed in the early years of adolescence, should be initiated in order to provide youngsters with adequate preparation in terms of healthy lifestyle habits.
Mesh-Begriff(e)	Humans ; Male ; Adolescent ; Female ; Sexual Behavior/statistics & numerical data ; Young Adult ; Life Style ; Students/statistics & numerical data ; Students/psychology ; Italy/epidemiology ; Adult ; Surveys and Questionnaires ; Sexually Transmitted Diseases/epidemiology ; Sexually Transmitted Diseases/prevention & control ; Risk-Taking ; Sicily/epidemiology ; Health Knowledge, Attitudes, Practice ; Alcohol Drinking/epidemiology
Sprache	Englisch
Erscheinungsdatum	2023-09-28
Erscheinungsland	Italy
Dokumenttyp	Journal Article
ZDB-ID	3062786-2
ISSN	2724-6116
ISSN (online)	2724-6116
DOI	10.23736/S2724-6507.23.03998-2
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Influence of 25-hydroxy-cholecalciferol levels on SARS-CoV-2 infection and COVID-19 severity: A systematic review and meta-analysis.

Crafa, Andrea / Cannarella, Rossella / Condorelli, Rosita A / Mongioì, Laura M / Barbagallo, Federica / Aversa, Antonio / La Vignera, Sandro / Calogero, Aldo E

EClinicalMedicine

2021 Band 37, Seite(n) 100967

Abstract: Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 19 (COVID-19), a respiratory infection that, starting from December 2019, has spread around the world in a few months, becoming ... ...

Abstract	Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 19 (COVID-19), a respiratory infection that, starting from December 2019, has spread around the world in a few months, becoming a pandemic. The lack of initial knowledge on its management has led to a great effort in developing vaccines and in finding therapeutic weapons capable of improving the clinical outcome of the affected patients. In particular, the possible role of vitamin D status in the management of COVID-19 has been widely analysed, resulting in a great amount of data. This systematic review and meta-analysis aimed to assess whether hypovitaminosis D is a risk factor for developing SARS-CoV-2 infection and whether it affects the worsening of the clinical course of COVID-19. Methods: Data were extracted through extensive searches in the Pubmed, MEDLINE, Cochrane, Academic One Files, Google Scholar, and Scopus databases from December 2019 to January 2021, using the keywords: "Vitamin D", "25 hydroxy Vitamin D", "25 hydroxycholecalciferol", "cholecalciferol", "COVID 19″, "SARS-CoV-2″. We included observational cohort, cross-sectional, and case-control studies that evaluated differences in serum levels of 25‑hydroxy-cholecalciferol [25(OH)D] in patients who were positive or negative for SARS-CoV-2, in patients with mild or severe forms of COVID-19, and in patients who died or were discharged from the hospital. Finally, studies that evaluated the risk of developing severe illness or death in patients with vitamin D deficiency (VDD), defined as levels of 25(OH) Findings: Out of 662 records, 30 articles met inclusion criteria and, therefore, were included in the meta-analysis Interpretation: This meta-analysis revealed a large heterogeneity of the studies included due to the different enrolment criteria of patient samples (age, body mass index, ethnicity, comorbidities), the country where they live, all factors influencing serum 25(OH)D levels, and the different criteria used to define the severity of COVID-19. Furthermore, the observational nature of these studies does not allow to establish a cause-effect relationship, even taking into account that 25(OH)D represents a marker of acute inflammation. Treatment with vitamin D might be considered for the primary prevention of SARS-CoV-2 infection and the management of patients with COVID-19. However, further intervention studies are needed to prove this hypothesis.
Sprache	Englisch
Erscheinungsdatum	2021-06-18
Erscheinungsland	England
Dokumenttyp	Journal Article
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2021.100967
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Corrigendum to: Influence of 25‑hydroxy-cholecalciferol levels on SARS-CoV-2 infection and COVID-19 severity: A systematic review and meta-analysis [EClinicalMedicine 37 (2021) 100,967].

Crafa, Andrea / Cannarella, Rossella / Condorelli, Rosita A / Mongioì, Laura M / Barbagallo, Federica / Aversa, Antonio / La Vignera, Sandro / Calogero, Aldo E

EClinicalMedicine

2021 Band 41, Seite(n) 101168

Abstract: This corrects the article DOI: 10.1016/j.eclinm.2021.100967.]. ...

Abstract	[This corrects the article DOI: 10.1016/j.eclinm.2021.100967.].
Sprache	Englisch
Erscheinungsdatum	2021-10-20
Erscheinungsland	England
Dokumenttyp	Published Erratum
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2021.101168
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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