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  1. Article ; Online: Chocolate-Colored Pseudochylothorax in a Woman with a History of Pleuropulmonary Tuberculosis.

    Monnerat, Laura Braga / Louzada, Elisa Barbosa / Braga, Vanessa Godinho Souza / da Cal, Mariana Soares / Lopes, Agnaldo José / Mafort, Thiago Thomaz

    The American journal of case reports

    2023  Volume 24, Page(s) e939473

    Abstract: BACKGROUND Pseudochylothorax is a rare entity, with only a few hundred case reports worldwide. It presents as a pleural effusion rich in lipids, typically with a cloudy, milky appearance. The diagnosis is made based on the levels of cholesterol and ... ...

    Abstract BACKGROUND Pseudochylothorax is a rare entity, with only a few hundred case reports worldwide. It presents as a pleural effusion rich in lipids, typically with a cloudy, milky appearance. The diagnosis is made based on the levels of cholesterol and triglycerides in the pleural fluid. CASE REPORT This is the case report of a 55-year-old woman with a history of pleuropulmonary tuberculosis that was treated in childhood, with a new infection and treatment in adulthood that evolved to a left pleural effusion. Thirteen years after completing her last treatment for tuberculosis, the patient developed general fatigue and dyspnea on exertion. Computed tomography of the chest confirmed the presence of a pleural collection in the same location as in adolescence, suggesting a chronic evolution with encystation. The patient underwent ultrasound-guided diagnostic thoracentesis. The collected liquid was thick, chocolate-colored, with the following biochemical characteristics: pH, 7.3; glucose, 37.9 mg/dL; LDL, 2059.8 IU/L; total protein, 8.8 mg/dL; triglycerides, 90 mg/dL; adenosine deaminase, 56 U/L; and cholesterol, 300 mg/dL. The effusion was characterized as a pseudochylothorax. The cell count showed 631 000 leukocytes/µL, with 87.9% polymorphonuclear cells. Owing to the patient's respiratory symptoms, an evacuatory thoracentesis was performed. After the procedure, the patient's symptoms improved. CONCLUSIONS Although pseudochylothorax is a rare condition, its possibility must always be kept in mind to avoid the hazards of misdiagnosis. In addition to the 'classic' milky and machine oil appearance, a chocolate-colored appearance should also serve as a clue to the diagnosis of pseudochylothorax.
    MeSH term(s) Adolescent ; Female ; Humans ; Middle Aged ; Chocolate ; Pleural Effusion/etiology ; Pleura ; Exudates and Transudates ; Dyspnea
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.939473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Assessment of short- and long-term functionality and quality of life in patients with post-acute COVID-19 syndrome.

    de Azevedo Vieira, João Eduardo / Mafort, Thiago Thomaz / Monnerat, Laura Braga / da Cal, Mariana Soares / Ghetti, Angelo Thomaz Abalada / Lopes, Agnaldo José

    Journal of back and musculoskeletal rehabilitation

    2023  Volume 36, Issue 3, Page(s) 541–550

    Abstract: Background: Although the number of new cases of coronavirus 2019 (COVID-19) has been drastically reduced worldwide, patients who demonstrate long-term symptoms need more attention from health systems, as these symptoms can negatively affect ... ...

