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  1. AU="Montero, Vincent"
  2. AU="Etevenon, Pierre"
  3. AU="Hyseni, Agon"
  4. AU="Seitzman, Natalie"
  5. AU="Loukil, Abdelhalim"
  6. AU="Giammusso, Bruno"
  7. AU="Kaplan, Jonathan E"
  8. AU=Francolini Giulio
  9. AU="Yuhu Li"
  10. AU=Kim Moojung
  11. AU="Vise, Luciana M"
  12. AU="Marcinowska, Zuzanna"
  13. AU="Graff, Pablo"

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  1. Artikel ; Online: Quinoxaline derivatives: Recent discoveries and development strategies towards anticancer agents.

    Montero, Vincent / Montana, Marc / Carré, Manon / Vanelle, Patrice

    European journal of medicinal chemistry

    2024  Band 271, Seite(n) 116360

    Abstract: Cancer is a leading cause of death and a major health problem worldwide. While many effective anticancer agents are available, most drugs currently on the market are not specific, raising issues like the common side effects of chemotherapy. However, ... ...

    Abstract Cancer is a leading cause of death and a major health problem worldwide. While many effective anticancer agents are available, most drugs currently on the market are not specific, raising issues like the common side effects of chemotherapy. However, recent research hold promises for the development of more efficient and safer anticancer drugs. Quinoxaline and its derivatives are becoming recognized as a novel class of chemotherapeutic agents with activity against different tumors. The present review compiles and discusses studies concerning the therapeutic potential of the anticancer activity of quinoxaline derivatives, covering articles published between January 2018 and January 2023.
    Mesh-Begriff(e) Quinoxalines/chemistry ; Quinoxalines/pharmacology ; Quinoxalines/chemical synthesis ; Humans ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Neoplasms/drug therapy ; Animals ; Molecular Structure ; Drug Development ; Cell Proliferation/drug effects ; Drug Discovery ; Drug Screening Assays, Antitumor ; Structure-Activity Relationship
    Chemische Substanzen Quinoxalines ; Antineoplastic Agents
    Sprache Englisch
    Erscheinungsdatum 2024-04-07
    Erscheinungsland France
    Dokumenttyp Journal Article ; Review
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2024.116360
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  2. Artikel ; Online: Quinoxaline Moiety: A Potential Scaffold against

    Montana, Marc / Montero, Vincent / Khoumeri, Omar / Vanelle, Patrice

    Molecules (Basel, Switzerland)

    2021  Band 26, Heft 16

    Abstract: ... ...

    Abstract Background
    Mesh-Begriff(e) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Mycobacterium tuberculosis/drug effects ; Quinoxalines/chemistry ; Quinoxalines/pharmacology ; Structure-Activity Relationship
    Chemische Substanzen Anti-Bacterial Agents ; Quinoxalines
    Sprache Englisch
    Erscheinungsdatum 2021-08-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26164742
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Quinoxaline Derivatives as Antiviral Agents: A Systematic Review.

    Montana, Marc / Montero, Vincent / Khoumeri, Omar / Vanelle, Patrice

    Molecules (Basel, Switzerland)

    2020  Band 25, Heft 12

    Abstract: Background: In recent decades, several viruses have jumped from animals to humans, triggering sizable outbreaks. The current unprecedent outbreak SARS-COV-2 is prompting a search for new cost-effective therapies to combat this deadly pathogen. Suitably ... ...

    Abstract Background: In recent decades, several viruses have jumped from animals to humans, triggering sizable outbreaks. The current unprecedent outbreak SARS-COV-2 is prompting a search for new cost-effective therapies to combat this deadly pathogen. Suitably functionalized polysubstituted quinoxalines show very interesting biological properties (antiviral, anticancer, and antileishmanial), ensuring them a bright future in medicinal chemistry.
    Objectives: Focusing on the promising development of new quinoxaline derivatives as antiviral drugs, this review forms part of our program on the anti-infectious activity of quinoxaline derivatives.
    Methods: Study compiles and discusses recently published studies concerning the therapeutic potential of the antiviral activity of quinoxaline derivatives, covering the literature between 2010 and 2020.
    Results: A final total of 20 studies included in this review.
    Conclusions: This review points to a growing interest in the development of compounds bearing a quinoxaline moiety for antiviral treatment. This promising moiety with different molecular targets warrants further investigation, which may well yield even more encouraging results regarding this scaffold.
    Mesh-Begriff(e) Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; COVID-19 ; Coronavirus Infections/drug therapy ; DNA Viruses/drug effects ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; Quinoxalines/chemistry ; Quinoxalines/therapeutic use ; SARS-CoV-2 ; Structure-Activity Relationship
    Chemische Substanzen Antiviral Agents ; Quinoxalines
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-06-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Systematic Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25122784
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Hefte anzeigen

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  4. Artikel: Synthesis, In Vitro Antiproliferative Activity, and In Silico Evaluation of Novel Oxiranyl-Quinoxaline Derivatives.

