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  1. AU="Monte, Natasha"
  2. AU="Sarma, D.K."
  3. AU=Deng Lisi AU=Deng Lisi
  4. AU=Deshmukh V
  5. AU="Gutiérrez-García, Carmen"
  6. AU="Johnson, Sally"
  7. AU="Sousa, Amanda Freire Tamburini"
  8. AU="Cronin, Chunxia"
  9. AU=Weder W
  10. AU="Nirja Thakur"
  11. AU="Jiang, Shimin"
  12. AU="Wu, Xue-Ying"
  13. AU="Carlos Augusto de Mattos"
  14. AU="Procopio, Francesco A"
  15. AU="Nagata, Kosei"
  16. AU="Kevin Pottie"
  17. AU=Das Tandrila AU=Das Tandrila
  18. AU="Couto Souza, Paulo Henrique"
  19. AU="Morris, Zachary"

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  1. Artikel ; Online: Genomic investigation on genes related to mercury metabolism in Amazonian indigenous populations.

    Carvalho, Victor Hugo Valente / Rodrigues, Juliana Carla Gomes / Vinagre, Lui Wallacy Morikawa Souza / Pereira, Esdras Edgar Batista / Monte, Natasha / Fernandes, Marianne Rodrigues / Ribeiro-Dos-Santos, André Maurício / Guerreiro, João Farias / Ribeiro-Dos-Santos, Ândrea / Dos Santos, Sidney Emanuel Batista / Dos Santos, Ney Pereira Carneiro

    The Science of the total environment

    2024  Band 923, Seite(n) 171232

    Abstract: Studies have identified elevated levels of mercury in Amazonian Indigenous individuals, highlighting them as one of the most exposed to risks. In the unique context of the Brazilian Indigenous population, it is crucial to identify genetic variants with ... ...

    Abstract Studies have identified elevated levels of mercury in Amazonian Indigenous individuals, highlighting them as one of the most exposed to risks. In the unique context of the Brazilian Indigenous population, it is crucial to identify genetic variants with clinical significance to better understand vulnerability to mercury and its adverse effects. Currently, there is a lack of research on the broader genomic profile of Indigenous people, particularly those from the Amazon region, concerning mercury contamination. Therefore, the aim of this study was to assess the genomic profile related to the processes of mercury absorption, distribution, metabolism, and excretion in 64 Indigenous individuals from the Brazilian Amazon. We aimed to determine whether these individuals exhibit a higher susceptibility to mercury exposure. Our study identified three high-impact variants (GSTA1 rs1051775, GSTM1 rs1183423000, and rs1241704212), with the latter two showing a higher frequency in the study population compared to global populations. Additionally, we discovered seven new variants with modifier impact and a genomic profile different from the worldwide populations. These genetic variants may predispose the study population to more harmful mercury exposure compared to global populations. As the first study to analyze broader genomics of mercury metabolism pathways in Brazilian Amazonian Amerindians, we emphasize that our research aims to contribute to public policies by utilizing genomic investigation as a method to identify populations with a heightened susceptibility to mercury exposure.
    Mesh-Begriff(e) Humans ; Mercury/analysis ; Indians, South American/genetics ; Indigenous Peoples ; Genomics ; Brazil
    Chemische Substanzen Mercury (FXS1BY2PGL)
    Sprache Englisch
    Erscheinungsdatum 2024-02-23
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171232
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  2. Artikel ; Online: Genomic Variants and Worldwide Epidemiology of Breast Cancer: A Genome-Wide Association Studies Correlation Analysis.

    da Costa Nunes, Giovanna Gilioli / de Freitas, Lilian Marques / Monte, Natasha / Gellen, Laura Patrícia Albarello / Santos, Aline Pasquini / de Moraes, Francisco Cezar Aquino / da Costa, Ana Caroline Alves / de Lima, Milena Cardoso / Fernandes, Marianne Rodrigues / Dos Santos, Sidney Emanuel Batista / Dos Santos, Ney Pereira Carneiro

    Genes

    2024  Band 15, Heft 2

    Abstract: Breast cancer (BCa) is the most common cancer and leading cause of cancer death among women globally. This can be explained by the genetic factor of this disease. This article aims to correlate the epidemiological data, worldwide incidence, and mortality ...