    Abstract Background: Although the number of new cases of coronavirus 2019 (COVID-19) has been drastically reduced worldwide, patients who demonstrate long-term symptoms need more attention from health systems, as these symptoms can negatively affect functionality and quality of life.
    Objective: To evaluate muscle function and quality of life at 3, 6, 9 and 12 months in patients with post-acute COVID-19 syndrome and to assess their associations with general fatigue and lung function.
    Methods: This observational and longitudinal study evaluated patients with post-acute COVID-19 syndrome. Participants were subjected to the following evaluations: Short Form-36; handgrip strength; Functional Assessment of Chronic Illness Therapy-Fatigue scale; and spirometry.
    Results: Among the 350 participants who were evaluated in the third month, 74.6%, 61.4% and 45.4% reported general fatigue, dyspnoea and cough, respectively. In the comparisons between the third month and the sixth month, there were significant increases in Functional Assessment of Chronic Illness Therapy-Fatigue scale, pulmonary function and several Short Form-36 domains. In the comparisons between the sixth month and the ninth month, there was a significant increase only in the social functioning domain of the Short Form-36. In the comparisons between the ninth month and the twelfth month, there was an increase only in some Short Form-36 domains. Significant correlations were observed between the Short Form-36 domains with Functional Assessment of Chronic Illness Therapy-Fatigue scale, handgrip strength and pulmonary function.
    Conclusion: In patients with post-acute COVID-19 syndrome, there was a progressive improvement in quality of life, general fatigue and pulmonary function during the 12 months of follow-up, with this improvement being more pronounced in the first 6 months. There was a relationship between functionality and quality of life in these patients.
    MeSH term(s) Humans ; Quality of Life ; Hand Strength ; Longitudinal Studies ; Post-Acute COVID-19 Syndrome ; COVID-19 ; Fatigue
    Language English
    Publishing date 2023-02-15
    Publishing country Netherlands
    Document type Observational Study ; Journal Article
    ZDB-ID 1184721-9
    ISSN 1878-6324 ; 1053-8127
    ISSN (online) 1878-6324
    ISSN 1053-8127
    DOI 10.3233/BMR-220308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4580: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Prediction models for physical function in COVID-19 survivors.

    Vieira, João Eduardo de Azevedo / Ferreira, Arthur de Sá / Monnerat, Laura Braga / Cal, Mariana Soares da / Ghetti, Angelo Thomaz Abalada / Mafort, Thiago Thomaz / Lopes, Agnaldo José

    Journal of bodywork and movement therapies

    2023  Volume 37, Page(s) 70–75

    Abstract: Background: The burden of caring for patients who have survived COVID-19 will be enormous in the coming years, especially with respect to physical function. Physical function has been routinely assessed using the Post-COVID-19 Functional Status (PCFS) ... ...

    Abstract Background: The burden of caring for patients who have survived COVID-19 will be enormous in the coming years, especially with respect to physical function. Physical function has been routinely assessed using the Post-COVID-19 Functional Status (PCFS) scale.
    Aim: This study built prediction models for the PCFS scale using sociodemographic data, clinical findings, lung function, and muscle strength.
    Method: Two hundred and one patients with post-COVID-19 syndrome (PCS) completed the PCFS scale to assess physical function. Their levels of general fatigue were also assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale, handgrip strength (HGS), and spirometry.
    Results: The number of participants who scored 0 (none), 1 (negligible), 2 (slight), 3 (moderate), and 4 (severe) on the PCFS scale was 25 (12%), 40 (20%), 39 (19%), 49 (24%), and 48 (24%), respectively. The PCFS scale was significantly correlated with the following variables: FACIT-F score (r = -0.424, P < 0.001), HGS (r = -0.339, P < 0.001), previous hospitalization (r = 0.226, P = 0.001), body mass index (r = 0.163, P = 0.021), and sex (r = -0.153, P = 0.030). The regression model with the highest coefficient of regression (R = 0.559) included the following variables: age, sex, body mass index, FACIT-F, HGS, and previous hospitalization.
    Conclusions: Worse general fatigue and HGS are associated with more severe physical function impairments in PCS patients. Furthermore, a history of prior hospitalization results in worse physical function. Thus, prediction models for the PCFS scale that incorporate objective measures enable a better assessment of the physical function of these patients, thus helping in the selection of candidates for a program of physical reconditioning.
    MeSH term(s) Humans ; Fatigue/epidemiology ; Hand Strength ; Muscle Strength ; Post-Acute COVID-19 Syndrome ; Survivors ; Male ; Female ; Physical Functional Performance ; Models, Statistical
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2029441-4
    ISSN 1532-9283 ; 1360-8592
    ISSN (online) 1532-9283
    ISSN 1360-8592
    DOI 10.1016/j.jbmt.2023.11.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5620: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: One-month outcomes of patients with SARS-CoV-2 infection and their relationships with lung ultrasound signs.

