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Article ; Online: Artificial intelligence and surgery: what's next?

Sikder, Shameema / Moore, Jonathan E

Journal of cataract and refractive surgery

2023 Volume 49, Issue 8, Page(s) 779–780

MeSH term(s)	Humans ; Artificial Intelligence ; Surgical Procedures, Operative
Language	English
Publishing date	2023-07-23
Publishing country	United States
Document type	Editorial
ZDB-ID	632744-8
ISSN	1873-4502 ; 0886-3350
ISSN (online)	1873-4502
ISSN	0886-3350
DOI	10.1097/j.jcrs.0000000000001245
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Article ; Online: An ensemble-based approach for estimating personalized intraocular lens power.

Moutari, Salissou / Moore, Jonathan E

Scientific reports

2021 Volume 11, Issue 1, Page(s) 22961

Abstract: The fundamental difference between modern formulae for intraocular lens (IOL) power calculation lies on the single ad hoc regression model they use to estimate the effective lens position (ELP). The ELP is very difficult to predict and its estimation is ... ...

Abstract	The fundamental difference between modern formulae for intraocular lens (IOL) power calculation lies on the single ad hoc regression model they use to estimate the effective lens position (ELP). The ELP is very difficult to predict and its estimation is considered critical for an accurate prediction of the required IOL power of the lens to be implanted during cataract surgery. Hence, more advanced prediction techniques, which improve the prediction accuracy of the ELP, could play a decisive role in improving patient refractive outcomes. This study introduced a new approach for the calculation of personalized IOL power, which used an ensemble of regression models to devise a more accurate and robust prediction of the ELP. The concept of cross-validation was used to rigorously assess the performance of the devised formula against the most commonly used and published formulae. The results from this study show that overall, the proposed approach outperforms the most commonly used modern formulae (namely, Haigis, Holladay I, Hoffer Q and SRK/T) in terms of mean absolute prediction errors and prediction accuracy i.e., the percentage of eyes within ± 0.5D and ± 1 D ranges of prediction, for various ranges of axial lengths of the eyes. The new formula proposed in this study exhibited some promising features in terms of robustness. This enables the new formula to cope with variations in the axial length, the pre-operative anterior chamber depth and the keratometry readings of the corneal power; hence mitigating the impact of their measurement accuracy. Furthermore, the new formula performed well for both monofocal and multifocal lenses.
MeSH term(s)	Accommodation, Ocular ; Adult ; Aged ; Aged, 80 and over ; Axial Length, Eye ; Biometry/methods ; Female ; Humans ; Lens Implantation, Intraocular/adverse effects ; Lens, Crystalline/pathology ; Lens, Crystalline/surgery ; Lenses, Intraocular ; Male ; Middle Aged ; Refraction, Ocular ; Retrospective Studies
Language	English
Publishing date	2021-11-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-02288-x
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Article ; Online: Accuracy of toric intraocular lens formulas with measured posterior corneal astigmatism of different orientations.

Stewart, Stephen / Yeo, Tun Kuan / Moutari, Salissou / McNeely, Richard / Moore, Jonathan E

American journal of ophthalmology

2024

Abstract: Purpose: To assess whether the use of measured posterior corneal astigmatism (PCA) values improves the prediction accuracy of toric intraocular lens power formulas, compared to predicted PCA values, when the orientation of the steep axis of PCA is non- ... ...

Abstract	Purpose: To assess whether the use of measured posterior corneal astigmatism (PCA) values improves the prediction accuracy of toric intraocular lens power formulas, compared to predicted PCA values, when the orientation of the steep axis of PCA is non-vertical. Design: Retrospective observational cohort study METHODS: 418 eyes of 344 patients were included in the study. Prediction errors (PE) for postoperative refractive astigmatism at 4 weeks postoperatively were determined using vector analysis and compared for the following toric intraocular lens power formulas: Barrett Toric with predicted posterior corneal astigmatism (PPCA); Barrett Toric with measured posterior corneal astigmatism (MPCA); EVO Toric PPCA; EVO Toric MPCA; Holladay I with Abulafia-Koch regression. Subgroup analysis compared PEs for eyes with a vertically orientated steep axis of PCA (60-120 Setting: Cathedral Eye Clinic, Belfast, United Kingdom and Tan Tock Seng Hospital, Singapoore. Results: Standard keratometry was with-the-rule in 48% of eyes, while the steep PCA axis was vertically orientated in 91% of eyes. For all eyes, EVO PPCA had a smaller mean absolute error than Barrett-MPCA, Barrett-PPCA and Abulafia-Koch (p < 0.01 for all). EVO-PPCA had the highest percentage of eyes within 0.50D of predicted postoperative astigmatism for eyes with vertical PCA (61%), while EVO-MPCA had the highest percentage for eyes with non-vertical PCA (54%). EVO-MPCA had the smallest centroid error for all eyes, and the subgroups (p < 0.01 for all). Eyes with non-vertical PCA had a lower percentage within 0.50D than eyes with vertical PCA when using PPCA (43% vs 61%, p = 0.034), but there was no significant difference between these groups when MPCA is used for eyes with non-vertical PCA (54% vs 61%, p = 0.40). Conclusions: hen the steep axis of posterior corneal astigmatism is not vertically orientated, the use of measured posterior keratometry values improves prediction accuracy.
Language	English
Publishing date	2024-05-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	80030-2
ISSN	1879-1891 ; 0002-9394
ISSN (online)	1879-1891
ISSN	0002-9394
DOI	10.1016/j.ajo.2024.04.029
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Article ; Online: Visual performance and subjective experience 3 months and 12 months after combined implantation of 2 new complementary continuous phase multifocal intraocular lenses.

McNeely, Richard N / Stewart, Stephen A / Moore, Jonathan E

Journal of cataract and refractive surgery

2023 Volume 49, Issue 9, Page(s) 921–928

Abstract: Purpose: To assess the 3-month and 12-month postoperative visual performance and subjective quality of vision (QoV) after combined implantation of complementary continuous phase multifocal intraocular lenses (IOLs).: Setting: Private practice, United ...

Abstract	Purpose: To assess the 3-month and 12-month postoperative visual performance and subjective quality of vision (QoV) after combined implantation of complementary continuous phase multifocal intraocular lenses (IOLs). Setting: Private practice, United Kingdom. Design: Case series. Methods: The study enrolled 44 patients undergoing phacoemulsification with implantation of an Artis Symbiose Mid in the dominant eye and an Artis Symbiose Plus in the nondominant eye. Refraction, uncorrected distance visual acuity (UDVA), corrected distance visual acuity, uncorrected intermediate visual acuity (UIVA), uncorrected near visual acuity (UNVA), electronic reading desk, and a QoV questionnaire were evaluated at 3 months and 12 months postoperatively. Results: The mean binocular UDVA was -0.06 ± 0.08 logMAR and -0.07 ± 0.06 logMAR at 3 months and 12 months ( P = .097), respectively. The mean binocular UIVA was 0.03 ± 0.13 logMAR and 0.03 ± 0.10 logMAR ( P = 1.0), respectively. The mean binocular UNVA was 0.07 ± 0.10 logMAR and 0.07 ± 0.08 logMAR ( P = .875), respectively. There was a significant improvement in QoV for both day and night between 3 and 12 months, with a significant reduction in halos at 12 months. Spectacle independence was reported in 93.2% of cases at 12 months. Conclusions: The Artis Symbiose Mid and Plus IOL combined implantation provided an excellent range of uncorrected vision at 3 and 12 months. There was a significant improvement in QoV and less halos at 12 months. This IOL combination provided very high rates of complete spectacle independence.
MeSH term(s)	Humans ; Multifocal Intraocular Lenses ; Lens Implantation, Intraocular ; Patient Satisfaction ; Prosthesis Design ; Lenses, Intraocular ; Refraction, Ocular ; Phacoemulsification ; Vision, Binocular
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	632744-8
ISSN	1873-4502 ; 0886-3350
ISSN (online)	1873-4502
ISSN	0886-3350
DOI	10.1097/j.jcrs.0000000000001236
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Article ; Online: An Illusion of Barriers to Gene Flow in Suburban Coyotes (Canis latrans): Spatial and Temporal Population Structure across a Fragmented Landscape in Southern California

Bird, Savanah / Monzón, Javier D. / Meyer, Wallace M. / Moore, Jonathan E.

Diversity. 2023 Apr. 01, v. 15, no. 4

2023

Abstract: Carnivores with large home ranges are especially vulnerable to habitat fragmentation. As coyotes (Canis latrans) are often found living in highly modified landscapes, it is unclear how urban and suburban development impact gene flow between their ... ...

Abstract	Carnivores with large home ranges are especially vulnerable to habitat fragmentation. As coyotes (Canis latrans) are often found living in highly modified landscapes, it is unclear how urban and suburban development impact gene flow between their populations. This study evaluated gene flow among coyotes inhabiting California sage scrub fragments within the highly developed Pomona Valley, California. We genotyped microsatellites from scat samples collected from four study sites to examine population structure between coyotes separated by a major freeway, coyotes separated by suburban development, and finally, coyotes in contiguous, natural habitat sites over 15 months. Though coyotes from all four sites were genetically distinct, near-complete turnover of individuals in sites and examination of temporal genetic structure and relatedness within one site indicated the movement of family groups through natural fragments over time. Thus, we argue that solely examining spatial genetic structure may create the illusion of genetic barriers among coyote populations where they may not exist, and that incorporating temporal components of genetic variation is critical to understanding gene flow across space and time in highly mobile animals. Understanding how to better study and manage coyotes, an apex predator, is key to the conservation of the endangered California sage scrub ecosystem.
Keywords	Canis latrans ; ecosystems ; feces ; gene flow ; genetic structure ; genetic variation ; habitat fragmentation ; habitats ; microsatellite repeats ; population structure ; roads ; shrublands ; space and time ; California
Language	English
Dates of publication	2023-0401
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2518137-3
ISSN	1424-2818
ISSN	1424-2818
DOI	10.3390/d15040498
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Visual outcomes and patient satisfaction 1 and 12 months after combined implantation of extended depth of focus and trifocal intraocular lenses.

McNeely, Richard N / Moutari, Salissou / Stewart, Stephen / Moore, Jonathan E

International ophthalmology

2021 Volume 41, Issue 12, Page(s) 3985–3998

Abstract: Purpose: To assess the 1-month and 12-month postoperative visual performance and subjective outcomes following combined implantation of an extended depth of focus (EDOF) intraocular lens (IOL) and a trifocal IOL.: Methods: The study enrolled ... ...

Abstract	Purpose: To assess the 1-month and 12-month postoperative visual performance and subjective outcomes following combined implantation of an extended depth of focus (EDOF) intraocular lens (IOL) and a trifocal IOL. Methods: The study enrolled consecutive patients undergoing refractive lens extraction or cataract surgery with combined implantation of an EDOF IOL (dominant eye) and trifocal IOL. Uncorrected (UDVA) and best-corrected (CDVA) distance visual acuities, uncorrected intermediate (UIVA) and near (UNVA) visual acuities, and subjective questionnaires were evaluated 1 month and 12 months postoperatively. Results: The study enrolled 58 consecutive patients. Binocular UDVA, UIVA and UNVA were - 0.08 ± 0.07 logMAR, 0.15 ± 0.14 logMAR and 0.17 ± 0.11 logMAR at 1 month, compared to - 0.09 ± 0.06 logMAR (P = .323), 0.11 ± 0.10 logMAR (P = .030) and 0.13 ± 0.10 logMAR (P = 0.008) at 12 months. Satisfaction was high with 93.1% of patients fulfilled or more than fulfilled postoperatively, and 84.5% and 86.3% reported spectacle independence for near at the respective postoperative assessments. The mean daytime and nighttime quality of vision (QoV) scores were 9.12 ± 0.94 and 7.88 ± 1.74 at 1 month, compared to 9.24 ± 0.78 (P = .183) and 8.26 ± 1.38 (P = .043) at 12 months. Conclusions: This IOL combination provides good unaided visual acuity at 1 and 12 months postoperatively, with high functional vision and postoperative satisfaction reported at 1 and 12 months. However, a significant improvement in overall nighttime QoV at the 12 months assessment was found.
MeSH term(s)	Eyeglasses ; Humans ; Lens Implantation, Intraocular ; Lenses, Intraocular ; Patient Satisfaction ; Phacoemulsification ; Prospective Studies ; Prosthesis Design ; Refraction, Ocular ; Vision, Binocular
Language	English
Publishing date	2021-09-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-021-01970-3
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Article: Visual and Refractive Outcomes Following Exchange of an Opacified Multifocal Intraocular Lens.

Stewart, Stephen A / McNeely, Richard N / Chan, Wing C / Moore, Jonathan E

Clinical ophthalmology (Auckland, N.Z.)

2022 Volume 16, Page(s) 1883–1891

Abstract: Purpose: To assess the visual and refractive outcomes following exchange of an opacified multifocal intraocular lens (IOL).: Patients and methods: A consecutive series of 37 eyes (31 patients) that underwent IOL exchange between November 2015 and May ...

Abstract	Purpose: To assess the visual and refractive outcomes following exchange of an opacified multifocal intraocular lens (IOL). Patients and methods: A consecutive series of 37 eyes (31 patients) that underwent IOL exchange between November 2015 and May 2021 were included in this study. The indication for surgery in all cases was opacification of a multifocal IOL. Outcome measures included design and anatomical location of the secondary IOL, intraoperative and postoperative complications, visual acuity and refractive accuracy. Results: An opacified Lentis Mplus multifocal IOL was explanted from all eyes and replaced with a monofocal IOL in 21 eyes (57%) and multifocal IOL in 16 eyes (43%). Secondary IOLs were implanted in the capsular bag or sulcus or were iris-fixated. IOL exchange was performed at a mean interval of 7 years after the primary surgery. Anterior vitrectomy was required for vitreous prolapse in 9 eyes (24%). Mean corrected distance visual acuity (CDVA) postoperatively was -0.02 ± 0.08 logMAR for eyes with a monofocal secondary IOL and 0.02 ± 0.08 logMAR for eyes with a multifocal secondary IOL. Mean refractive prediction error was -0.57 ± 0.67 D in the multifocal-monofocal group and -0.33 ± 0.59 D in the multifocal-multifocal group. Conclusion: An opacified multifocal IOL can be exchanged for a monofocal or multifocal IOL, depending on available capsular support and the patient's desired refractive outcome. Vitreous prolapse requiring anterior vitrectomy is the most common intraoperative complication. An improvement in visual acuity and a low postoperative complication rate were achieved in this cohort of patients.
Language	English
Publishing date	2022-06-09
Publishing country	New Zealand
Document type	Journal Article
ISSN	1177-5467
ISSN	1177-5467
DOI	10.2147/OPTH.S362930
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Article ; Online: Teaching a biology laboratory course using Dictyostelium.

Knecht, David A / Cooper, Kate M / Moore, Jonathan E

The International journal of developmental biology

2019 Volume 63, Issue 8-9-10, Page(s) 551–561

Abstract: The Dictyostelium discoideum model system is a powerful tool for undergraduate cell biology teaching laboratories. The cells are biologically safe, grow at room temperature and it is easy to experimentally induce, observe, and perturb a breadth of ... ...

Abstract	The Dictyostelium discoideum model system is a powerful tool for undergraduate cell biology teaching laboratories. The cells are biologically safe, grow at room temperature and it is easy to experimentally induce, observe, and perturb a breadth of cellular processes making the system amenable to many teaching lab situations and goals. Here we outline the advantages of Dictyostelium, discuss laboratory courses we teach in three very different educational settings, and provide tips for both the novice and experienced Dictyostelium researcher. With this article and the extensive sets of protocols and tools referenced here, implementing these labs, or parts of them, will be relatively straightforward for any instructor.
MeSH term(s)	Biology/education ; California ; Cell Adhesion ; Cell Movement ; Cell Proliferation ; Chemotaxis ; Connecticut ; Cytoskeleton/metabolism ; Dictyostelium/genetics ; Dictyostelium/physiology ; Electroporation ; Endocytosis ; Folic Acid/metabolism ; Humans ; Iowa ; Models, Biological ; Phagocytosis ; Phototaxis ; Students ; Teaching ; Universities
Chemical Substances	Folic Acid (935E97BOY8)
Language	English
Publishing date	2019-12-12
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1036070-0
ISSN	1696-3547 ; 0214-6282
ISSN (online)	1696-3547
ISSN	0214-6282
DOI	10.1387/ijdb.190249dk
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Article ; Online: Reply.

McNeely, Richard N / Moore, Jonathan E

Journal of cataract and refractive surgery

2019 Volume 45, Issue 10, Page(s) 1526

MeSH term(s)	Cornea ; Dilatation, Pathologic ; Humans
Language	English
Publishing date	2019-09-30
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	632744-8
ISSN	1873-4502 ; 0886-3350
ISSN (online)	1873-4502
ISSN	0886-3350
DOI	10.1016/j.jcrs.2019.07.040
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Article ; Online: Reply.

McNeely, Richard N / Moore, Jonathan E

Journal of cataract and refractive surgery

2019 Volume 45, Issue 10, Page(s) 1524–1525

MeSH term(s)	Humans ; Keratoconus ; Tomography, Optical Coherence
Language	English
Publishing date	2019-09-30
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	632744-8
ISSN	1873-4502 ; 0886-3350
ISSN (online)	1873-4502
ISSN	0886-3350
DOI	10.1016/j.jcrs.2019.07.038
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