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  1. AU="Moore, Alexander I G"
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  3. AU="Pańczyszyn, Elżbieta"
  4. AU="Patrick Lam"
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  7. AU="Dehal, A (Kaiser Permanente Panorama City Medical Center)"
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  1. Article ; Online: Does Industry Really Develop Less Medicines With Clinical Benefit?

    Moore, Alexander I G / Beattie, Alice / Ramagopalan, Sreeram V

    JAMA internal medicine

    2024  Volume 184, Issue 5, Page(s) 586–587

    MeSH term(s) Humans ; Drug Industry ; Drug Development
    Language English
    Publishing date 2024-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2024.0177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.119: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Sense of direction in vestibular disorders.

    Moore, Alexander I G / Golding, John F / Alenova, Anastasia / Castro, Patricia / Bronstein, Adolfo M

    Journal of vestibular research : equilibrium & orientation

    2024  Volume 34, Issue 2-3, Page(s) 113–123

    Abstract: Background: Our sense of direction (SOD) ability relies on the sensory integration of both visual information and self-motion cues from the proprioceptive and vestibular systems. Here, we assess how dysfunction of the vestibular system impacts perceived ...

    Abstract Background: Our sense of direction (SOD) ability relies on the sensory integration of both visual information and self-motion cues from the proprioceptive and vestibular systems. Here, we assess how dysfunction of the vestibular system impacts perceived SOD in varying vestibular disorders, and secondly, we explore the effects of dizziness, migraine and psychological symptoms on SOD ability in patient and control groups.
    Methods: 87 patients with vestibular disorder and 69 control subjects were assessed with validated symptom and SOD questionnaires (Santa Barbara Sense of Direction scale and the Object Perspective test).
    Results: While patients with vestibular disorders performed significantly worse than controls at the group level, only central and functional disorders (vestibular migraine and persistent postural perceptual dizziness), not peripheral disorders (benign-paroxysmal positional vertigo, bilateral vestibular failure and Meniere's disease) showed significant differences compared to controls on the level of individual vestibular groups. Additionally, orientational abilities associated strongly with spatial anxiety and showed clear separation from general dizziness and psychological factors in both patient and control groups.
    Conclusions: SOD appears to be less affected by peripheral vestibular dysfunction than by functional and/or central diagnoses, indicating that higher level disruptions to central vestibular processing networks may impact SOD more than reductions in sensory peripheral inputs. Additionally, spatial anxiety is highly associated with orientational abilities in both patients and control subjects.
    MeSH term(s) Humans ; Vestibular Diseases/psychology ; Vestibular Diseases/diagnosis ; Vestibular Diseases/physiopathology ; Female ; Male ; Middle Aged ; Dizziness/psychology ; Dizziness/diagnosis ; Dizziness/physiopathology ; Adult ; Aged ; Migraine Disorders/psychology ; Migraine Disorders/diagnosis ; Migraine Disorders/physiopathology ; Orientation/physiology ; Proprioception/physiology ; Surveys and Questionnaires ; Space Perception/physiology
    Language English
    Publishing date 2024-03-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1051840-x
    ISSN 1878-6464 ; 0957-4271
    ISSN (online) 1878-6464
    ISSN 0957-4271
    DOI 10.3233/VES-230082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3072: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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