    Mafort, Thiago Thomaz / Rufino, Rogério / da Costa, Claudia Henrique / da Cal, Mariana Soares / Monnerat, Laura Braga / Litrento, Patrícia Frascari / Parra, Laura Lizeth Zuluaga / Marinho, Arthur de Sá Earp de Souza / Lopes, Agnaldo José

    The ultrasound journal

    2021  Volume 13, Issue 1, Page(s) 19

    Abstract: Background: The role of lung ultrasound (LUS) in evaluating the mid- and long-term prognoses of patients with COVID-19 pneumonia is not yet known. The objectives of this study were to evaluate associations between LUS signs at the time of screening and ... ...

    Abstract Background: The role of lung ultrasound (LUS) in evaluating the mid- and long-term prognoses of patients with COVID-19 pneumonia is not yet known. The objectives of this study were to evaluate associations between LUS signs at the time of screening and clinical outcomes 1 month after LUS and to assess LUS signs at the time of presentation with known risk factors for COVID-19 pneumonia.
    Methods: This was a retrospective study of data prospectively collected 1 month after LUS screening of 447 adult patients diagnosed with COVID-19 pneumonia. Sonographic examination was performed in screening tents with the participants seated. The LUS signs (B-lines > 2, coalescent B-lines, and subpleural consolidations) were captured in six areas of each hemithorax and a LUS aeration score was calculated; in addition, the categories of disease probability based on patterns of LUS findings (high-probability, intermediate-probability, alternate, and low-probability patterns) were evaluated. The LUS signs at patients' initial evaluation were related to the following outcomes: symptomatology, the need for hospitalization or invasive mechanical ventilation (IMV), and COVID-19-related death.
    Results: According to the evaluations performed 1 month after LUS screening, 36 patients were hospitalised, eight of whom required intensive care unit (ICU) admission and three of whom died. The presence of coalescent B-lines was associated with the need for hospitalization (p = 0.008). The presence of subpleural consolidations was associated with dyspnoea (p < 0.0001), cough (p = 0.003), the need for hospitalization (p < 0.0001), the need for ICU admission (p < 0.0001), and death (p = 0.002). A higher aeration score was associated with dyspnoea (p < 0.0001), the need for hospitalization (p < 0.0001), the need for ICU admission (p < 0.0001), and death (p = 0.003). In addition, patients with a high-probability LUS pattern had a higher aeration score (p < 0.0001) and more dyspnoea (p = 0.024) and more often required hospitalization (p < 0.0001) and ICU admission (p = 0.031).
    Conclusions: In patients with COVID-19 pneumonia, LUS signs were related to respiratory symptoms 1 month after LUS screening. Strong relationships were identified between LUS signs and the need for hospitalization and death.
    Language English
    Publishing date 2021-04-09
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2965029-X
    ISSN 2524-8987 ; 2036-3176
    ISSN (online) 2524-8987
    ISSN 2036-3176
    DOI 10.1186/s13089-021-00223-9
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  5. Article ; Online: Small airway dysfunction on impulse oscillometry and pathological signs on lung ultrasound are frequent in post-COVID-19 patients with persistent respiratory symptoms.

    Lopes, Agnaldo José / Litrento, Patrícia Frascari / Provenzano, Bruna Cuoco / Carneiro, Alícia Sales / Monnerat, Laura Braga / da Cal, Mariana Soares / Ghetti, Angelo Thomaz Abalada / Mafort, Thiago Thomaz

    PloS one

    2021  Volume 16, Issue 11, Page(s) e0260679

    Abstract: Background: Thousands of people worldwide are suffering the consequences of coronavirus disease-2019 (COVID-19), and impulse oscillometry (IOS) and lung ultrasound (LUS) might be important tools for the follow-up of this population. Our objective was to ...

