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  1. Article ; Online: Combined regimens of cisplatin and metformin in cancer therapy: A systematic review and meta-analysis.

    Jafarzadeh, Emad / Montazeri, Vahideh / Aliebrahimi, Shima / Sezavar, Ahmad Habibian / Ghahremani, Mohammad H / Ostad, Seyed Nasser

    Life sciences

    2022  Volume 304, Page(s) 120680

    Abstract: Introduction: Cancer cell resistance to chemotherapy agents is a challenging issue in treating patients with cancer. Findings suggest that a combination of drugs may have synergistic or additive effects. in the present study, we systematically reviewed ... ...

    Abstract Introduction: Cancer cell resistance to chemotherapy agents is a challenging issue in treating patients with cancer. Findings suggest that a combination of drugs may have synergistic or additive effects. in the present study, we systematically reviewed the combined regimens of metformin with cisplatin in various treating cancers.
    Methods: A comprehensive systematic search was performed in PubMed, Scopus, Embase, and other relevant databases with the following keyword "metformin", "cisplatin", "combination", "using all their equivalents and similar terms. Pooled odds ratio (OR) and 95% confidence intervals of cell viability and tumor volume as primary outcomes were calculated using Der-Simonian and Laird method while random effects meta-analysis was used, taking into account clinical and statistical heterogeneity.
    Results: Overall, 44 studies were retrieved, Findings of the present meta-analysis showed that combined regimens of metformin plus cisplatin was significantly associated with decreased odds of tumor volume and cell viability for all cancers compared with cisplatin alone (pooled OR: 0.40; 95% CI: 0.27, 0.58) and (pooled OR: 0.49; 95% CI: 0.42, 0.58) respectively. The result was same for cell viability in lung cancer (pooled OR: 0.59; 95% CI: 0.49, 0.70). The tumor size reduction and the response rate were evident in the animal xenografts model.
    Conclusion: Findings indicated that combining metformin with cisplatin is a practical therapeutic approach to increase treatment efficacy in the case of cell viability and tumor volume and minimize side effects. A combination of metformin with cisplatin could enhance treatment efficacy through synergistic inhibitory effects on the growth of cancer cells.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Cisplatin/adverse effects ; Humans ; Lung Neoplasms/pathology ; Metformin/pharmacology ; Metformin/therapeutic use
    Chemical Substances Antineoplastic Agents ; Metformin (9100L32L2N) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2022-06-02
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2022.120680
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  2. Article ; Online: The Impact of Cancer-Associated Fibroblasts on Drug Resistance, Stemness, and Epithelial-Mesenchymal Transition in Bladder Cancer: A Comparison between Recurrent and Non-Recurrent Patient-Derived CAFs.

    Rastegar-Pouyani, Nima / Montazeri, Vahideh / Marandi, Nikoo / Aliebrahimi, Shima / Andalib, Melika / Jafarzadeh, Emad / Montazeri, Hamed / Ostad, Seyed Nasser

    Cancer investigation

    2023  Volume 41, Issue 7, Page(s) 656–671

    Abstract: This study comparatively evaluated the possible effects of recurrent and non-recurrent patient-derived Cancer-Associated Fibroblasts (CAFs-R and -NR) on the bladder cancer cell line, EJ138. Both groups of CAFs increased cisplatin resistance and altered ... ...

    Abstract This study comparatively evaluated the possible effects of recurrent and non-recurrent patient-derived Cancer-Associated Fibroblasts (CAFs-R and -NR) on the bladder cancer cell line, EJ138. Both groups of CAFs increased cisplatin resistance and altered cell cycle distribution alongside induced resistance to apoptosis. Later, the scratch assay confirmed the cell migration-inducing effects of CAFs on cells. Nonetheless, only CAFs-R managed to increase sphere-formation and clonogenic levels in EJ138 cells, which were later validated by upregulating pluripotency transcription factors. Besides, CAFs-R also affected the expression levels of some of the EMT markers. Our study suggests that CAFs-R had stronger pro-tumorigenic effects on EJ138 cells.
    MeSH term(s) Humans ; Cancer-Associated Fibroblasts/metabolism ; Epithelial-Mesenchymal Transition ; Cell Line, Tumor ; Cell Proliferation ; Urinary Bladder Neoplasms/metabolism ; Cell Movement ; Drug Resistance, Neoplasm ; Fibroblasts/metabolism
    Language English
    Publishing date 2023-07-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 604942-4
    ISSN 1532-4192 ; 0735-7907
    ISSN (online) 1532-4192
    ISSN 0735-7907
    DOI 10.1080/07357907.2023.2237576
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  3. Article: Combined regimens of cisplatin and metformin in cancer therapy: A systematic review and meta-analysis

