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Article ; Online: Courage, Cancer and COVID.

Moore, Carol Kerrigan

Delaware journal of public health

2020 Volume 6, Issue 2, Page(s) 48–49

Language	English
Publishing date	2020-07-01
Publishing country	United States
Document type	Journal Article
ISSN	2639-6378
ISSN (online)	2639-6378
DOI	10.32481/djph.2020.07.014
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Article ; Online: Phosphodiesterase-5 (PDE-5) Inhibitors as Therapy for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury.

Kalyani, Priyanka / Lippa, Sara M / Werner, J Kent / Amyot, Franck / Moore, Carol B / Kenney, Kimbra / Diaz-Arrastia, Ramon

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

2023 Volume 20, Issue 6, Page(s) 1629–1640

Abstract: Multiple phase III randomized controlled trials (RCTs) for pharmacologic interventions in traumatic brain injury (TBI) have failed despite promising results in experimental models. The heterogeneity of TBI, in terms of pathomechanisms and impacted brain ... ...

Abstract	Multiple phase III randomized controlled trials (RCTs) for pharmacologic interventions in traumatic brain injury (TBI) have failed despite promising results in experimental models. The heterogeneity of TBI, in terms of pathomechanisms and impacted brain structures, likely contributes to these failures. Biomarkers have been recommended to identify patients with relevant pathology (predictive biomarkers) and confirm target engagement and monitor therapy response (pharmacodynamic biomarkers). Our group focuses on traumatic cerebrovascular injury as an understudied endophenotype of TBI and is validating a predictive and pharmacodynamic imaging biomarker (cerebrovascular reactivity; CVR) in moderate-severe TBI. We aim to extend these studies to milder forms of TBI to determine the optimal dose of sildenafil for maximal improvement in CVR. We will conduct a phase II dose-finding study involving 160 chronic TBI patients (mostly mild) using three doses of sildenafil, a phosphodiesterase-5 (PDE-5) inhibitor. The study measures baseline CVR and evaluates the effect of escalating sildenafil doses on CVR improvement. A 4-week trial of thrice daily sildenafil will assess safety, tolerability, and clinical efficacy. This dual-site 4-year study, funded by the Department of Defense and registered in ClinicalTrials.gov (NCT05782244), plans to launch in June 2023. Biomarker-informed RCTs are essential for developing effective TBI interventions, relying on an understanding of underlying pathomechanisms. Traumatic microvascular injury (TMVI) is an attractive mechanism which can be targeted by vaso-active drugs such as PDE-5 inhibitors. CVR is a potential predictive and pharmacodynamic biomarker for targeted interventions aimed at TMVI. (Trial registration: NCT05782244, ClinicalTrials.gov ).
MeSH term(s)	Humans ; Phosphodiesterase 5 Inhibitors/therapeutic use ; Cyclic Nucleotide Phosphodiesterases, Type 5 ; Sildenafil Citrate/therapeutic use ; Cerebrovascular Circulation/physiology ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/drug therapy ; Brain Injuries, Traumatic/pathology ; Biomarkers
Chemical Substances	Phosphodiesterase 5 Inhibitors ; Cyclic Nucleotide Phosphodiesterases, Type 5 (EC 3.1.4.35) ; Sildenafil Citrate (BW9B0ZE037) ; Biomarkers
Language	English
Publishing date	2023-09-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2316693-9
ISSN	1878-7479 ; 1933-7213
ISSN (online)	1878-7479
ISSN	1933-7213
DOI	10.1007/s13311-023-01430-z
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Article ; Online: Cerebrovascular Reactivity Measurement with Functional Near Infrared Spectroscopy.

Amyot, Franck / Davis, Cora / Sangobowale, Mike / Moore, Carol / Silverman, Erika / Gandjbakhche, Amir / Diaz-Arrastia, Ramon / Kenney, Kimbra

Journal of visualized experiments : JoVE

2022 , Issue 184

Abstract: Cerebrovascular reactivity (CVR) is the capacity of blood vessels in the brain to alter cerebral blood flow (either with dilation or constriction) in response to chemical or physical stimuli. The amount of reactivity in the cerebral microvasculature ... ...

Abstract	Cerebrovascular reactivity (CVR) is the capacity of blood vessels in the brain to alter cerebral blood flow (either with dilation or constriction) in response to chemical or physical stimuli. The amount of reactivity in the cerebral microvasculature depends on the integrity of the capacitance vasculature and is the primary function of endothelial cells. CVR is, therefore, an indicator of the microvasculature's physiology and overall health. Imaging methods that can measure CVR are available but can be costly, and require magnetic resonance imaging centers and technical expertise. In this study, we used fNIRS technology to monitor changes of oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) in the cerebral microvasculature to assess the CVR of 15 healthy controls (HC) in response to a vasoactive stimulus (inhaled 5% carbon dioxide or CO2). Our results suggest that this is a promising imaging technology that offers a non-invasive, accurate, portable, and cost-effective method of mapping cortical CVR and associated microvasculature function, resulting from a traumatic brain injury or other conditions associated with cerebral microvasculopathy.
MeSH term(s)	Brain/blood supply ; Brain/diagnostic imaging ; Carbon Dioxide ; Cerebrovascular Circulation/physiology ; Endothelial Cells ; Magnetic Resonance Imaging/methods ; Spectroscopy, Near-Infrared
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2022-06-02
Publishing country	United States
Document type	Journal Article ; Video-Audio Media ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/61284
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Article: Regioselective degradation of [beta] 1,3 glucan by ferrous ion and hydrogen peroxide (Fenton oxidation)

Ovalle, Rafael / Chen, Lijie / Soll, Clifford E / Moore, Carol Wood / Lipke, Peter N

Carbohydrate research. 2020 Nov., v. 497

2020

Abstract: Many species use Fe⁺² and H₂O₂ to oxidize a wide variety of compounds to simpler molecules. Both pathogen killing by leukocytes (neutrophils and lymphocytes) and degradation of cellulose by brown rot fungi rely on excretion of Fe⁺² ions and H₂O₂, the ... ...

Abstract	Many species use Fe⁺² and H₂O₂ to oxidize a wide variety of compounds to simpler molecules. Both pathogen killing by leukocytes (neutrophils and lymphocytes) and degradation of cellulose by brown rot fungi rely on excretion of Fe⁺² ions and H₂O₂, the Fenton reagent. To elucidate the mechanism of Fenton oxidation of carbohydrates, β1,3 glucan (laminaran), a major fungal wall polysaccharide, was oxidized using a molar ratio of monomer/Fe⁺²/H₂O₂ of 10:1:1 (primarily). We labeled the reaction products and profiled them as fluorescent-labeled molecules in polyacrylamide gels and as hydrophobic-tagged molecules using reverse phase liquid chromatography/mass spectrometry (HPLC/MS).Sub-stoichiometric concentrations of Fe⁺² and H₂O₂ fragmented laminaran into smaller molecules containing carbonyl and carboxylic acid groups visible on fluorescent-labeled carbohydrate polyacrylamide gel electrophoresis. HPLC/MS analysis of glucan fragments showed masses consistent with six classes of molecules: aldoses, dialdoses, uronic acids, hexosuloses, aldonic acids, and hexulosonic acids.The results were consistent with published mechanisms where hydrogen radical (H•) abstraction from a C–H or O–H bond begins a cascade of reactions leading to 1) C–C bond cleavage to produce aldose/dialdose pairs; 2) oxo-group (O =) addition to produce uronic and aldonic acids; 3) hydroxyl group (HO-) addition to produce gluconolactone and hexosuloses; and 4) hexulosonic acids. Most products resulted from regioselective H• abstractions characteristic of oxidations by ferryl-oxo ion [(FeO)⁺²] or perferryl-oxo ion [(FeO)⁺³] in close contact with specific positions in the glycan. Therefore, oxidations initiated by regioselectively-bound Fe ions were the predominant initiators of polysaccharide degradations.
Keywords	aldoses ; carboxylic acids ; cellulose ; cleavage (chemistry) ; excretion ; fluorescent labeling ; gluconolactone ; hydrogen ; hydrogen peroxide ; mass spectrometry ; neutrophils ; oxidation ; pathogens ; polyacrylamide ; polyacrylamide gel electrophoresis ; regioselectivity ; research ; reversed-phase liquid chromatography
Language	English
Dates of publication	2020-11
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1435-7
ISSN	1873-426X ; 0008-6215
ISSN (online)	1873-426X
ISSN	0008-6215
DOI	10.1016/j.carres.2020.108124
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Regioselective degradation of [beta] 1,3 glucan by ferrous ion and hydrogen peroxide (Fenton oxidation).

Ovalle, Rafael / Chen, Lijie / Soll, Clifford E / Moore, Carol Wood / Lipke, Peter N

Carbohydrate research

2020 Volume 497, Page(s) 108124

Abstract: Many species use ... ...

Abstract	Many species use Fe
Language	English
Publishing date	2020-08-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1435-7
ISSN	1873-426X ; 0008-6215
ISSN (online)	1873-426X
ISSN	0008-6215
DOI	10.1016/j.carres.2020.108124
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Article: As we age who will care for us?

Moore, Carol

The Kansas nurse

2005 Volume 80, Issue 7, Page(s) 12–13

MeSH term(s)	Aged ; Aged, 80 and over ; Frail Elderly ; Geriatric Nursing/manpower ; Geriatric Nursing/standards ; Geriatric Nursing/trends ; Geriatrics/manpower ; Geriatrics/standards ; Geriatrics/trends ; Health Services Needs and Demand/trends ; Humans ; Kansas ; Personnel Turnover ; Population Dynamics
Language	English
Publishing date	2005-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	603710-0
ISSN	0022-8710
ISSN	0022-8710
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Article ; Online: Activation of the Calcium Receptor by Calcimimetic Agents Is Preserved Despite Modest Attenuating Effects of Hyperphosphatemia.

Goodman, William G / Ward, Donald T / Martin, Kevin J / Drayer, Debra / Moore, Carol / Xu, Jiahong / Lai, James / Chon, Yun / Nemeth, Edward F

Journal of the American Society of Nephrology : JASN

2021 Volume 33, Issue 1, Page(s) 201–212

Abstract: Background: Phosphorus levels in the range seen clinically among patients undergoing dialysis have been reported to attenuate calcium receptor activation and modify parathyroid hormone (PTH) release from isolated parathyroid glands : Methods: To ... ...

Abstract	Background: Phosphorus levels in the range seen clinically among patients undergoing dialysis have been reported to attenuate calcium receptor activation and modify parathyroid hormone (PTH) release from isolated parathyroid glands Methods: To determine whether hyperphosphatemia diminishes the therapeutic response to calcimimetic agents, we used data from large clinical trials to analyze the effects of etelcalcetide and cinacalcet to lower plasma PTH levels in individuals on hemodialysis who had secondary hyperparathyroidism and varying degrees of hyperphosphatemia. Results: Plasma PTH levels declined progressively during 26 weeks of treatment with either etelcalcetide or cinacalcet without regard to the degree of hyperphosphatemia at baseline. However, with each calcimimetic agent, the decreases in PTH from baseline were less at each interval of follow-up during the trials among participants with serum phosphorus levels above one of three prespecified threshold values compared with those with serum phosphorus levels below these thresholds. Conclusions: These
MeSH term(s)	Aged ; Calcimimetic Agents/therapeutic use ; Cinacalcet/therapeutic use ; Female ; Humans ; Hyperparathyroidism, Secondary/blood ; Hyperparathyroidism, Secondary/complications ; Hyperparathyroidism, Secondary/drug therapy ; Hyperphosphatemia/blood ; Hyperphosphatemia/complications ; Male ; Middle Aged ; Parathyroid Hormone/blood ; Peptides/therapeutic use ; Phosphorus/blood ; Renal Dialysis ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy ; Retrospective Studies
Chemical Substances	Calcimimetic Agents ; Parathyroid Hormone ; Peptides ; Phosphorus (27YLU75U4W) ; etelcalcetide hydrochloride (72PT5993DU) ; Cinacalcet (UAZ6V7728S)
Language	English
Publishing date	2021-11-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.2021060825
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Article ; Online: Bone-specific alkaline phosphatase and bone turnover in African American hemodialysis patients.

Yessayan, Lenar / Moore, Carol / Lu, Mei / Yee, Jerry

Hemodialysis international. International Symposium on Home Hemodialysis

2016 Volume 21, Issue 1, Page(s) 90–96

Abstract: Introduction: Noninvasive measures of bone activity include intact parathyroid hormone (iPTH) and bone-specific alkaline phosphatase (BSAP). Whether BSAP measurement alone or in combination with other biochemical data provides more reliable information ... ...

Abstract	Introduction: Noninvasive measures of bone activity include intact parathyroid hormone (iPTH) and bone-specific alkaline phosphatase (BSAP). Whether BSAP measurement alone or in combination with other biochemical data provides more reliable information about bone turnover than iPTH alone in African Americans on hemodialysis is unknown. Methods: This cross-sectional study aimed to determine the optimal predictor and cutoff points for BSAP, iPTH, calcium and phosphorus in classifying bone biopsy findings. Forty-three African American hemodialysis patients were available for analysis. Biochemical data on the day of biopsy across a spectrum of qualitative histologic bone features were compared. Classification and regression tree analysis was used to determine both the optimal predictor and cutoff points for BSAP, iPTH, calcium and phosphorus in identifying bone turnover status. Findings: Seven subjects had adynamic disease, 31 had mild/moderate hyperparathyroid bone features, and five had severe hyperparathyroid bone disease. BSAP was the optimal predictor of bone biopsy with a cutoff point of 22 ng/mL. Calcium and phosphorus had no predictive value. At BSAP ≤ 22 ng/mL, subjects had either adynamic bone disease or mild/moderate hyperparathyroid bone disease but iPTH was not useful in further classifying biopsy findings. When BSAP was >22 ng/mL, subjects had either mild/moderate or severe hyperparathyroid bone disease, and iPTH was useful in further classifying biopsy findings. With BSAP > 22 ng/mL and iPTH < 726 pg/mL, all subjects had mild/moderate bone turnover features. Discussion: Compared to iPTH, BSAP was shown to be the optimal predictor of biopsy findings with an optimal cutoff at 22 ng/mL.
MeSH term(s)	Adult ; African Americans ; Alkaline Phosphatase/metabolism ; Bone Remodeling/physiology ; Chronic Kidney Disease-Mineral and Bone Disorder ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Renal Dialysis/methods
Chemical Substances	Alkaline Phosphatase (EC 3.1.3.1)
Language	English
Publishing date	2016-06-27
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2192458-2
ISSN	1542-4758 ; 1492-7535
ISSN (online)	1542-4758
ISSN	1492-7535
DOI	10.1111/hdi.12454
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Article ; Online: Dialysis: Two for the price of one: is rt-PA ready for prime time?

Besarab, Anatole / Moore, Carol L

Nature reviews. Nephrology

2011 Volume 7, Issue 6, Page(s) 310–311

MeSH term(s)	Graft Occlusion, Vascular/drug therapy ; Graft Occlusion, Vascular/epidemiology ; Graft Occlusion, Vascular/prevention & control ; Humans ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Prosthesis-Related Infections/epidemiology ; Prosthesis-Related Infections/prevention & control ; Recombinant Proteins/therapeutic use ; Renal Dialysis ; Risk Factors ; Tissue Plasminogen Activator/therapeutic use
Chemical Substances	Recombinant Proteins ; Tissue Plasminogen Activator (EC 3.4.21.68)
Language	English
Publishing date	2011-05-17
Publishing country	England
Document type	News
ZDB-ID	2490366-8
ISSN	1759-507X ; 1759-5061
ISSN (online)	1759-507X
ISSN	1759-5061
DOI	10.1038/nrneph.2011.54
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Article ; Online: A Protein in the Yeast

Farooqi, Kanwal / Ghazvini, Marjan / Pride, Leah D / Mazzella, Louis / White, David / Pramanik, Ajay / Bargonetti, Jill / Moore, Carol Wood

Biomolecules

2020 Volume 10, Issue 3

Abstract: Saccharomyces ... ...

Abstract	Saccharomyces cerevisiae
MeSH term(s)	Humans ; Oligonucleotides/chemistry ; Oligonucleotides/genetics ; Oligonucleotides/metabolism ; Response Elements ; Saccharomyces cerevisiae/chemistry ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Tumor Suppressor Protein p53
Chemical Substances	Oligonucleotides ; Saccharomyces cerevisiae Proteins ; TP53 protein, human ; Tumor Suppressor Protein p53
Language	English
Publishing date	2020-03-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom10030417
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