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Article ; Online: An Unusual Cause of Stroke in a Young Adult.

Montgomery, Claire L / Murphy, Alexandra M / Joseph, Jijin

Journal of cardiothoracic and vascular anesthesia

2020 Volume 34, Issue 8, Page(s) 2269–2271

Abstract: Stroke is an uncommon presentation in young adults, with different causes and risks factors implicated. Cardiogenic cerebral embolus is one of the most common causes in younger patients and must be considered in the investigation of young patients ... ...

Abstract	Stroke is an uncommon presentation in young adults, with different causes and risks factors implicated. Cardiogenic cerebral embolus is one of the most common causes in younger patients and must be considered in the investigation of young patients presenting with stroke. The authors describe a case of a young patient presenting with stroke as a result of distal embolization from a previously undiagnosed congenital mitral valve defect.
MeSH term(s)	Humans ; Intracranial Embolism ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Stroke/diagnostic imaging ; Stroke/etiology ; Young Adult
Language	English
Publishing date	2020-01-21
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2020.01.021
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Zs.A 2203: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Dimethyl fumarate dose-dependently increases mitochondrial gene expression and function in muscle and brain of Friedreich's ataxia model mice.

Hui, Chun Kiu / Dedkova, Elena N / Montgomery, Claire / Cortopassi, Gino

Human molecular genetics

2021 Volume 29, Issue 24, Page(s) 3954–3965

Abstract: Previously we showed that dimethyl fumarate (DMF) dose-dependently increased mitochondrial gene expression and function in cells and might be considered as a therapeutic for inherited mitochondrial disease, including Friedreich's ataxia (FA). Here we ... ...

Abstract	Previously we showed that dimethyl fumarate (DMF) dose-dependently increased mitochondrial gene expression and function in cells and might be considered as a therapeutic for inherited mitochondrial disease, including Friedreich's ataxia (FA). Here we tested DMF's ability to dose-dependently increase mitochondrial function, mitochondrial gene expression (frataxin and cytochrome oxidase protein) and mitochondrial copy number in C57BL6 wild-type mice and the FXNKD mouse model of FA. We first dosed DMF at 0-320 mg/kg in C57BL6 mice and observed significant toxicity above 160 mg/kg orally, defining the maximum tolerated dose. Oral dosing of C57BL6 mice in the range 0-160 mg/kg identified a maximum increase in aconitase activity and mitochondrial gene expression in brain and quadriceps at 110 mg/kg DMF, thus defining the maximum effective dose (MED). The MED of DMF in mice overlaps the currently approved human-equivalent doses of DMF prescribed for multiple sclerosis (480 mg/day) and psoriasis (720 mg/day). In the FXNKD mouse model of FA, which has a doxycycline-induced deficit of frataxin protein, we observed significant decreases of multiple mitochondrial parameters, including deficits in brain mitochondrial Complex 2, Complex 4 and aconitase activity, supporting the idea that frataxin deficiency reduces mitochondrial gene expression, mitochondrial functions and biogenesis. About 110 mg/kg of oral DMF rescued these enzyme activities in brain and rescued frataxin and cytochrome oxidase expression in brain, cerebellum and quadriceps muscle of the FXNKD mouse model. Taken together, these results support the idea of using fumarate-based molecules to treat FA or other mitochondrial diseases.
MeSH term(s)	Animals ; Brain/drug effects ; Brain/physiology ; Dimethyl Fumarate/pharmacology ; Dose-Response Relationship, Drug ; Friedreich Ataxia/drug therapy ; Friedreich Ataxia/metabolism ; Friedreich Ataxia/pathology ; Gene Expression Regulation/drug effects ; Immunosuppressive Agents/pharmacology ; Mice ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Mitochondria/physiology ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Muscles/drug effects ; Muscles/physiology
Chemical Substances	Immunosuppressive Agents ; Mitochondrial Proteins ; Dimethyl Fumarate (FO2303MNI2)
Language	English
Publishing date	2021-01-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1108742-0
ISSN	1460-2083 ; 0964-6906
ISSN (online)	1460-2083
ISSN	0964-6906
DOI	10.1093/hmg/ddaa282
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Article ; Online: Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer's mouse model and stimulates synaptic plasticity pathway enzymes.

Di Lucente, Jacopo / Persico, Giuseppe / Zhou, Zeyu / Jin, Lee-Way / Ramsey, Jon J / Rutkowsky, Jennifer M / Montgomery, Claire M / Tomilov, Alexey / Kim, Kyoungmi / Giorgio, Marco / Maezawa, Izumi / Cortopassi, Gino A

Communications biology

2024 Volume 7, Issue 1, Page(s) 195

Abstract: The Ketogenic Diet (KD) improves memory and longevity in aged C57BL/6 mice. We tested 7 months KD vs. control diet (CD) in the mouse Alzheimer's Disease (AD) model APP/PS1. KD significantly rescued Long-Term-Potentiation (LTP) to wild-type levels, not by ...

Abstract	The Ketogenic Diet (KD) improves memory and longevity in aged C57BL/6 mice. We tested 7 months KD vs. control diet (CD) in the mouse Alzheimer's Disease (AD) model APP/PS1. KD significantly rescued Long-Term-Potentiation (LTP) to wild-type levels, not by changing Amyloid-β (Aβ) levels. KD's 'main actor' is thought to be Beta-Hydroxy-butyrate (BHB) whose levels rose significantly in KD vs. CD mice, and BHB itself significantly rescued LTP in APP/PS1 hippocampi. KD's 6 most significant pathways induced in brains by RNAseq all related to Synaptic Plasticity. KD induced significant increases in synaptic plasticity enzymes p-ERK and p-CREB in both sexes, and of brain-derived neurotrophic factor (BDNF) in APP/PS1 females. We suggest KD rescues LTP through BHB's enhancement of synaptic plasticity. LTP falls in Mild-Cognitive Impairment (MCI) of human AD. KD and BHB, because they are an approved diet and supplement respectively, may be most therapeutically and translationally relevant to the MCI phase of Alzheimer's Disease.
MeSH term(s)	Humans ; Mice ; Animals ; Aged ; Long-Term Potentiation ; Alzheimer Disease/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Diet, Ketogenic ; Mice, Transgenic ; Mice, Inbred C57BL ; Neuronal Plasticity
Chemical Substances	Amyloid beta-Protein Precursor
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-024-05860-z
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Article: Fire

Montgomery, Claire A

The Oxford handbook of land economics , p. 281-301

an agent and a consequence of land use change

2014 , Page(s) 281–301

Author's details	Claire A. Montgomery
Language	English
Publisher	Oxford Univ. Press
Publishing place	Oxford [u.a.]
Document type	Article
ISBN	978-0-19-976374-0 ; 0-19-976374-7
Database	ECONomics Information System

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Article ; Online: Shc inhibitor idebenone ameliorates liver injury and fibrosis in dietary NASH in mice.

Jiang, Joy X / Tomilov, Alexey / Montgomery, Claire / Hui, Chun Kui / Török, Natalie J / Cortopassi, Gino

Journal of biochemical and molecular toxicology

2021 Volume 35, Issue 10, Page(s) e22876

Abstract: Shc expression rises in human nonalcoholic steatohepatitis (NASH) livers, and Shc-deficient mice are protected from NASH-thus Shc inhibition could be a novel therapeutic strategy for NASH. Idebenone was recently identified as the first small-molecule Shc ...

Abstract	Shc expression rises in human nonalcoholic steatohepatitis (NASH) livers, and Shc-deficient mice are protected from NASH-thus Shc inhibition could be a novel therapeutic strategy for NASH. Idebenone was recently identified as the first small-molecule Shc inhibitor drug. We tested idebenone in the fibrotic methionine-choline deficient (MCD) diet and the metabolic fast food diet (FFD) mouse models of NASH. In the fibrotic MCD NASH model, idebenone reduced Shc expression and phosphorylation in peripheral blood mononuclear cells and Shc expression in the liver; decreased serum alanine aminotransferase and aspartate aminotransferase; and attenuated liver fibrosis as observed by quantitative polymerase chain reaction (qPCR) and hydroxyproline quantification. In the metabolic FFD model, idebenone administration improved insulin resistance, and reduced inflammation and fibrosis shown with qPCR, hydroxyproline measurement, and histology. Thus, idebenone ameliorates NASH in two mouse models. As an approved drug with a benign safety profile, Idebenone could be a reasonable human NASH therapy.
MeSH term(s)	Alanine Transaminase/blood ; Animals ; Aspartate Aminotransferases/blood ; Choline Deficiency/complications ; Diet/adverse effects ; Disease Models, Animal ; Fast Foods/adverse effects ; Leukocytes, Mononuclear/metabolism ; Liver/injuries ; Liver/metabolism ; Liver Cirrhosis/blood ; Liver Cirrhosis/complications ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/etiology ; Male ; Methionine/deficiency ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/etiology ; Phosphorylation/drug effects ; Protective Agents/administration & dosage ; Shc Signaling Adaptor Proteins/antagonists & inhibitors ; Shc Signaling Adaptor Proteins/metabolism ; Signal Transduction/drug effects ; Therapeutics ; Ubiquinone/administration & dosage ; Ubiquinone/analogs & derivatives
Chemical Substances	Protective Agents ; Shc Signaling Adaptor Proteins ; Ubiquinone (1339-63-5) ; Methionine (AE28F7PNPL) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2) ; idebenone (HB6PN45W4J)
Language	English
Publishing date	2021-08-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1410020-4
ISSN	1099-0461 ; 1095-6670
ISSN (online)	1099-0461
ISSN	1095-6670
DOI	10.1002/jbt.22876
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Evaluating wildland fire liability standards – does regulation incentivise good management?

Lauer, Christopher J / Montgomery, Claire A / Dietterich, Thomas G

International journal of wildland fire. 2020, v. 29, no. 7

2020

Abstract: Fire spread on forested landscapes depends on vegetation conditions across the landscape that affect the fire arrival probability and forest stand value. Landowners can control some forest characteristics that facilitate fire spread, and when a single ... ...

Abstract	Fire spread on forested landscapes depends on vegetation conditions across the landscape that affect the fire arrival probability and forest stand value. Landowners can control some forest characteristics that facilitate fire spread, and when a single landowner controls the entire landscape, a rational landowner accounts for spatial interactions when making management decisions. With multiple landowners, management activity by one may impact outcomes for the others. Various liability regulations have been proposed, and some enacted, to make landowners account for these impacts by changing the incentives they face. In this paper, the effects of two different types of liability regulations are examined – strict liability and negligence standards. We incorporate spatial information into a model of land manager decision-making about the timing and spatial location of timber harvest and fuel treatment. The problem is formulated as a dynamic game and solved via multi-agent approximate dynamic programming. We found that, in some cases, liability regulation can increase expected land values for individual land ownerships and for the landscape as a whole. But in other cases, it may create perverse incentives that reduce expected land value. We also showed that regulations may increase risk for individual landowners by increasing the variability of potential outcomes.
Keywords	decision making ; fire spread ; forest stands ; forests ; land values ; landscapes ; models ; risk ; spatial data ; wildfires
Language	English
Size	p. 572-580.
Publishing place	CSIRO Publishing
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1331562-6
ISSN	1448-5516 ; 1049-8001
ISSN (online)	1448-5516
ISSN	1049-8001
DOI	10.1071/WF19090
Database	NAL-Catalogue (AGRICOLA)

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Article: Institutional environments and arrangements for managing complex aquatic ecosystems in forested landscapes

Montgomery, Claire A

Forest policy and economics. 2013 Oct., v. 35

2013

Abstract: The forested watersheds of the Pacific Northwest are complex aquatic ecosystems. They are adapted to disturbance cycles that occur at multiple temporal and spatial scales. They are embedded in a complex institutional system involving multiple governance ... ...

Abstract	The forested watersheds of the Pacific Northwest are complex aquatic ecosystems. They are adapted to disturbance cycles that occur at multiple temporal and spatial scales. They are embedded in a complex institutional system involving multiple governance structures spanning multiple ownership types. The salmon populations that inhabit the streams, rivers, and estuaries are diffuse and provide heterogeneous values to a heterogeneous user population. Management of these watersheds has been controlled by “top down” hierarchical land management agencies with policy dictated at the federal level, but there appears to be a transition to a more collaborative multi-level, polycentric approach based on local watershed councils. In this paper, the relevance of an emerging sub-discipline of economics, known as the New Institutional Economics, is explored as a vehicle for understanding how institutional governance structures relate to characteristics of the resource and the resource user community and guiding future watershed management policy. The recently established Watershed Councils in the state of Oregon, U.S., are explored as an example of how institutional arrangements for resource management may evolve over time. While some studies evaluate the effectiveness of this decentralized approach based on participants' opinions about process, the question of effectiveness with regards to ecosystem health remains to be addressed. This is a topic for future research.
Keywords	aquatic ecosystems ; attitudes and opinions ; economics ; estuaries ; forested watersheds ; governance ; issues and policy ; landscapes ; ownership ; resource management ; rivers ; salmon ; streams ; watershed management ; Oregon
Language	English
Dates of publication	2013-10
Size	p. 50-56.
Publishing place	Elsevier B.V.
Document type	Article
ISSN	1389-9341
DOI	10.1016/j.forpol.2013.06.008
Database	NAL-Catalogue (AGRICOLA)

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Article: A spatial, simultaneous model of social capital and poverty

Harrison, Jane L. / Montgomery, Claire A. / Jeanty, P. Wilner

Journal of Behavioral and Experimental Economics. 2019 Feb. 01, v. 78

2019

Abstract: This study explores the interrelationship between social capital and poverty, a negative indicator of well-being, in the Western United States. Econometric models that account for the endogeneity of poverty and social capital, spatial dependence, and ... ...

Abstract	This study explores the interrelationship between social capital and poverty, a negative indicator of well-being, in the Western United States. Econometric models that account for the endogeneity of poverty and social capital, spatial dependence, and cross-equation error correlation were used to explore two questions: is the presence of social capital associated with reduced poverty levels and does the presence of poverty impact social capital stocks? We found evidence that communities with higher social capital levels tend to have lower poverty rates and that poverty may pose barriers to social capital formation. This suggests that policies to reduce poverty will be more effective if coupled with policies to support social capital formation. The study's findings are particularly salient for communities in persistent poverty. These results emerged only after accounting for endogeneity and spatial relationships. Because many factors contributing to well-being are jointly determined with well-being and indicators of well-being are frequently spatially clustered, this situation is likely to be more common than has been typically recognized in the literature.
Keywords	econometric models ; journals ; poverty ; public policy ; social barriers ; social capital ; social impact ; social support ; wills ; Western United States
Language	English
Dates of publication	2019-0201
Size	p. 183-192.
Publishing place	Elsevier BV
Document type	Article
ZDB-ID	2763246-5
ISSN	2214-8043
ISSN	2214-8043
DOI	10.1016/j.socec.2018.09.001
Database	NAL-Catalogue (AGRICOLA)

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Article: The influence of age-specific migration on housing growth in the rural Midwest (USA)

Lee, Yohan / Kline, Jeffrey D / Montgomery, Claire A

Elsevier B.V. Landscape and urban planning. 2016 Apr., v. 148

2016

Abstract: Natural resource policymakers and planners increasingly rely on regional and national-level spatial data describing projections of future housing growth, to anticipate development impacts on natural resources and identify policy and planning needs. Such ... ...

Abstract	Natural resource policymakers and planners increasingly rely on regional and national-level spatial data describing projections of future housing growth, to anticipate development impacts on natural resources and identify policy and planning needs. Such projections have not always been well-grounded in demographic and other factors that influence population and thus housing growth. We develop an empirical model describing population change and housing growth in the rural Midwestern U.S., as a function of demographic transition, socioeconomic factors, and natural amenities. The empirical model is estimated as a set of three equations characterizing: (1) population growth within three age groups, (2) the influence of farmland cover and other county level variables, and (3) household size, housing services, and second home ownership. The estimated population and housing growth models provide a consistent estimate of past change and can be used to project future change. We found age-structure to be an important factor in housing location decisions. Specifically, the influence of natural amenities on both population growth within counties and subsequent housing density changes varies by age group.
Keywords	age structure ; agricultural land ; equations ; growth models ; home ownership ; issues and policy ; planning ; population growth ; socioeconomic factors ; spatial data ; Midwestern United States
Language	English
Dates of publication	2016-04
Size	p. 68-79.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	742504-1
ISSN	1872-6062 ; 0169-2046
ISSN (online)	1872-6062
ISSN	0169-2046
DOI	10.1016/j.landurbplan.2015.12.005
Database	NAL-Catalogue (AGRICOLA)

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Article: The Histone H3 K4me3, K27me3, and K27ac Genome-Wide Distributions Are Differently Influenced by Sex in Brain Cortexes and Gastrocnemius of the Alzheimer’s Disease PSAPP Mouse Model

Casciaro, Francesca / Persico, Giuseppe / Rusin, Martina / Amatori, Stefano / Montgomery, Claire / Rutkowsky, Jennifer R. / Ramsey, Jon J. / Cortopassi, Gino / Fanelli, Mirco / Giorgio, Marco

Epigenomes. 2021 Nov. 25, v. 5, no. 4

2021

Abstract: Background: Women represent the majority of Alzheimer’s disease patients and show typical symptoms. Genetic, hormonal, and behavioral mechanisms have been proposed to explain sex differences in dementia prevalence. However, whether sex differences exist ... ...

Abstract	Background: Women represent the majority of Alzheimer’s disease patients and show typical symptoms. Genetic, hormonal, and behavioral mechanisms have been proposed to explain sex differences in dementia prevalence. However, whether sex differences exist in the epigenetic landscape of neuronal tissue during the progression of the disease is still unknown. Methods: To investigate the differences of histone H3 modifications involved in transcription, we determined the genome-wide profiles of H3K4me3, H3K27ac, and H3K27me3 in brain cortexes of an Alzheimer mouse model (PSAPP). Gastrocnemius muscles were also tested since they are known to be different in the two sexes and are affected during the disease progression. Results: Correlation analysis distinguished the samples based on sex for H3K4me3 and H3K27me3 but not for H3K27ac. The analysis of transcription starting sites (TSS) signal distribution, and analysis of bounding sites revealed that gastrocnemius is more influenced than brain by sex for the three histone modifications considered, exception made for H3K27me3 distribution on the X chromosome which showed sex-related differences in promoters belonging to behavior and cellular or neuronal spheres in mice cortexes. Conclusions: H3K4me3, H3K27ac, and H3K27me3 signals are slightly affected by sex in brain, with the exception of H3K27me3, while a higher number of differences can be found in gastrocnemius.
Keywords	brain ; disease progression ; epigenetics ; histones ; mice ; neurons
Language	English
Dates of publication	2021-1125
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ISSN	2075-4655
DOI	10.3390/epigenomes5040026
Database	NAL-Catalogue (AGRICOLA)

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