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  1. Article: Endovascular mechanical thrombectomy of iliofemoral venous stent occlusion with the novel RevCore thrombectomy system: case reports and literature review.

    Montoya, Christopher / Polania-Sandoval, Camilo / Almeida, Jose I

    Journal of vascular surgery cases and innovative techniques

    2024  Volume 10, Issue 3, Page(s) 101432

    Abstract: Venous in-stent restenosis is not completely understood, and the currently available treatment is usually unsatisfactory. We describe the cases of two patients treated with the RevCore thrombectomy system (Inari Medical), designed for venous in-stent ... ...

    Abstract Venous in-stent restenosis is not completely understood, and the currently available treatment is usually unsatisfactory. We describe the cases of two patients treated with the RevCore thrombectomy system (Inari Medical), designed for venous in-stent thrombosis. Case 1 involves a 62-year-old woman with post-thrombotic syndrome from iliac vein stent placement 15 years earlier. Case 2 describes a 30-year-old woman with post-thrombotic syndrome from recurrent iliac vein stent occlusion, despite therapeutic anticoagulation. Both patients had previous recanalization attempts at outside facilities that were unsuccessful. The RevCore system was safe and feasible in these initial cases, and more studies are warranted.
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Case Reports
    ISSN 2468-4287
    ISSN 2468-4287
    DOI 10.1016/j.jvscit.2024.101432
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  2. Article: Azygos vein stenting as an alternate route for inferior vena cava obstruction.

    Montoya, Christopher / Polanía-Sandoval, Camilo / Almeida, Jose I

    Journal of vascular surgery cases and innovative techniques

    2023  Volume 9, Issue 4, Page(s) 101351

    Abstract: Chronic venous insufficiency, caused by inferior vena cava occlusion, can lead to thromboembolic complications and tissue loss. We present two cases of azygos vein stenting (AVS) in which vena cava recanalization techniques were exhausted. In the first ... ...

    Abstract Chronic venous insufficiency, caused by inferior vena cava occlusion, can lead to thromboembolic complications and tissue loss. We present two cases of azygos vein stenting (AVS) in which vena cava recanalization techniques were exhausted. In the first case, the left iliac vein and vena cava were recanalized and stented; however, the right iliac vein had been previously resected and required AVS. Conventional recanalization attempts from the right and left iliac systems failed in the second patient with congenital inferior vena cava occlusion; therefore, AVS was chosen to establish in-line drainage.
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Case Reports
    ISSN 2468-4287
    ISSN 2468-4287
    DOI 10.1016/j.jvscit.2023.101351
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  3. Article ; Online: Inferior Vena Cava Filter Long Term Complications and Retrieval Techniques: A Case Series and Literature Review.

    Montoya, Christopher / Rey, Jorge / Polania-Sandoval, Camilo A / Bornak, Arash / Shao, Tony / Kenel-Pierre, Stefan

    Vascular and endovascular surgery

    2024  Volume 58, Issue 5, Page(s) 559–566

    Abstract: Introduction and importance: Long-term mechanical complications after inferior vena cava (IVC) filter placement include embedded or tilted filters, erosion of the vena cava, filter thrombosis. In the setting of caval thrombosis, patients may ... ...

    Abstract Introduction and importance: Long-term mechanical complications after inferior vena cava (IVC) filter placement include embedded or tilted filters, erosion of the vena cava, filter thrombosis. In the setting of caval thrombosis, patients may subsequently develop venous hypertension and post-thrombotic syndrome (PTS). Here we present three unique cases of IVC filter complications and surgical management.
    Case presentation: A 30-year-old female presented with acute abdominal pain, revealing a duodenal perforation caused by an IVC filter eroding into her duodenum. A 42-year-old female with an IVC filter in place for 20 years due to a prior pulmonary embolism underwent laser-assisted retrieval of the filter due to concerns of caval adherence. A 48-year-old male with a history of DVT, venous stasis ulcer, and an IVC filter presented for filter retrieval.
    Clinical findings and investigations: The surgical techniques described in this report include complicated IVC filter retrieval, performed in cases of filter complications including migration, fracture, duodenal perforation and IVC thrombosis resulting in PTS. One case, requiring open retrieval, is explained and the surgical technique is provided. There are images and videos of these procedures to enrich the learning experience.
    Intervention and outcomes: The surgical techniques described in this report include complicated inferior vena cava filter retrieval, performed in cases of filter complications including migration, fracture, duodenal perforation and IVC thrombosis. One case, requiring open retrieval, is explained and the surgical technique is provided. There are images and videos of these procedures to enrich the learning experience.
    Relevance and impact: Endovascular retrieval of long-term complicated IVC filters is challenging, but it can be a safely performed in many patients. However, open surgery may be necessary in selected patients.
    MeSH term(s) Humans ; Vena Cava Filters/adverse effects ; Device Removal ; Male ; Middle Aged ; Female ; Adult ; Treatment Outcome ; Foreign-Body Migration/etiology ; Foreign-Body Migration/diagnostic imaging ; Foreign-Body Migration/surgery ; Vena Cava, Inferior/diagnostic imaging ; Vena Cava, Inferior/injuries ; Vena Cava, Inferior/surgery ; Venous Thrombosis/etiology ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/therapy ; Intestinal Perforation/etiology ; Intestinal Perforation/surgery ; Intestinal Perforation/diagnostic imaging ; Prosthesis Implantation/instrumentation ; Prosthesis Implantation/adverse effects ; Time Factors ; Prosthesis Design ; Phlebography
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review ; Video-Audio Media
    ZDB-ID 2076272-0
    ISSN 1938-9116 ; 1538-5744
    ISSN (online) 1938-9116
    ISSN 1538-5744
    DOI 10.1177/15385744231226048
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    Zs.A 622: Show issues Location:
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  4. Article ; Online: Examination of vesicular stomatitis virus-induced morphology changes in individual Vero cells by QMod microscopy.

    Scholz, Isabel / Montoya, Christopher / Vela, Eric

    BioTechniques

    2020  Volume 68, Issue 6, Page(s) 305–310

    Abstract: Viral infection of cultured cells induces changes in the biophysical characteristics of the affected cells. Advanced microscopic cameras such as Ovizio's QMod, coupled with the appropriate software, can measure a variety of characteristics on a per-cell ... ...

    Abstract Viral infection of cultured cells induces changes in the biophysical characteristics of the affected cells. Advanced microscopic cameras such as Ovizio's QMod, coupled with the appropriate software, can measure a variety of characteristics on a per-cell basis. We have employed this system to monitor the progression of vesicular stomatitis virus infection in Vero cells and to describe the cellular changes associated with advancing vesicular stomatitis virus infection. The measurements of cellular characteristics are operator-independent, and the goal is to establish a robust method to mathematically determine viral infection levels in a given sample. This will provide a means to measure viral titer in a faster and less subjective way than manual reading of plaque assays or tissue culture infectious dose 50 assays.
    MeSH term(s) Animals ; Cell Line ; Chlorocebus aethiops/virology ; Microscopy ; Vero Cells/virology ; Vesicular Stomatitis/diagnosis ; Vesicular Stomatitis/diagnostic imaging ; Vesicular Stomatitis/virology ; Vesicular stomatitis Indiana virus/isolation & purification ; Vesicular stomatitis Indiana virus/pathogenicity ; Virus Diseases/diagnosis ; Virus Diseases/diagnostic imaging ; Virus Diseases/virology
    Language English
    Publishing date 2020-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 48453-2
    ISSN 1940-9818 ; 0736-6205
    ISSN (online) 1940-9818
    ISSN 0736-6205
    DOI 10.2144/btn-2019-0137
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    Zs.A 2435: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Maintaining Weight Loss by Decreasing Sedentary Time: A Patient and Physician's Perspective.

    Montoya, Christopher / Lazarus, Ethan

    Advances in therapy

    2017  Volume 34, Issue 4, Page(s) 1007–1012

    Abstract: This article, co-authored by a patient living with obesity and his obesity medicine specialist, reviews how the patient has successfully lost 200 lb and maintained that loss for over a decade. This was achieved primarily with a behavioral intervention ... ...

    Abstract This article, co-authored by a patient living with obesity and his obesity medicine specialist, reviews how the patient has successfully lost 200 lb and maintained that loss for over a decade. This was achieved primarily with a behavioral intervention including support visits, a structured food plan, and changes in his physical activity. He did not undergo bariatric surgery. For the majority of this time, he was not treated with anti-obesity medication. This article will review how the patient lost the weight and kept it off, particularly in relationship to the importance of decreasing sedentary time.
    MeSH term(s) Diet ; Exercise ; Health Behavior ; Humans ; Life Style ; Male ; Obesity/psychology ; Obesity/therapy ; Weight Loss
    Language English
    Publishing date 2017-03-17
    Publishing country United States
    Document type Letter
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-017-0515-x
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    Zs.A 2101: Show issues Location:
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  6. Article: Development of a high-yield live-virus vaccine production platform using a novel fixed-bed bioreactor

    Berrie, Dalton M / Waters, Robin C / Montoya, Christopher / Chatel, Alex / Vela, Eric M

    Vaccine. 2020 Apr. 29, v. 38, no. 20

    2020  

    Abstract: The increasing importance of viral vaccine manufacturing has driven the need for high cell density process optimization that allows for higher production levels. Vero cells are one of the more popular adherent cell lines used for viral vaccine production. ...

    Abstract The increasing importance of viral vaccine manufacturing has driven the need for high cell density process optimization that allows for higher production levels. Vero cells are one of the more popular adherent cell lines used for viral vaccine production. However, production is limited due to the logistical limitations surrounding adherent cell line processes, such as large equipment footprints, time and labor-intensive processes, and larger costs per dose. We have addressed this limitation with the establishment of a viral vaccine production system utilizing the novel single use scale-XTM carbo bioreactor. The unit is compact and is scalable and one of the novel features of the system is the continuous in-line downstream purification and concentration processes associated with the bioreactor vessel. We present the results from a campaign featuring a proprietary Vero cell line for production of a live recombinant Vesicular stomatitis virus vaccine that features the Lassa Fever virus glycoproteins. Metabolite analyses and viral yield comparison between traditional flasks, cell factories, and the scale-X carbo bioreactor were performed, and on average, the single use bioreactor produced 2–4 logs higher titers per surface area, approximately 5 × 1010 pfu/cm2, compared to classical flatstock, 2.67 × 106 pfu/cm2, and cell factories production, 5.77 × 108 pfu/cm2. Overall, we describe a novel bioreactor platform that allows for a cost-efficient and scalable process for viral vaccine production.
    Keywords Lassa virus fever ; Vesiculovirus ; bioreactors ; cell lines ; cost effectiveness ; glycoproteins ; manufacturing ; metabolites ; surface area ; viral vaccines ; viruses
    Language English
    Dates of publication 2020-0429
    Size p. 3639-3645.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2020.03.041
    Database NAL-Catalogue (AGRICOLA)

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    Zs.MO 458: Show issues

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  7. Article ; Online: Development of a high-yield live-virus vaccine production platform using a novel fixed-bed bioreactor.

    Berrie, Dalton M / Waters, Robin C / Montoya, Christopher / Chatel, Alex / Vela, Eric M

    Vaccine

    2020  Volume 38, Issue 20, Page(s) 3639–3645

    Abstract: The increasing importance of viral vaccine manufacturing has driven the need for high cell density process optimization that allows for higher production levels. Vero cells are one of the more popular adherent cell lines used for viral vaccine production. ...

