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  1. Article ; Online: Aspetti medico-legali e organizzativi nell’era del Patient blood management.

    Bolcato, Matteo / Agostini, Vanessa / Altini, Mattia / Basili, Consuelo / Pocaforza, Maurizio / Montella, Maria Teresa

    Recenti progressi in medicina

    2023  Volume 114, Issue 12, Page(s) 730–734

    Abstract: In recent decades, the approach to blood transfusion has changed radically around the world. In the past, transfusion represented the only solution for anemia, today the paradigm has changed: through the implementation of the Patient blood management ( ... ...

    Title translation Medico-legal and management issues in patient blood management era.
    Abstract In recent decades, the approach to blood transfusion has changed radically around the world. In the past, transfusion represented the only solution for anemia, today the paradigm has changed: through the implementation of the Patient blood management (Pbm) program it is possible to manage the patient's own blood in order to reduce and, in many cases, eliminate the administration of blood components for transfusion. This approach increases patient safety by reducing clinical risks as well as costs. The implementation of the PBM program in Australia has demonstrated that the use of blood is not strictly necessary but, on the contrary, is largely avoidable. Through change management the traditional attitude of doctors and healthcare facilities can be modified. Law no. 24/2017 focuses on the safety of care by encouraging the necessary implementation of Pbm in hospital settings; the failure to adopt an organized Pbm program may constitute, in the event of an adverse transfusion event, a clear profile of health responsibility on the part of the management and clinicians.
    MeSH term(s) Humans ; Blood Transfusion ; Anemia/therapy ; Patient Safety
    Language Italian
    Publishing date 2023-11-30
    Publishing country Italy
    Document type English Abstract ; Journal Article
    ZDB-ID 138266-4
    ISSN 2038-1840 ; 0034-1193
    ISSN (online) 2038-1840
    ISSN 0034-1193
    DOI 10.1701/4142.41390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The infinite game in the public healthcare system: don't stop playing.

    Agnoletti, Vanni / Catena, Rodolfo / Bravi, Francesca / Montella, Maria Teresa / Ansaloni, Luca / Russo, Emanuele / Catena, Fausto

    Discover health systems

    2022  Volume 1, Issue 1, Page(s) 7

    Language English
    Publishing date 2022-11-21
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2731-7501
    ISSN (online) 2731-7501
    DOI 10.1007/s44250-022-00007-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fall predictors in hospitalized patients living with cancer: a case-control study.

    Zeneli, Anita / Montalti, Sandra / Masciangelo, Itria / Manieri, Gloria / Golinucci, Monica / Nanni, Oriana / Montella, Maria Teresa / Martinelli, Giovanni / Petracci, Elisabetta

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2022  Volume 30, Issue 10, Page(s) 7835–7843

    Abstract: Purpose: To identify fall predictors and develop an assessment tool to be used for screening hospitalized cancer patients at risk for fall.: Methods: A retrospective case-control study was conducted in 2018 at a cancer center in Northern Italy. The ... ...

    Abstract Purpose: To identify fall predictors and develop an assessment tool to be used for screening hospitalized cancer patients at risk for fall.
    Methods: A retrospective case-control study was conducted in 2018 at a cancer center in Northern Italy. The study participants were 448 adult cancer patients admitted to the oncology ward from 2009 to 2013. The case group consisted of 112 patients presenting at least one fall, while controls were randomly chosen by matching each case for age, sex, and admission period with three patients who did not fall. Data for the fall predictors were extracted from the electronic medical records. Conditional logistic regression was used to evaluate the association between patient's characteristics and fall risk.
    Results: The overall prevalence of patients having at least one candidate fall predictor was high (98%). Seven of the studied variables showed an independent association with fall risk at multivariate analysis. These were tumor site, the presence of neurologic diseases, gait imbalance disorders, fatigue, and the assumption of certain medications such as diuretics, hypnotics, and opioids (odds ratios and 95% confidence intervals in brackets were 3.78 (1.78-8.13), 2.26 (1.08-4.77), 4.22 (1.87-9.52), 2.76 (1.45-5.26), 2.66 (1.52-4.66), 2.41 (1.20-4.85), and 3.03 (1.68-5.45), respectively).
    Conclusions: In this study, we identified falling risk factors in an Italian population of hospitalized cancer patients and developed a new risk assessment tool. An external validation is necessary before implementing our screening tool in clinical practice.
    MeSH term(s) Adult ; Case-Control Studies ; Diuretics ; Humans ; Inpatients ; Neoplasms/epidemiology ; Retrospective Studies ; Risk Assessment ; Risk Factors
    Chemical Substances Diuretics
    Language English
    Publishing date 2022-06-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-022-07208-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: How has COVID-19 pandemic changed flu vaccination attitudes among an Italian cancer center healthcare workers?

    Bertoni, Lucia / Roncadori, Andrea / Gentili, Nicola / Danesi, Valentina / Massa, Ilaria / Nanni, Oriana / Altini, Mattia / Gabutti, Giovanni / Montella, Maria Teresa

    Human vaccines & immunotherapeutics

    2021  Volume 18, Issue 1, Page(s) 1978795

    Abstract: A retrospective study was conducted among Italian cancer healthcare workers (HCWs) to describe how influenza vaccination attitudes have changed during the COVID-19 pandemic. The analysis was conducted on the last three influenza seasons (2018/19, 2019/20 ...

    Abstract A retrospective study was conducted among Italian cancer healthcare workers (HCWs) to describe how influenza vaccination attitudes have changed during the COVID-19 pandemic. The analysis was conducted on the last three influenza seasons (2018/19, 2019/20 and 2020/21). To account for different relationships and proximity with patients, the study population was grouped into three main professional categories: health personnel, administrative staff and technicians. Moreover, to explore the factors affecting the coverage of influenza vaccine, a multinomial regression analysis was performed.Over the years, the influenza vaccination uptake showed a gradual increase across the overall staff, the highest coverage (53.8%) was observed in the season 2020/21, in particular, for health personnel (57.7%). In general, males resulted in more adherent to vaccination campaigns; nevertheless, this gap decreased in the last season. A total of 28.6% workers were always vaccinated throughout the past three seasons, a remarkable 25.2% (mainly young and females) received for the first time the influenza vaccination in 2020/21.In this dramatic health crisis, the attitudes of HCWs toward flu vaccination have changed. The COVID-19 outbreak increased adherence to flu vaccination, reaching the highest coverage in the campaign 2020/21. However, further efforts should be made to achieve greater vaccination coverage.
    MeSH term(s) Attitude ; Attitude of Health Personnel ; COVID-19/prevention & control ; Female ; Health Personnel ; Humans ; Influenza Vaccines ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Male ; Neoplasms/epidemiology ; Pandemics/prevention & control ; Retrospective Studies ; SARS-CoV-2 ; Seasons ; Surveys and Questionnaires ; Vaccination
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2021-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2021.1978795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Appropriateness and Economic Analysis of Conventional Circulating Biomarkers Assessment in Early Breast Cancer: A Real-World Experience from the E.Pic.A Study.

    Maltoni, Roberta / Balzi, William / Rossi, Tania / Fabbri, Francesco / Bravaccini, Sara / Montella, Maria Teresa / Massa, Ilaria / Bertoni, Lucia / Falcini, Fabio / Altini, Mattia

    Current oncology (Toronto, Ont.)

    2022  Volume 29, Issue 2, Page(s) 433–438

    Abstract: The risk of relapse for early breast cancer (BC) patients persists even after decades and to date, no specific and sensitive effective circulating biomarker for recurrence prediction has been identified yet. The international guidelines do not recommend ... ...

    Abstract The risk of relapse for early breast cancer (BC) patients persists even after decades and to date, no specific and sensitive effective circulating biomarker for recurrence prediction has been identified yet. The international guidelines do not recommend the assessment of the serum tumor markers CEA and CA15-3 in the follow-up of asymptomatic early BC patients. In our institute, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", as part of the E.Pic.A study, which was designed to assess the economic appropriateness of integrated care pathways in early BC, the use of CEA and CA15-3 as circulating tumor biomarkers in early BC patients was evaluated in 1502 patients one year after surgery, from 2015 to 2018, with an overall expense of EUR 51,764. A total of EUR 47,780 (92%) was used for execution of circulating tumor markers in early BC patients with stage 0, I and II tumors, neglecting the current guidelines and considered inappropriate by our professional board. We found that no patients with stage I BC experienced relapse in the 365 days after surgery, and in any case examination of the circulating markers CEA and CA15-3 was considered crucial for diagnosis of relapse. Our findings suggest that this inadequacy is a low-value area, supporting the reallocation of economic resources for interventions of a higher value for patients.
    MeSH term(s) Biomarkers, Tumor ; Breast Neoplasms/diagnosis ; Female ; Humans ; Mucin-1 ; Neoplasm Recurrence, Local
    Chemical Substances Biomarkers, Tumor ; Mucin-1
    Language English
    Publishing date 2022-01-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol29020039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Emilia-Romagna Surgical Colorectal Cancer Audit (ESCA): a value-based healthcare retro-prospective study to measure and improve the quality of surgical care in colorectal cancer.

    Massa, Ilaria / Ghignone, Federico / Ugolini, Giampaolo / Ercolani, Giorgio / Montroni, Isacco / Capelli, Patrizio / Garulli, Gianluca / Catena, Fausto / Lucchi, Andrea / Ansaloni, Luca / Gentili, Nicola / Danesi, Valentina / Montella, Maria Teresa / Altini, Mattia

    International journal of colorectal disease

    2022  Volume 37, Issue 7, Page(s) 1727–1738

    Abstract: Purpose: Surgery is the main treatment for non-metastatic colorectal cancer. Despite huge improvements in perioperative care, colorectal surgery is still associated with a significant burden of postoperative complications and ultimately costs for ... ...

    Abstract Purpose: Surgery is the main treatment for non-metastatic colorectal cancer. Despite huge improvements in perioperative care, colorectal surgery is still associated with a significant burden of postoperative complications and ultimately costs for healthcare organizations. Systematic clinical auditing activity has already proven to be effective in measuring and improving clinical outcomes, and for this reason, we decided to evaluate its impact in a large area of northern Italy.
    Methods: The Emilia-Romagna Surgical Colorectal Audit (ESCA) is an observational, multicentric, retro-prospective study, carried out by 7 hospitals located in the Emilia-Romagna region. All consecutive patients undergoing surgery for colorectal cancer during a 54-month study period will be enrolled. Data regarding baseline conditions, preoperative diagnostic work-up, surgery and postoperative course will be collected in a dedicated case report form. Primary outcomes regard postoperative complications and mortality. Secondary outcomes include each center's adherence to the auditing (enrolment rate) and evaluation of the systematic feedback activity on key performance indicators for the entire perioperative process.
    Conclusion: This protocol describes the methodology of the Emilia-Romagna Surgical Colorectal Audit. The study will provide real-world clinical data essential for benchmarking and feedback activity, to positively impact outcomes and ultimately to improve the entire healthcare process of patients undergoing colorectal cancer surgery.
    Clinical trial registration: The study ESCA is registered on the clinicaltrials.gov platform (Identifier: NCT03982641).
    MeSH term(s) Colorectal Neoplasms/complications ; Colorectal Neoplasms/surgery ; Colorectal Surgery ; Delivery of Health Care ; Humans ; Postoperative Complications/etiology ; Prospective Studies
    Language English
    Publishing date 2022-07-02
    Publishing country Germany
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-022-04203-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Postoperative patient blood management: transfusion appropriateness in cancer patients.

