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Article ; Online: Membrana de circulación extracorpórea en shock obstructivo secundario a enfermedad linfoproliferativa.

Las Heras, Marcos J / Carboni Bisso, Indalecio / Fernández Ceballos, Ignacio / Montserrat Rivero, Ana / Dianti, José / San Román, Eduardo

Medicina

2019 Volume 79, Issue 6, Page(s) 506–508

Abstract: The arteriovenous extracorporeal membrane is used in patients with hemodynamic and respiratory failure, unresponsive to conventional treatment. It provides transitory hemodynamic support, oxygenation and removal of CO2, allowing pulmonary rest. Moreover ... ...

Title translation	Oxygenation with extracorporeal membrane in obstructive shock secondary to lymphoproliferative disease.
Abstract	The arteriovenous extracorporeal membrane is used in patients with hemodynamic and respiratory failure, unresponsive to conventional treatment. It provides transitory hemodynamic support, oxygenation and removal of CO2, allowing pulmonary rest. Moreover it offers the possibility of ultraprotective ventilation and avoids generation of VILI (Ventilation-Induced Lung Injury). It is not frequently used in patients with hemodynamic failure secondary to obstructive shock due to mediastinal compromise. We present the case of a patient with obstructive shock, mediastinal mass of lymphoproliferative origin that was treated with extracorporeal arteriovenous circulation membrane.
MeSH term(s)	Adult ; Computed Tomography Angiography/methods ; Extracorporeal Membrane Oxygenation/methods ; Female ; Hemodynamics ; Humans ; Lymphoma, Large B-Cell, Diffuse/complications ; Lymphoma, Large B-Cell, Diffuse/diagnostic imaging ; Lymphoma, Large B-Cell, Diffuse/pathology ; Respiratory Insufficiency/therapy ; Shock, Cardiogenic/diagnostic imaging ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/therapy ; Tomography, X-Ray/methods ; Treatment Outcome
Language	Spanish
Publishing date	2019-12-12
Publishing country	Argentina
Document type	Case Reports
ZDB-ID	411586-7
ISSN	1669-9106 ; 0025-7680 ; 0325-951X
ISSN (online)	1669-9106
ISSN	0025-7680 ; 0325-951X
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Article ; Online: Oxygenation with extracorporeal membrane in obstructive shock secondary to lymphoproliferative disease

Marcos J. Las Heras / Indalecio Carboni Bisso / Ignacio Fernández Ceballos / Ana Montserrat Rivero / José Dianti / Eduardo San Román

Medicina (Buenos Aires), Vol 79, Iss 6, Pp 506-

2019 Volume 508

Abstract	The arteriovenous extracorporeal membrane is used in patients with hemodynamic and respiratory failure, unresponsive to conventional treatment. It provides transitory hemodynamic support, oxygenation and removal of CO2, allowing pulmonary rest. Moreover it offers the possibility of ultraprotective ventilation and avoids generation of VILI (Ventilation-Induced Lung Injury). It is not frequently used in patients with hemodynamic failure secondary to obstructive shock due to mediastinal compromise. We present the case of a patient with obstructive shock, mediastinal mass of lymphoproliferative origin that was treated with extracorporeal arteriovenous circulation membrane.
Keywords	lymphoma ; extracorporeal membrane oxygenation ; shock ; Medicine ; R ; Immunologic diseases. Allergy ; RC581-607 ; Infectious and parasitic diseases ; RC109-216
Language	English
Publishing date	2019-12-01T00:00:00Z
Publisher	Fundación Revista Medicina
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Splenic rupture after colorectal cancer screening

María José García-García / Ramón Castañera-González / Berta Martín-Rivas / Marcos Gómez-Ruiz / Montserrat Rivero-Tirado

Revista Espanola de Enfermedades Digestivas, Vol 107, Iss 11, Pp 705-

2015 Volume 706

Keywords	Medicine ; R ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951 ; Diseases of the digestive system. Gastroenterology ; RC799-869
Publishing date	2015-11-01T00:00:00Z
Publisher	The Spanish Society of Digestive Pathology
Document type	Article ; Online
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Article ; Online: Assessment of the intake of tryptophan-enriched cereals in the elderly and its influence on the sleep-wake circadian rhythm

Rafael Bravo / Sergio Matito / Javier Cubero / Lourdes Franco / Cristina Sánchez / Ana B. Rodríguez / Montserrat Rivero / Carmen Barriga

Antropologia Portuguesa, Iss

2012 Volume 29

Abstract: Sleep-wake circadian rhythm disturbances are a common problem associated to aging. Although this problem can be caused by several factors, low levels of the indol melatonin are related with these alterations. Our aim was to evaluate if the consumption of ...