    Jafarzadeh, Emad / Montazeri, Vahideh / Aliebrahimi, Shima / Sezavar, Ahmad Habibian / Ghahremani, Mohammad H. / Ostad, Seyed Nasser

    Life sciences. 2022 Sept. 01, v. 304

    2022  

    Abstract: Cancer cell resistance to chemotherapy agents is a challenging issue in treating patients with cancer. Findings suggest that a combination of drugs may have synergistic or additive effects. in the present study, we systematically reviewed the combined ... ...

    Abstract Cancer cell resistance to chemotherapy agents is a challenging issue in treating patients with cancer. Findings suggest that a combination of drugs may have synergistic or additive effects. in the present study, we systematically reviewed the combined regimens of metformin with cisplatin in various treating cancers. A comprehensive systematic search was performed in PubMed, Scopus, Embase, and other relevant databases with the following keyword “metformin”, “cisplatin”, “combination”, “using all their equivalents and similar terms. Pooled odds ratio (OR) and 95% confidence intervals of cell viability and tumor volume as primary outcomes were calculated using Der-Simonian and Laird method while random effects meta-analysis was used, taking into account clinical and statistical heterogeneity. Overall, 44 studies were retrieved, Findings of the present meta-analysis showed that combined regimens of metformin plus cisplatin was significantly associated with decreased odds of tumor volume and cell viability for all cancers compared with cisplatin alone (pooled OR: 0.40; 95% CI: 0.27, 0.58) and (pooled OR: 0.49; 95% CI: 0.42, 0.58) respectively. The result was same for cell viability in lung cancer (pooled OR: 0.59; 95% CI: 0.49, 0.70). The tumor size reduction and the response rate were evident in the animal xenografts model. Findings indicated that combining metformin with cisplatin is a practical therapeutic approach to increase treatment efficacy in the case of cell viability and tumor volume and minimize side effects. A combination of metformin with cisplatin could enhance treatment efficacy through synergistic inhibitory effects on the growth of cancer cells.
    Keywords animals ; cancer therapy ; cell viability ; cisplatin ; drug therapy ; lung neoplasms ; meta-analysis ; metformin ; models ; neoplasm cells ; odds ratio ; systematic review ; xenotransplantation
    Language English
    Dates of publication 2022-0901
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2022.120680
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  4. Article ; Online: Thermal stress and TiO

    Habibi, Peymaneh / Ostad, Seyed Nasser / Monazzam, Mohammad Reza / Foroushani, Abbas Rahimi / Ghazi-Khansari, Mahmoud / Aliebrahimi, Shima / Montazeri, Vahideh / Golbabaei, Farideh

    Environmental science and pollution research international

    2022  Volume 29, Issue 60, Page(s) 90128–90139

    Abstract: Titanium dioxide (nano- ... ...

    Abstract Titanium dioxide (nano-TiO
    MeSH term(s) Humans ; Animals ; Mice ; Policy ; Oxidative Stress ; Apoptosis
    Language English
    Publishing date 2022-07-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-21796-5
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  5. Article ; Online: Effect of heat stress on DNA damage: a systematic literature review

    Habibi, Peymaneh / Ostad, Seyed Naser / Heydari, Ahad / Aliebrahimi, Shima / Montazeri, Vahideh / Foroushani, Abbas Rahimi / Monazzam, Mohammad Reza / Ghazi-Khansari, Mahmoud / Golbabaei, Farideh

    Int J Biometeorol. 2022 Nov., v. 66, no. 11 p.2147-2158

    2022  

    Abstract: Thermal stress has a direct effect on various types of DNA damage, which depends on the stage of the cell cycle when the cell is exposed to different climate conditions. A literature review was conducted to systematically investigate and assess the ... ...