    Montero, Vincent / Montana, Marc / Khoumeri, Omar / Correard, Florian / Estève, Marie-Anne / Vanelle, Patrice

    Pharmaceuticals (Basel, Switzerland)

    2022  Band 15, Heft 7

    Abstract: The quinoxaline core is a promising scaffold in medicinal chemistry. Multiple quinoxaline derivatives, such as the topoisomerase IIβ inhibitor XK-469 and the tissue transglutaminase 2 inhibitor GK-13, have been evaluated for their antiproliferative ... ...

    Abstract The quinoxaline core is a promising scaffold in medicinal chemistry. Multiple quinoxaline derivatives, such as the topoisomerase IIβ inhibitor XK-469 and the tissue transglutaminase 2 inhibitor GK-13, have been evaluated for their antiproliferative activity. Previous work reported that quinoxaline derivatives bearing an oxirane ring present antiproliferative properties against neuroblastoma cell lines SK-N-SH and IMR-32. Likewise, quinoxalines with an arylethynyl group displayed promising antineoplastic properties against glioblastoma and lung cancer cell lines, U87-MG and A549 respectively. Here, 40 new quinoxaline derivatives bearing an oxirane ring were synthesized using a tetrakis(dimethylamino)ethylene (TDAE) strategy and a Sonogashira cross-coupling reaction. Each reaction with TDAE furnished a pair of diastereoisomers
    Sprache Englisch
    Erscheinungsdatum 2022-06-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15070781
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Antibiotic-induced neurological adverse drug reactions.

    Lacroix, Clémence / Pietri, Tessa / Montero, Vincent / Soeiro, Thomas / Rouby, Frank / Blin, Olivier / Guilhaumou, Romain / Micallef, Joëlle

    Therapie

    2023  Band 79, Heft 2, Seite(n) 181–188

    Abstract: Antibiotics are drugs widely used all around the world. Central nervous system adverse drug reactions (CNS ADRs) are mostly under-suspected with antibiotics. Nevertheless, these ADRs could lead to severe complications such as encephalopathy. To ... ...

    Abstract Antibiotics are drugs widely used all around the world. Central nervous system adverse drug reactions (CNS ADRs) are mostly under-suspected with antibiotics. Nevertheless, these ADRs could lead to severe complications such as encephalopathy. To illustrate the clinical patterns of these off-target ADRs, we here present data from pharmacovigilance system, through different populations and points of view (worldwide, French population, vulnerable population and individual). These data could help clinicians to better know about CNS ADRs with antibiotics, to better identify risk factors and vulnerable patients and to highlight the importance to set up the right diagnostic explorations in the best timing to avoid complications. Clinicians should request a pharmacological opinion from pharmacologist (biologists and pharmacovigilance clinicians) in front of vulnerable population before or during antibiotics. Pharmacovigilance advice could help clinicians in the diagnosis and the management of an ADR. Therapeutic drug monitoring is particularly contributive to adjust doses of antibiotics administered in vulnerable patients. Pharmacovigilance advice and TDM are essential to perform personalized medicine, and contribute to the proper use of drugs.
    Mesh-Begriff(e) Humans ; Anti-Bacterial Agents/adverse effects ; Adverse Drug Reaction Reporting Systems ; Drug-Related Side Effects and Adverse Reactions/diagnosis ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Health Personnel ; Pharmacovigilance
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2023-10-31
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 603474-3
    ISSN 1958-5578 ; 0040-5957
    ISSN (online) 1958-5578
    ISSN 0040-5957
    DOI 10.1016/j.therap.2023.09.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Verfügbar in ZB MED Köln/Königswinter

    Ue I Zs.272: Hefte anzeigen Standort:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

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  6. Artikel: Quinoxaline Derivatives as Antiviral Agents: A Systematic Review

    Montana, Marc / Montero, Vincent / Khoumeri, Omar / Vanelle, Patrice

    Molecules (Basel)

    Abstract: BACKGROUND: In recent decades, several viruses have jumped from animals to humans, triggering sizable outbreaks. The current unprecedent outbreak SARS-COV-2 is prompting a search for new cost-effective therapies to combat this deadly pathogen. Suitably ... ...

    Abstract BACKGROUND: In recent decades, several viruses have jumped from animals to humans, triggering sizable outbreaks. The current unprecedent outbreak SARS-COV-2 is prompting a search for new cost-effective therapies to combat this deadly pathogen. Suitably functionalized polysubstituted quinoxalines show very interesting biological properties (antiviral, anticancer, and antileishmanial), ensuring them a bright future in medicinal chemistry. OBJECTIVES: Focusing on the promising development of new quinoxaline derivatives as antiviral drugs, this review forms part of our program on the anti-infectious activity of quinoxaline derivatives. METHODS: Study compiles and discusses recently published studies concerning the therapeutic potential of the antiviral activity of quinoxaline derivatives, covering the literature between 2010 and 2020. RESULTS: A final total of 20 studies included in this review. CONCLUSIONS: This review points to a growing interest in the development of compounds bearing a quinoxaline moiety for antiviral treatment. This promising moiety with different molecular targets warrants further investigation, which may well yield even more encouraging results regarding this scaffold.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #32560203
    Datenquelle COVID19

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