LIVIVO - Search results -

Search results

Result 1 - 10 of total 38

Search options

Article ; Online: Diazoxide and moderate-intensity exercise improve skeletal muscle function by decreasing oxidants and enhancing antioxidant defenses in hypertensive male rats.

Bravo Sánchez, Estefanía / Nolasco Ruíz, César J / Gómez-Barroso, Mariana / Cortés Rojo, Christian / Rodríguez Orozco, Alain R / Saavedra Molina, Alfredo / Manzo Ávalos, Salvador / Montoya Pérez, Rocío

Physiological reports

2024 Volume 12, Issue 8, Page(s) e16026

Abstract: High sodium intake is decisive in the incidence increase and prevalence of hypertension, which has an impact on skeletal muscle functionality. Diazoxide is an antihypertensive agent that inhibits insulin secretion and is an opener of ... ...

Abstract	High sodium intake is decisive in the incidence increase and prevalence of hypertension, which has an impact on skeletal muscle functionality. Diazoxide is an antihypertensive agent that inhibits insulin secretion and is an opener of K
MeSH term(s)	Animals ; Diazoxide/pharmacology ; Male ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/drug effects ; Rats, Wistar ; Hypertension/metabolism ; Hypertension/physiopathology ; Physical Conditioning, Animal/physiology ; Rats ; Antioxidants/metabolism ; Antioxidants/pharmacology ; Oxidative Stress/drug effects ; Oxidants/metabolism
Chemical Substances	Diazoxide (O5CB12L4FN) ; Antioxidants ; Oxidants
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.16026
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Psychometric properties of the Gaudiebility (Enjoyment modulators) Scale for Adults of Morelia (GSAM).

Padrós-Blázquez, Ferrán / Martínez-Medina, María Patricia / Montoya-Pérez, Karina Salud / Montoya-Pérez, Rocío

PloS one

2021 Volume 16, Issue 7, Page(s) e0252543

Abstract: Gaudiebility refers to the set of modulators that regulate the enjoyment experienced, there is only one scale to assess gaudiebility, and it is univariate, which is not congruent with the construct. Therefore, this work's objective was to build a ... ...

Abstract	Gaudiebility refers to the set of modulators that regulate the enjoyment experienced, there is only one scale to assess gaudiebility, and it is univariate, which is not congruent with the construct. Therefore, this work's objective was to build a multifactorial scale and study the psychometric properties of the Gaudiebility Scale for Adults of Morelia (GSAM). 1,884 adults participated; 273 in the pilot study and 1,611 in the final study. They responded to the final version of the GSAM, with 24 items and a scale of experienced enjoyment. The adequate fit of the model of 6 related factors of the GSAM was corroborated through confirmatory factor analysis. Adequate Cronbach's alpha values were observed for the factors (Concentration (α = .796), Enjoyment in Solitude (α = .784), Sense of Humor (α = .760), Imagination (α = .740), Interest (α = .653) and Irrational Beliefs (α = .633)) and the total scale (α = .803). All the factors and the full scale showed positive relationships with the scale of experienced enjoyment. The GSAM obtained good indicators regarding its internal consistency and validity; therefore, it is concluded that the GSAM is adequate to assess gaudiebility in adults.
MeSH term(s)	Adult ; Factor Analysis, Statistical ; Humans ; Middle Aged ; Pilot Projects ; Pleasure ; Psychometrics ; Quality of Life ; Surveys and Questionnaires
Language	English
Publishing date	2021-07-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0252543
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Antioxidant effects of silver nanoparticles obtained by green synthesis from the aqueous extract of Eryngium carlinae on the brain mitochondria of streptozotocin-induced diabetic rats.

Lemus-de la Cruz, Jenaro / Trejo-Hurtado, Mitchell / Landa-Moreno, Cinthia / Peña-Montes, Donovan / Landeros-Páramo, José Luis / Cortés-Rojo, Christian / Montoya-Pérez, Rocío / Rosas, Gerardo / Saavedra-Molina, Alfredo

Journal of bioenergetics and biomembranes

2023 Volume 55, Issue 2, Page(s) 123–135

Abstract: Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia that affects practically all tissues and organs, being the brain one of most susceptible, due to overproduction of reactive oxygen species induced by diabetes. Eryngium ... ...