    Abstract Thermal stress has a direct effect on various types of DNA damage, which depends on the stage of the cell cycle when the cell is exposed to different climate conditions. A literature review was conducted to systematically investigate and assess the overall effect of heat stress and DNA damage following heat exposure. In this study, electronic databases including PubMed, Scopus, and Web of Science were searched to find relevant literature on DNA damage in different ambient temperatures. Outcomes included (1) measurement of DNA damage in heat exposure, (2) three different quantification methods (comet assay, 8-hydroxy-2-deoxyguanosine (8-OHdG), and γ-H2AX), and (3) protocols used for moderate (31) and high temperatures (42). The evidence shows that long exposure and very high temperature can induce an increase in DNA damage through aggregate in natural proteins, ROS generation, cell death, and reproductive damage in hot-humid and hot-dry climate conditions. A substantial increase in DNA damage occurs following acute heat stress exposure, especially in tropical and subtropical climate conditions. The results of this systematic literature review showed a positive association between thermal stress exposure and inhibition of repair of DNA damage.
    Keywords DNA damage ; cell cycle ; cell death ; comet assay ; heat ; heat stress ; subtropics ; temperature
    Language English
    Dates of publication 2022-11
    Size p. 2147-2158.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    Note Review
    ZDB-ID 127361-9
    ISSN 0067-8902 ; 0020-7128
    ISSN 0067-8902 ; 0020-7128
    DOI 10.1007/s00484-022-02351-w
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  6. Article ; Online: Thermal stress and TiO2 nanoparticle–induced oxidative DNA damage and apoptosis in mouse hippocampus

    Habibi, Peymaneh / Ostad, Seyed Nasser / Monazzam, Mohammad Reza / Foroushani, Abbas Rahimi / Ghazi-Khansari, Mahmoud / Aliebrahimi, Shima / Montazeri, Vahideh / Golbabaei, Farideh

    Environ Sci Pollut Res. 2022 Dec., v. 29, no. 60 p.90128-90139

    2022  

    Abstract: Titanium dioxide (nano-TiO₂) is used abundantly in various industrial products and novel medical therapies. In addition, the impact of climate change on the health and safety will undoubtedly increase in the future. However, the effects of exposure to ... ...

    Abstract Titanium dioxide (nano-TiO₂) is used abundantly in various industrial products and novel medical therapies. In addition, the impact of climate change on the health and safety will undoubtedly increase in the future. However, the effects of exposure to these nanoparticles and heat stress on hippocampal DNA damage and apoptosis remain unclear. This study was conducted to evaluate the DNA damage and apoptosis in the hippocampal tissue and the physiological responses in mice induced by intraperitoneal (i.p.) administration of TiO₂ nanoparticles (NPs) and heat stress for 14 consecutive days. The results showed that heat stress and TiO₂-NPs were induced in the mouse hippocampus that led to hippocampal reactive oxygen species generation, oxidative damage of DNA, and apoptosis in a partly dose-dependent manner, especially at very hot temperature. High doses of nanosized TiO₂ and severe heat stress significantly damaged the function of the hippocampus, as shown in the comet assay and apoptosis tests. The results of this study may provide data for appropriate measures to control and assess the risk of nano-TiO₂ and thermal stress hazards to human health, especially workers. Safety guidelines and policies should be considered when handling nanomaterials in a hot environment.
    Keywords DNA ; DNA damage ; apoptosis ; climate change ; comet assay ; dose response ; heat stress ; hippocampus ; human health ; mice ; nanoparticles ; reactive oxygen species ; risk assessment ; temperature ; titanium dioxide
    Language English
    Dates of publication 2022-12
    Size p. 90128-90139.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-21796-5
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  7. Article ; Online: The Inhibitory Effect of Curcumin on Hypoxia Inducer Factors (Hifs) as a Regulatory Factor in the Growth of Tumor Cells in Breast Cancer Stem-Like Cells.

    Sarighieh, Mehrnaz Asadi / Montazeri, Vahideh / Shadboorestan, Amir / Ghahremani, Mohammad Hossein / Ostad, Seyed Nasser

    Drug research

    2020  Volume 70, Issue 11, Page(s) 512–518

    Abstract: Hypoxia in the microenvironment is related to chemotherapy resistance, tumor progression, and metastasis. Curcumin, as a phenolic compound extracted from the turmeric, has been used as an anti-cancer agent with low toxicity in recent years. Since ... ...