    Abstract Breast cancer (BCa) is the most common cancer and leading cause of cancer death among women globally. This can be explained by the genetic factor of this disease. This article aims to correlate the epidemiological data, worldwide incidence, and mortality of BCa with the Single-Nucleotide Polymorphisms (SNPs) associated with the susceptibility and severity in different populations. Two hundred and forty genetic variants associated with BCa susceptibility/severity were selected from the literature through Genome-Wide Association Studies (GWAS). The allele frequencies were obtained from the 1000 Genomes Project, and the epidemiological data were obtained from the World Health Organization (WHO). The BCa incidence, mortality rates, and allele frequencies of the variants were evaluated using Pearson's correlation. Our study demonstrated that 11 SNPs (rs3817578, rs4843437, rs3754934, rs61764370, rs780092, rs2290203, rs10411161, rs6001930, rs16886165, rs8051542 and rs4973768) were significantly correlated with the epidemiological data in different ethnic groups. Seven polymorphisms (rs3817578, rs3754934, rs780092, rs2290203, rs10411161, rs6001930 and rs16886165) were inversely correlated with the incidence rate and four polymorphisms (rs4843437, rs61764370, rs8051542 and rs4973768) were directly correlated with the incidence rate. African and South-East Asian populations have a lower risk of developing BCa when evaluated in terms of genetic factors since they possess variants characterized as protective, as their higher incidence is associated with a lower frequency of BCa cases. The genetic variants investigated here are likely to predispose individuals to BCa. The genetic study described here is promising for implementing personalized strategies to screen for breast cancer in diverse populations.
    Mesh-Begriff(e) Humans ; Female ; Genome-Wide Association Study ; Genetic Predisposition to Disease ; Breast Neoplasms/epidemiology ; Breast Neoplasms/genetics ; Polymorphism, Single Nucleotide ; Genomics
    Sprache Englisch
    Erscheinungsdatum 2024-01-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes15020145
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Molecular Profile of Important Genes for Radiogenomics in the Amazon Indigenous Population.

    de Lima, Milena Cardoso / de Castro, Cinthia Costa / Aguiar, Kaio Evandro Cardoso / Monte, Natasha / Nunes, Giovanna Gilioli da Costa / Costa, Ana Caroline Alves da / Rodrigues, Juliana Carla Gomes / Guerreiro, João Farias / Ribeiro-Dos-Santos, Ândrea / Assumpção, Paulo Pimentel de / Burbano, Rommel Mario Rodríguez / Fernandes, Marianne Rodrigues / Dos Santos, Sidney Emanuel Batista / Dos Santos, Ney Pereira Carneiro

    Journal of personalized medicine

    2024  Band 14, Heft 5

    Abstract: Radiotherapy is focused on the tumor but also reaches healthy tissues, causing toxicities that are possibly related to genomic factors. In this context, radiogenomics can help reduce the toxicity, increase the effectiveness of radiotherapy, and ... ...

    Abstract Radiotherapy is focused on the tumor but also reaches healthy tissues, causing toxicities that are possibly related to genomic factors. In this context, radiogenomics can help reduce the toxicity, increase the effectiveness of radiotherapy, and personalize treatment. It is important to consider the genomic profiles of populations not yet studied in radiogenomics, such as the indigenous Amazonian population. Thus, our objective was to analyze important genes for radiogenomics, such as
    Sprache Englisch
    Erscheinungsdatum 2024-04-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14050484
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Influence of APOE locus on poor prognosis of COVID-19

    Rodrigues, Juliana Carla Gomes / Pinto, Pablo / Leitão, Luciana Pereira Colares / Vinagre, Lui Wallacy Morikawa Souza / Monte, Natasha / Fernandes, Marianne Rodrigues / Khayat, André Salim / de Assumpção, Paulo Pimentel / Santos, Ney Pereira Carneiro dos / Santos, Sidney Emanuel Batista dos

    Heliyon. 2021 June, v. 7, no. 6

    2021  

    Abstract: The COVID-19 pandemic has infected over 25 million of people worldwide, 5% of whom evolved to death and, among of the active cases, more than 60 thousand are classified as critical or severe. Recent studies revealed that ApoE, a protein encoded by APOE ... ...