Abstract	Sleep-wake circadian rhythm disturbances are a common problem associated to aging. Although this problem can be caused by several factors, low levels of the indol melatonin are related with these alterations. Our aim was to evaluate if the consumption of cereals enriched with tryptophan, the precursor of both serotonin and melatonin, can enhance sleep problems in elderly people. Participants (n=12; aged 55-67 yr) were selected from Elderly people University of The University of Extremadura. During all the assay participants wore a wrist actimeter and they filled every week an STAI anxiety test. Data were collected following this schedule: Control week: participants ingested a control cereal both at breakfast and dinner (22.5 mg tryptophan/ 30g product per dose); Treatment Week: volunteers consumed a tryptophan enriched cereal both at breakfast and dinner (60mg tryptophan/30g product per dose); Post-treatment week: participants ingested their habitual diet. We observed a decrease in sleep latency (p<0.01), wake bouts (p>0.05) and sleep fragmentation (p<0.001); on the other hand, an increase in actual sleep time (p<0.01), sleep efficiency (p<0.01) and immobile time (p<0.01) were detected. With respect to the anxiety test, there was an improvement in the state of anxiety. In conclusion, through a tryptophanenriched diet age related sleep problems can be improved.
Keywords	Chrononutrition ; tryptophan ; sleep ; elderly ; Anthropology ; GN1-890 ; Ethnology. Social and cultural anthropology ; GN301-674
Subject code	150
Language	English
Publishing date	2012-06-01T00:00:00Z
Publisher	Coimbra University Press
Document type	Article ; Online
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Article ; Online: Nationwide COVID-19-EII Study

Yamile Zabana / Ignacio Marín-Jiménez / Iago Rodríguez-Lago / Isabel Vera / María Dolores Martín-Arranz / Iván Guerra / Javier P. Gisbert / Francisco Mesonero / Olga Benítez / Carlos Taxonera / Ángel Ponferrada-Díaz / Marta Piqueras / Alfredo J. Lucendo / Berta Caballol / Míriam Mañosa / Pilar Martínez-Montiel / Maia Bosca-Watts / Jordi Gordillo / Luis Bujanda /

Noemí Manceñido / Teresa Martínez-Pérez / Alicia López / Cristina Rodríguez-Gutiérrez / Santiago García-López / Pablo Vega / Montserrat Rivero / Luigi Melcarne / Maria Calvo / Marisa Iborra / Manuel Barreiro de-Acosta / Beatriz Sicilia / Jesús Barrio / José Lázaro Pérez / David Busquets / Isabel Pérez-Martínez / Mercè Navarro-Llavat / Vicent Hernández / Federico Argüelles-Arias / Fernando Ramírez Esteso / Susana Meijide / Laura Ramos / Fernando Gomollón / Fernando Muñoz / Gerard Suris / Jone Ortiz de Zarate / José María Huguet / Jordina Llaó / Mariana Fe García-Sepulcre / Mónica Sierra / Miguel Durà

Journal of Clinical Medicine, Vol 11, Iss 421, p

Incidence, Environmental Risk Factors and Long-Term Follow-Up of Patients with Inflammatory Bowel Disease and COVID-19 of the ENEIDA Registry

2022 Volume 421

Abstract: We aim to describe the incidence and source of contagion of COVID-19 in patients with IBD, as well as the risk factors for a severe course and long-term sequelae. This is a prospective observational study of IBD and COVID-19 included in the ENEIDA ... ...

Abstract	We aim to describe the incidence and source of contagion of COVID-19 in patients with IBD, as well as the risk factors for a severe course and long-term sequelae. This is a prospective observational study of IBD and COVID-19 included in the ENEIDA registry (53,682 from 73 centres) between March–July 2020 followed-up for 12 months. Results were compared with data of the general population (National Centre of Epidemiology and Catalonia). A total of 482 patients with COVID-19 were identified. Twenty-eight percent were infected in the work environment, and 48% were infected by intrafamilial transmission, despite having good adherence to lockdown. Thirty-five percent required hospitalization, 7.9% had severe COVID-19 and 3.7% died. Similar data were reported in the general population (hospitalisation 19.5%, ICU 2.1% and mortality 4.6%). Factors related to death and severe COVID-19 were being aged ≥ 60 years (OR 7.1, 95% CI: 1.8–27 and 4.5, 95% CI: 1.3–15.9), while having ≥2 comorbidities increased mortality (OR 3.9, 95% CI: 1.3–11.6). None of the drugs for IBD were related to severe COVID-19. Immunosuppression was definitively stopped in 1% of patients at 12 months. The prognosis of COVID-19 in IBD, even in immunosuppressed patients, is similar to that in the general population. Thus, there is no need for more strict protection measures in IBD.
Keywords	COVID-19 ; SARS-CoV-2 ; inflammatory bowel disease ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

Ana Gutiérrez / Pedro Zapater / Elena Ricart / María González-Vivó / Jordi Gordillo / David Olivares / Isabel Vera / Míriam Mañosa / Javier P. Gisbert / Mariam Aguas / Eugenia Sánchez-Rodríguez / Maia Bosca-Watts / Viviana Laredo / Blau Camps / Ignacio Marín-Jiménez / Yamile Zabana / María Dolores Martín-Arranz / Roser Muñoz / Mercè Navarro /

Eva Sierra / Lucía Madero / Milagros Vela / José Lázaro Pérez-Calle / Empar Sainz / Xavier Calvet / Lara Arias / Victor Morales / Fernando Bermejo / Luis Fernández-Salazar / Manuel Van Domselaar / Luisa De Castro / Cristina Rodríguez / Carmen Muñoz-Villafranca / Rufo Lorente / Montserrat Rivero / Eva Iglesias

Frontiers in Medicine, Vol

2022 Volume 9

Abstract: BackgroundPrevious studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain.MethodsProspective, observational, ... ...

Abstract	BackgroundPrevious studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain.MethodsProspective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients.ResultsWe included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92–2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0–1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses.ConclusionsCompared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe.
Keywords	immigrant ; phenotype ; biologics ; inflammatory bowel disease ; Crohn's disease ; ulcerative colitis ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease

Sabino Riestra / Carlos Taxonera / Yamile Zabana / Daniel Carpio / María Chaparro / Jesús Barrio / Montserrat Rivero / Antonio López-Sanroman / María Esteve / Ruth de Francisco / Guillermo Bastida / Santiago García-López / Miriam Mañosa / María Dolores Martin-Arranz / José Lázaro Pérez-Calle / Jordi Guardiola / Fernando Muñoz / Laura Arranz / José Luis Cabriada /

Journal of Clinical Medicine, Vol 11, Iss 13, p

Results from the ENEIDA Registry of GETECCU

2022 Volume 3915

Abstract: 1) Aims: Patients receiving antitumor necrosis factor (anti-TNF) therapy are at risk of developing tuberculosis (TB), usually due to the reactivation of a latent TB infection (LTBI). LTBI screening and treatment decreases the risk of TB. This study ... ...

Abstract	(1) Aims: Patients receiving antitumor necrosis factor (anti-TNF) therapy are at risk of developing tuberculosis (TB), usually due to the reactivation of a latent TB infection (LTBI). LTBI screening and treatment decreases the risk of TB. This study evaluated the diagnostic performance of different LTBI screening strategies in patients with inflammatory bowel disease (IBD). (2) Methods: Patients in the Spanish ENEIDA registry with IBD screened for LTBI between January 2003 and January 2018 were included. The diagnostic yield of different strategies (dual screening with tuberculin skin test [TST] and interferon-ץ-release assay [IGRA], two-step TST, and early screening performed at least 12 months before starting biological treatment) was analyzed. (3) Results: Out of 7594 screened patients, 1445 (19%; 95% CI 18–20%) had LTBI. Immunomodulator (IMM) treatment at screening decreased the probability of detecting LTBI (20% vs. 17%, p = 0.001). Regarding screening strategies, LTBI was more frequently diagnosed by dual screening than by a single screening strategy (IGRA, OR 0.60; 95% CI 0.50–0.73, p < 0.001; TST, OR 0.76; 95% CI 0.66–0.88, p < 0.001). Two-step TST increased the diagnostic yield of a single TST by 24%. More cases of LTBI were diagnosed by early screening than by routine screening before starting anti-TNF agents (21% [95% CI 20–22%] vs. 14% [95% CI 13–16%], p < 0.001). The highest diagnostic performance for LTBI (29%) was obtained by combining early and TST/IGRA dual screening strategies in patients without IMM. (4): Conclusions: Both early screening and TST/IGRA dual screening strategies significantly increased diagnostic performance for LTBI in patients with IBD, with optimal performance achieved when they are used together in the absence of IMM.
Keywords	inflammatory bowel disease ; latent tuberculosis infection ; tuberculin skin test ; interferon gamma release assays ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Frequency, predictors, and consequences of maintenance infliximab therapy intensification in ulcerative colitis

Luis Fernández-Salazar / Jesús Barrio / Fernando Muñoz / Concepción Muñoz / Ramón Pajares / Montserrat Rivero / Vanesa Prieto / Jesús Legido / Abdel Bouhmidi / Maite Herranz / Guillermo González-Redondo / Nereida Fernández / Fernando Santos / Ramón Sánchez-Ocaña / Diana Joao

Revista Espanola de Enfermedades Digestivas, Vol 107, Iss 9, Pp 527-

2015 Volume 533

Abstract: Introduction: Infliximab (IFX) therapy intensification in ulcerative colitis (UC) is more common than established in pivotal studies. Objectives: To establish the frequency and form of intensification for UC in clinical practice, as well as predictors, ... ...

Abstract	Introduction: Infliximab (IFX) therapy intensification in ulcerative colitis (UC) is more common than established in pivotal studies. Objectives: To establish the frequency and form of intensification for UC in clinical practice, as well as predictors, and to compare outcomes between intensified and non-intensified treatment. Methods: A retrospective study of 10 hospitals and 144 patients with response to infliximab (IFX) induction. Predictive variables for intensification were analyzed using a Cox regression analysis. Outcome, loss of response to IFX, and colectomy were compared between intensified and non-intensified therapy. Results: Follow-up time from induction to data collection: 38 months [interquartile range (IQR), 20-62]. Time on IFX therapy: 24 months (IQR, 10-44). In all, 37% of patients required intensification. Interval was shortened for 36 patients, dose was increased for 7, and 10 subjects received both. Concurrent thiopurine immunosuppressants (IMM) and IFX initiation was an independent predictor of intensification [Hazard ratio, 0.034; p, 0.006; CI, 0.003-0.371]. In patients on intensified therapy IFX discontinuation for loss of response (30.4% vs. 10.2%; p, 0.002), steroid reintroduction (35% vs. 18%; p, 0.018), and colectomy (22% vs. 6.4%; p, 0.011) were more common. Of patients on intensification, 17% returned to receiving 5 mg/kg every 8 weeks. Conclusions: Intensification is common and occasionally reversible. IMM initiation at the time of induction with IFX predicts non-intensification. Intensification, while effective, is associated with poorer outcome.
Keywords	Intensificación ; Optimización ; antiTNF ; Infliximab ; Colitis ulcerosa ; Medicine ; R ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951 ; Diseases of the digestive system. Gastroenterology ; RC799-869
Subject code	610
Publishing date	2015-09-01T00:00:00Z
Publisher	The Spanish Society of Digestive Pathology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease

María José García / Montserrat Rivero / José Miranda-Bautista / Iria Bastón-Rey / Francisco Mesonero / Eduardo Leo-Carnerero / Diego Casas-Deza / Carmen Cagigas Fernández / Albert Martin-Cardona / Ismael El Hajra / Nerea Hernández-Aretxabaleta / Isabel Pérez-Martínez / Esteban Fuentes-Valenzuela / Nuria Jiménez / Cristina Rubín de Célix / Ana Gutiérrez / Cristina Suárez Ferrer / José María Huguet / Agnes Fernández-Clotet /

María González-Vivó / Blanca Del Val / Jesús Castro-Poceiro / Luigi Melcarne / Carmen Dueñas / Marta Izquierdo / David Monfort / Abdel Bouhmidi / Patricia Ramírez De la Piscina / Eva Romero / Gema Molina / Jaime Zorrilla / Cristina Calvino-Suárez / Eugenia Sánchez / Andrea Nuñez / Olivia Sierra / Beatriz Castro / Yamile Zabana / Irene González-Partida / Saioa De la Maza / Andrés Castaño / Rodrigo Nájera-Muñoz / Luis Sánchez-Guillén / Micaela Riat Castro / José Luis Rueda / José Manuel Benítez / Pedro Delgado-Guillena / Carlos Tardillo / Elena Peña / Santiago Frago-Larramona / María Carmen Rodríguez-Grau

Journal of Clinical Medicine, Vol 10, Iss 4402, p

A Multicentre Study of Geteccu

2021 Volume 4402

Abstract: Background: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of ... ...