Abstract	Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia that affects practically all tissues and organs, being the brain one of most susceptible, due to overproduction of reactive oxygen species induced by diabetes. Eryngium carlinae is a plant used in traditional Mexican medicine to treat diabetes, which has already been experimentally shown have hypoglycemic, antioxidant and hypolipidemic properties. The green synthesis of nanoparticles is a technique that combines plant extracts with metallic nanoparticles, so that the nanoparticles reduce the absorption and distribution time of drugs or compounds, increasing their effectiveness. In this work, the antioxidant effects and mitochondrial function in the brain were evaluated, as well as the hypoglycemic and hypolipidemic effect in serum of both the aqueous extract of the aerial part of E. carlinae, as well as its combination with silver nanoparticles of green synthesis. Administration with both, extract and the combination significantly decreased the production of reactive oxygen species, lipid peroxidation, and restored the activity of superoxide dismutase 2, glutathione peroxidase, and electron transport chain complexes in brain, while that the extract-nanoparticle combination decreased blood glucose and triglyceride levels. The results obtained suggest that both treatments have oxidative activity and restore mitochondrial function in the brain of diabetic rats.
MeSH term(s)	Rats ; Animals ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Streptozocin/metabolism ; Streptozocin/pharmacology ; Streptozocin/therapeutic use ; Eryngium/metabolism ; Silver/pharmacology ; Silver/metabolism ; Silver/therapeutic use ; Reactive Oxygen Species/metabolism ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Metal Nanoparticles ; Oxidative Stress ; Rats, Wistar ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/metabolism ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Lipid Peroxidation ; Brain/metabolism ; Mitochondria/metabolism
Chemical Substances	Antioxidants ; Streptozocin (5W494URQ81) ; Silver (3M4G523W1G) ; Reactive Oxygen Species ; Hypoglycemic Agents ; Plant Extracts
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	198499-8
ISSN	1573-6881 ; 0145-479X ; 0449-5705
ISSN (online)	1573-6881
ISSN	0145-479X ; 0449-5705
DOI	10.1007/s10863-023-09963-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1005: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Effects of Apocynin on Heart Muscle Oxidative Stress of Rats with Experimental Diabetes: Implications for Mitochondria.

Bravo-Sánchez, Estefanía / Peña-Montes, Donovan / Sánchez-Duarte, Sarai / Saavedra-Molina, Alfredo / Sánchez-Duarte, Elizabeth / Montoya-Pérez, Rocío

Antioxidants (Basel, Switzerland)

2021 Volume 10, Issue 3

Abstract: Diabetes mellitus (DM) constitutes one of the public health problems today. It is characterized by hyperglycemia through a defect in the β-cells function and/or decreased insulin sensitivity. Apocynin has been tasted acting directly as an NADPH oxidase ... ...

Abstract	Diabetes mellitus (DM) constitutes one of the public health problems today. It is characterized by hyperglycemia through a defect in the β-cells function and/or decreased insulin sensitivity. Apocynin has been tasted acting directly as an NADPH oxidase inhibitor and reactive oxygen species (ROS) scavenger, exhibiting beneficial effects against diabetic complications. Hence, the present study's goal was to dissect the possible mechanisms by which apocynin could mediate its cardioprotective effect against DM-induced oxidative stress. Male Wistar rats were assigned into 4 groups: Control (C), control + apocynin (C+A), diabetes (D), diabetes + apocynin (D+A). DM was induced with streptozotocin. Apocynin treatment (3 mg/kg/day) was applied for 5 weeks. Treatment significantly decreased blood glucose levels and insulin resistance in diabetic rats. In cardiac tissue, ROS levels were higher, and catalase enzyme activity was reduced in the D group compared to the C group; the apocynin treatment significantly attenuated these responses. In heart mitochondria, Complexes I and II of the electron transport chain (ETC) were significantly enhanced in the D+A group. Total glutathione, the level of reduced glutathione (GSH) and the GSH/ oxidized glutathione (GSSG) ratio were increased in the D+A group. Superoxide dismutase (SOD) and the glutathione peroxidase (GSH-Px) activities were without change. Apocynin enhances glucose uptake and insulin sensitivity, preserving the antioxidant defense and mitochondrial function.
Language	English
Publishing date	2021-02-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10030335
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Effects of Apocynin on Heart Muscle Oxidative Stress of Rats with Experimental Diabetes: Implications for Mitochondria

Bravo-Sánchez, Estefanía / Peña-Montes, Donovan / Sánchez-Duarte, Sarai / Saavedra-Molina, Alfredo / Sánchez-Duarte, Elizabeth / Montoya-Pérez, Rocío

Antioxidants. 2021 Feb. 24, v. 10, no. 3

2021

Abstract	Diabetes mellitus (DM) constitutes one of the public health problems today. It is characterized by hyperglycemia through a defect in the β-cells function and/or decreased insulin sensitivity. Apocynin has been tasted acting directly as an NADPH oxidase inhibitor and reactive oxygen species (ROS) scavenger, exhibiting beneficial effects against diabetic complications. Hence, the present study’s goal was to dissect the possible mechanisms by which apocynin could mediate its cardioprotective effect against DM-induced oxidative stress. Male Wistar rats were assigned into 4 groups: Control (C), control + apocynin (C+A), diabetes (D), diabetes + apocynin (D+A). DM was induced with streptozotocin. Apocynin treatment (3 mg/kg/day) was applied for 5 weeks. Treatment significantly decreased blood glucose levels and insulin resistance in diabetic rats. In cardiac tissue, ROS levels were higher, and catalase enzyme activity was reduced in the D group compared to the C group; the apocynin treatment significantly attenuated these responses. In heart mitochondria, Complexes I and II of the electron transport chain (ETC) were significantly enhanced in the D+A group. Total glutathione, the level of reduced glutathione (GSH) and the GSH/ oxidized glutathione (GSSG) ratio were increased in the D+A group. Superoxide dismutase (SOD) and the glutathione peroxidase (GSH-Px) activities were without change. Apocynin enhances glucose uptake and insulin sensitivity, preserving the antioxidant defense and mitochondrial function.
Keywords	NAD(P)H oxidase (H2O2-forming) ; antioxidant activity ; blood glucose ; cardioprotective effect ; catalase ; electron transport chain ; enzyme activity ; glucose ; glutathione ; glutathione peroxidase ; hyperglycemia ; insulin resistance ; males ; mitochondria ; myocardium ; oxidative stress ; public health ; reactive oxygen species ; streptozotocin ; superoxide dismutase
Language	English
Dates of publication	2021-0224
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10030335
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: An Ethyl Acetate Extract of

Trejo-Hurtado, Cristian M / Landa-Moreno, Cinthia I / la Cruz, Jenaro Lemus-de / Peña-Montes, Donovan J / Montoya-Pérez, Rocío / Salgado-Garciglia, Rafael / Manzo-Avalos, Salvador / Cortés-Rojo, Christian / Monribot-Villanueva, Juan Luis / Guerrero-Analco, José Antonio / Saavedra-Molina, Alfredo

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 6

Abstract: Secondary metabolites such as flavonoids are promising in the treatment of non-alcoholic fatty liver disease (NAFLD), which is one of the complications of diabetes due to oxidative stress and inflammation. Some plants, such ... ...

Abstract	Secondary metabolites such as flavonoids are promising in the treatment of non-alcoholic fatty liver disease (NAFLD), which is one of the complications of diabetes due to oxidative stress and inflammation. Some plants, such as
Language	English
Publishing date	2023-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12061235
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Dietary Iron Restriction Improves Muscle Function, Dyslipidemia, and Decreased Muscle Oxidative Stress in Streptozotocin-Induced Diabetic Rats.

Vargas-Vargas, Manuel Alejandro / Saavedra-Molina, Alfredo / Gómez-Barroso, Mariana / Peña-Montes, Donovan / Cortés-Rojo, Christian / Miguel, Huerta / Trujillo, Xochitl / Montoya-Pérez, Rocío

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 4

Abstract: Diabetes mellitus is a chronic degenerative disease characterized by hyperglycemia and oxidative stress. Iron catalyzes free radical overproduction. High iron concentrations have previously been reported to promote an increase in oxidative stress; ... ...

Abstract	Diabetes mellitus is a chronic degenerative disease characterized by hyperglycemia and oxidative stress. Iron catalyzes free radical overproduction. High iron concentrations have previously been reported to promote an increase in oxidative stress; however, the effect of iron restriction in diabetes has not yet been explored, so we tested to see if iron restriction in diabetic rats reduces oxidative damage and improved muscle function. Wistar rats were assigned to 4 groups: Control; Diabetic; Diabetic rats with a high iron diet, and Diabetic with dietary iron restriction. After 8 weeks the rats were sacrificed, the muscles were extracted to prepare homogenates, and serum was obtained for biochemical measurements. Low iron diabetic rats showed an increase in the development of muscle strength in both muscles. Dietary iron restriction decreased triglyceride concentrations compared to the untreated diabetic rats and the levels of extremely low-density lipoproteins. Aggravation of lipid peroxidation was observed in the diabetic group with a high iron diet, while these levels remained low with iron restriction. Iron restriction improved muscle strength development and reduced fatigue times; this was related to better lipid profile control and decreased oxidant stress markers.
Language	English
Publishing date	2022-04-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11040731
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Comparative Effect of Three Different Exercise Intensities in Combination with Diazoxide on Contraction Capacity and Oxidative Stress of Skeletal Muscle in Obese Rats.

Gómez-Barroso, Mariana / Vargas-Vargas, Manuel A / Peña-Montes, Donovan J / Cortés-Rojo, Christian / Saavedra-Molina, Alfredo / Sánchez-Duarte, Elizabeth / Rodríguez-Orozco, Alain R / Montoya-Pérez, Rocío

Biology

2022 Volume 11, Issue 9

Abstract: Obesity is a chronic disease that impairs skeletal muscle function, affects the ability to contract, and promotes the development of fatigue. For this reason, the study of treatments that seek to reduce the harmful effects of obesity on muscle tissue has ...

Abstract	Obesity is a chronic disease that impairs skeletal muscle function, affects the ability to contract, and promotes the development of fatigue. For this reason, the study of treatments that seek to reduce the harmful effects of obesity on muscle tissue has been deepened. Diazoxide treatment and various exercise protocols have been proposed to protect skeletal muscle against oxidative stress and its effects. However, the intensity and duration of exercise combined with diazoxide that would obtain the best results for improving skeletal muscle function in obese rats is unknown. To this end, this study evaluated the effects of three different exercise intensities combined with diazoxide on contraction capacity, resistance to fatigue, markers of oxidative stress, lipid peroxidation, ROS, and glutathione redox status of skeletal muscle. The results showed that treatments with diazoxide and exercise at different intensities improved muscle contraction capacity by reducing oxidative stress during obesity, with the best results being obtained with low-intensity exercise in combination with diazoxide. Therefore, these results suggest that diazoxide and low-intensity exercise improve muscle function during obesity by decreasing oxidative stress with the same efficiency as a moderate-intensity exercise protocol.
Language	English
Publishing date	2022-09-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology11091367
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Linolenic Acid Plus Ethanol Exacerbates Cell Death in

Olmos-Orizaba, Berenice Eridani / Arroyo-Peñaloza, José Santos / Martínez-Alcántar, Lorena / Montoya-Pérez, Rocío / Flores-García, Alberto / Rodríguez-Orozco, Alain Raimundo / Calderón-Cortés, Elizabeth / Saavedra-Molina, Alfredo / Campos-García, Jesús / Cortés-Rojo, Christian

Life (Basel, Switzerland)

2022 Volume 12, Issue 7

Abstract: Polyunsaturated fatty acids (PUFA) hypersensitize yeast to oxidative stress. Ethanol accumulation during fermentation is another factor that induces oxidative stress via mitochondrial dysfunction and ROS overproduction. Since this microorganism has ... ...

