LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Monserrat, Nuria"
  2. AU="Dufresne, Philippe J"
  3. AU="Dickey, Erin M"
  4. AU="Alessia Nava"
  5. AU="Yamoah, Peter"
  6. AU="Solit, David"
  7. AU="Raymond, Benjamin"
  8. AU="Maddi, Abhiram"
  9. AU="Rodríguez, Johanna G"
  10. AU="Frans, J"
  11. AU="Elisa Palazzari"

Suchergebnis

Treffer 1 - 2 von insgesamt 2

Suchoptionen

  1. Artikel ; Online: ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts.

    Hyun, Insoo / Clayton, Ellen Wright / Cong, Yali / Fujita, Misao / Goldman, Steven A / Hill, Lori R / Monserrat, Nuria / Nakauchi, Hiromitsu / Pedersen, Roger A / Rooke, Heather M / Takahashi, Jun / Knoblich, Jürgen A

    Stem cell reports

    2021  Band 16, Heft 6, Seite(n) 1409–1415

    Abstract: The newly revised 2021 ISSCR Guidelines for Stem Cell Research and Clinical Translation includes scientific and ethical guidance for the transfer of human pluripotent stem cells and their direct derivatives into animal models. In this white paper, the ... ...

    Abstract The newly revised 2021 ISSCR Guidelines for Stem Cell Research and Clinical Translation includes scientific and ethical guidance for the transfer of human pluripotent stem cells and their direct derivatives into animal models. In this white paper, the ISSCR subcommittee that drafted these guidelines for research involving the use of nonhuman embryos and postnatal animals explains and summarizes their recommendations.
    Mesh-Begriff(e) Animals ; Chimera ; Embryo Research/ethics ; Humans ; Pluripotent Stem Cells ; Practice Guidelines as Topic ; Societies, Scientific/ethics ; Societies, Scientific/standards ; Stem Cell Research/ethics ; Stem Cell Transplantation/ethics ; Stem Cell Transplantation/standards
    Sprache Englisch
    Erscheinungsdatum 2021-05-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2021.05.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel ; Online: Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells.

    Monteil, Vanessa M / Wright, Shane C / Dyczynski, Matheus / Kellner, Max J / Appelberg, Sofia / Platzer, Sebastian W / Ibrahim, Ahmed / Kwon, Hyesoo / Pittarokoilis, Ioannis / Mirandola, Mattia / Michlits, Georg / Devignot, Stephanie / Elder, Elizabeth / Abdurahman, Samir / Bereczky, Sándor / Bagci, Binnur / Youhanna, Sonia / Aastrup, Teodor / Lauschke, Volker M /
    Salata, Cristiano / Elaldi, Nazif / Weber, Friedemann / Monserrat, Nuria / Hawman, David W / Feldmann, Heinz / Horn, Moritz / Penninger, Josef M / Mirazimi, Ali

    Nature microbiology

    2024  

    Abstract: Climate change and population densities accelerated transmission of highly pathogenic viruses to humans, including the Crimean-Congo haemorrhagic fever virus (CCHFV). Here we report that the Low Density Lipoprotein Receptor (LDLR) is a critical receptor ... ...

    Abstract Climate change and population densities accelerated transmission of highly pathogenic viruses to humans, including the Crimean-Congo haemorrhagic fever virus (CCHFV). Here we report that the Low Density Lipoprotein Receptor (LDLR) is a critical receptor for CCHFV cell entry, playing a vital role in CCHFV infection in cell culture and blood vessel organoids. The interaction between CCHFV and LDLR is highly specific, with other members of the LDLR protein family failing to bind to or neutralize the virus. Biosensor experiments demonstrate that LDLR specifically binds the surface glycoproteins of CCHFV. Importantly, mice lacking LDLR exhibit a delay in CCHFV-induced disease. Furthermore, we identified the presence of Apolipoprotein E (ApoE) on CCHFV particles. Our findings highlight the essential role of LDLR in CCHFV infection, irrespective of ApoE presence, when the virus is produced in tick cells. This discovery holds profound implications for the development of future therapies against CCHFV.
    Sprache Englisch
    Erscheinungsdatum 2024-03-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-024-01672-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang