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  1. Article ; Online: Measuring Outcomes in the Treatment of Obesity.

    Jenkins, Megan / Kurian, Marina / Moore, Rachel

    JAMA surgery

    2024  Volume 159, Issue 3, Page(s) 314

    MeSH term(s) Humans ; Obesity ; Body Mass Index ; Outcome Assessment, Health Care ; Treatment Outcome
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2023.6274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Delta-Notch Signaling: The Long and The Short of a Neuron's Influence on Progenitor Fates.

    Moore, Rachel / Alexandre, Paula

    Journal of developmental biology

    2020  Volume 8, Issue 2

    Abstract: Maintenance of the neural progenitor pool during embryonic development is essential to promote growth of the central nervous system (CNS). The CNS is initially formed by tightly compacted proliferative neuroepithelial cells that later acquire radial ... ...

    Abstract Maintenance of the neural progenitor pool during embryonic development is essential to promote growth of the central nervous system (CNS). The CNS is initially formed by tightly compacted proliferative neuroepithelial cells that later acquire radial glial characteristics and continue to divide at the ventricular (apical) and pial (basal) surface of the neuroepithelium to generate neurons. While neural progenitors such as neuroepithelial cells and apical radial glia form strong connections with their neighbours at the apical and basal surfaces of the neuroepithelium, neurons usually form the mantle layer at the basal surface. This review will discuss the existing evidence that supports a role for neurons, from early stages of differentiation, in promoting progenitor cell fates in the vertebrates CNS, maintaining tissue homeostasis and regulating spatiotemporal patterning of neuronal differentiation through Delta-Notch signalling.
    Language English
    Publishing date 2020-03-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720870-9
    ISSN 2221-3759 ; 2221-3759
    ISSN (online) 2221-3759
    ISSN 2221-3759
    DOI 10.3390/jdb8020008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Delta-Notch Signaling: The Long and the Short of a Neuron’s Influence on Progenitor Fates

    Moore, Rachel / Alexandre, Paula

    Journal of developmental biology. 2020 Mar. 26, v. 8, no. 2

    2020  

    Abstract: Maintenance of the neural progenitor pool during embryonic development is essential to promote growth of the central nervous system (CNS). The CNS is initially formed by tightly compacted proliferative neuroepithelial cells that later acquire radial ... ...

    Abstract Maintenance of the neural progenitor pool during embryonic development is essential to promote growth of the central nervous system (CNS). The CNS is initially formed by tightly compacted proliferative neuroepithelial cells that later acquire radial glial characteristics and continue to divide at the ventricular (apical) and pial (basal) surface of the neuroepithelium to generate neurons. While neural progenitors such as neuroepithelial cells and apical radial glia form strong connections with their neighbours at the apical and basal surfaces of the neuroepithelium, neurons usually form the mantle layer at the basal surface. This review will discuss the existing evidence that supports a role for neurons, from early stages of differentiation, in promoting progenitor cell fates in the vertebrates CNS, maintaining tissue homeostasis and regulating spatiotemporal patterning of neuronal differentiation through Delta-Notch signalling.
    Keywords central nervous system ; embryogenesis ; homeostasis ; neuroglia ; neurons ; stem cells
    Language English
    Dates of publication 2020-0326
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720870-9
    ISSN 2221-3759
    ISSN 2221-3759
    DOI 10.3390/jdb8020008
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Microtubules are not required to generate a nascent axon in embryonic spinal neurons in vivo.

    Moore, Rachel E / Pop, Sînziana / Alleyne, Caché / Clarke, Jonathan D W

    EMBO reports

    2022  Volume 23, Issue 11, Page(s) e52493

    Abstract: Our understanding of the cell behaviours and cytoskeletal requirements of axon formation is largely derived from in vitro models but how these relate to axon formation in vivo is not clear. In vitro, neurons progress through a well-defined multineurite ... ...