    Merolle, Lucia / Marraccini, Chiara / Di Bartolomeo, Erminia / Montella, Maria T / Pertinhez, Thelma A / Baricchi, Roberto / Bonini, Alessandro

    Blood transfusion = Trasfusione del sangue

    2020  Volume 18, Issue 5, Page(s) 359–365

    Abstract: Background: While patient blood management (PBM) principles are not specific to cancer patients, their application contains the pathophysiological premises that could also benefit this patient population. In this study, we assessed the effects of ... ...

    Abstract Background: While patient blood management (PBM) principles are not specific to cancer patients, their application contains the pathophysiological premises that could also benefit this patient population. In this study, we assessed the effects of implementing a PBM bundle for cancer patients in the postoperative period.
    Materials and methods: The Azienda USL-IRCCS of Reggio Emilia implemented a two-step PBM bundle for the postoperative period of cancer patients hospitalised in the semi-intensive post-surgery (SIPO) ward. Step 1 included seminars and lessons specifically targeting SIPO personnel; Step 2 introduced Points of Care (POCs) for the continuous monitoring of haemoglobin (Radical7, Masimo Corp, Irvine, CA, USA). We conducted 3 audits on 600 cancer patients recruited between 2014 and 2017: Audit 1 on 200 patients before the application of our PBM bundle; Audit 2 after Step 1 on 200 patients; Audit 3 after Step 2 on 200 patients monitored with POCs. Red blood cell (RBC) transfusion appropriateness in the postoperative period was evaluated using the Italian Society of Transfusion Medicine and Immunohaematology (SIMTI) recommendations.
    Results: RBC transfusion appropriateness in the postoperative period of cancer patients rose from 38% to 75% after seminars, and reached 79% after the introduction of POC. The mean number of RBC units each patient received remained unchanged after training sessions (1.8 units/patient) while the introduction of POCs saw a simultaneous decrease in the number of prescribed units (1.3 units/patient).
    Discussion: Our PBM bundle positively impacted RBC transfusion appropriateness in postsurgical cancer patients, both in terms of quality and quantity. A structured PBM programme specifically dedicated to surgical oncology should cover the entire perioperative period and might further improve transfusion appropriateness in these patients. The publication of guidelines on the management of anaemia in surgical oncology should be a priority.
    MeSH term(s) Aged ; Aged, 80 and over ; Blood Loss, Surgical ; Erythrocyte Transfusion ; Female ; Humans ; Male ; Medical Audit ; Middle Aged ; Neoplasms/surgery ; Point-of-Care Systems ; Postoperative Care ; Postoperative Period
    Language English
    Publishing date 2020-07-22
    Publishing country Italy
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2135732-8
    ISSN 2385-2070 ; 0041-1787 ; 1723-2007
    ISSN (online) 2385-2070
    ISSN 0041-1787 ; 1723-2007
    DOI 10.2450/2020.0048-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Effects on Clinical Outcomes of a 5-Year Surgical Safety Checklist Implementation Experience: A Large-scale Population-Based Difference-in-Differences Study.

    Rodella, Stefania / Mall, Sabine / Marino, Massimiliano / Turci, Graziella / Gambale, Giorgio / Montella, Maria Teresa / Bonilauri, Stefano / Gelmini, Roberta / Zuin, Piera

    Health services insights

    2018  Volume 11, Page(s) 1178632918785127

    Abstract: The adoption of a surgical checklist is strongly recommended worldwide as an effective practice to improve patient safety; however, several studies have reported mixed results and a number of issues are still unresolved. The main objective of this study ... ...

