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  1. AU="Monteiro, Elodie"
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  1. Article ; Online: RAR Inhibitors Display Photo-Protective and Anti-Inflammatory Effects in A2E Stimulated RPE Cells In Vitro through Non-Specific Modulation of PPAR or RXR Transactivation.

    Fontaine, Valérie / Boumedine, Thinhinane / Monteiro, Elodie / Fournié, Mylène / Gersende, Gendre / Sahel, José-Alain / Picaud, Serge / Veillet, Stanislas / Lafont, René / Latil, Mathilde / Dilda, Pierre J / Camelo, Serge

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: ... ...

    Abstract N
    MeSH term(s) Anti-Inflammatory Agents ; Carotenoids ; Drug Inverse Agonism ; Inflammation ; Macular Degeneration/metabolism ; para-Aminobenzoates ; Peroxisome Proliferator-Activated Receptors/metabolism ; Quinolines ; Retinoic Acid Receptor alpha/metabolism ; Retinoid X Receptors/metabolism ; Retinoids/metabolism ; Transcriptional Activation ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances 4-(5,6-dihydro-5,5-dimethyl-8-(quinolin-3-yl)naphthalen-2-carboxamido)benzoic acid ; Anti-Inflammatory Agents ; Carotenoids (36-88-4) ; norbixin (E8M59E17AI) ; para-Aminobenzoates ; Peroxisome Proliferator-Activated Receptors ; Quinolines ; Retinoic Acid Receptor alpha ; Retinoid X Receptors ; Retinoids ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25053037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Anti-Inflammatory Effects and Photo- and Neuro-Protective Properties of BIO203, a New Amide Conjugate of Norbixin, in Development for the Treatment of Age-Related Macular Degeneration (AMD).

    Fontaine, Valérie / Balducci, Christine / Dinan, Laurence / Monteiro, Elodie / Boumedine, Thinhinane / Fournié, Mylène / Nguyen, Vincent / Guibout, Louis / Clatot, Justine / Latil, Mathilde / Veillet, Stanislas / Sahel, José-Alain / Lafont, René / Dilda, Pierre J / Camelo, Serge

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: 9'- ...

    Abstract 9'-
    MeSH term(s) Animals ; Mice ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Anti-Inflammatory Agents/metabolism ; ATP-Binding Cassette Transporters/metabolism ; Carotenoids/metabolism ; Macular Degeneration/drug therapy ; Macular Degeneration/metabolism ; Retinal Degeneration/drug therapy ; Retinal Degeneration/metabolism ; Retinal Pigment Epithelium/metabolism ; Retinoids/pharmacology ; Rats
    Chemical Substances Abca4 protein, mouse ; Anti-Inflammatory Agents ; ATP-Binding Cassette Transporters ; Carotenoids (36-88-4) ; norbixin (E8M59E17AI) ; Retinoids
    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A2E-induced inflammation and angiogenesis in RPE cells

    Fontaine, Valérie / Fournié, Mylène / Monteiro, Elodie / Boumedine, Thinhinane / Balducci, Christine / Guibout, Louis / Latil, Mathilde / Sahel, José-Alain / Veillet, Stanislas / Dilda, Pierre J / Lafont, René / Camelo, Serge

    Aging

    2021  Volume 13, Issue 18, Page(s) 22040–22058

    Abstract: ... ...

    Abstract N
    MeSH term(s) Angiogenesis Inhibitors/administration & dosage ; Animals ; Carotenoids/administration & dosage ; Humans ; Macular Degeneration/chemically induced ; Macular Degeneration/drug therapy ; Macular Degeneration/genetics ; Macular Degeneration/immunology ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/etiology ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/immunology ; PPAR alpha/genetics ; PPAR alpha/immunology ; PPAR delta/genetics ; PPAR delta/immunology ; PPAR gamma/genetics ; PPAR gamma/immunology ; PPAR-beta/genetics ; PPAR-beta/immunology ; Retinal Pigment Epithelium/drug effects ; Retinal Pigment Epithelium/immunology ; Retinoid X Receptors/agonists ; Retinoid X Receptors/genetics ; Retinoid X Receptors/immunology ; Retinoids/adverse effects ; Retinoids/immunology ; Swine ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/immunology
    Chemical Substances A2-E (N-retinylidene-N-retinylethanolamine) ; Angiogenesis Inhibitors ; PPAR alpha ; PPAR delta ; PPAR gamma ; PPAR-beta ; Retinoid X Receptors ; Retinoids ; Vascular Endothelial Growth Factor A ; Carotenoids (36-88-4) ; norbixin (E8M59E17AI)
    Language English
    Publishing date 2021-09-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.203558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease.

    Fontaine, Valérie / Monteiro, Elodie / Fournié, Mylène / Brazhnikova, Elena / Boumedine, Thinhinane / Vidal, Cécile / Balducci, Christine / Guibout, Louis / Latil, Mathilde / Dilda, Pierre J / Veillet, Stanislas / Sahel, José-Alain / Lafont, René / Camelo, Serge

    Aging

    2020  Volume 12, Issue 7, Page(s) 6151–6171

    Abstract: Atrophic A\age-related macular degeneration (AMD) and Stargardt disease (STGD) are major blinding diseases affecting millions of patients worldwide, but no treatment is available. In dry AMD and STGD oxidative stress and subretinal accumulation ... ...

    Abstract Atrophic A\age-related macular degeneration (AMD) and Stargardt disease (STGD) are major blinding diseases affecting millions of patients worldwide, but no treatment is available. In dry AMD and STGD oxidative stress and subretinal accumulation of
    MeSH term(s) Animals ; Carotenoids/pharmacology ; Drug Monitoring/methods ; Electroretinography/methods ; Injections, Intraperitoneal ; Macular Degeneration/drug therapy ; Macular Degeneration/metabolism ; Macular Degeneration/prevention & control ; Mice ; Neuroprotective Agents/pharmacology ; Photoreceptor Cells, Vertebrate/drug effects ; Photoreceptor Cells, Vertebrate/metabolism ; Retinoids/antagonists & inhibitors ; Retinoids/metabolism ; Stargardt Disease/drug therapy ; Stargardt Disease/metabolism ; Stargardt Disease/prevention & control ; Treatment Outcome
    Chemical Substances A2-E (N-retinylidene-N-retinylethanolamine) ; Neuroprotective Agents ; Retinoids ; Carotenoids (36-88-4) ; norbixin (E8M59E17AI)
    Language English
    Publishing date 2020-04-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.103014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo.

    Fontaine, Valérie / Monteiro, Elodie / Brazhnikova, Elena / Lesage, Laëtitia / Balducci, Christine / Guibout, Louis / Feraille, Laurence / Elena, Pierre-Paul / Sahel, José-Alain / Veillet, Stanislas / Lafont, René

    PloS one

    2016  Volume 11, Issue 12, Page(s) e0167793

    Abstract: The accumulation of N-retinylidene-N-retinylethanolamine (A2E, a toxic by-product of the visual pigment cycle) in the retinal pigment epithelium (RPE) is a major cause of visual impairment in the elderly. Photooxidation of A2E results in retinal pigment ... ...

    Abstract The accumulation of N-retinylidene-N-retinylethanolamine (A2E, a toxic by-product of the visual pigment cycle) in the retinal pigment epithelium (RPE) is a major cause of visual impairment in the elderly. Photooxidation of A2E results in retinal pigment epithelium degeneration followed by that of associated photoreceptors. Present treatments rely on nutrient supplementation with antioxidants. 9'-cis-Norbixin (a natural diapocarotenoid, 97% purity) was prepared from Bixa orellana seeds. It was first evaluated in primary cultures of porcine retinal pigment epithelium cells challenged with A2E and illuminated with blue light, and it provided an improved photo-protection as compared with lutein or zeaxanthin. In Abca4-/- Rdh8-/- mice (a model of dry AMD), intravitreally-injected norbixin maintained the electroretinogram and protected photoreceptors against light damage. In a standard rat blue-light model of photodamage, norbixin was at least equally as active as phenyl-N-tert-butylnitrone, a free radical spin-trap. Chronic experiments performed with Abca4-/- Rdh8-/- mice treated orally for 3 months with norbixin showed a reduced A2E accumulation in the retina. Norbixin appears promising for developing an oral treatment of macular degeneration. A drug candidate (BIO201) with 9'-cis-norbixin as the active principle ingredient is under development, and its potential will be assessed in a forthcoming clinical trial.
    MeSH term(s) ATP-Binding Cassette Transporters/genetics ; Alcohol Oxidoreductases/genetics ; Animals ; Bixaceae/chemistry ; Carotenoids/administration & dosage ; Carotenoids/pharmacology ; Cells, Cultured ; Disease Models, Animal ; In Vitro Techniques ; Intravitreal Injections ; Macular Degeneration/chemically induced ; Macular Degeneration/drug therapy ; Macular Degeneration/genetics ; Macular Degeneration/metabolism ; Mice ; Mice, Knockout ; Photoreceptor Cells, Vertebrate/drug effects ; Plant Extracts/administration & dosage ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Rats ; Retinal Pigment Epithelium/cytology ; Retinal Pigment Epithelium/drug effects ; Retinoids/adverse effects ; Swine
    Chemical Substances A2-E (N-retinylidene-N-retinylethanolamine) ; Abca4 protein, mouse ; Plant Extracts ; Retinoids ; Carotenoids (36-88-4) ; norbixin (E8M59E17AI) ; Alcohol Oxidoreductases (EC 1.1.-) ; Rdh8 protein, mouse (EC 1.1.1.105)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0167793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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