    Abstract Our understanding of the cell behaviours and cytoskeletal requirements of axon formation is largely derived from in vitro models but how these relate to axon formation in vivo is not clear. In vitro, neurons progress through a well-defined multineurite stage to form an axon and both actin and microtubules cooperate to drive the first steps in neurite and axon morphogenesis. However, these steps are not recapitulated in vivo, and it is not clear whether the underlying cell biological mechanisms may differ also. Here, we investigate the mechanisms that regulate axon formation in embryonic zebrafish spinal neurons in vivo. We find microtubule organising centres are located distant from the site of axon initiation, and microtubule plus-ends are not enriched in the axon during axon initiation. Focal F-actin accumulation precedes axon formation, and we find that nocodazole-treated neurons with no detectable microtubules are still able to form nascent axonal protrusions that are approximately 10-μm long, dilated and relatively long-lived. We suggest spinal axon formation in vivo is fundamentally different from axon formation in in vitro models.
    MeSH term(s) Animals ; Zebrafish ; Microtubules ; Axons/physiology ; Neurons ; Neurites ; Actins
    Chemical Substances Actins
    Language English
    Publishing date 2022-10-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202152493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening.

    Lanne, Alice / Bardelle, Catherine / Davies, Gareth / Turberville, Antonia / Semple, Hannah / Moore, Rachel / Holdgate, Geoffrey A

    SLAS discovery : advancing life sciences R & D

    2024  Volume 29, Issue 4, Page(s) 100156

    Abstract: Fluorescent probe modulation assays are a widely used approach to monitor displacement or stabilisation of fluorescently labelled tool ligands by test compounds. These assays allow an optical read-out of probe-receptor binding and can be used to detect ... ...

    Abstract Fluorescent probe modulation assays are a widely used approach to monitor displacement or stabilisation of fluorescently labelled tool ligands by test compounds. These assays allow an optical read-out of probe-receptor binding and can be used to detect compounds that compete with the labelled ligand, either directly or indirectly. Probes for both orthosteric and allosteric sites are often employed. The method can also be used to identify test compounds that may stabilise the ternary complex, offering an opportunity to discover novel molecular glues. The utility of these fluorescence-based assays within high-throughput screening has been facilitated by the use of streptavidin labelled terbium as a donor and access to a range of different acceptor fluorophores. During 2023, the High-throughput Screening group at AstraZeneca carried out 8 high-throughput screens using these approaches. In this manuscript we will present the types of assays used, an overview of the timelines for assay development and screening, the application of orthogonal artefact methods to aid hit finding and the results of the screens in terms of hit rate and the number of compounds identified with IC
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2885123-7
    ISSN 2472-5560 ; 2472-5552
    ISSN (online) 2472-5560
    ISSN 2472-5552
    DOI 10.1016/j.slasd.2024.100156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Author Correction: Unveiling metabolic pathways involved in the extreme desiccation tolerance of an Atacama cyanobacterium.

    Moore, Rachel A / Azua-Bustos, Armando / González-Silva, Carlos / Carr, Christopher E

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 17677

    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-44829-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Unveiling metabolic pathways involved in the extreme desiccation tolerance of an Atacama cyanobacterium.

    Moore, Rachel A / Azua-Bustos, Armando / González-Silva, Carlos / Carr, Christopher E

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 15767

    Abstract: Gloeocapsopsis dulcis strain AAB1 is an extremely xerotolerant cyanobacterium isolated from the Atacama Desert (i.e., the driest and oldest desert on Earth) that holds astrobiological significance due to its ability to biosynthesize compatible solutes at ...

    Abstract Gloeocapsopsis dulcis strain AAB1 is an extremely xerotolerant cyanobacterium isolated from the Atacama Desert (i.e., the driest and oldest desert on Earth) that holds astrobiological significance due to its ability to biosynthesize compatible solutes at ultra-low water activities. We sequenced and assembled the G. dulcis genome de novo using a combination of long- and short-read sequencing, which resulted in high-quality consensus sequences of the chromosome and two plasmids. We leveraged the G. dulcis genome to generate a genome-scale metabolic model (iGd895) to simulate growth in silico. iGd895 represents, to our knowledge, the first genome-scale metabolic reconstruction developed for an extremely xerotolerant cyanobacterium. The model's predictive capability was assessed by comparing the in silico growth rate with in vitro growth rates of G. dulcis, in addition to the synthesis of trehalose. iGd895 allowed us to explore simulations of key metabolic processes such as essential pathways for water-stress tolerance, and significant alterations to reaction flux distribution and metabolic network reorganization resulting from water limitation. Our study provides insights into the potential metabolic strategies employed by G. dulcis, emphasizing the crucial roles of compatible solutes, metabolic water, energy conservation, and the precise regulation of reaction rates in their adaptation to water stress.
    MeSH term(s) Desiccation ; Cyanobacteria/genetics ; Metabolic Networks and Pathways ; Brassicaceae ; Consensus Sequence ; Dehydration
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-41879-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Risk and Resilient Functioning of Families of Children with Cancer during the COVID-19 Pandemic.

    Gilbert, Renee / Bates, Carolyn R / Khetawat, Devanshi / Dreyer Gillette, Meredith L / Moore, Rachel

    International journal of environmental research and public health

    2023  Volume 20, Issue 6

    Abstract: Previous literature highlights the impact of COVID-19 on family functioning. Less is known about the impact of the pandemic on families of pediatric cancer patients. In order to determine universal and unique risk and resilience factors of these families ...

    Abstract Previous literature highlights the impact of COVID-19 on family functioning. Less is known about the impact of the pandemic on families of pediatric cancer patients. In order to determine universal and unique risk and resilience factors of these families during the pandemic, a qualitative analysis was conducted on families currently receiving cancer treatment at a Midwestern hospital. Results of the data analysis depict ways in which these families have been impacted by and have adapted to COVID-19. These findings suggest that families of pediatric cancer patients have unique experiences in the context of COVID-19, in addition to universal experiences outlined in previous literature.
    MeSH term(s) Humans ; Child ; COVID-19/epidemiology ; Pandemics ; Neoplasms/epidemiology
    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20065208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Barriers and facilitators of family rules and routines during pediatric cancer treatment.

    Bates, Carolyn R / Pallotto, Isabella K / Moore, Rachel M / Covitz, Lynne M / Dreyer Gillette, Meredith L

    Journal of pediatric nursing

    2023  Volume 72, Page(s) e33–e39

    Abstract: Objective: Pediatric nurses work closely with families of children with new cancer diagnoses and can provide essential supports to promote coping and adjustment. This cross-sectional qualitative study aimed to gather caregiver perspectives on barriers ... ...

    Abstract Objective: Pediatric nurses work closely with families of children with new cancer diagnoses and can provide essential supports to promote coping and adjustment. This cross-sectional qualitative study aimed to gather caregiver perspectives on barriers and facilitators to adaptive family functioning during the early phases of cancer treatment, with a focus on family rules and routines.
    Methods: Caregivers (N = 44) of a child diagnosed with cancer and receiving active treatment completed a semi-structured interview about their engagement in family rules and routines. Time since diagnosis was abstracted from the medical record. A multi-pass inductive coding strategy was utilized to extract themes identifying caregiver-reported facilitators and barriers to maintaining consistent family rules and routines during the first year of pediatric treatment.
    Results: Caregivers identified three primary contexts that presented barriers and facilitators to engagement in family rules and routines: the hospital setting (n = 40), the family system (n = 36), and the broader social and community setting (n = 26). Caregivers reported barriers primarily related to the demands of their child's treatment, additional caregiving needs, and needing to prioritize basic daily tasks (e.g., food, rest, household needs). Caregivers reported that different networks of support across contexts facilitated family rules and routines by expanding caregiver capacity in distinctive ways.
    Conclusions: Findings provided insight into the importance of having multiple networks of support to extend caregiving capacity in the context of cancer treatment demands.
    Practice implications: Providing nurses with training to facilitate problem-solving skills in the context of competing demands may provide a new avenue of clinical intervention at the bedside.
    MeSH term(s) Child ; Humans ; Cross-Sectional Studies ; Adaptation, Psychological ; Caregivers ; Hospitals ; Qualitative Research ; Neoplasms/therapy
    Language English
    Publishing date 2023-06-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632731-x
    ISSN 1532-8449 ; 0882-5963
    ISSN (online) 1532-8449
    ISSN 0882-5963
    DOI 10.1016/j.pedn.2023.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Protrusion-Mediated Signaling Regulates Patterning of the Developing Nervous System.

    Moore, Rachel E / Clarke, Jon / Alexandre, Paula

    Frontiers in cell and developmental biology

    2020  Volume 8, Page(s) 579073

    Abstract: During brain development, the tissue pattern and specification are the foundation of neuronal circuit formation. Contact-mediated lateral inhibition is well known to play an important role in determining cell fate decisions in the nervous system by ... ...

    Abstract During brain development, the tissue pattern and specification are the foundation of neuronal circuit formation. Contact-mediated lateral inhibition is well known to play an important role in determining cell fate decisions in the nervous system by either regulating tissue boundary formation or the classical salt-and-pepper pattern of differentiation that results from direct neighboring cell contacts. In many systems, however, such as the
    Language English
    Publishing date 2020-09-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2020.579073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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