    Abstract The COVID-19 pandemic has infected over 25 million of people worldwide, 5% of whom evolved to death and, among of the active cases, more than 60 thousand are classified as critical or severe. Recent studies revealed that ApoE, a protein encoded by APOE gene, may increase the risk of severe COVID-19 cases. ApoE has been involved with prevention of tissue damage and promotion of adaptative immune response in the lungs. This study investigated frequencies distribution of alleles that alter the ApoE expression in lung tissues to trace a profile of these variants and associate them to COVID-19 clinical outcomes. Data about APOE expression levels was obtained from the Genotype-Tissue Expression Project and the allele frequencies of APOE variants was acquired from the populations included in the phase 3 release of the 1000 Genomes Project. A total of 128 variants showed a significant impact on the APOE expression in lung tissues (p < 0.0001). Linkage Disequilibrium analysis revealed that 98 variants were closely grouped into seven distinct haplotype blocks, of which six were composed of variants that significantly decrease APOE gene expression in the lungs. Most of the haplotypes with higher impact on APOE expression showed greater frequencies in Europeans and lower in Africans, which implies that European populations might be more susceptible to SARS-CoV-2 infection. The present study indicates a potential genetic contribution of APOE expression-modifying variants in modulating the prognosis of COVID-19.
    Schlagwörter COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; alleles ; death ; gene expression ; haplotypes ; immune response ; linkage disequilibrium ; loci ; lungs ; prognosis ; risk
    Sprache Englisch
    Erscheinungsverlauf 2021-06
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2021.e07379
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel ; Online: Epidemiological-molecular profile of variants associated with type 2 diabetes mellitus in indigenous populations from the Brazilian Amazon.

    Monte, Natasha / Carla Gomes Rodrigues, Juliana / Wallacy Morikawa Souza Vinagre, Lui / Favacho Pastana, Lucas / Leite de Alcântara, Angélica / Pereira Colares Leitão, Luciana / Maurício Ribeiro-Dos-Santos, André / Rodrigues Fernandes, Marianne / Ribeiro-Dos-Santos, Ândrea / Farias Guerreiro, João / Pimentel Assumpção, Paulo / Santos, Sidney / José de Souza, Sandro / Pereira Carneiro Dos Santos, Ney

    Diabetes research and clinical practice

    2023  Band 199, Seite(n) 110641

    Abstract: Aims: While lifestyle factors are strongly associated with Type 2 diabetes (T2DM), genetic characteristics also play a role. However, much of the research on T2DM genetics focuses on European and Asian populations, leaving underrepresented groups, such ... ...

    Abstract Aims: While lifestyle factors are strongly associated with Type 2 diabetes (T2DM), genetic characteristics also play a role. However, much of the research on T2DM genetics focuses on European and Asian populations, leaving underrepresented groups, such as indigenous populations with high diabetes prevalence, understudied.
    Methods: We characterized the molecular profile of 10 genes involved in T2DM risk through complete exome sequencing of 64 indigenous individuals belonging to 12 different Amazonian ethnic groups.
    Results: The analysis revealed 157 variants, including four exclusive variants in the indigenous population located in the NOTCH2 and WFS1 genes with a modifier or moderate impact on protein effectiveness. Furthermore, a high impact variant in NOTCH2 was also found. Additionally, the frequency of 10 variants in the indigenous group showed significant differences when compared to other global populations that were evaluated.
    Conclusion: Our study identified 4 novel variants associated with T2DM in the NOTCH2 and WFS1 genes in the Amazonian indigenous populations we studied. In addition, a variant with a high predicted impact in NOTCH2 was also observed. These findings represent a valuable starting point for conducting further association and functional studies, which could help to improve our understanding of the unique characteristics of this population.
    Mesh-Begriff(e) Humans ; Brazil/epidemiology ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; Ethnicity ; Genetic Predisposition to Disease ; Indigenous Peoples/genetics
    Sprache Englisch
    Erscheinungsdatum 2023-03-24
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2023.110641
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2047: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Artikel: Influence of

    Rodrigues, Juliana Carla Gomes / Pinto, Pablo / Leitão, Luciana Pereira Colares / Vinagre, Lui Wallacy Morikawa Souza / Monte, Natasha / Fernandes, Marianne Rodrigues / Khayat, André Salim / de Assumpção, Paulo Pimentel / Santos, Ney Pereira Carneiro Dos / Santos, Sidney Emanuel Batista Dos

    Heliyon

    2021  Band 7, Heft 6, Seite(n) e07379

    Abstract: The COVID-19 pandemic has infected over 25 million of people worldwide, 5% of whom evolved to death and, among of the active cases, more than 60 thousand are classified as critical or severe. Recent studies revealed that ApoE, a protein encoded ... ...

    Abstract The COVID-19 pandemic has infected over 25 million of people worldwide, 5% of whom evolved to death and, among of the active cases, more than 60 thousand are classified as critical or severe. Recent studies revealed that ApoE, a protein encoded by
    Sprache Englisch
    Erscheinungsdatum 2021-06-23
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2021.e07379
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon population.

    Monte, Natasha / Pantoja, Karla B C C / Rodrigues, Juliana C G / de Carvalho, Darlen C / Azevedo, Tereza C B / Pereira, Esdras E B / de Assumpção, Paulo P / Dos Santos, Sidney E B / Fernandes, Marianne R / Dos Santos, Ney P C

    Molecular genetics & genomic medicine

    2021  Band 9, Heft 7, Seite(n) e1694

    Abstract: Background: Susceptibility to Chronic Myeloid Leukemia (CML) may be modulated by genetic variables. However, the majority of previous investigations have focused on genetically homogeneous populations, resulting in a lack of evidence on how genetic ... ...

    Abstract Background: Susceptibility to Chronic Myeloid Leukemia (CML) may be modulated by genetic variables. However, the majority of previous investigations have focused on genetically homogeneous populations, resulting in a lack of evidence on how genetic factors may influence the development of CML in miscegenated populations. We analyzed 30 polymorphisms in genes related to DNA repair, folate metabolism, transmembrane transport, xenobiotic metabolism, and pyrimidine synthesis in relation to their potential role in the susceptibility of the individual to CML.
    Methods: This case-control study included 126 healthy individuals and 143 patients diagnosed with CML from the admixed population of the Brazilian Amazon. The samples were genotyped by real-time PCR and the genetic ancestry analysis was based on a panel of 61 ancestry informative markers.
    Results: The results indicated a protective effect against the development of CML in carriers of the C allele of the rs28399433 (CYP2A6) gene and the CC genotype of the rs3742106 (ABCC4) gene.
    Conclusion: Our findings suggest that the rs3742106 (ABCC4) and rs28399433 (CYP2A6) polymorphisms may modulate susceptibility to CML in a population of the Brazilian Amazon region.
    Mesh-Begriff(e) Adult ; Brazil ; Cytochrome P-450 CYP2A6/genetics ; Female ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Male ; Middle Aged ; Multidrug Resistance-Associated Proteins/genetics ; Polymorphism, Single Nucleotide
    Chemische Substanzen ABCC4 protein, human ; Multidrug Resistance-Associated Proteins ; CYP2A6 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP2A6 (EC 1.14.14.1)
    Sprache Englisch
    Erscheinungsdatum 2021-05-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2734884-2
    ISSN 2324-9269 ; 2324-9269
    ISSN (online) 2324-9269
    ISSN 2324-9269
    DOI 10.1002/mgg3.1694
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Molecular Profile of Variants Potentially Associated with Severe Forms of COVID-19 in Amazonian Indigenous Populations.

    Coelho, Rita de Cássia Calderaro / Martins, Carlliane Lima E Lins Pinto / Pastana, Lucas Favacho / Rodrigues, Juliana Carla Gomes / Aguiar, Kaio Evandro Cardoso / Cohen-Paes, Amanda de Nazaré / Gellen, Laura Patrícia Albarello / Moraes, Francisco Cezar Aquino de / Calderaro, Maria Clara Leite / de Assunção, Letícia Almeida / Monte, Natasha / Pereira, Esdras Edgar Batista / Ribeiro-Dos-Santos, André Maurício / Ribeiro-do-Santos, Ândrea / Rodriguez Burbano, Rommel Mario / de Souza, Sandro José / Guerreiro, João Farias / Assumpção, Paulo Pimentel de / Santos, Sidney Emanuel Batista Dos /
    Fernandes, Marianne Rodrigues / Santos, Ney Pereira Carneiro Dos

    Viruses

    2024  Band 16, Heft 3

    Abstract: Coronavirus disease 2019 (COVID-19) is an infection caused by SARS-CoV-2. Genome-wide association studies (GWASs) have suggested a strong association of genetic factors with the severity of the disease. However, many of these studies have been completed ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is an infection caused by SARS-CoV-2. Genome-wide association studies (GWASs) have suggested a strong association of genetic factors with the severity of the disease. However, many of these studies have been completed in European populations, and little is known about the genetic variability of indigenous peoples' underlying infection by SARS-CoV-2. The objective of the study is to investigate genetic variants present in the genes
    Mesh-Begriff(e) Humans ; COVID-19/epidemiology ; COVID-19/genetics ; SARS-CoV-2/genetics ; Genome-Wide Association Study ; Gene Frequency ; Indigenous Peoples/genetics ; Intracellular Signaling Peptides and Proteins ; LIM Domain Proteins
    Chemische Substanzen LIMD1 protein, human ; Intracellular Signaling Peptides and Proteins ; LIM Domain Proteins
    Sprache Englisch
    Erscheinungsdatum 2024-02-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16030359
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Impact of Variants in the ATIC and ARID5B Genes on Therapeutic Failure with Imatinib in Patients with Chronic Myeloid Leukemia

    Cereja Pantoja, Karla Beatriz Cardias / Azevedo, Tereza Cristina de Brito / Carvalho, Darlen Cardoso de / Monte, Natasha / Cohen Paes, Amanda de Nazaré / Barros, Maria Clara da Costa / Vinagre, Lui Wallacy Morikawa Souza / Freitas, Ana Rosa Sales de / Burbano, Rommel Mario Rodríguez / Assumpção, Paulo Pimentel de / Santos, Sidney Emanuel Batista dos / Fernandes, Marianne Rodrigues / Santos, Ney Pereira Carneiro dos

    Genes. 2022 Feb. 10, v. 13, no. 2

    2022  

    Abstract: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm derived from the balanced reciprocal translocation of chromosomes 9 and 22 t (9q34 and 22q11), which leads to the formation of the Philadelphia chromosome and fusion of the BCR-ABL genes. ... ...

    Abstract Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm derived from the balanced reciprocal translocation of chromosomes 9 and 22 t (9q34 and 22q11), which leads to the formation of the Philadelphia chromosome and fusion of the BCR-ABL genes. The first-line treatment for CML is imatinib, a tyrosine kinase inhibitor that acts on the BCR-ABL protein. However, even though it is a target-specific drug, about 25% of patients do not respond to this treatment. The resistance mechanisms involved in this process have been investigated and studies have shown that germinal alterations can influence this mechanism. The aim of this work was to investigate 32 polymorphisms in 24 genes of carcinogenic pathway to verify the influence of these genetic variants on the response to treatment with imatinib. Our results demonstrated that individuals with the recessive GG genotype for the rs2372536 variant in the ATIC gene are approximately three times more likely to experience treatment failure with imatinib (p = 0.045, HR = 2.726, 95% CI = 0.9986–7.441), as well as individuals with the TT genotype for the rs10821936 variant in the ARID5B gene, who also have a higher risk for treatment failure with imatinib over time (p = 0.02, HR = 0.4053, IC 95% = 0.1802–0.911). In conclusion, we show that variants in the ATIC and ARIDB5 gene, never screened in previous studies, could potentially influence the therapeutic response to imatinib in patients treated for CML.
    Schlagwörter carcinogenicity ; chromosomes ; drugs ; genes ; genotype ; myeloid leukemia ; reciprocal translocation ; risk ; therapeutics ; tyrosine
    Sprache Englisch
    Erscheinungsverlauf 2022-0210
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13020330
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel ; Online: Impact of Variants in the

    Cereja Pantoja, Karla Beatriz Cardias / Azevedo, Tereza Cristina de Brito / Carvalho, Darlen Cardoso de / Monte, Natasha / Cohen Paes, Amanda de Nazaré / Barros, Maria Clara da Costa / Vinagre, Lui Wallacy Morikawa Souza / Freitas, Ana Rosa Sales de / Burbano, Rommel Mario Rodríguez / Assumpção, Paulo Pimentel de / Santos, Sidney Emanuel Batista Dos / Fernandes, Marianne Rodrigues / Santos, Ney Pereira Carneiro Dos

    Genes

    2022  Band 13, Heft 2

    Abstract: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm derived from the balanced reciprocal translocation of chromosomes 9 and 22 t (9q34 and 22q11), which leads to the formation of the Philadelphia chromosome and fusion of ... ...

    Abstract Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm derived from the balanced reciprocal translocation of chromosomes 9 and 22 t (9q34 and 22q11), which leads to the formation of the Philadelphia chromosome and fusion of the
    Mesh-Begriff(e) Benzamides ; DNA-Binding Proteins/genetics ; Drug Resistance, Neoplasm/genetics ; Humans ; Hydroxymethyl and Formyl Transferases ; Imatinib Mesylate/therapeutic use ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Multienzyme Complexes ; Nucleotide Deaminases ; Piperazines ; Pyrimidines/therapeutic use ; Transcription Factors/genetics ; Translocation, Genetic
    Chemische Substanzen ARID5B protein, human ; Benzamides ; DNA-Binding Proteins ; Multienzyme Complexes ; Piperazines ; Pyrimidines ; Transcription Factors ; inosine monophosphate synthase ; Imatinib Mesylate (8A1O1M485B) ; Hydroxymethyl and Formyl Transferases (EC 2.1.2.-) ; Nucleotide Deaminases (EC 3.5.4.-)
    Sprache Englisch
    Erscheinungsdatum 2022-02-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13020330
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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