    Abstract The adoption of a surgical checklist is strongly recommended worldwide as an effective practice to improve patient safety; however, several studies have reported mixed results and a number of issues are still unresolved. The main objective of this study was to explore the impact of the first 5-year period of a surgical checklist-based intervention in a large regional health care system in Italy (4 500 000 inhabitants). We conducted a retrospective longitudinal study on 1 166 424 patients who underwent surgery in 48 public hospitals between 2006 and 2014. The adherence to the checklist was measured between 2011 and 2013 through a computerized database. The effects of the intervention were explored through multivariable logistic regression and difference-in-differences (DID) approaches, based on current administrative data sources. In-hospital and 30-days mortality, 30-days readmissions and length-of-stay (LOS) ⩾8 days were the observed outcomes. Adherence to the checklist showed marked variations across hospitals (0%-93.3%). A pre/post analysis detected statistically significant differences between surgical interventions performed in hospitals with higher adherence to the checklist (⩾75% of the surgeries) and those performed in
    Language English
    Publishing date 2018-07-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2803340-1
    ISSN 1178-6329
    ISSN 1178-6329
    DOI 10.1177/1178632918785127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: La malattia celiaca in Emilia Romagna.

    Cacciari, P / Montella, M T / Alvisi, P

    Annali di igiene : medicina preventiva e di comunita

    2010  Volume 22, Issue 4, Page(s) 337–343

    Abstract: The prevalence of celiac disease is still significantly under-estimated world-wide. We compared the Emilia Romagna's with international data. We studied symptomatic patients recorded in reimbursement regional health service program. In year 2008, the ... ...

    Title translation Celiac disease in Emilia Romagna.
    Abstract The prevalence of celiac disease is still significantly under-estimated world-wide. We compared the Emilia Romagna's with international data. We studied symptomatic patients recorded in reimbursement regional health service program. In year 2008, the patients were 7811. Our investigation did not show age related prevalence, except in the age group 0 to 1 probably due to breastfeeding. The overall prevalence is 1,8 patient/1000 of Emilia Romagna citizens. The prevalence is extremely variable in the different districts from 1:384 Parma's area to 1:909 Piacenza's. Our data confirm the underestimation previously found in other countries. Diagnosis (tests and small bowel histology) are performed, but probably a multidisciplinary effort must be made to promote knowledge and to understand pathogenesis of CD.
    MeSH term(s) Adolescent ; Adult ; Celiac Disease/diagnosis ; Celiac Disease/epidemiology ; Child ; Child, Preschool ; Female ; Humans ; Incidence ; Infant ; Italy/epidemiology ; Male ; Prevalence
    Language Italian
    Publishing date 2010-07
    Publishing country Italy
    Document type Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 1018045-x
    ISSN 1120-9135 ; 0029-6287
    ISSN 1120-9135 ; 0029-6287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Analisi dei costi della Centrale di Sterilizzazione dell'Istituto Rizzoli: analisi dei diversi modelli organizzativi.

    Montella, Maria Teresa / Onofri, Claudio / Onofri, Daniela / Bullini, Deborah / Vandelli, Cristina / Effat, Sara / Pasquarella, Cesira

    Igiene e sanita pubblica

    2015  Volume 71, Issue 1, Page(s) 73–82

    Abstract: Preventing healthcare-associated infections requires a number of actions, including adequate disinfection and sterilization of medical devices. A cost analysis of hospital sterilization processes is fundamental to increase quality and safety, reduce ... ...

    Title translation Cost analysis of sterilization facilities in the Rizzoli Hospital (Bologna, Italy): a study of different organizational models.
    Abstract Preventing healthcare-associated infections requires a number of actions, including adequate disinfection and sterilization of medical devices. A cost analysis of hospital sterilization processes is fundamental to increase quality and safety, reduce costs and to make a decision about outsourcing. The aim of this analysis was to determine the cost of sterilization and the average cost of surgical procedures at the Rizzoli hospital in Bologna (Italy), a largesurgical hospital that performs more than 11,000 surgical procedures per year.
    MeSH term(s) Costs and Cost Analysis ; Hospitals ; Italy ; Models, Organizational ; Sterilization/economics ; Sterilization/organization & administration
    Language Italian
    Publishing date 2015-01
    Publishing country Italy
    Document type English Abstract ; Journal Article
    ISSN 0019-1639
    ISSN 0019-1639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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