    Abstract Hypoxia in the microenvironment is related to chemotherapy resistance, tumor progression, and metastasis. Curcumin, as a phenolic compound extracted from the turmeric, has been used as an anti-cancer agent with low toxicity in recent years. Since curcumin has inhibitory activities against hypoxia-inducible factors (HIFs) in several cancers, this study was conducted to examine the effect of curcumin on MCF-7 cells and cancer stem-like cells (CS-LCs) under hypoxic and normoxic conditions. CS-LCs were isolated from MCF-7 cells using the magnet activated cell sorting (MACS) method based on CD
    MeSH term(s) Apoptosis/drug effects ; Apoptosis/genetics ; Aryl Hydrocarbon Receptor Nuclear Translocator/metabolism ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Curcumin/pharmacology ; Curcumin/therapeutic use ; Female ; G1 Phase Cell Cycle Checkpoints/drug effects ; G1 Phase Cell Cycle Checkpoints/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; MCF-7 Cells ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/pathology ; Tumor Hypoxia/drug effects ; Tumor Hypoxia/genetics ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics
    Chemical Substances ARNT protein, human ; Basic Helix-Loop-Helix Transcription Factors ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; Aryl Hydrocarbon Receptor Nuclear Translocator (138391-32-9) ; endothelial PAS domain-containing protein 1 (1B37H0967P) ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2020-09-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2703847-6
    ISSN 2194-9387 ; 2194-9379
    ISSN (online) 2194-9387
    ISSN 2194-9379
    DOI 10.1055/a-1201-2602
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  8. Article ; Online: Effect of heat stress on DNA damage: a systematic literature review.

    Habibi, Peymaneh / Ostad, Seyed Naser / Heydari, Ahad / Aliebrahimi, Shima / Montazeri, Vahideh / Foroushani, Abbas Rahimi / Monazzam, Mohammad Reza / Ghazi-Khansari, Mahmoud / Golbabaei, Farideh

    International journal of biometeorology

    2022  Volume 66, Issue 11, Page(s) 2147–2158

    Abstract: Thermal stress has a direct effect on various types of DNA damage, which depends on the stage of the cell cycle when the cell is exposed to different climate conditions. A literature review was conducted to systematically investigate and assess the ... ...

    Abstract Thermal stress has a direct effect on various types of DNA damage, which depends on the stage of the cell cycle when the cell is exposed to different climate conditions. A literature review was conducted to systematically investigate and assess the overall effect of heat stress and DNA damage following heat exposure. In this study, electronic databases including PubMed, Scopus, and Web of Science were searched to find relevant literature on DNA damage in different ambient temperatures. Outcomes included (1) measurement of DNA damage in heat exposure, (2) three different quantification methods (comet assay, 8-hydroxy-2-deoxyguanosine (8-OHdG), and γ-H2AX), and (3) protocols used for moderate (31) and high temperatures (42). The evidence shows that long exposure and very high temperature can induce an increase in DNA damage through aggregate in natural proteins, ROS generation, cell death, and reproductive damage in hot-humid and hot-dry climate conditions. A substantial increase in DNA damage occurs following acute heat stress exposure, especially in tropical and subtropical climate conditions. The results of this systematic literature review showed a positive association between thermal stress exposure and inhibition of repair of DNA damage.
    MeSH term(s) Humans ; DNA Damage ; 8-Hydroxy-2'-Deoxyguanosine ; Heat Stress Disorders ; Heat-Shock Response ; Hot Temperature
    Chemical Substances 8-Hydroxy-2'-Deoxyguanosine (88847-89-6)
    Language English
    Publishing date 2022-09-30
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 280324-0
    ISSN 1432-1254 ; 0020-7128
    ISSN (online) 1432-1254
    ISSN 0020-7128
    DOI 10.1007/s00484-022-02351-w
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    Zs.A 998: Show issues Location:
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  9. Article ; Online: Dual drug delivery system based on layered double hydroxides/carboxymethyl cellulose-poly ethylene oxide bionanocomposite electrospun fibrous mats: Fabrication, characterization, in-vitro and in-vivo studies.

    Yoosefi, Sepideh / Rakhshani, Amir / Montazeri, Vahideh / Tavakoli, Mohamadreza / Aliabadi, Amin / Fatahi, Yousef / Behrouzfar, Helia / Keihankhadiv, Shadi / Darbasizadeh, Behzad / Motasadizadeh, Hamidreza / Farhadnejad, Hassan

    International journal of biological macromolecules

    2022  Volume 222, Issue Pt B, Page(s) 3142–3154

    Abstract: The main goal of the present project was to design and develop ibuprofen (IBU) and layered double hydroxides-vancomycin (LDH-VAN) nanohybrid loaded bionanocomposite fibrous mats to increase the wound healing rate. Thus, first, LDH-VAN nanohybrid ... ...

