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  1. Article ; Online: Coronavirus Disease 2019: Challenges in the Pacific Islands.

    Poignant, Simon / Baudouin, Laure / Vinclair, Marc / Mons, Sandrine

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 72, Issue 4, Page(s) 722–723

    MeSH term(s) COVID-19 ; Humans ; New Caledonia ; Pacific Islands/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study.

    Cao-Lormeau, Van-Mai / Blake, Alexandre / Mons, Sandrine / Lastère, Stéphane / Roche, Claudine / Vanhomwegen, Jessica / Dub, Timothée / Baudouin, Laure / Teissier, Anita / Larre, Philippe / Vial, Anne-Laure / Decam, Christophe / Choumet, Valérie / Halstead, Susan K / Willison, Hugh J / Musset, Lucile / Manuguerra, Jean-Claude / Despres, Philippe / Fournier, Emmanuel /
    Mallet, Henri-Pierre / Musso, Didier / Fontanet, Arnaud / Neil, Jean / Ghawché, Frédéric

    Lancet (London, England)

    2016  Volume 387, Issue 10027, Page(s) 1531–1539

    Abstract: Background: Between October, 2013, and April, 2014, French Polynesia experienced the largest Zika virus outbreak ever described at that time. During the same period, an increase in Guillain-Barré syndrome was reported, suggesting a possible association ... ...

    Abstract Background: Between October, 2013, and April, 2014, French Polynesia experienced the largest Zika virus outbreak ever described at that time. During the same period, an increase in Guillain-Barré syndrome was reported, suggesting a possible association between Zika virus and Guillain-Barré syndrome. We aimed to assess the role of Zika virus and dengue virus infection in developing Guillain-Barré syndrome.
    Methods: In this case-control study, cases were patients with Guillain-Barré syndrome diagnosed at the Centre Hospitalier de Polynésie Française (Papeete, Tahiti, French Polynesia) during the outbreak period. Controls were age-matched, sex-matched, and residence-matched patients who presented at the hospital with a non-febrile illness (control group 1; n=98) and age-matched patients with acute Zika virus disease and no neurological symptoms (control group 2; n=70). Virological investigations included RT-PCR for Zika virus, and both microsphere immunofluorescent and seroneutralisation assays for Zika virus and dengue virus. Anti-glycolipid reactivity was studied in patients with Guillain-Barré syndrome using both ELISA and combinatorial microarrays.
    Findings: 42 patients were diagnosed with Guillain-Barré syndrome during the study period. 41 (98%) patients with Guillain-Barré syndrome had anti-Zika virus IgM or IgG, and all (100%) had neutralising antibodies against Zika virus compared with 54 (56%) of 98 in control group 1 (p<0.0001). 39 (93%) patients with Guillain-Barré syndrome had Zika virus IgM and 37 (88%) had experienced a transient illness in a median of 6 days (IQR 4-10) before the onset of neurological symptoms, suggesting recent Zika virus infection. Patients with Guillain-Barré syndrome had electrophysiological findings compatible with acute motor axonal neuropathy (AMAN) type, and had rapid evolution of disease (median duration of the installation and plateau phases was 6 [IQR 4-9] and 4 days [3-10], respectively). 12 (29%) patients required respiratory assistance. No patients died. Anti-glycolipid antibody activity was found in 13 (31%) patients, and notably against GA1 in eight (19%) patients, by ELISA and 19 (46%) of 41 by glycoarray at admission. The typical AMAN-associated anti-ganglioside antibodies were rarely present. Past dengue virus history did not differ significantly between patients with Guillain-Barré syndrome and those in the two control groups (95%, 89%, and 83%, respectively).
    Interpretation: This is the first study providing evidence for Zika virus infection causing Guillain-Barré syndrome. Because Zika virus is spreading rapidly across the Americas, at risk countries need to prepare for adequate intensive care beds capacity to manage patients with Guillain-Barré syndrome.
    Funding: Labex Integrative Biology of Emerging Infectious Diseases, EU 7th framework program PREDEMICS. and Wellcome Trust.
    MeSH term(s) Adult ; Case-Control Studies ; Dengue Virus/isolation & purification ; Disease Outbreaks/statistics & numerical data ; Female ; Guillain-Barre Syndrome/epidemiology ; Guillain-Barre Syndrome/virology ; Humans ; Male ; Middle Aged ; Polynesia/epidemiology ; Severe Dengue/complications ; Severe Dengue/epidemiology ; Zika Virus/isolation & purification ; Zika Virus Infection/complications ; Zika Virus Infection/epidemiology
    Language English
    Publishing date 2016-03-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(16)00562-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Serum levels of macrophage-colony stimulating factor (M-CSF): a marker of kidney allograft rejection.

    Le Meur, Yannick / Leprivey-Lorgeot, Valérie / Mons, Sandrine / José, Mattew / Dantal, Jacques / Lemauff, Brigitte / Aldigier, Jean-Claude / Leroux-Robert, Claude / Praloran, Vincent

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2004  Volume 19, Issue 7, Page(s) 1862–1865

    Abstract: Background: Macrophage-colony stimulating factor (M-CSF) is the principal factor for survival of monocytes and macrophages that play an important role in allograft rejection. We studied M-CSF serum levels during successful renal transplantation and ... ...

    Abstract Background: Macrophage-colony stimulating factor (M-CSF) is the principal factor for survival of monocytes and macrophages that play an important role in allograft rejection. We studied M-CSF serum levels during successful renal transplantation and acute graft rejection.
    Methods: A total of 114 kidney allograft recipients were assessed for M-CSF levels by enzyme-linked immunosorbent assay (ELISA).
    Results: M-CSF serum levels were elevated in pre-transplant haemodialysis patients (611+/-355 IU/ml vs 168+/-61 in normal controls, P<0.01). Following successful renal transplantation, M-CSF decreased in the first month, stabilizing at 257+/-222 IU/ml (not significantly different from normal controls) in 52 post-transplant stable patients. There was no correlation between M-CSF level and creatinine clearance. M-CSF levels increased significantly (2-5 times) during biopsy-proven acute rejection episodes in 20 of 25 patients. All rejection episodes were successfully treated and serum M-CSF decreased rapidly to pre-rejection levels in 17/20 patients. In contrast, in five patients with cyclosporin toxicity and four patients with other causes of allograft dysfunction, M-CSF serum levels did not change.
    Conclusions: M-CSF serum level might be a specific marker of acute rejection. The source of increased production during rejection warrants further investigation, with infiltrating T cells and resident kidney cells being likely candidates.
    MeSH term(s) Acute Disease ; Biomarkers/blood ; Graft Rejection/blood ; Humans ; Kidney Transplantation ; Macrophage Colony-Stimulating Factor/blood ; Retrospective Studies
    Chemical Substances Biomarkers ; Macrophage Colony-Stimulating Factor (81627-83-0)
    Language English
    Publishing date 2004-07
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfh257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 329: Show issues

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