    Abstract The increasing importance of viral vaccine manufacturing has driven the need for high cell density process optimization that allows for higher production levels. Vero cells are one of the more popular adherent cell lines used for viral vaccine production. However, production is limited due to the logistical limitations surrounding adherent cell line processes, such as large equipment footprints, time and labor-intensive processes, and larger costs per dose. We have addressed this limitation with the establishment of a viral vaccine production system utilizing the novel single use scale-X™ carbo bioreactor. The unit is compact and is scalable and one of the novel features of the system is the continuous in-line downstream purification and concentration processes associated with the bioreactor vessel. We present the results from a campaign featuring a proprietary Vero cell line for production of a live recombinant Vesicular stomatitis virus vaccine that features the Lassa Fever virus glycoproteins. Metabolite analyses and viral yield comparison between traditional flasks, cell factories, and the scale-X carbo bioreactor were performed, and on average, the single use bioreactor produced 2-4 logs higher titers per surface area, approximately 5 × 10
    MeSH term(s) Animals ; Bioreactors ; Cell Line ; Chlorocebus aethiops ; Vaccines, Attenuated ; Vero Cells ; Viral Vaccines ; Virus Cultivation
    Chemical Substances Vaccines, Attenuated ; Viral Vaccines
    Language English
    Publishing date 2020-04-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2020.03.041
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  8. Article ; Online: Utility of Closed Suction Drains in Groin Incisions after Femoral Artery Exposure.

    Manzur-Pineda, Karen / Bornak, Arash / Montoya, Christopher / Hamad, Naser / Shao, Tony / Kang, Naixin / Kenel-Pierre, Stefan / Tabbara, Marwan / Velazquez, Omaida C / Rey, Jorge

    Annals of vascular surgery

    2023  Volume 92, Page(s) 249–255

    Abstract: Background: Surgical groin wounds are at risk of delayed healing and infection, leading to costly and prolonged postoperative recoveries. This study assesses the use of closed suction drains (CSDs) as a wound care adjunct in groin incisions to prevent ... ...

    Abstract Background: Surgical groin wounds are at risk of delayed healing and infection, leading to costly and prolonged postoperative recoveries. This study assesses the use of closed suction drains (CSDs) as a wound care adjunct in groin incisions to prevent surgical site infections (SSI).
    Methods: A single-center retrospective review was performed on 210 consecutive patients after vascular surgery with common femoral artery exposure from 2016 to 2021. The cohort was divided into 2 groups, groins with and without CSD, looking for surgical site complications. A subgroup analysis comparing postoperative outcomes between complicated and uncomplicated groin incisions within both groups was also performed.
    Results: Of 293 surgical groins, 20% (n = 59) had drains. Overall, the CSD group had higher SSI rates (14% vs. 5.6%), but also had higher proportion of smokers (92% vs. 83%; P = 0.019), diabetes (56% vs. 36%; P = 0.005), coronary artery disease (69% vs. 46%; P = 0.001), hyperlipidemia (69% vs. 51%; P = 0.01), and previous groin surgery (54% vs. 17%; P < 0.001). The higher risk of SSI was not significant after adjustment of these confounders. A separate analysis within each group showed SSI groins with CSD had lower reintervention rates (37.5%) than those without CSD (69%), as well as shorter length of hospital stay (7 [5-11] vs. 22 [7-25] days).
    Conclusions: Our study suggests that CSDs can be a beneficial adjunct for groin wounds after common femoral artery exposure in patients with comorbidities cited above. CSDs decrease the risk of reintervention and length of hospital stay.
    MeSH term(s) Humans ; Femoral Artery/surgery ; Groin/blood supply ; Suction ; Treatment Outcome ; Lower Extremity/blood supply ; Surgical Wound Infection/etiology ; Surgical Wound Infection/prevention & control ; Vascular Surgical Procedures/adverse effects ; Surgical Wound ; Retrospective Studies
    Language English
    Publishing date 2023-01-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1027366-9
    ISSN 1615-5947 ; 0890-5096
    ISSN (online) 1615-5947
    ISSN 0890-5096
    DOI 10.1016/j.avsg.2022.12.093
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    Zs.A 2882: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article: Vein morphometry in end-stage kidney disease: Teasing out the contribution of age, comorbidities, and vintage to chronic wall remodeling.

    Labissiere, Xochilt / Zigmond, Zachary M / Challa, Akshara / Montoya, Christopher / Manzur-Pineda, Karen / Abraham, Amalia / Tabbara, Marwan / Salama, Alghidak / Pan, Yue / Salman, Loay H / Yang, Xiaofeng / Vazquez-Padron, Roberto I / Martinez, Laisel

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 1005030

    Abstract: Background: Chronic kidney disease (CKD) is a highly comorbid condition with significant effects on vascular health and remodeling. Upper extremity veins are important in end-stage kidney disease (ESKD) due to their potential use to create vascular ... ...

    Abstract Background: Chronic kidney disease (CKD) is a highly comorbid condition with significant effects on vascular health and remodeling. Upper extremity veins are important in end-stage kidney disease (ESKD) due to their potential use to create vascular accesses. However, unlike arteries, the contribution of CKD-associated factors to the chronic remodeling of veins has been barely studied.
    Methods: We measured morphometric parameters in 315 upper extremity veins, 131 (85% basilic) from stage 5 CKD/ESKD patients and 184 (89% basilic) from non-CKD organ donors. Associations of demographic and clinical characteristics with intimal hyperplasia (IH) and medial fibrosis were evaluated using multivariate regression models.
    Results: The study cohort included 33% females, 30% blacks, 32% Hispanics, and 37% whites. Over 60% had hypertension, and 25% had diabetes independent of CKD status. Among kidney disease participants, 26% had stage 5 CKD, while 22 and 52% had ESKD with and without history of a previous arteriovenous fistula/graft (AVF/AVG), respectively. Intimal hyperplasia was associated with older age (β = 0.13 per year, confidence interval [CI] = 0.002-0.26), dialysis vintage > 12 months (β = 0.22, CI = 0.09-0.35), and previous AVF/AVG creation (β = 0.19, CI = 0.06-0.32). Upper quartile values of IH were significantly associated with diabetes (odds ratio [OR] = 2.02, CI = 1.08-3.80), which demonstrated an additive effect with previous AVF/AVG history and longer vintage in exacerbating IH. Medial fibrosis also increased as a function of age (β = 0.17, CI = 0.04-0.30) and among patients with diabetes (β = 0.15, CI = 0.03-0.28). Age was the predominant factor predicting upper quartile values of fibrosis (OR = 1.03 per year, CI = 1.01-1.05) independent of other comorbidities.
    Conclusion: Age and diabetes are the most important risk factors for chronic development of venous IH and fibrosis independent of CKD status. Among kidney disease patients, longer dialysis vintage, and history of a previous AVF/AVG are strong predictors of IH.
    Language English
    Publishing date 2022-11-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.1005030
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  10. Article: Echelon I interventions and triage are effective and concordant with echelon II care in combat operations.

    Hurtado, Timothy R / Montoya, Christopher

    Military medicine

    2009  Volume 174, Issue 8, Page(s) 786–790

    Abstract: We describe identified injuries, effectiveness of treatment, and triage categories for combat casualties at echelon 1 from April 1 to June 30, 2005 from western Iraq. A total of 133 casualties were evaluated including 12 who were killed in action and 7 ... ...

    Abstract We describe identified injuries, effectiveness of treatment, and triage categories for combat casualties at echelon 1 from April 1 to June 30, 2005 from western Iraq. A total of 133 casualties were evaluated including 12 who were killed in action and 7 who died of wounds. A medic or corpsman treated 75% of the remaining patients, 9% were treated by bystanders, 2% were seen by a physician or physician assistant, and 15% administered self-aid. Most injuries (84%) were blast related. Commonly wounded regions were the head (47%), lower extremities (40%), upper extremities (22%), and back (11%). Common interventions included dressings (37%), splints (8%), and intramuscular morphine (8%). Field triage categories at echelon I and casualty evacuation categories at echelon II were congruent. No significant injuries were missed and there were no detrimental interventions. In conclusion, combat casualties were assessed, treated, and evacuated appropriately by echelon I providers during this time frame.
    MeSH term(s) Adolescent ; Adult ; Confidence Intervals ; Female ; Humans ; Iraq/epidemiology ; Iraq War, 2003-2011 ; Male ; Military Medicine ; Military Personnel ; Program Development ; Program Evaluation ; Retrospective Studies ; Triage/statistics & numerical data ; United States/epidemiology ; Wounds and Injuries/epidemiology ; Young Adult
    Language English
    Publishing date 2009-09-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.7205/milmed-d-04-1508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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