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  1. Article: The SEACIT complex is involved in the maintenance of vacuole–mitochondria contact sites and controls mitophagy

    Ma, Yinxing / Moors, Alexis / Camougrand, Nadine / Dokudovskaya, Svetlana

    Cellular and molecular life sciences. 2019 Apr., v. 76, no. 8

    2019  

    Abstract: The major signaling pathway that regulates cell growth and metabolism is under the control of the target of rapamycin complex 1 (TORC1). In Saccharomyces cerevisiae the SEA complex is one of the TORC1 upstream regulators involved in amino acid sensing ... ...

    Abstract The major signaling pathway that regulates cell growth and metabolism is under the control of the target of rapamycin complex 1 (TORC1). In Saccharomyces cerevisiae the SEA complex is one of the TORC1 upstream regulators involved in amino acid sensing and autophagy. Here, we performed analysis of the expression, interactions and localization of SEA complex proteins under different conditions, varying parameters such as sugar source, nitrogen availability and growth phase. Our results show that the SEA complex promotes mitochondria degradation either by mitophagy or by general autophagy. In addition, the SEACIT subcomplex is involved in the maintenance of the vacuole–mitochondria contact sites. Thus, the SEA complex appears to be an important link between the TORC1 pathway and regulation of mitochondria quality control.
    Keywords Saccharomyces cerevisiae ; amino acids ; cell growth ; developmental stages ; metabolism ; mitochondria ; mitophagy ; nitrogen ; proteins ; rapamycin ; signal transduction ; sugars
    Language English
    Dates of publication 2019-04
    Size p. 1623-1640.
    Publishing place Springer International Publishing
    Document type Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-019-03015-6
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: The SEACIT complex is involved in the maintenance of vacuole-mitochondria contact sites and controls mitophagy.

    Ma, Yinxing / Moors, Alexis / Camougrand, Nadine / Dokudovskaya, Svetlana

    Cellular and molecular life sciences : CMLS

    2019  Volume 76, Issue 8, Page(s) 1623–1640

    Abstract: The major signaling pathway that regulates cell growth and metabolism is under the control of the target of rapamycin complex 1 (TORC1). In Saccharomyces cerevisiae the SEA complex is one of the TORC1 upstream regulators involved in amino acid sensing ... ...

    Abstract The major signaling pathway that regulates cell growth and metabolism is under the control of the target of rapamycin complex 1 (TORC1). In Saccharomyces cerevisiae the SEA complex is one of the TORC1 upstream regulators involved in amino acid sensing and autophagy. Here, we performed analysis of the expression, interactions and localization of SEA complex proteins under different conditions, varying parameters such as sugar source, nitrogen availability and growth phase. Our results show that the SEA complex promotes mitochondria degradation either by mitophagy or by general autophagy. In addition, the SEACIT subcomplex is involved in the maintenance of the vacuole-mitochondria contact sites. Thus, the SEA complex appears to be an important link between the TORC1 pathway and regulation of mitochondria quality control.
    MeSH term(s) Autophagy/physiology ; Gene Deletion ; Glucose/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mitochondria/metabolism ; Mitochondrial Degradation/physiology ; Nitrogen/metabolism ; Oxygen/metabolism ; Reactive Oxygen Species/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/growth & development ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Vacuoles/metabolism
    Chemical Substances Membrane Proteins ; Reactive Oxygen Species ; Saccharomyces cerevisiae Proteins ; TORC1 protein complex, S cerevisiae ; Transcription Factors ; Glucose (IY9XDZ35W2) ; Nitrogen (N762921K75) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2019-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-019-03015-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

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