LIVIVO - Search results -

Search results

Result 1 - 10 of total 23

Search options

Article ; Online: Is there a role for immune-enhancing therapies for acutely ill patients with coronavirus disease 2019?

Wittebole, Xavier / Montiel, Virginie / Mesland, Jean-Baptiste

2021 Volume 27, Issue 5, Page(s) 480–486

Abstract: Purpose of review: Although the so-called cytokine storm has been early described and related to a dramatic evolution in severe COVID-19 patients, it soon became clear that those patients display clinical and biological evidence of an immunosuppressive ... ...

Abstract	Purpose of review: Although the so-called cytokine storm has been early described and related to a dramatic evolution in severe COVID-19 patients, it soon became clear that those patients display clinical and biological evidence of an immunosuppressive state characterized, among other, by a profound lymphopenia. The negative role of this immune suppression on the outcome raises the question on immune therapies that might improve patient's condition. Recent findings: Important positive effects of active immune therapies, such as IL-7 or thymosin-α are already described and warrant confirmation in larger prospective trials. For other therapies, such as interferons, firm conclusions for critically ill COVID-19 patients are lacking as those patients were often excluded from the published trials. Treatment with immunoglobulins or convalescent plasma is a passive strategy to provide specific immunity. Unfortunately, results from large RCTs do not support their use presently. Summary: In this article, we provide a review on active and passive immune boosting strategies that might help treating the most severe COVID-19 patients. We mainly focus on active strategies that include IL-7, thymosin-α, interferons, and vitamin D. Although some positive effects are described, they certainly warrant confirmation in large randomized controlled trials.
MeSH term(s)	COVID-19/therapy ; Coronavirus Infections ; Humans ; Immunization, Passive ; Prospective Studies ; SARS-CoV-2 ; COVID-19 Serotherapy
Language	English
Publishing date	2021-07-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1235629-3
ISSN	1531-7072 ; 1070-5295
ISSN (online)	1531-7072
ISSN	1070-5295
DOI	10.1097/MCC.0000000000000862
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4999: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Administration of Supplemental Oxygen.

Wittebole, Xavier / Duprez, Frédéric / Montiel, Virginie

The New England journal of medicine

2021 Volume 385, Issue 17, Page(s) e61

MeSH term(s)	Humans ; Oxygen
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2021-10-18
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2113496
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.34: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Biological Assessment of the NO-Dependent Endothelial Function.

Boughaleb, Hasnae / Lobysheva, Irina / Dei Zotti, Flavia / Balligand, Jean-Luc / Montiel, Virginie

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 22

Abstract: Nitric oxide (NO) is implicated in numerous physiological processes, including vascular homeostasis. Reduced NO bioavailability is a hallmark of endothelial dysfunction, a prequel to many cardiovascular diseases. Biomarkers of an early NO-dependent ... ...

Abstract	Nitric oxide (NO) is implicated in numerous physiological processes, including vascular homeostasis. Reduced NO bioavailability is a hallmark of endothelial dysfunction, a prequel to many cardiovascular diseases. Biomarkers of an early NO-dependent endothelial dysfunction obtained from routine venous blood sampling would be of great interest but are currently lacking. The direct measurement of circulating NO remains a challenge due by its high reactivity and short half-life. The current techniques measure stable products from the NO signaling pathway or metabolic end products of NO that do not accurately represent its bioavailability and, therefore, endothelial function per se. In this review, we will concentrate on an original technique of low temperature electron paramagnetic resonance spectroscopy capable to directly measure the 5-α-coordinated heme nitrosyl-hemoglobin in the T (tense) state (5-α-nitrosyl-hemoglobin or HbNO) obtained from fresh venous human erythrocytes. In humans, HbNO reflects the bioavailability of NO formed in the vasculature from vascular endothelial NOS or exogenous NO donors with minor contribution from erythrocyte NOS. The HbNO signal is directly correlated with the vascular endothelial function and inversely correlated with vascular oxidative stress. Pilot studies support the validity of HbNO measurements both for the detection of endothelial dysfunction in asymptomatic subjects and for the monitoring of such dysfunction in patients with known cardiovascular disease. The impact of therapies or the severity of diseases such as COVID-19 infection involving the endothelium could also be monitored and their incumbent risk of complications better predicted through serial measurements of HbNO.
MeSH term(s)	Humans ; Nitric Oxide/metabolism ; COVID-19 ; Hemoglobins/metabolism ; Endothelium, Vascular/metabolism
Chemical Substances	hemoglobin A, glycosylated-nitric oxide complex ; Nitric Oxide (31C4KY9ESH) ; Hemoglobins
Language	English
Publishing date	2022-11-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27227921
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.MO 81: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: HELIOS-expressing human CD8 T cells exhibit limited effector functions.

Neyens, Damien / Hirsch, Thibault / Abdel Aziz Issa Abdel Hadi, Achraqat / Dauguet, Nicolas / Vanhaver, Christophe / Bayard, Alexandre / Wildmann, Claude / Luyckx, Mathieu / Squifflet, Jean-Luc / D'Hondt, Quentin / Duhamel, Céline / Huaux, Antoine / Montiel, Virginie / Dechamps, Mélanie / van der Bruggen, Pierre

Frontiers in immunology

2023 Volume 14, Page(s) 1308539

Abstract: Introduction: The transcription factor HELIOS is primarily known for its expression in CD4 regulatory T cells, both in humans and mice. In mice, HELIOS is found in exhausted CD8 T cells. However, information on human HELIOS: Methods: In this study, ... ...

Abstract	Introduction: The transcription factor HELIOS is primarily known for its expression in CD4 regulatory T cells, both in humans and mice. In mice, HELIOS is found in exhausted CD8 T cells. However, information on human HELIOS Methods: In this study, we characterized by flow cytometry and transcriptomic analyses human HELIOS Results: These T cells primarily consist of memory cells and constitute approximately 21% of blood CD8 T cells. In comparison with memory HELIOS Discussion: Our findings emphasize that HELIOS is expressed across various CD8 T cell populations, highlighting its significance beyond its role as a transcription factor for Treg or exhausted murine CD8 T cells. The significance of the connection between HELIOS and HLA-E restriction is yet to be understood.
MeSH term(s)	Humans ; Animals ; Mice ; HLA-E Antigens ; CD8-Positive T-Lymphocytes ; Tumor Necrosis Factor-alpha ; Transcription Factors/genetics ; Cytomegalovirus Infections
Chemical Substances	HLA-E Antigens ; Tumor Necrosis Factor-alpha ; Transcription Factors
Language	English
Publishing date	2023-12-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1308539
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Development of SARS-CoV2 humoral response including neutralizing antibodies is not sufficient to protect patients against fatal infection.

Choteau, Mathilde / Scohy, Anaïs / Messe, Stéphane / Luyckx, Mathieu / Dechamps, Mélanie / Montiel, Virginie / Yombi, Jean Cyr / Gruson, Damien / Limaye, Nisha / Michiels, Thomas / Dumoutier, Laure

Scientific reports

2022 Volume 12, Issue 1, Page(s) 2077

Abstract: More than a year after the start of the pandemic, COVID-19 remains a global health emergency. Although the immune response against SARS-CoV-2 has been extensively studied, some points remain controversial. One is the role of antibodies in viral clearance ...

Abstract	More than a year after the start of the pandemic, COVID-19 remains a global health emergency. Although the immune response against SARS-CoV-2 has been extensively studied, some points remain controversial. One is the role of antibodies in viral clearance and modulation of disease severity. While passive transfer of neutralizing antibodies protects against SARS-CoV-2 infection in animal models, titers of anti-SARS-CoV-2 antibodies have been reported to be higher in patients suffering from more severe forms of the disease. A second key question for pandemic management and vaccine design is the persistence of the humoral response. Here, we characterized the antibody response in 187 COVID-19 patients, ranging from asymptomatic individuals to patients who died from COVID-19, and including patients who recovered. We developed in-house ELISAs to measure titers of IgG, IgM and IgA directed against the RBD or N regions in patient serum or plasma, and a spike-pseudotyped neutralization assay to analyse seroneutralization. Higher titers of virus-specific antibodies were detected in patients with severe COVID-19, including deceased patients, compared to asymptomatic patients. This demonstrates that fatal infection is not associated with defective humoral response. Finally, most of recovered patients still had anti-SARS-CoV-2 IgG more than 3 months after infection.
MeSH term(s)	Adult ; Aged ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/immunology ; COVID-19/mortality ; Female ; Humans ; Immunity, Humoral ; Male ; Middle Aged ; SARS-CoV-2/immunology
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral
Language	English
Publishing date	2022-02-08
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-06038-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Surgical mask on top of high-flow nasal cannula improves oxygenation in critically ill COVID-19 patients with hypoxemic respiratory failure.

Montiel, Virginie / Robert, Arnaud / Robert, Annie / Nabaoui, Anas / Marie, Tourneux / Mestre, Natalia Morales / Guillaume, Maerckx / Laterre, Pierre-François / Wittebole, Xavier

Annals of intensive care

2020 Volume 10, Issue 1, Page(s) 125

Abstract: Objective: Critically ill patients admitted in ICU because of COVID-19 infection display severe hypoxemic respiratory failure. The Surviving Sepsis Campaign recommends oxygenation through high-flow nasal cannula over non-invasive ventilation. The ... ...

Abstract	Objective: Critically ill patients admitted in ICU because of COVID-19 infection display severe hypoxemic respiratory failure. The Surviving Sepsis Campaign recommends oxygenation through high-flow nasal cannula over non-invasive ventilation. The primary outcome of our study was to evaluate the effect of the addition of a surgical mask on a high-flow nasal cannula system on oxygenation parameters in hypoxemic COVID-19 patients admitted in ICU who do not require urgent intubation. The secondary outcomes were relevant changes in PaCO Design: We prospectively assessed 21 patients admitted in our mixed Intensive Care Unit of the Cliniques Universitaires Saint Luc. Main results: While FiO2 was unchanged, we demonstrate a significant increase of PaO Conclusion: A surgical mask placed on patient's face already treated by a High-flow nasal cannula device improves COVID-19 patient's oxygenation admitted in Intensive Care Unit for severe hypoxemic respiratory failure without any clinically relevant side.
Keywords	covid19
Language	English
Publishing date	2020-09-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2617094-2
ISSN	2110-5820
ISSN	2110-5820
DOI	10.1186/s13613-020-00744-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Increased Angiotensin-Converting Enzyme 2 and Loss of Alveolar Type II Cells in COVID-19-related Acute Respiratory Distress Syndrome.

Gerard, Ludovic / Lecocq, Marylene / Bouzin, Caroline / Hoton, Delphine / Schmit, Gregory / Pereira, Joao Pinto / Montiel, Virginie / Plante-Bordeneuve, Thomas / Laterre, Pierre-François / Pilette, Charles

American journal of respiratory and critical care medicine

2021 Volume 204, Issue 9, Page(s) 1024–1034

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Adult ; Aged ; Alveolar Epithelial Cells/metabolism ; Angiotensin-Converting Enzyme 2/metabolism ; Biomarkers/metabolism ; COVID-19/diagnosis ; COVID-19/metabolism ; COVID-19/physiopathology ; Case-Control Studies ; Female ; Humans ; Immunohistochemistry ; Logistic Models ; Male ; Middle Aged ; Peptidyl-Dipeptidase A/metabolism ; Proportional Hazards Models ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/metabolism ; Respiratory Distress Syndrome/virology ; Retrospective Studies ; Severity of Illness Index ; Up-Regulation
Chemical Substances	Biomarkers ; ACE protein, human (EC 3.4.15.1) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-08-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202012-4461OC
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh II Zs.80: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Nitric oxide synthase in post-ischaemic remodelling: new pathways and mechanisms.

Manoury, Boris / Montiel, Virginie / Balligand, Jean-Luc

Cardiovascular research

2012 Volume 94, Issue 2, Page(s) 304–315

Abstract: The three isoforms of nitric oxide synthase (NOS), spatially confined in specific intracellular compartments in cardiac cells, have distinct roles in the regulation of contractility in pathophysiological situations. Recently, evidence has emerged that ... ...

Abstract	The three isoforms of nitric oxide synthase (NOS), spatially confined in specific intracellular compartments in cardiac cells, have distinct roles in the regulation of contractility in pathophysiological situations. Recently, evidence has emerged that implicates NOS in modulating myocardial remodelling during cardiac stress, including after ischaemic insults. As long as they remain in a coupled state the NOS mostly attenuate hypertrophic remodelling through both cGMP-dependent and independent mechanisms. We review the evidence provided from the phenotype of genetic mouse models as well as from in vitro cell experiments dissecting the signalling effectors involved in the NOS-mediated regulation that justify new therapeutic interventions on the NOS-cGMP axis to attenuate the development of heart failure.
MeSH term(s)	Animals ; Heart Failure/metabolism ; Heart Failure/physiopathology ; Humans ; Mice ; Myocardium/metabolism ; Myocardium/pathology ; Nitric Oxide/metabolism ; Nitric Oxide Synthase/physiology ; Signal Transduction ; Ventricular Remodeling/physiology
Chemical Substances	Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase (EC 1.14.13.39)
Language	English
Publishing date	2012-05-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80340-6
ISSN	1755-3245 ; 0008-6363
ISSN (online)	1755-3245
ISSN	0008-6363
DOI	10.1093/cvr/cvr360
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 565: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Diltiazem poisoning treated with hyperinsulinemic euglycemia therapy and intravenous lipid emulsion.

