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  1. Article: Emerging therapeutic strategies in hypoxic-ischemic encephalopathy: a focus on cognitive outcomes.

    Marques, Kethely L / Rodrigues, Victor / Balduci, Cassiana T N / Montes, Guilherme C / Barradas, Penha C / Cunha-Rodrigues, Marta C

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1347529

    Abstract: Perinatal hypoxia-ischemia represents a significant risk to CNS development, leading to high mortality rates, diverse damages, and persistent neurological deficits. Despite advances in neonatal medicine in recent decades, the incidence of HIE remains ... ...

    Abstract Perinatal hypoxia-ischemia represents a significant risk to CNS development, leading to high mortality rates, diverse damages, and persistent neurological deficits. Despite advances in neonatal medicine in recent decades, the incidence of HIE remains substantial. Motor deficits can manifest early, while cognitive impairments may be diagnosed later, emphasizing the need for extended follow-up. This review aims to explore potential candidates for therapeutic interventions for hypoxic-ischemic encephalopathy (HIE), with a focus on cognitive deficits. We searched randomized clinical trials (RCT) that tested drug treatments for HIE and evaluated cognitive outcomes. The results included studies on erythropoietin, melatonin, magnesium sulfate, topiramate, and a combination of vitamin C and ibuprofen. Although there are several indications of the efficacy of these drugs among animal models, considering neuroprotective properties, the RCTs failed to provide complete effectiveness in the context of cognitive impairments derived from HIE. More robust RCTs are still needed to advance our knowledge and to establish standardized treatments for HIE.
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1347529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Evaluation of Pain Prevalence in Children Who Experienced Perinatal Hypoxia-Ischemia Events: Characteristics and Associations With Sociodemographic Factors.

    Von Adamovich, Giovanna Maria G / Bastos Torres, João Antonio G / Vianna, Felipe S / Barradas, Penha C / Alves de Oliveira, Beatriz F / Villela, Nivaldo R / De Rodrigues, Maura Calixto C / Montes, Guilherme C

    Cureus

    2023  Volume 15, Issue 10, Page(s) e46359

    Abstract: Introduction: Pain in children who suffer from hypoxia-ischemia (HI) events is still not widely studied. Hypoxia-ischemia is characterized by the momentary or permanent cessation of blood flow and, consequently, of oxygen supply, becoming the main cause ...

    Abstract Introduction: Pain in children who suffer from hypoxia-ischemia (HI) events is still not widely studied. Hypoxia-ischemia is characterized by the momentary or permanent cessation of blood flow and, consequently, of oxygen supply, becoming the main cause of encephalopathy in children. Hyperalgesia was identified in animals undergoing prenatal hypoxia-ischemia by researchers from the Universidade do Estado do Rio de Janeiro (UERJ). Premature and asphyxiated newborns have been admitted to the neonatal intensive care unit (NICU) of Pedro Ernesto University Hospital (HUPE) in Brazil and are monitored by the Outpatient Follow-up of High-Risk Newborns Project (SARAR), but no pain assessment was performed.
    Objective: To assess pain in children born in high-risk situations, such as prematurity and perinatal asphyxia, with higher chances of perinatal HI, discharged from the NICU/HUPE, and followed by SARAR.
    Methodology: The study was approved by the HUPE Research Ethics Committee. The epidemiological, descriptive, cross-sectional study started in 2021 and finished in 2023, with the application of the pain assessment tool or instrument adapted from the Lübeck Pain-Screening Questionnaire to the caregivers and with the collection of growth and development data. The population consisted of asphyxiated infants born with a gestational age greater than 35 weeks and submitted to the Therapeutic Hypothermia protocol and premature infants discharged from the NICU between two (gestational age 1 (GA1)) and 12 years old. For most of them, pain prevalence was assessed according to its frequency and intensity, as were sociodemographic variables of the child and mother, neural alterations, and the Children's Developmental Scale (DENVER II). The percentage differences between the evaluated factors and the presence of pain were performed using Fisher's exact test and medians using the non-parametric Wilcoxon rank-sum test, both appropriate for the small sample of children. Significance levels of 10% were considered for trends and 5% for statistically significant differences.
    Results: Of the 86 children included in our search, 26 (30%) were born with a gestational age greater than 35 weeks and diagnosed with perinatal asphyxia (hereinafter referred to as the asphyxiation group), and 60 (70%) were premature. Pain was reported by 22 (25%) children, of whom 54.4% reported moderate or severe pain. The head and abdomen were the most reported sites (36%). Differences were observed in the percentage distribution of pain between asphyxiates and premature infants (11% vs. 32%; p-value 0.061 on the Fisher test) and between females and males (34% vs. 17%; p-value 0.085 on the Fisher test). Black and Brown children had higher median pain scale values than White children (p-value < 0.027, Wilcoxon rank sum test).
    Conclusion: There is a higher prevalence of pain in girls, in the head, in premature infants, and greater intensity among Black and Brown children. Therefore, knowing the pain profile can help improve their quality of life by offering treatments.
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.46359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension.

    Alencar, Allan K N / Montes, Guilherme C / Barreiro, Eliezer J / Sudo, Roberto T / Zapata-Sudo, Gisele

    Frontiers in pharmacology

    2017  Volume 8, Page(s) 858

    Abstract: Pulmonary arterial hypertension (PAH) is a clinical condition characterized by pulmonary arterial remodeling and vasoconstriction, which promote chronic vessel obstruction and elevation of pulmonary vascular resistance. Long-term right ventricular (RV) ... ...

    Abstract Pulmonary arterial hypertension (PAH) is a clinical condition characterized by pulmonary arterial remodeling and vasoconstriction, which promote chronic vessel obstruction and elevation of pulmonary vascular resistance. Long-term right ventricular (RV) overload leads to RV dysfunction and failure, which are the main determinants of life expectancy in PAH subjects. Therapeutic options for PAH remain limited, despite the introduction of prostacyclin analogs, endothelin receptor antagonists, phosphodiesterase type 5 inhibitors, and soluble guanylyl cyclase stimulators within the last 15 years. Through addressing the pulmonary endothelial and smooth muscle cell dysfunctions associated with PAH, these interventions delay disease progression but do not offer a cure. Emerging approaches to improve treatment efficacy have focused on beneficial actions to both the pulmonary vasculature and myocardium, and several new targets have been investigated and validated in experimental PAH models. Herein, we review the effects of adenosine and adenosine receptors (A
    Language English
    Publishing date 2017-12-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2017.00858
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Novel agonist of α

    Sudo, Roberto T / Hayashida, Kenichiro / Santos, Aluizio N / Kawatani, Masahito / Monteiro, Carlos Es / Moreira, Roberto D / Trachez, Margarete M / Montes, Guilherme C / Zapata-Sudo, Gisele

    Journal of pain research

    2018  Volume 11, Page(s) 2453–2462

    Abstract: Objective: To demonstrate the antinociceptive and antihypersensitivity mechanisms of Cris-104 (1-{2-[5-(4-fluorophenyl)-1H-pyrazol-4-yl]ethyl}piperidine), a novel selective α: Materials and methods: Hot-plate and formalin tests in mice were used to ... ...

    Abstract Objective: To demonstrate the antinociceptive and antihypersensitivity mechanisms of Cris-104 (1-{2-[5-(4-fluorophenyl)-1H-pyrazol-4-yl]ethyl}piperidine), a novel selective α
    Materials and methods: Hot-plate and formalin tests in mice were used to examine Cris-104-induced antinociceptive effects on thermal/inflammatory pain. Cris-104 effects on hypersensitivity, norepinephrine (NE) release in the spinal dorsal horn, and neuronal activity in the locus coeruleus (LC) were examined in rats with lumbar spinal nerve ligation using behavioral, microdialysis, and extracellular recording methods. Cris-104 effects on spontaneous locomotion were examined in an open-field test.
    Results: Cris-104 induced dose-dependent antinociception effects in hot-plate and formalin tests, and these effects were blocked by the general nAChR antagonist mecamylamine, the selective α
    Conclusion: The α
    Language English
    Publishing date 2018-10-30
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495284-9
    ISSN 1178-7090
    ISSN 1178-7090
    DOI 10.2147/JPR.S169637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cardioprotection Induced by Activation of GPER in Ovariectomized Rats With Pulmonary Hypertension.

    Alencar, Allan K N / Montes, Guilherme C / Costa, Daniele G / Mendes, Luiza V P / Silva, Ananssa M S / Martinez, Sabrina T / Trachez, Margarete M / Cunha, Valéria do M N / Montagnoli, Tadeu L / Fraga, Aline G M / Wang, Hao / Groban, Leanne / Fraga, Carlos A M / Sudo, Roberto T / Zapata-Sudo, Gisele

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2018  Volume 73, Issue 9, Page(s) 1158–1166

    Abstract: Pulmonary hypertension (PH) is a disease of women (female-to-male ratio 4:1), and is associated with cardiac and skeletal muscle dysfunction. Herein, the activation of a new estrogen receptor (GPER) by the agonist G1 was evaluated in oophorectomized rats ...

    Abstract Pulmonary hypertension (PH) is a disease of women (female-to-male ratio 4:1), and is associated with cardiac and skeletal muscle dysfunction. Herein, the activation of a new estrogen receptor (GPER) by the agonist G1 was evaluated in oophorectomized rats with monocrotaline (MCT)-induced PH. Depletion of estrogen was induced by bilateral oophorectomy (OVX) in Wistar rats. Experimental groups included SHAM or OVX rats that received a single intraperitoneal injection of MCT (60 mg/kg) for PH induction. Animals received s.c. injection of either vehicle or G1, a GPER agonist, (400 µg/kg/day) for 14 days after the onset of disease. Rats with PH exhibited exercise intolerance and cardiopulmonary alterations, including reduced pulmonary artery flow, biventricular remodeling, and left ventricular systolic and diastolic dysfunction. The magnitude of these PH-induced changes was significantly greater in OVX versus SHAM rats. G1 treatment reversed both cardiac and skeletal muscle functional aberrations caused by PH in OVX rats. G1 reversed PH-related cardiopulmonary dysfunction and exercise intolerance in female rats, a finding that may have important implications for the ongoing clinical evaluation of new drugs for the treatment of the disease in females after the loss of endogenous estrogens.
    MeSH term(s) Animals ; Cardiotonic Agents/metabolism ; Cardiotonic Agents/pharmacology ; Disease Models, Animal ; Estrogens/metabolism ; Estrogens/pharmacology ; Exercise Tolerance/drug effects ; Female ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/metabolism ; Hypertension, Pulmonary/physiopathology ; Monocrotaline/pharmacology ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/physiopathology ; Ovariectomy/methods ; Pulmonary Artery/metabolism ; Pulmonary Artery/physiopathology ; Rats ; Receptors, G-Protein-Coupled/metabolism ; Ventricular Dysfunction/metabolism ; Ventricular Dysfunction/physiopathology ; Ventricular Dysfunction/prevention & control ; Ventricular Remodeling/drug effects
    Chemical Substances Cardiotonic Agents ; Estrogens ; Gper1 protein, rat ; Receptors, G-Protein-Coupled ; Monocrotaline (73077K8HYV)
    Language English
    Publishing date 2018-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/gly068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.242/A: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Activation of GPER ameliorates experimental pulmonary hypertension in male rats.

    Alencar, Allan K / Montes, Guilherme C / Montagnoli, Tadeu / Silva, Ananssa M / Martinez, Sabrina T / Fraga, Aline G / Wang, Hao / Groban, Leanne / Sudo, Roberto T / Zapata-Sudo, Gisele

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    2016  Volume 97, Page(s) 208–217

    Abstract: Rationale: Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling that leads to pulmonary congestion, uncompensated right-ventricle (RV) failure, and premature death. Preclinical studies have demonstrated that the G protein- ... ...

    Abstract Rationale: Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling that leads to pulmonary congestion, uncompensated right-ventricle (RV) failure, and premature death. Preclinical studies have demonstrated that the G protein-coupled estrogen receptor (GPER) is cardioprotective in male rats and that its activation elicits vascular relaxation in rats of either sex.
    Objectives: To study the effects of GPER on the cardiopulmonary system by the administration of its selective agonist G1 in male rats with monocrotaline (MCT)-induced PH.
    Methods: Rats received a single intraperitoneal injection of MCT (60mg/kg) for PH induction. Experimental groups were as follows: control, MCT+vehicle, and MCT+G1 (400μg/kg/daysubcutaneous). Animals (n=5pergroup) were treated with vehicle or G1 for 14days after disease onset.
    Measurements and main results: Activation of GPER attenuated exercise intolerance and reduced RV overload in PH rats. Rats with PH exhibited echocardiographic alterations, such as reduced pulmonary flow, RV hypertrophy, and left-ventricle dysfunction, by the end of protocol. G1 treatment reversed these PH-related abnormalities of cardiopulmonary function and structure, in part by promoting pulmonary endothelial nitric oxide synthesis, Ca
    Conclusions: G1 was effective to reverse PH-induced RV dysfunction and exercise intolerance in male rats, a finding that have important implications for ongoing clinical evaluation of new cardioprotective and vasodilator drugs for the treatment of the disease.
    MeSH term(s) Animals ; Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Hypertension, Pulmonary/diagnostic imaging ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/metabolism ; Male ; Random Allocation ; Rats ; Rats, Wistar ; Receptors, G-Protein-Coupled/agonists ; Receptors, G-Protein-Coupled/metabolism
    Chemical Substances Antihypertensive Agents ; Gper1 protein, rat ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2016-11-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1154366-8
    ISSN 1879-0720 ; 0928-0987
    ISSN (online) 1879-0720
    ISSN 0928-0987
    DOI 10.1016/j.ejps.2016.11.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3705: Show issues Location:
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  7. Article: Human Mesenchymal Stem Cell Therapy Reverses Su5416/Hypoxia-Induced Pulmonary Arterial Hypertension in Mice.

    Alencar, Allan K N / Pimentel-Coelho, Pedro M / Montes, Guilherme C / da Silva, Marina de M C / Mendes, Luiza V P / Montagnoli, Tadeu L / Silva, Ananssa M S / Vasques, Juliana Ferreira / Rosado-de-Castro, Paulo Henrique / Gutfilen, Bianca / Cunha, Valéria do M N / Fraga, Aline G M / Silva, Patrícia M R E / Martins, Marco Aurélio / Ferreira, Tatiana Paula Teixeira / Mendes-Otero, Rosalia / Trachez, Margarete M / Sudo, Roberto T / Zapata-Sudo, Gisele

    Frontiers in pharmacology

    2018  Volume 9, Page(s) 1395

    Abstract: Aims: ...

    Abstract Aims:
    Language English
    Publishing date 2018-12-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2018.01395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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