Abstract	Background: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of biologics on the risk of PC. Methods: A retrospective study was performed in 37 centres. Patients treated with biologics within 12 weeks before surgery were considered “exposed”. The impact of the exposure on the risk of 30-day PC and the risk of infections was assessed by logistic regression and propensity score-matched analysis. Results: A total of 1535 surgeries were performed on 1370 patients. Of them, 711 surgeries were conducted in the exposed cohort (584 anti-TNF, 58 vedolizumab and 69 ustekinumab). In the multivariate analysis, male gender (OR: 1.5; 95% CI: 1.2–2.0), urgent surgery (OR: 1.6; 95% CI: 1.2–2.2), laparotomy approach (OR: 1.5; 95% CI: 1.1–1.9) and severe anaemia (OR: 1.8; 95% CI: 1.3–2.6) had higher risk of PC, while academic hospitals had significantly lower risk. Exposure to biologics (either anti-TNF, vedolizumab or ustekinumab) did not increase the risk of PC (OR: 1.2; 95% CI: 0.97–1.58), although it could be a risk factor for postoperative infections (OR 1.5; 95% CI: 1.03–2.27). Conclusions: Preoperative administration of biologics does not seem to be a risk factor for overall PC, although it may be so for postoperative infections.
Keywords	inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; anti-TNF ; ustekinumab ; vedolizumab ; Medicine ; R
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain

María Chaparro / Ana Garre / Andrea Núñez Ortiz / María Teresa Diz-Lois Palomares / Cristina Rodríguez / Sabino Riestra / Milagros Vela / José Manuel Benítez / Estela Fernández Salgado / Eugenia Sánchez Rodríguez / Vicent Hernández / Rocío Ferreiro-Iglesias / Ángel Ponferrada Díaz / Jesús Barrio / José María Huguet / Beatriz Sicilia / María Dolores Martín-Arranz / Xavier Calvet / Daniel Ginard /

Inmaculada Alonso-Abreu / Luis Fernández-Salazar / Pilar Varela Trastoy / Montserrat Rivero / Isabel Vera-Mendoza / Pablo Vega / Pablo Navarro / Mónica Sierra / José Luis Cabriada / Mariam Aguas / Raquel Vicente / Mercè Navarro-Llavat / Ana Echarri / Fernando Gomollón / Elena Guerra del Río / Concepción Piñero / María José Casanova / Katerina Spicakova / Jone Ortiz de Zarate / Emilio Torrella Cortés / Ana Gutiérrez / Horacio Alonso-Galán / Álvaro Hernández-Martínez / José Miguel Marrero / Rufo Lorente Poyatos / Margalida Calafat / Lidia Martí Romero / Pilar Robledo / Orencio Bosch / Nuria Jiménez / María Esteve Comas / José María Duque / Ana María Fuentes Coronel / Manuela Josefa Sampedro / Eva Sesé Abizanda / Belén Herreros Martínez / Liliana Pozzati / Hipólito Fernández Rosáenz / Belén Crespo Suarez / Pilar López Serrano / Alfredo J. Lucendo / Margarita Muñoz Vicente / Fernando Bermejo / José Joaquín Ramírez Palanca / Margarita Menacho / Amalia Carmona / Raquel Camargo / Sandra Torra Alsina / Nuria Maroto / Juan Nerín de la Puerta / Elena Castro / Ignacio Marín-Jiménez / Belén Botella / Amparo Sapiña / Noelia Cruz / José Luis F. Forcelledo / Abdel Bouhmidi / Carlos Castaño-Milla / Verónica Opio / Isabel Nicolás / Marcos Kutz / Alfredo Abraldes Bechiarelli / Jordi Gordillo / Yolanda Ber / Yolanda Torres Domínguez / María Teresa Novella Durán / Silvia Rodríguez Mondéjar / Francisco J. Martínez-Cerezo / Lilyan Kolle / Miriam Sabat / Cesar Ledezma / Eduardo Iyo / Óscar Roncero / Rebeca Irisarri / Laia Lluis / Isabel Blázquez Gómez / Eva María Zapata / María José Alcalá / Cristina Martínez Pascual / María Montealegre / Laura Mata / Ana Monrobel / Alejandro Hernández Camba / Luis Hernández / María Tejada / Alberto Mir / María Luisa Galve / Marta Soler / Daniel Hervías / José Antonio Gómez-Valero / Manuel Barreiro-de Acosta / Fernando Rodríguez-Artalejo / Esther García-Esquinas / Javier P. Gisbert / on behalf of the EpidemIBD study group of GETECCU

Journal of Clinical Medicine, Vol 10, Iss 2885, p

Large-Scale Epidemiological Study

2021 Volume 2885

Abstract: 1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: ... ...

Abstract	(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD—Crohn’s disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)—during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31–56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery.
Keywords	epidemiology ; incidence ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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