Montiel, Virginie / Gougnard, Thierry / Hantson, Philippe

European journal of emergency medicine : official journal of the European Society for Emergency Medicine

2011 Volume 18, Issue 2, Page(s) 121–123

Abstract: Intravenous lipid emulsion (ILE) has been proposed as a rescue therapy for severe local anesthetic drugs toxicity, but experience is limited with other lipophilic drugs. An 18-year-old healthy woman was admitted 8 h after the voluntary ingestion of ... ...

Abstract	Intravenous lipid emulsion (ILE) has been proposed as a rescue therapy for severe local anesthetic drugs toxicity, but experience is limited with other lipophilic drugs. An 18-year-old healthy woman was admitted 8 h after the voluntary ingestion of sustained-release diltiazem (3600 mg), with severe hypotension refractory to fluid therapy, calcium salts, and high-dose norepinephrine (6.66 μg/kg/min). Hyperinsulinemic euglycemia therapy was initiated and shortly after was followed by a protocol of ILE (intralipid 20%, 1.5 ml/kg as bolus, followed by 0.25 ml/kg over 1h). The main finding attributed to ILE was an apparent rapid decrease in insulin resistance, despite a prolonged serum diltiazem elimination half-life. Diltiazem is a lipophilic cardiotoxic drug, which could be sequestered in an expanded plasma lipid phase. The mechanism of action of ILE is not known, including its role in insulin resistance and myocardial metabolism in calcium-channel blocker poisoning.
MeSH term(s)	Adolescent ; Blood Glucose/analysis ; Combined Modality Therapy ; Diltiazem/poisoning ; Emergency Treatment ; Fat Emulsions, Intravenous/administration & dosage ; Female ; Follow-Up Studies ; Glucose Clamp Technique ; Humans ; Hyperinsulinism ; Insulin/administration & dosage ; Intensive Care Units ; Poisoning/therapy ; Risk Assessment ; Suicide, Attempted ; Treatment Outcome
Chemical Substances	Blood Glucose ; Fat Emulsions, Intravenous ; Insulin ; Diltiazem (EE92BBP03H)
Language	English
Publishing date	2011-04
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1233544-7
ISSN	1473-5695 ; 0969-9546
ISSN (online)	1473-5695
ISSN	0969-9546
DOI	10.1097/MEJ.0b013e32834130ab
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4264: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Surgical mask on top of high-flow nasal cannula improves oxygenation in critically ill COVID-19 patients with hypoxemic respiratory failure

Montiel, Virginie / Robert, Arnaud / Robert, Annie / Nabaoui, Anas / Marie, Tourneux / Mestre, Natalia Morales / Guillaume, Maerckx / Laterre, Pierre-François / Wittebole, Xavier

Annals of Intensive Care

2020 Volume 10, Issue 1

Abstract: Abstract Objective Critically ill patients admitted in ICU because of COVID-19 infection display severe hypoxemic respiratory failure. The Surviving Sepsis Campaign recommends oxygenation through high-flow nasal cannula over non-invasive ventilation. The ...

Abstract	Abstract Objective Critically ill patients admitted in ICU because of COVID-19 infection display severe hypoxemic respiratory failure. The Surviving Sepsis Campaign recommends oxygenation through high-flow nasal cannula over non-invasive ventilation. The primary outcome of our study was to evaluate the effect of the addition of a surgical mask on a high-flow nasal cannula system on oxygenation parameters in hypoxemic COVID-19 patients admitted in ICU who do not require urgent intubation. The secondary outcomes were relevant changes in PaCO 2 associated with clinical modifications and patient’s feelings. Design We prospectively assessed 21 patients admitted in our mixed Intensive Care Unit of the Cliniques Universitaires Saint Luc. Main results While FiO2 was unchanged, we demonstrate a significant increase of PaO 2 (from 59 (± 6), to 79 mmHg (± 16), p < 0.001), PaO 2 /FiO 2 from 83 (± 22), to 111 (± 38), p < 0.001) and SaO 2 (from 91% (± 1.5), to 94% (± 1.6), p < 0.001), while the patients were under the surgical mask. The SpO 2 returned to pre-treatment values when the surgical mask was removed confirming the effect of the device rather than a spontaneous positive evolution. Conclusion A surgical mask placed on patient’s face already treated by a High-flow nasal cannula device improves COVID-19 patient’s oxygenation admitted in Intensive Care Unit for severe hypoxemic respiratory failure without any clinically relevant side.
Keywords	Critical Care and Intensive Care Medicine ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ZDB-ID	2617094-2
ISSN	2110-5820
ISSN	2110-5820
DOI	10.1186/s13613-020-00744-x
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Order via subito

Details ▾
- Full text online
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito