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  1. Book: Biopsy interpretation

    Taxy, Jerome B. / Husain, Aliya N. / Montag, Anthony G.

    the frozen section

    (Biopsy interpretation series)

    2014  

    Author's details Jerome B. Taxy ; Aliya N. Husain ; Anthony G. Montag
    Series title Biopsy interpretation series
    Keywords Frozen Sections / methods ; Biopsy / methods ; Frozen tissue sections ; Biopsy
    Language English
    Size XIII, 426 S. : zahlr. Ill., graph. Darst., 23 cm
    Edition 2. ed.
    Publisher Wolters Kluwer Lippincott Williams & Wilkins
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    Accompanying material Zugang zu zusätzlichem Internetmaterial über Code
    HBZ-ID HT017752739
    ISBN 978-1-4511-8679-6 ; 1-4511-8679-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 527 available for loan (reading room) Lesesaal EG
    Zugang zu zusätzlichem Internetmaterial über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Book: Biopsy interpretation

    Taxy, Jerome B. / Husain, Aliya N. / Montag, Anthony G.

    the frozen section

    (Biopsy interpretation series)

    2010  

    Author's details Jerome B. Taxy ; Aliya N. Husain ; Anthony G. Montag
    Series title Biopsy interpretation series
    Keywords Frozen Sections / methods ; Biopsy / methods ; Frozen tissue sections ; Biopsy
    Subject code 616.0758
    Language English
    Size X, 351 S. : zahlr. Ill., 23 cm
    Publisher Wolters Kluwer Lippincott Williams & Wilkins
    Publishing place Philadelphia, Pa. u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    Accompanying material Zugang zu zusätzlichem Internetmaterial über Code
    HBZ-ID HT016139641
    ISBN 978-0-7817-6779-8 ; 0-7817-6779-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 5831 order for loan Magazin
    Zugang zu zusätzlichem Internetmaterial aus lizenzrechtlichen Gründen nicht verfügbar

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  3. Book ; Online: Biopsy interpretation

    Taxy, Jerome B. / Husain, Aliya N. / Montag, Anthony G.

    the frozen section

    (Biopsy interpretation series)

    2010  

    Author's details Jerome B. Taxy, Aliya N. Husain, Anthony G. Montag
    Series title Biopsy interpretation series
    Keywords Frozen sections - methods ; Biopsy - methods
    Language English
    Size 1 Online-Ressource (x, 351 Seiten), Illustrationen
    Edition 1st ed.
    Publisher Wolters Kluwer/Lippincott Williams & Wilkins Health
    Publishing place Philadelphia
    Document type Book ; Online
    Note Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 978-0-7817-6779-8 ; 0-7817-6779-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  4. Article ; Online: Infarct-Associated Bone Sarcomas: Multimodality Imaging Findings.

    Stacy, Gregory Scott / Lo, Ryan / Montag, Anthony

    AJR. American journal of roentgenology

    2015  Volume 205, Issue 4, Page(s) W432–41

    Abstract: Objective: The objective of our study was to characterize infarct-associated bone sarcoma and its imaging features.: Materials and methods: Our databases were searched for instances of sarcoma arising in association with osteonecrosis. Demographic ... ...

    Abstract Objective: The objective of our study was to characterize infarct-associated bone sarcoma and its imaging features.
    Materials and methods: Our databases were searched for instances of sarcoma arising in association with osteonecrosis. Demographic and imaging data were recorded. The imaging studies of 258 patients with sarcomas were reviewed to determine whether underlying osteonecrosis was present. Radiographic and MRI studies of patients with bone infarction were reviewed to categorize the various appearances of infarction and to determine if sarcomas tended to arise in a particular pattern. A literature review was performed.
    Results: Nine infarct-associated bone sarcomas were found in eight patients: seven malignant fibrous histiocytomas (MFHs) and two osteosarcomas. All occurred in the femur or tibia; multifocal infarction was documented in all patients except one. Sarcomas were commonly associated with a so-called "mature"-type pattern of osteonecrosis-that is, with well-defined calcified margins. Osteolysis of infarct-associated MFHs was often overlooked at initial presentation and was often detected only after pathologic fracture. CT and MRI revealed cortical penetration in all cases; infarct margin disruption was evident, but preservation of fat within the infarct was typical. Increased radiotracer activity with relative central photopenia was characteristic of large infarct-associated bone sarcomas on scintigraphy. All lesions, including those treated at our institution and those found in the literature, were metaphyseal or diaphyseal, and although epiphyseal extension of sarcoma from a metadiaphyseal infarct was common, no purely epiphyseal lesions were encountered.
    Conclusion: Radiologists must remain vigilant for this rare occurrence, especially in patients with new pain in an area of known bone infarction.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Bone Neoplasms/diagnosis ; Bone Neoplasms/etiology ; Female ; Femur/blood supply ; Humans ; Infarction/complications ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multimodal Imaging ; Osteonecrosis/complications ; Radionuclide Imaging ; Retrospective Studies ; Sarcoma/diagnosis ; Sarcoma/etiology ; Tibia/blood supply ; Tomography, X-Ray Computed
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Clinical Study ; Journal Article
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.14.13871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.57: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Reactive bone lesions mimicking neoplasms.

