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  1. Article ; Online: Detection of subclinical hypertrophic cardiomyopathy.

    Joy, George / Moon, James C / Lopes, Luis R

    Nature reviews. Cardiology

    2023  Volume 20, Issue 6, Page(s) 369–370

    MeSH term(s) Humans ; Cardiomyopathy, Hypertrophic/diagnosis ; Echocardiography
    Language English
    Publishing date 2023-03-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-023-00853-7
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  2. Article ; Online: Top Cats Often Begin as Underdogs: The Ascent of Trabecular Fractal Analysis with Cardiac MRI.

    Captur, Gabriella / Moon, James C

    Radiology

    2020  Volume 298, Issue 1, Page(s) 80–81

    MeSH term(s) Cardiomyopathy, Hypertrophic ; Fractals ; Humans ; Magnetic Resonance Imaging ; Prognosis ; Radiography
    Language English
    Publishing date 2020-10-20
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2020203800
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  3. Article: The use of attention-deficit hyperactivity disorder medications in cardiac disease.

    Topriceanu, Constantin-Cristian / Moon, James C / Captur, Gabriella / Perera, Bhathika

    Frontiers in neuroscience

    2022  Volume 16, Page(s) 1020961

    Abstract: Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with onset usually in childhood characterized by inattention, impulsivity, and hyperactivity causing a functional impairment. Untreated ADHD, or treatment delay is ... ...

    Abstract Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with onset usually in childhood characterized by inattention, impulsivity, and hyperactivity causing a functional impairment. Untreated ADHD, or treatment delay is associated with adverse outcomes and poor quality of life. Although conservative management strategies such as behavioral and psychological interventions are important, pharmacological treatment has a strong evidence base with improved outcomes. ADHD medications are broadly divided into stimulant and non-stimulant medications. Stimulant medications are generally more effective than non-stimulants. Cardiovascular safety of ADHD medication has been a matter of debate for decades. Treatment guidelines advise the careful consideration of risks and benefits in people with cardiovascular diseases such as congenital heart disease or cardiomyopathy. Although stimulants can increase systemic blood pressure and heart rate, no significant associations were found between their use and serious cardiovascular events. Concerns regarding QT effects and attendant sudden cardiac death risks deter clinicians from initiating much-needed ADHD medications in patients with heart disease. This overly cautious approach is potentially depriving low-risk individuals from significant benefits associated with timely ADHD drug treatment. This review discusses the cardiovascular risks reportedly associated with ADHD medications, the evidence base for their safe usage in persons with established cardiovascular disease, and highlights future research directions.
    Language English
    Publishing date 2022-10-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2022.1020961
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  4. Article ; Online: Mapping Phenotype Development in Fabry Disease.

    Augusto, João B / Moon, James C

    Circulation. Cardiovascular imaging

    2019  Volume 12, Issue 4, Page(s) e009067

    MeSH term(s) Fabry Disease ; Humans ; Myocardium ; Phenotype
    Language English
    Publishing date 2019-04-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2435045-X
    ISSN 1942-0080 ; 1941-9651
    ISSN (online) 1942-0080
    ISSN 1941-9651
    DOI 10.1161/CIRCIMAGING.119.009067
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  5. Article ; Online: T

    Topriceanu, Constantin-Cristian / Pierce, Iain / Moon, James C / Captur, Gabriella

    Magnetic resonance imaging

    2022  Volume 93, Page(s) 15–32

    Abstract: Cardiac imaging is progressing from simple imaging of heart structure and function to techniques visualizing and measuring underlying tissue biological changes that can potentially define disease and therapeutic options. These techniques exploit ... ...

    Abstract Cardiac imaging is progressing from simple imaging of heart structure and function to techniques visualizing and measuring underlying tissue biological changes that can potentially define disease and therapeutic options. These techniques exploit underlying tissue magnetic relaxation times: T
    MeSH term(s) Cardiomyopathies ; Edema ; Heart/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Imaging, Cine/methods ; Myocardium ; Predictive Value of Tests
    Language English
    Publishing date 2022-07-30
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 604885-7
    ISSN 1873-5894 ; 0730-725X
    ISSN (online) 1873-5894
    ISSN 0730-725X
    DOI 10.1016/j.mri.2022.07.012
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  6. Article ; Online: Meta-Analysis of Penetrance and Systematic Review on Transition to Disease in Genetic Hypertrophic Cardiomyopathy.

    Topriceanu, Constantin-Cristian / Pereira, Alexandre C / Moon, James C / Captur, Gabriella / Ho, Carolyn Y

    Circulation

    2023  Volume 149, Issue 2, Page(s) 107–123

    Abstract: Background: Hypertrophic cardiomyopathy (HCM) is characterized by unexplained left ventricular hypertrophy and is classically caused by pathogenic or likely pathogenic variants (P/LP) in genes encoding sarcomere proteins. Not all subclinical variant ... ...

    Abstract Background: Hypertrophic cardiomyopathy (HCM) is characterized by unexplained left ventricular hypertrophy and is classically caused by pathogenic or likely pathogenic variants (P/LP) in genes encoding sarcomere proteins. Not all subclinical variant carriers will manifest clinically overt disease because penetrance (proportion of sarcomere or sarcomere-related P/LP variant carriers who develop disease) is variable, age dependent, and not reliably predicted.
    Methods: A systematic search of the literature was performed. We used random-effects generalized linear mixed model meta-analyses to contrast the cross-sectional prevalence and penetrance of sarcomere or sarcomere-related genes in 2 different contexts: clinically-based studies on patients and families with HCM versus population or community-based studies. Longitudinal family/clinical studies were additionally analyzed to investigate the rate of phenotypic conversion from subclinical to overt HCM during follow-up.
    Results: In total, 455 full-text manuscripts and articles were assessed. In family/clinical studies, the prevalence of sarcomere variants in patients diagnosed with HCM was 34%. The penetrance across all genes in nonproband relatives carrying P/LP variants identified during cascade screening was 57% (95% CI, 52%-63%), and the mean age at HCM diagnosis was 38 years (95% CI, 36%-40%). Penetrance varied from ≈32% for
    Conclusions: The penetrance of P/LP variants is highly variable and influenced by currently undefined and context-dependent genetic and environmental factors. Additional longitudinal studies are needed to improve our understanding of true lifetime penetrance in families and in the community and to identify drivers of the transition from subclinical to overt HCM.
    MeSH term(s) Humans ; Adult ; Penetrance ; Mutation ; Cross-Sectional Studies ; Pedigree ; Cardiomyopathy, Hypertrophic/diagnosis ; Cardiomyopathy, Hypertrophic/epidemiology ; Cardiomyopathy, Hypertrophic/genetics ; Troponin T/genetics
    Chemical Substances Troponin T
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Systematic Review ; Meta-Analysis ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.123.065987
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  7. Article ; Online: Does Fractal Analysis of the Right Side of the Heart Provide Insight into Pulmonary Hypertension?

    Moon, James C / Captur, Gabriella

    Radiology

    2018  Volume 288, Issue 2, Page(s) 396–397

    MeSH term(s) Fractals ; Heart ; Heart Failure ; Humans ; Hypertension, Pulmonary ; Ventricular Dysfunction, Right
    Language English
    Publishing date 2018
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2018180703
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  8. Article ; Online: Looking for the Right Diagnosis? Cardiovascular Magnetic Resonance Imaging Can Help Differentiate Cardiomyopathies.

    Kozor, Rebecca / Cole, Ben / Ugander, Martin / Moon, James C

    Heart, lung & circulation

    2021  Volume 31, Issue 1, Page(s) 7–16

    Abstract: Differentiating cardiomyopathies is a common clinical quandary in cardiology. Getting the right diagnosis is important for guiding patient management and providing prognosis. Incorrect or uncertain diagnoses can lead to further unnecessary investigations ...

    Abstract Differentiating cardiomyopathies is a common clinical quandary in cardiology. Getting the right diagnosis is important for guiding patient management and providing prognosis. Incorrect or uncertain diagnoses can lead to further unnecessary investigations and/or treatment decisions applied inappropriately, which can have consequences for both the patient and health care costs. Cardiovascular magnetic resonance (CMR) imaging offers strength here due to its precision and breadth in assessing cardiac function and tissue characterisation. This review aims to raise awareness among cardiologists and physicians of the important insights provided by CMR-insights that can improve diagnosis and guide management, as well as aid in risk stratification, in different cardiomyopathies.
    MeSH term(s) Cardiology ; Cardiomyopathies/diagnostic imaging ; Humans ; Magnetic Resonance Imaging
    Language English
    Publishing date 2021-09-02
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/j.hlc.2021.07.020
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  9. Article ; Online: Subclinical Hypertrophic Cardiomyopathy in Elite Athletes: Knowledge Gaps Persist.

    Chan, Fiona / Lockie, Tim / Monserrat, Lorenzo / Moon, James C / Captur, Gabriella

    JACC. Case reports

    2022  Volume 4, Issue 2, Page(s) 94–98

    Abstract: Subclinical hypertrophic cardiomyopathy (HCM) is a phenotypic entity that has emerged from the increased use of cardiovascular magnetic resonance imaging in the evaluation and family screening of patients with HCM. We describe the case of a competitive ... ...

    Abstract Subclinical hypertrophic cardiomyopathy (HCM) is a phenotypic entity that has emerged from the increased use of cardiovascular magnetic resonance imaging in the evaluation and family screening of patients with HCM. We describe the case of a competitive athlete with a sarcomere gene mutation and family history of HCM who was found to exhibit the subclinical HCM phenotype on cardiovascular magnetic resonance imaging in the absence of left ventricular hypertrophy. We discuss the clinical uncertainties in her management. (
    Language English
    Publishing date 2022-01-19
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2021.11.004
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  10. Article: Declining Levels and Bioavailability of IGF-I in Cardiovascular Aging Associate With QT Prolongation-Results From the 1946 British Birth Cohort.

    Charalambous, Christos / Moon, James C / Holly, Jeff M P / Chaturvedi, Nishi / Hughes, Alun D / Captur, Gabriella

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 863988

    Abstract: Background: As people age, circulating levels of insulin-like growth factors (IGFs) and IGF binding protein 3 (IGFBP-3) decline. In rat cardiomyocytes, IGF-I has been shown to regulate sarcolemmal potassium channel activity and late sodium current thus ... ...

    Abstract Background: As people age, circulating levels of insulin-like growth factors (IGFs) and IGF binding protein 3 (IGFBP-3) decline. In rat cardiomyocytes, IGF-I has been shown to regulate sarcolemmal potassium channel activity and late sodium current thus impacting cardiac repolarization and the heart rate-corrected QT (QTc). However, the relationship between IGFs and IGFBP-3 with the QTc interval in humans, is unknown.
    Objectives: To examine the association of IGFs and IGFBP-3 with QTc interval in an older age population-based cohort.
    Methods: Participants were from the 1946 Medical Research Council (MRC) National Survey of Health and Development (NSHD) British birth cohort. Biomarkers from blood samples at age 53 and 60-64 years (y, exposures) included IGF-I/II, IGFBP-3, IGF-I/IGFBP-3 ratio and the change (Δ) in marker levels between the 60-64 and 53y sampled timepoints. QTc (outcome) was recorded from electrocardiograms at the 60-64y timepoint. Generalized linear multivariable models with adjustments for relevant demographic and clinical factors, were used for complete-cases and repeated after multiple imputation.
    Results: One thousand four hundred forty-eight participants were included (48.3% men; QTc mean 414 ms interquartile range 26 ms). Univariate analysis revealed an association between low IGF-I and IGF-I/IGFBP-3 ratio at 60-64y with QTc prolongation [respectively: β -0.30 ms/nmol/L, (95% confidence intervals -0.44, -0.17),
    Conclusion: Over a decade, in an older age population-based cohort, declining levels and bioavailability of IGF-I associate with prolongation of the QTc interval. As QTc prolongation associates with increased risk for sudden death even in apparently healthy people, further research into the antiarrhythmic effects of IGF-I on cardiomyocytes is warranted.
    Language English
    Publishing date 2022-04-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.863988
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