Abstract	Polyunsaturated fatty acids (PUFA) hypersensitize yeast to oxidative stress. Ethanol accumulation during fermentation is another factor that induces oxidative stress via mitochondrial dysfunction and ROS overproduction. Since this microorganism has raised growing interest as a PUFA factory, we have studied if the combination of PUFA plus ethanol enhances yeast death. Respiration, ROS generation, lipid peroxidation, mitochondrial cardiolipin content, and cell death were assessed in yeast grown in the presence of 10% ethanol (ETOH) or linolenic acid (C18:3), or ethanol plus C18:3 (ETOH+C18:3). Lipid peroxidation and cardiolipin loss were several-fold higher in cells with ETOH+C18:3 than with C18:3. On the contrary, ETOH tended to increase cardiolipin content without inducing changes in lipid peroxidation. This was consistent with a remarkable diminution of cell growth and an exacerbated propidium iodide staining in cells with only ETOH+C18:3. The respiration rate decreased with all the treatments to a similar degree, and this was paralleled with similar increments in ROS between all the treatments. These results indicate that PUFA plus ethanol hypersensitize yeast to necrotic cell death by exacerbating membrane damage and mitochondrial cardiolipin loss, independent of mitochondrial dysfunction and ROS generation. The implications of these observations for some biotechnological applications in yeast and its physiology are discussed.
Language	English
Publishing date	2022-07-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12071052
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Apocynin Attenuates Diabetes-Induced Skeletal Muscle Dysfunction by Mitigating ROS Generation and Boosting Antioxidant Defenses in Fast-Twitch and Slow-Twitch Muscles.

Sánchez-Duarte, Sarai / Montoya-Pérez, Rocío / Márquez-Gamiño, Sergio / Vera-Delgado, Karla S / Caudillo-Cisneros, Cipriana / Sotelo-Barroso, Fernando / Sánchez-Briones, Luis A / Sánchez-Duarte, Elizabeth

Life (Basel, Switzerland)

2022 Volume 12, Issue 5

Abstract: In response to diabetes mellitus, skeletal muscle is negatively affected, as is evident by reduced contractile force production, increased muscle fatigability, and increased levels of oxidative stress biomarkers. Apocynin is a widely used NADPH oxidase ... ...

Abstract	In response to diabetes mellitus, skeletal muscle is negatively affected, as is evident by reduced contractile force production, increased muscle fatigability, and increased levels of oxidative stress biomarkers. Apocynin is a widely used NADPH oxidase inhibitor, with antioxidant and anti-inflammatory potential. It has been effective for amelioration of a variety of disorders, including diabetic complications. Therefore, the present study was conducted to evaluate the effects and action mechanisms of apocynin in slow- and fast-twitch diabetic rat muscles. Male Wistar rats were rendered diabetic by applying intraperitoneally a single dose of streptozotocin (45 mg/kg). Apocynin treatment (3 mg/kg/day) was administered over 8 weeks. Fasting blood glucose (FBG), insulin tolerance and body weight gain were measured. Both slow (soleus) and fast (extensor digitorum longus, EDL) skeletal muscles were used for muscle function evaluation, oxidative stress markers, and evaluating gene expression using qRT-PCR. Treatment with apocynin significantly reduced FBG levels and enhanced insulin tolerance. Apocynin also prevented muscle contractile dysfunction in EDL muscle but had no significant effect on this parameter in soleus muscles. However, in both types of muscles, apocynin mitigated the oxidative stress by decreasing ROS levels and increasing total glutathione levels and redox state. Concomitantly, apocynin also statistically enhanced Nrf-2 and GLU4 mRNA expression and downregulated NOX2, NOX4, and NF-κB mRNA. Collectively, apocynin exhibits properties myoprotective in diabetic animals. These findings indicate that apocynin predominantly acts as an antioxidant in fast-twitch and slow-twitch muscles but has differential impact on contractile function.
Language	English
Publishing date	2022-05-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12050674
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito