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  1. Article: Direct thermal injury to the popliteal artery after total knee arthroplasty.

    Moon, S H / Kang, D G / Byun, J H

    Nigerian journal of clinical practice

    2023  Volume 26, Issue 5, Page(s) 646–648

    Abstract: Vascular damage after total knee arthroplasty is rare. However, delayed diagnosis and management may cause adverse outcomes for patients. In particular, direct thermal injury to the popliteal artery after total knee arthroplasty is extremely rare. A 74- ... ...

    Abstract Vascular damage after total knee arthroplasty is rare. However, delayed diagnosis and management may cause adverse outcomes for patients. In particular, direct thermal injury to the popliteal artery after total knee arthroplasty is extremely rare. A 74-year-old woman presented to another institution with a left popliteal artery injury after left total knee arthroplasty. Arteriography revealed total occlusion of the popliteal artery, and emergency surgery was performed. Because of the total occlusion of the popliteal artery due to severe direct thermal injury, anastomosis was performed in an end-to-end fashion with a right great saphenous vein graft. At the time of discharge, she had no specific symptoms other than pain at the surgical site, with a palpable left dorsalis pedis pulse. While performing total knee arthroplasty, the anatomical position of the popliteal artery should be carefully considered to prevent injury.
    MeSH term(s) Female ; Humans ; Aged ; Popliteal Artery/diagnostic imaging ; Popliteal Artery/surgery ; Popliteal Artery/injuries ; Arthroplasty, Replacement, Knee/adverse effects ; Angiography ; Lower Extremity/surgery
    Language English
    Publishing date 2023-06-23
    Publishing country India
    Document type Case Reports
    ZDB-ID 1458330-6
    ISSN 1119-3077
    ISSN 1119-3077
    DOI 10.4103/njcp.njcp_778_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Genome characterization of a Korean isolate of porcine epidemic diarrhea virus.

    Kim, Dae-Min / Moon, Sung-Hyun / Kim, Seung-Chai / Lee, Taek Geun / Cho, Ho-Seong / Tark, Dongseob

    Microbiology resource announcements

    2023  Volume 13, Issue 1, Page(s) e0011823

    Abstract: Porcine epidemic diarrhea (PED) outbreaks occur annually in the Republic of Korea. The complete genome sequence of the PED virus isolate CKK1-1 obtained from an infected pig was determined. The genome is 28,037 nt long, excluding the poly(A) tail, and ... ...

    Abstract Porcine epidemic diarrhea (PED) outbreaks occur annually in the Republic of Korea. The complete genome sequence of the PED virus isolate CKK1-1 obtained from an infected pig was determined. The genome is 28,037 nt long, excluding the poly(A) tail, and contains seven open reading frames flanked by two untranslated regions.
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00118-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cytoprotective effects of taxifolin against cadmium-induced apoptosis in human keratinocytes.

    Moon, S H / Lee, C M / Nam, M J

    Human & experimental toxicology

    2019  Volume 38, Issue 8, Page(s) 992–1003

    Abstract: Cadmium (Cd) is a heavy metal widely used in industry, and the skin is an important target of this metal. Taxifolin (Tax), a natural source of bioflavonoids found in various conifers, exerts multiple biologic effects on skin cells. However, the ... ...

    Abstract Cadmium (Cd) is a heavy metal widely used in industry, and the skin is an important target of this metal. Taxifolin (Tax), a natural source of bioflavonoids found in various conifers, exerts multiple biologic effects on skin cells. However, the mechanisms by which Tax protects keratinocytes against Cd are currently unclear. We investigated the cytoprotective effects of Tax against Cd-induced apoptosis in the human HaCaT keratinocyte. The water-soluble tetrazolium salt (WST-1) assay and Annexin V/propidium iodide double-staining assay results showed that Cd-induced cell death was lower in cells treated with Tax (0-100 μM) than in cells treated with Cd alone. Additionally, a reduction of Cd-induced DNA fragmentation by Tax was shown by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling assay. The levels of reactive oxygen species were also lower in Cd/Tax-treated cells than in Cd-treated cells. We employed a two-dimensional electrophoresis-based proteomic analysis to identify treatment-related alterations in protein expression. Tax downregulated cathepsin B and D and upregulated hsp27, cyclophilin A, and peroxiredowin-1. Western blotting confirmed the downregulation of cathepsin B and D and the upregulation of hsp27. The cytoprotective effects of Tax against Cd-induced apoptosis were also characterized by the changes in the activity of caspase 3, -7, poly ADP-ribose polymerase, the cellular proliferation-related ERK1/2, and AKT. Furthermore, the levels of cell cycle-related proteins, such as SP1 and p21, decreased, whereas p53 level increased. We concluded that Tax reduced Cd cytotoxicity and Cd-induced apoptosis by inhibiting the apoptotic pathway.
    MeSH term(s) Apoptosis/drug effects ; Cadmium/toxicity ; Cell Line ; Cell Survival/drug effects ; Cytoprotection/drug effects ; Humans ; Keratinocytes/drug effects ; Quercetin/analogs & derivatives ; Quercetin/pharmacology ; Reactive Oxygen Species/metabolism
    Chemical Substances Reactive Oxygen Species ; Cadmium (00BH33GNGH) ; Quercetin (9IKM0I5T1E) ; taxifolin (9SOB9E3987)
    Language English
    Publishing date 2019-05-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1027454-6
    ISSN 1477-0903 ; 0144-5952 ; 0960-3271
    ISSN (online) 1477-0903
    ISSN 0144-5952 ; 0960-3271
    DOI 10.1177/0960327119846941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Head-to-head comparison of [

    Aguero, Cinthya / Dhaynaut, Maeva / Amaral, Ana C / Moon, S-H / Neelamegam, Ramesh / Scapellato, Margaret / Carazo-Casas, Carlos / Kumar, Sunny / El Fakhri, Georges / Johnson, Keith / Frosch, Matthew P / Normandin, Marc D / Gómez-Isla, Teresa

    Acta neuropathologica

    2024  Volume 147, Issue 1, Page(s) 25

    Abstract: We and others have shown that [ ...

    Abstract We and others have shown that [
    MeSH term(s) Humans ; Neurodegenerative Diseases/pathology ; Melanins/metabolism ; Brain/pathology ; Tauopathies/pathology ; Monoamine Oxidase/metabolism ; DNA-Binding Proteins/metabolism ; tau Proteins/metabolism ; Positron-Emission Tomography/methods ; Alzheimer Disease/pathology ; Carbolines ; Isoquinolines ; Pyridines
    Chemical Substances PI-2620 ; 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (J09QS3Z3WB) ; MK-6240 ; Melanins ; Monoamine Oxidase (EC 1.4.3.4) ; DNA-Binding Proteins ; tau Proteins ; Carbolines ; Isoquinolines ; Pyridines
    Language English
    Publishing date 2024-01-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1079-0
    ISSN 1432-0533 ; 0001-6322
    ISSN (online) 1432-0533
    ISSN 0001-6322
    DOI 10.1007/s00401-023-02672-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Anti-elastase and anti-hyaluronidase activity of phosvitin isolated from hen egg yolk

    Lee, J. H / Moon, S. H / Hong, Y / Ahn, D. U / Paik, H.-D

    British poultry science. 2020 Jan. 2, v. 61, no. 1

    2020  

    Abstract: 1. Phosvitin, a major phosphoprotein found in egg yolk, has strong antioxidant activity. Activation of elastase, collagenase, and hyaluronidase by reactive oxygen species are related to the degradation of ECM and skin aging. The objective of this study ... ...

    Abstract 1. Phosvitin, a major phosphoprotein found in egg yolk, has strong antioxidant activity. Activation of elastase, collagenase, and hyaluronidase by reactive oxygen species are related to the degradation of ECM and skin aging. The objective of this study was to determine the anti-elastase and anti-hyaluronidase activity of phosvitin. 2. Elastase from porcine pancreas and hyaluronidase from bovine testes were used to study the inhibitory activity of phosvitin. To elucidate the mechanism of enzyme inhibition, a Lineweaver-Burk plot was constructed. 3. Phosvitin inhibited elastase and hyaluronidase activity in a dose-dependent manner. The IC₅₀ value of phosvitin was 31.6 μg/ml and 1,270 μg/ml against elastase and hyaluronidase, respectively. The analysis of elastase and hyaluronidase kinetics indicated that the apparent Michaelis constant (ₐₚₚKₘ) was increased by phosvitin but the Vₘₐₓ value was not affected. 4. In conclusion, phosvitin exhibited competitive inhibitory activity against elastase and hyaluronidase. Thus, phosvitin could be used as a natural anti-aging agent in the cosmetics industry.
    Keywords antioxidant activity ; cattle ; collagenase ; cosmetics ; dose response ; egg yolk ; elastase ; enzyme activity ; enzyme inhibition ; enzyme kinetics ; hens ; hyaluronoglucosaminidase ; industry ; inhibitory concentration 50 ; pancreas ; phosphoproteins ; reactive oxygen species ; swine ; testes
    Language English
    Dates of publication 2020-0102
    Size p. 17-21.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 956653-3
    ISSN 1466-1799 ; 0007-1668
    ISSN (online) 1466-1799
    ISSN 0007-1668
    DOI 10.1080/00071668.2019.1686124
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Anti-elastase and anti-hyaluronidase activity of phosvitin isolated from hen egg yolk.

    Lee, J H / Moon, S H / Hong, Y / Ahn, D U / Paik, H-D

    British poultry science

    2020  Volume 61, Issue 1, Page(s) 17–21

    Abstract: 1. Phosvitin, a major phosphoprotein found in egg yolk, has strong antioxidant activity. Activation of elastase, collagenase, and hyaluronidase by reactive oxygen species are related to the degradation of ECM and skin aging. The objective of this study ... ...

    Abstract 1. Phosvitin, a major phosphoprotein found in egg yolk, has strong antioxidant activity. Activation of elastase, collagenase, and hyaluronidase by reactive oxygen species are related to the degradation of ECM and skin aging. The objective of this study was to determine the anti-elastase and anti-hyaluronidase activity of phosvitin.2. Elastase from porcine pancreas and hyaluronidase from bovine testes were used to study the inhibitory activity of phosvitin. To elucidate the mechanism of enzyme inhibition, a Lineweaver-Burk plot was constructed.3. Phosvitin inhibited elastase and hyaluronidase activity in a dose-dependent manner. The IC
    MeSH term(s) Animals ; Cattle ; Chickens ; Egg Yolk ; Female ; Hyaluronoglucosaminidase ; Phosvitin ; Swine
    Chemical Substances Phosvitin (9008-96-2) ; Hyaluronoglucosaminidase (EC 3.2.1.35)
    Language English
    Publishing date 2020-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 956653-3
    ISSN 1466-1799 ; 0007-1668
    ISSN (online) 1466-1799
    ISSN 0007-1668
    DOI 10.1080/00071668.2019.1686124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Heterofermentative lactic acid bacteria as a starter culture to control kimchi fermentation

    Moon, S. H. / Kim, C. R. / Chang, H. C.

    LWT - food science and technology

    2018  Volume 88, Issue -, Page(s) 181

    Language English
    Document type Article
    ZDB-ID 2169058-3
    ISSN 0023-6438
    Database Current Contents Nutrition, Environment, Agriculture

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  8. Article ; Online: Evaluation of the efficacy and safety of NVP-1203 and aceclofenac in patients with acute low back pain and muscle spasm: A randomized, double-blind, active-controlled, parallel, multicenter, phase 3 clinical trial.

    Lee, S / Kim, H-J / Kim, J H / Kim, T K / Kang, C-N / Lee, J-H / Cho, J H / Kim, S H / Moon, S-H

    European review for medical and pharmacological sciences

    2022  Volume 27, Issue 1, Page(s) 315–324

    Abstract: Objective: Acute low back pain (LBP) is a common condition that can be chronic if not properly treated. Aceclofenac and eperisone hydrochloride are commonly prescribed drugs for acute LBP and muscle spasms. Therefore, NVP-1203, a fixed-dose combination ... ...

    Abstract Objective: Acute low back pain (LBP) is a common condition that can be chronic if not properly treated. Aceclofenac and eperisone hydrochloride are commonly prescribed drugs for acute LBP and muscle spasms. Therefore, NVP-1203, a fixed-dose combination of 100 mg aceclofenac and 75 mg eperisone hydrochloride, is being developed. This study aimed to evaluate the efficacy and safety of NVP-1203 compared to those of a single administration of 100 mg aceclofenac in patients with acute LBP and muscle spasms.
    Patients and methods: Overall, 455 patients with acute LBP and muscle spasms were enrolled. The patients were assigned to NVP-1203 or Airtal group (aceclofenac 100 mg). The primary efficacy endpoint was the mean change in the 100 mm pain movement and resting visual analog scale (VAS) scores on treatment day 7.
    Results: The mean change in the 100 mm pain movement/resting VAS scores from baseline to day 7 was -49.7 ± 21.5/-41.0 ± 19.4 mm and -38.8 ± 18.9/-33.8 ± 18.0 mm for the NVP-1203 and Airtal groups, respectively. The differences between the two groups were statistically significant (movement, p < 0.0001; resting, p = 0.0002). Differences in least-square (LS) mean change of the 100 mm pain movement/resting VAS score between the two groups using the analysis of covariance (ANCOVA) model was -10.2/-7.4 mm, and the upper limit of the 95% confidence interval was -6.44/-4.16 mm.
    Conclusions: NVP-1203 is more effective in reducing pain than the 100 mg aceclofenac alone. However, the two drugs have similar safety profiles in patients with acute LBP and muscle spasms.
    MeSH term(s) Humans ; Low Back Pain/drug therapy ; Pain Measurement ; Spasm ; Double-Blind Method ; Acute Pain ; Treatment Outcome
    Chemical Substances aceclofenac (RPK779R03H) ; eperisone (2M2P0551D3)
    Language English
    Publishing date 2022-12-24
    Publishing country Italy
    Document type Randomized Controlled Trial ; Multicenter Study ; Clinical Trial, Phase III ; Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202301_30878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Relationship between serum magnesium concentration during the transition period, peri‐ and postpartum disorders, and reproductive performance in dairy cows

    Jeong, J.K / Choi, I.S / Moon, S.H / Kang, H.G / Kim, I.H

    Livestock science. 2018 July, v. 213

    2018  

    Abstract: This study evaluated the relationship between serum magnesium concentration, peri‐ and postpartum disorders, and reproductive performance in dairy cows. Blood samples were collected from 198 Holstein cows 4 weeks prepartum, after calving, and 1, 2, 4, 6, ...

    Abstract This study evaluated the relationship between serum magnesium concentration, peri‐ and postpartum disorders, and reproductive performance in dairy cows. Blood samples were collected from 198 Holstein cows 4 weeks prepartum, after calving, and 1, 2, 4, 6, and 8 weeks postpartum to measure serum magnesium and/or progesterone concentrations. To determine the relationship between serum magnesium concentration and peri‐ or postpartum disorders, cows were divided into two groups based on their mean serum magnesium concentration 4 weeks prepartum and just after calving: a Low-Mg group (1.45–2.65 mg/dL, n = 110) and a High-Mg group (2.70–5.40 mg/dL, n = 88). Analysis of these groups showed that the incidences of dystocia, retained placenta, endometritis, and lameness were lower (P < 0.05–0.01) in the High-Mg than in the Low-Mg groups. To determine the relationship between serum magnesium concentration during the transition period and reproductive performance, cows were divided into two groups based on their mean serum magnesium concentration from 4 weeks prepartum to 4 weeks postpartum: a Low-Mg group (1.80–2.59 mg/dL, n = 116) and a High-Mg group (2.60–4.17 mg/dL, n = 82). The probability of cyclicity resuming (shown by a progesterone concentration ≥ 1 ng/mL) by 8 weeks postpartum was higher in the High-Mg group (hazard ratio [HR]: 1.70; P < 0.01) than that in the Low-Mg group. Moreover, the probabilities of first insemination by 150 days and pregnancy by 210 days postpartum were higher (HRs: 2.16 and 2.36, respectively; P ≤ 0.0001) in the High-Mg than in the Low-Mg groups, resulting in the mean calving-to-conception interval being 25 days shorter in the High-Mg group. In conclusion, high serum magnesium concentration during the transition period is associated with lower incidences of peri‐ and postpartum disorders and improved reproductive performance in dairy cows.
    Keywords Holstein ; blood sampling ; blood serum ; calving ; dairy cows ; dystocia ; endometritis ; insemination ; lameness ; magnesium ; periodicity ; pregnancy ; probability ; progesterone ; reproductive performance ; retained placenta
    Language English
    Dates of publication 2018-07
    Size p. 1-6.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2226176-X
    ISSN 1878-0490 ; 1871-1413
    ISSN (online) 1878-0490
    ISSN 1871-1413
    DOI 10.1016/j.livsci.2018.04.013
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Anterior resection syndrome: a randomized clinical trial of a 5-HT3 receptor antagonist (ramosetron) in male patients with rectal cancer.

    Ryoo, S-B / Park, J W / Lee, D W / Lee, M A / Kwon, Y-H / Kim, M J / Moon, S H / Jeong, S-Y / Park, K J

    The British journal of surgery

    2021  Volume 108, Issue 6, Page(s) 644–651

    Abstract: Background: No effective treatment exists for anterior resection syndrome (ARS) following sphincter-saving surgery for rectal cancer. This RCT assessed the safety and efficacy of a 5-HT3 receptor antagonist, ramosetron, for ARS.: Methods: A single- ... ...

    Abstract Background: No effective treatment exists for anterior resection syndrome (ARS) following sphincter-saving surgery for rectal cancer. This RCT assessed the safety and efficacy of a 5-HT3 receptor antagonist, ramosetron, for ARS.
    Methods: A single-centre, randomized, controlled, open-label, parallel group trial was conducted. Male patients with ARS 1 month after rectal cancer surgery or ileostomy reversal were enrolled and randomly assigned (1 : 1) to 5 μg of ramosetron (Irribow®) daily or conservative treatment for 4 weeks. Low ARS (LARS) score was calculated after randomization and 4 weeks after treatment. The study was designed as a superiority test with a primary endpoint of the proportion of patients with major LARS between the groups. Primary outcome analysis was based on the modified intention-to-treat population. Safety was assessed by monitoring adverse events during the study.
    Results: : A total of 100 patients were randomized to the ramosetron (49 patients) or conservative treatment group (51 patients). Two patients were excluded, and 48 and 50 patients were analysed in the ramosetron and control groups, respectively. The proportion of major LARS after 4 weeks was 58 per cent (28 of 48 patients) in the ramosetron group versus 82 per cent (41 of 50 patients) in the control group, with a difference of 23.7 per cent (95 per cent c.i. 5.58 to 39.98, P = 0.011). There were minor adverse events in five patients, which were hard stool, frequent stool or anal pain. These were not different between the two groups. There were no serious adverse events.
    Conclusion: : Ramosetron could be safe and feasible for male patients with ARS.
    Trial registration number: NCT02869984 (http://www.clinicaltrials.gov).
    MeSH term(s) Benzimidazoles/therapeutic use ; Humans ; Male ; Middle Aged ; Proctectomy/adverse effects ; Proctectomy/methods ; Rectal Neoplasms/surgery ; Rectum/surgery ; Serotonin 5-HT3 Receptor Antagonists/therapeutic use ; Syndrome ; Treatment Outcome
    Chemical Substances Benzimidazoles ; Serotonin 5-HT3 Receptor Antagonists ; ramosetron (7ZRO0SC54Y)
    Language English
    Publishing date 2021-04-23
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znab071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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