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  1. Article ; Online: RE: Cognitive Algorithms and Digitized Tissue-based Diagnosis. Jürgen Görtler, Klaus Kayser, Stephan Borkenfeld, Rita Carvalho, Gian Kayser. Diagnostic Pathology 2017, 3:248

    Gasparrini, Silvia / Montironi, Maria Alessandra / Cimadamore, Alessia / Lopez-Beltran, Antonio / Cheng, Liang / Scarpelli, Marina / Montironi, Rodolfo

    Diagnostic pathology 3,252 , 4 Seiten

    Large Format Histology, Whole Slide Imaging and Multi-Criteria Decision Making

    2017  

    Author's details Silvia Gasparrini (Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy), Maria Alessandra Montironi (Department of Mechanical and Aerospace Engineering, University of California, Davis, CA, USA), Alessia Cimadamore (Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy), Antonio Lopez-Beltran (Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal), Liang Cheng (Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA), Marina Scarpelli (Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy) and Rodolfo Montironi (Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy)
    Subject code 610
    Language English
    Publishing place Waltrop, 2017-10-18
    Publishing country Germany
    Document type Article ; Online
    Note Sofern nicht anders angegeben, ist dieses Werk lizenziert unter einer Creative Commons Namensnennung - Weitergabe unter gleichen Bedingungen 4.0 Lizenz (https://creativecommons.org/licenses/by-sa/4.0/)
    HBZ-ID HT019841284
    DOI 10.17629/www.diagnosticpathology.eu-2017-3:252
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  2. Article ; Online: Whole Slide Imaging of Large Format Histology in Prostate Pathology: Potential for Information Fusion.

    Montironi, Rodolfo / Cimadamore, Alessia / Massari, Francesco / Montironi, Maria Alessandra / Lopez-Beltran, Antonio / Cheng, Liang / Montorsi, Francesco / Scarpelli, Marina

    Archives of pathology & laboratory medicine

    2017  Volume 141, Issue 11, Page(s) 1460–1461

    MeSH term(s) Histological Techniques ; Humans ; Male ; Microscopy ; Pathology, Clinical ; Prostate
    Language English
    Publishing date 2017-12-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2017-0198-LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Re: Kenneth A. Iczkowski's Letter to the Editor re: Re: Rodolfo Montironi, Silvia Gasparrini, Roberta Mazzucchelli, et al's Letter to the Editor re: Karim A. Touijer, James A. Eastham. The Sentinel Lymph Node Concept and Novel Approaches in Detecting Lymph Node Metastasis in Prostate Cancer. Eur Urol 2016;70:738-9: Sentinel Lymph Nodes in Adipose Tissue Surrounding the Prostate Gland and Seminal Vesicles as Observed in Virtual Whole-mount Histologic Slides. Eur Urol 2017;71:e73-5.

    Montironi, Rodolfo / Lopez-Beltran, Antonio / Cheng, Liang / Gasparrini, Silvia / Montironi, Maria Alessandra / Massari, Francesco / Scarpelli, Marina / Montorsi, Francesco

    European urology

    2017  Volume 72, Issue 2, Page(s) e37–e38

    Language English
    Publishing date 2017-08
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2017.02.032
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    Zs.A 1247: Show issues Location:
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  4. Article ; Online: A low grade PIN-like neoplasm of the transition zone immunohistochemically negative for basal cell markers: a possible example of low grade adenocarcinoma with stratified epithelium.

    Montironi, Rodolfo / Cheng, Liang / Lopez-Beltran, Antonio / Montironi, Maria Alessandra / Galosi, Andrea B / Scarpelli, Marina

    Pathology

    2014  Volume 46, Issue 1, Page(s) 88–91

    MeSH term(s) Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Aged ; Biomarkers, Tumor/metabolism ; Diagnosis, Differential ; Epithelium/pathology ; Humans ; Immunohistochemistry ; Male ; Prostate/pathology ; Prostatic Hyperplasia/pathology ; Prostatic Hyperplasia/surgery ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2014-01
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1097/PAT.0000000000000036
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    Zs.A 723: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Immunohistochemical analysis of chromatin remodeler DAXX in high grade urothelial carcinoma.

    Zizzi, Antonio / Montironi, Maria Alessandra / Mazzucchelli, Roberta / Scarpelli, Marina / Lopez-Beltran, Antonio / Cheng, Liang / Paone, Nicola / Castellini, Paolo / Montironi, Rodolfo

    Diagnostic pathology

    2013  Volume 8, Page(s) 111

    Abstract: Background/aims: The chromatin remodeler DAXX, a predominantly nuclear protein, regulates the status of chromatin organization. The aim of this exploratory immunohistochemical study was to evaluate DAXX protein expression in high grade invasive ... ...

    Abstract Background/aims: The chromatin remodeler DAXX, a predominantly nuclear protein, regulates the status of chromatin organization. The aim of this exploratory immunohistochemical study was to evaluate DAXX protein expression in high grade invasive urothelial carcinoma (UC) of the bladder as a biological regulator of aggressiveness.
    Methods: Quantitative analysis was made on DAXX immunostained nuclei in tissue sections from 5 cases of bladder normal urothelium (NU) and 5 cases of bladder pT1 UC. Carcinoma in situ (CIS) and high grade papillary carcinoma (HGPCa) were identified in 2 out of 5 UC cases.
    Results: The nuclei in UC show an open configuration of the chromatin composed of granules varying in size and distribution and a mean nuclear area 1.7 times greater than that in NU (UC: mean and SD 24.4 ± 11.4 square microns; NU: 14.8 6.5 square microns. The differences are statistically significant). 70% of the NU nuclei are immunostained, whereas 90% of UC nuclei are positive. The mean gray level value in UC, related to the intensity of nuclear immunostaining, is lower than in NU by a factor of 0.94 (UC: mean and SD 100 ± 15; NU: 106 ± 15. The differences are statistically significant). In particular, the value in the nuclei adjacent to the stroma in UC is slightly lower than in the intermediate cell layers by factor of 0.98, whereas in NU it is slightly greater by a factor 1.02 and 1.04 compared to the intermediate and superficial cell layers. The values in CIS and HGPCa are similar to those in UC.
    Conclusions: The quantitative immunohistochemical analysis shows an altered protein expression of chromatin remodeler DAXX in UC and in its preinvasive phases, when compared to NU. DAXX evaluation, if associated with markers related to global DNA methylation and histone acetylation, could be used in clinical practice as a marker of aggressiveness.
    Virtual slides: The virtual slides for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/1398457297102379.
    MeSH term(s) Adaptor Proteins, Signal Transducing/analysis ; Biomarkers, Tumor/analysis ; Carcinoma in Situ/chemistry ; Carcinoma in Situ/pathology ; Carcinoma, Papillary/chemistry ; Carcinoma, Papillary/pathology ; Cell Nucleus/chemistry ; Cell Nucleus/pathology ; Cell Nucleus Size ; Chromatin Assembly and Disassembly ; Co-Repressor Proteins ; Humans ; Immunohistochemistry ; Molecular Chaperones ; Neoplasm Grading ; Neoplasm Invasiveness ; Nuclear Proteins/analysis ; Predictive Value of Tests ; Urinary Bladder Neoplasms/chemistry ; Urinary Bladder Neoplasms/pathology ; Urothelium/chemistry ; Urothelium/pathology
    Chemical Substances Adaptor Proteins, Signal Transducing ; Biomarkers, Tumor ; Co-Repressor Proteins ; DAXX protein, human ; Molecular Chaperones ; Nuclear Proteins
    Language English
    Publishing date 2013-07-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1746-1596
    ISSN (online) 1746-1596
    DOI 10.1186/1746-1596-8-111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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