    Hoch, Benjamin / Montag, Anthony

    Seminars in diagnostic pathology

    2011  Volume 28, Issue 1, Page(s) 102–112

    Abstract: Reactive lesions of bone and soft tissue can appear alarming on histologic examination because they are often cellular and have atypical (activated) cytologic features, such as distinct nucleoli and mild hyperchromasia, and mitotic activity. Reactive ... ...

    Abstract Reactive lesions of bone and soft tissue can appear alarming on histologic examination because they are often cellular and have atypical (activated) cytologic features, such as distinct nucleoli and mild hyperchromasia, and mitotic activity. Reactive lesions of bone and periosteum also produce bone and cartilage matrix, resulting in confusion with osteosarcoma or chondrosarcoma. Careful attention to key cytomorphological features such as the pattern of bone formation, uniform appearance of cells, and absence of atypical mitoses should help identify the reactive nature of a lesion. Correlation with clinical and radiological findings is also imperative to avoid misclassification of the tumor because reactive lesions often arise at sites where osteosarcoma and chondrosarcoma are rare (e.g., the hand) and lack aggressive radiological features. In this review we discuss reactive lesions of bone that are commonly confused with malignant neoplasms and that the practicing pathologist is likely to encounter at some point. Several of these lesions have had characteristic chromosomal translocations documented in recent years, but continue to be included as reactive lesions based on their overall clinicopathological features.
    MeSH term(s) Bone Cysts, Aneurysmal/diagnosis ; Bone Neoplasms/diagnosis ; Bony Callus/pathology ; Diagnosis, Differential ; Exostoses/diagnosis ; Fibromatosis, Aggressive/diagnosis ; Fracture Healing ; Humans ; Myositis Ossificans/diagnosis ; Osteochondroma/diagnosis ; Osteosarcoma/diagnosis ; Periostitis/diagnosis ; Tendon Injuries/diagnosis
    Language English
    Publishing date 2011-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605834-6
    ISSN 1930-1111 ; 0740-2570
    ISSN (online) 1930-1111
    ISSN 0740-2570
    DOI 10.1053/j.semdp.2011.02.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1988: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Epithelioid Trophoblastic Tumor: Expanding the Clinicopathologic Spectrum of a Rare Malignancy.

    McGregor, Stephanie M / Furtado, Larissa V / Montag, Anthony G / Brooks, Rebecca / Lastra, Ricardo R

    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists

    2018  Volume 39, Issue 1, Page(s) 8–18

    Abstract: Epithelioid trophoblastic tumor is a malignancy derived from the chorionic laeve-type intermediate trophoblast with sufficient rarity that the vast majority of literature on the topic exists in the form of case reports and small series. Classically, it ... ...

    Abstract Epithelioid trophoblastic tumor is a malignancy derived from the chorionic laeve-type intermediate trophoblast with sufficient rarity that the vast majority of literature on the topic exists in the form of case reports and small series. Classically, it is regarded as a well-circumscribed tumor with an expansile growth pattern that occurs in reproductive-aged women, usually after a normal pregnancy. However, we recently encountered a case of epithelioid trophoblastic tumor with aggressive spread throughout the abdomen and pelvis in a 68-yr-old female presenting 30 yr after her last delivery. Although to our knowledge this is the first report in a postmenopausal patient to be confirmed by molecular analysis of short tandem repeats, there are multiple similar case reports spanning a variety of clinical settings that deviate from the original description. We therefore sought to synthesize the clinicopathologic data among the available reports in the English literature, with emphasis on pathologic findings. While the overarching themes are largely unchanged, this series of 77 patients reveals a broader spectrum of disease and highlights frequent misdiagnosis. Here we present a clinicopathologic update on this rare entity, with emphasis on a practical approach to diagnosis.
    MeSH term(s) Adolescent ; Adult ; Aged ; Epithelioid Cells/pathology ; Female ; Genotyping Techniques ; Humans ; Immunohistochemistry ; Middle Aged ; Postmenopause ; Pregnancy ; Rare Diseases/diagnosis ; Rare Diseases/genetics ; Rare Diseases/pathology ; Time Factors ; Trophoblastic Neoplasms/diagnosis ; Trophoblastic Neoplasms/genetics ; Trophoblastic Neoplasms/pathology ; Uterine Neoplasms/diagnosis ; Uterine Neoplasms/genetics ; Uterine Neoplasms/pathology ; Young Adult
    Language English
    Publishing date 2018-10-29
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 604859-6
    ISSN 1538-7151 ; 0277-1691
    ISSN (online) 1538-7151
    ISSN 0277-1691
    DOI 10.1097/PGP.0000000000000563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1814: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The Stem Cell-associated Transcription Factor SOX2 as a Diagnostic Marker of High-grade Squamous Intraepithelial Lesion of the Uterine Cervix in Comparison With p16 and Ki-67.

    Wolsky, Rebecca J / Harbour, Lori N / Mirza, Kamran M / Montag, Anthony G / Gwin, Katja

    Applied immunohistochemistry & molecular morphology : AIMM

    2016  Volume 26, Issue 6, Page(s) 403–410

    Abstract: The transcription factor SOX2 has been identified as an oncogene involved in the pathogenesis of squamous cell carcinoma (SCC) of multiple sites, including the uterine cervix. The relationship between SOX2 overexpression and the continuum of precancerous ...

    Abstract The transcription factor SOX2 has been identified as an oncogene involved in the pathogenesis of squamous cell carcinoma (SCC) of multiple sites, including the uterine cervix. The relationship between SOX2 overexpression and the continuum of precancerous lesions of the cervix has not been previously elucidated. We evaluated SOX2 immunohistochemical expression in normal cervix, low-grade squamous intraepithelial lesion (LSIL) (mild squamous dysplasia), high-grade squamous intraepithelial lesion (HSIL) (moderate and severe dysplasia) and SCC of the cervix in comparison with p16 and Ki-67. Staining patterns were scored as negative, basal one third of the epithelium, lower two third, or full thickness. The results showed that SOX2 expression was limited to the basal one third in 84% of LSIL cases, whereas 95% of HSIL showed SOX2 expression up to two third or full thickness (P<0.0001). p16 and Ki-67 displayed similar results. The difference in SOX2 expression between moderate and severe dysplasia was not statistically significant (P=0.53). Invasive SCC positivity was as follows: SOX2 94%; p16 89%; and Ki-67 100%. Our findings support a role for SOX2 in the progression of squamous dysplasia to SCC. The Lower Anogenital Standardization Terminology Project's recent assertion of a lack of a biological correlate to cervical intraepithelial neoplasia II is also upheld by SOX2. For equivocal situations in which a diagnosis of cervical intraepithelial neoplasia II would have been made, Lower Anogenital Standardization Terminology recommends p16, or other biomarkers such as Ki-67 to clarify the diagnosis. SOX2, with a clean nuclear staining pattern, may also be suitable for this role.
    MeSH term(s) Biomarkers, Tumor/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Female ; Humans ; Immunohistochemistry ; Ki-67 Antigen/metabolism ; Neoplasm Grading ; SOXB1 Transcription Factors/metabolism ; Squamous Intraepithelial Lesions of the Cervix/diagnosis ; Uterine Cervical Neoplasms/diagnosis
    Chemical Substances Biomarkers, Tumor ; CDKN2A protein, human ; Cyclin-Dependent Kinase Inhibitor p16 ; Ki-67 Antigen ; SOX2 protein, human ; SOXB1 Transcription Factors
    Language English
    Publishing date 2016-08-01
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 1473273-7
    ISSN 1533-4058 ; 1062-3345 ; 1541-2016
    ISSN (online) 1533-4058
    ISSN 1062-3345 ; 1541-2016
    DOI 10.1097/PAI.0000000000000434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3783: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Effects of Slide Storage on Detection of Molecular Markers by IHC and FISH in Endometrial Cancer Tissues From a Clinical Trial: An NRG Oncology/GOG Pilot Study.

    Grushko, Tatyana A / Filiaci, Virginia L / Montag, Anthony G / Apushkin, Marsha / Gomez, Maria J / Monovich, Laura / Ramirez, Nilsa C / Schwab, Carlton / Kesterson, Joshua P / Seward, Shelly M / Method, Michael W / Olopade, Olufunmilayo I / Fleming, Gini F / Birrer, Michael J

    Applied immunohistochemistry & molecular morphology : AIMM

    2021  Volume 30, Issue 1, Page(s) 27–35

    Abstract: We performed a pilot study in anticipation of using long-aged precut formalin-fixed paraffin-embedded tissue sections stored in real-world conditions for translational biomarker studies of topoisomerase 2A (TOP2A), Ki67, and human epidermal growth factor ...

    Abstract We performed a pilot study in anticipation of using long-aged precut formalin-fixed paraffin-embedded tissue sections stored in real-world conditions for translational biomarker studies of topoisomerase 2A (TOP2A), Ki67, and human epidermal growth factor receptor 2 (HER2) in endometrial cancer. Formalin-fixed paraffin-embedded tissue blocks or unstained slides or both from GOG-0177 were collected centrally (1999-2000) and stored at room temperature. During 2004 to 2011 specimens were stored at 4°C. Matched pairs of stored slides and freshly cut slides from stored blocks were analyzed for TOP2A (KiS1), Ki67 (MIB1), and HER2 (HercepTest) proteins. To assess DNA stability (HER2 PathVision), fluorescence in situ hybridization (FISH) was repeated on stored slides from 21 cases previously shown to be HER2 amplified. Immunohistochemistry (IHC) staining intensity and extent, mean FISH copies/cell, and copy number ratios were compared using the κ statistic for concordance or signed rank test for differences in old cut versus new cut slides. IHC results reflected some protein degradation in stored slides. The proportion of cells with TOP2A staining was lower on average by 12% in older sections (P=0.03). The proportion of Ki67-positive cells was lower in stored slides by an average of 10% (P<0.01). Too few cases in the IHC cohort were FISH positive for any conclusions. HER2 amplification by FISH was unaffected by slide storage. We conclude that use of aged stored slides for proliferation markers TOP2A and Ki67 is feasible but may modestly underestimate true values in endometrial cancer. Pilot studies for particular storage conditions/durations/antigens to be used in translational studies are warranted.
    MeSH term(s) Aged ; Breast Neoplasms ; Endometrial Neoplasms/diagnosis ; Female ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Pilot Projects ; Receptor, ErbB-2/metabolism
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2021-06-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1473273-7
    ISSN 1533-4058 ; 1062-3345 ; 1541-2016
    ISSN (online) 1533-4058
    ISSN 1062-3345 ; 1541-2016
    DOI 10.1097/PAI.0000000000000949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3783: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Book: Biopsy interpretation

    Taxy, Jerome B / Husain, Aliya N / Montag, Anthony G

    the frozen section

    (Biopsy interpretation series)

    2014  

    Author's details Jerome B. Taxy, Aliya N. Husain, Anthony G. Montag
    Series title Biopsy interpretation series
    MeSH term(s) Frozen Sections/methods ; Biopsy/methods
    Language English
    Size xiii, 426 pages :, illustrations, portraits
    Edition Second edition.
    Document type Book
    ISBN 9781451186796 ; 1451186797
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article ; Online: Epithelioid and epithelial neoplasms of bone.

    Deyrup, Andrea T / Montag, Anthony G

    Archives of pathology & laboratory medicine

    2006  Volume 131, Issue 2, Page(s) 205–216

    Abstract: Context: Epithelioid and epithelial neoplasms seen in bone are rare and include epithelioid variants of vascular lesions, osteoblastoma, osteosarcoma, chordoma, and chondroblastoma as well as adamantinoma and metastatic carcinoma.: Objective: To ... ...

    Abstract Context: Epithelioid and epithelial neoplasms seen in bone are rare and include epithelioid variants of vascular lesions, osteoblastoma, osteosarcoma, chordoma, and chondroblastoma as well as adamantinoma and metastatic carcinoma.
    Objective: To provide an overview of tumors with epithelioid histology and address the clinical context and diagnostic issues.
    Data sources: Pertinent literature is reviewed with emphasis on recent and controversial issues.
    Conclusions: The differential diagnosis in epithelioid/epithelial lesions of bone is limited. The primary consideration in many cases is distinguishing primary from metastatic lesions.
    MeSH term(s) Biomarkers, Tumor/analysis ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Diagnosis, Differential ; Humans ; Immunohistochemistry ; Neoplasm Metastasis/pathology ; Neoplasms, Glandular and Epithelial/metabolism ; Neoplasms, Glandular and Epithelial/pathology
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2006-01-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/2007-131-205-EAENOB
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.36: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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