    Abstract The main goal of the present project was to design and develop ibuprofen (IBU) and layered double hydroxides-vancomycin (LDH-VAN) nanohybrid loaded bionanocomposite fibrous mats to increase the wound healing rate. Thus, first, LDH-VAN nanohybrid particles was synthesized by in-situ incorporation of VAN into the Mg-Al-LDH interlayers during the co-precipitation of hydroxides. Then, LDH-VAN/IBU/CMC-PEO bionanocomposite fibrous mats were fabricated by electrospinning technique. Test samples were examined XRD, SEM, TEM, TGA, and FTIR. In vitro drug release test was performed in the phosphate buffer solution (pH = 7.4) to prove the efficiency of the fabricated bionanocomposite fibrous mats as a sustained-release carrier for both VAN and IBU. All the fabricated bionanocomposite fibrous mats did not displayed any significant cytotoxicity on NIH/3 T3 fibroblast cells. The wound area in the rats treated with LDH-VAN/IBU/CMC-PEO bionanocomposite fibrous mats was less than other treatment groups. Based on histological analysis, the LDH-VAN/IBU/CMC-PEO bionanocomposite fibrous mats possess a faster wound healing than other nanofibrous mats. Data obtained from the present project indicated that LDH-VAN/IBU/CMC-PEO bionanocomposite fibrous mats could accelerate the wound healing process.
    MeSH term(s) Rats ; Animals ; Carboxymethylcellulose Sodium/chemistry ; Polyethylene Glycols/chemistry ; Ethylene Oxide ; Drug Delivery Systems ; Nanofibers/chemistry ; Hydroxides ; Ibuprofen/pharmacology
    Chemical Substances Carboxymethylcellulose Sodium (K679OBS311) ; Polyethylene Glycols (3WJQ0SDW1A) ; Ethylene Oxide (JJH7GNN18P) ; Hydroxides ; Ibuprofen (WK2XYI10QM)
    Language English
    Publishing date 2022-10-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2022.10.087
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  10. Article: [No title information]

    Sarighieh, Mehrnaz Asadi / Montazeri, Vahideh / Shadboorestan, Amir / Ghahremani, Mohammad Hossein / Ostad, Seyed Nasser

    Drug Research

    2020  Volume 70, Issue 11, Page(s) 512–518

    Abstract: Hypoxia in the microenvironment is related to chemotherapy resistance, tumor progression, and metastasis. Curcumin, as a phenolic compound extracted from the turmeric, has been used as an anti-cancer agent with low ...

    Abstract Hypoxia in the microenvironment is related to chemotherapy resistance, tumor progression, and metastasis. Curcumin, as a phenolic compound extracted from the turmeric, has been used as an anti-cancer agent with low toxicity in recent years. Since curcumin has inhibitory activities against hypoxia-inducible factors (HIFs) in several cancers, this study was conducted to examine the effect of curcumin on MCF-7 cells and cancer stem-like cells (CS-LCs) under hypoxic and normoxic conditions. CS-LCs were isolated from MCF-7 cells using the magnet activated cell sorting (MACS) method based on CD 44 / CD 24 surface markers. The effects of curcumin on the viability of MCF-7 cells and CS-LCs were examined in hypoxic and normoxic conditions using the MTT test. The effects of curcumin on apoptosis and cell cycle of CS-LCs and MCF-7 cells were analyzed using flow cytometry. Moreover, the inhibitory effects of curcumin on the levels of HIF-1 and HIF-2α protein in CS-LCs were investigated using the western blot method. Early apoptosis occurred in CSC-LCs more than MCF-7 cells under hypoxic conditions. Flow cytometry assay showed that curcumin caused cell cycle arrest of CSC-LCs and MCF-7 at the G2/M phase under hypoxic conditions while under normoxic conditions, arrest occurred at the G0/G1 phase in MCF-7 cells and at S and G2/M phases in CS-LCs. Based on the results, the curcumin inhibited the expression of HIF-1 by degrading ARNT in CS-LCs. In conclusion, curcumin has inhibitory effects on MCF- 7 cells and CS- LCs and thus may be used as an antitumor agent.
    Keywords anticancer drugs ; apoptosis ; toxicology
    Language English
    Publishing date 2020-09-22
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2703847-6
    ISSN 2194-9387 ; 2194-9379
    ISSN (online) 2194-9387
    ISSN 2194-9379
    DOI 10.1055/a-1201-2602
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