    Abstract Background: Thousands of people worldwide are suffering the consequences of coronavirus disease-2019 (COVID-19), and impulse oscillometry (IOS) and lung ultrasound (LUS) might be important tools for the follow-up of this population. Our objective was to prospectively evaluate abnormalities detected using these two methods in a cohort of COVID-19 survivors with respiratory symptoms.
    Methods: In this follow-up study, 59 patients underwent clinical evaluations, spirometry, IOS and LUS in the 2nd (M1) and 5th (M2) months after diagnostic confirmation of COVID-19 by real-time reverse transcriptase-polymerase chain reaction. Aeration scores were obtained from the LUS exams based on the following findings: B-lines >2, coalescent B-lines, and subpleural consolidations.
    Results: Fifty-nine (100%) participants had cough and/or dyspnea at M1, which decreased to 38 (64.4%) at M2 (p = 0.0001). Spirometry was abnormal in 26 (44.1%) and 20 (33.9%) participants at M1 and M2, respectively, although without statistical significance (p = 0.10). Normal examination, restrictive patterns, and obstructive patterns were observed in 33 (55.9%), 18 (30.5%), and 8 (13.6%) participants, respectively, at M1 and in 39 (66.1%), 13 (22%), and 7 (11.9%) participants at M2 (p = 0.14). Regarding IOS, considering changes in resistive and reactive parameters, abnormal exams were detected in 52 (88.1%) and 42 (71.2%) participants at M1 and M2, respectively (p = 0.002). Heterogeneity of resistance between 4 and 20 Hz >20% was observed in 38 (64.4%) and 33 (55.9%) participants at M1 and M2, respectively (p = 0.30). Abnormal LUS was observed in 46 (78%) and 36 (61%) participants at M1 and M2, respectively (p = 0.002), with a reduction in aeration scores between M1 and M2 [5 (2-8) vs. 3 (0-6) points, p<0.0001].
    Conclusions: IOS and LUS abnormalities are frequent in the first 5 months post-COVID-19 infection; however, when prospectively evaluated, significant improvement is evident in the parameters measured by these two methods.
    MeSH term(s) COVID-19/diagnostic imaging ; COVID-19/pathology ; COVID-19/physiopathology ; Cost of Illness ; Female ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Lung/physiopathology ; Lung/virology ; Male ; Oscillometry ; Respiration ; Spirometry ; Ultrasonography ; Vital Capacity
    Language English
    Publishing date 2021-11-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0260679
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  6. Article: The Importance of Radiological Patterns and Small Airway Disease in Long-Term Follow-Up of Postacute COVID-19: A Preliminary Study.

    Mogami, Roberto / Araújo Filho, Ronaldo Carvalho / Cobo Chantong, Carolina Gianella / Santos de Almeida, Fernando Carlos / Baptista Koifman, Ana Célia / Jauregui, Gustavo Federico / Mafort, Thiago Thomaz / da Silva Bessa da Costa, Hanna / Peres Dos Santos, Glenda Aparecida / Zangerolame de Carvalho, Bruna / da Silva Passos, Gabriel / de Souza Barbosa, Erick / Abalada Ghetti, Angelo Thomaz / Monnerat, Laura Braga / Soares da Cal, Mariana / Souza Santos Batista, Desiree Louise / Affonso, Helen Aksenow / Bousquet, Gabriel Oliveira / Marenco Avila, Jose Ignacio /
    Bento Dutra, Anna Luiza / Leidersnaider, Caio Leal / Malta da Costa Messeder, Alexandre / Monteiro, Alexandra / Lopes, Agnaldo José

    Radiology research and practice

    2022  Volume 2022, Page(s) 7919033

    Abstract: Postacute COVID-19 has become a relevant public health problem, and radiological and pulmonary function tests are tools that help physicians in decision-making. The objectives of this study are to characterize the findings and patterns on a chest ... ...

    Abstract Postacute COVID-19 has become a relevant public health problem, and radiological and pulmonary function tests are tools that help physicians in decision-making. The objectives of this study are to characterize the findings and patterns on a chest radiograph (CXR) and computed tomography (CT) that are most important in the postacute phase and to evaluate how these changes correlate with clinical data, spirometry, and impulse oscillometry (IOS). This was a retrospective study of 29 patients who underwent CXR, CT, spirometry, and IOS. The inclusion criteria were age >18 years and persistent respiratory symptoms after four weeks. The exclusion criteria were radiological exams with low technical quality and non-COVID-19 acute lung diseases. The inferential analysis was carried out with the chi-square (
    Language English
    Publishing date 2022-05-05
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2594649-3
    ISSN 2090-195X ; 2090-1941
    ISSN (online) 2090-195X
    ISSN 2090-1941
    DOI 10.1155/2022/7919033
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