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Article: Increase in pediatric recurrent fever evaluations during the first year of the COVID-19 pandemic in North America.

Mansfield, Leanne M / Lapidus, Sivia K / Romero, Samira Nazzar / Moorthy, Lakshmi N / Adler-Shohet, Felice C / Hollander, Matthew / Cherian, Julie / Twilt, Marinka / Lionetti, Geraldina / Mohan, Smriti / DeLaMora, Patricia A / Durrant, Karen L / Muskardin, Theresa Wampler / Correia Marques, Mariana / Onel, Karen B / Dedeoglu, Fatma / Gutierrez, Maria J / Schulert, Grant

Frontiers in pediatrics

2023 Volume 11, Page(s) 1240242

Abstract: The impact of the COVID-19 pandemic on new diagnoses of recurrent fevers and autoinflammatory diseases is largely unknown. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) PFAPA/AID Working Group aimed to investigate the impact of the ... ...

Abstract	The impact of the COVID-19 pandemic on new diagnoses of recurrent fevers and autoinflammatory diseases is largely unknown. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) PFAPA/AID Working Group aimed to investigate the impact of the COVID-19 pandemic on the number of pediatric patients evaluated for recurrent fevers and autoinflammatory diseases in North America. The absolute number of new outpatient visits and the proportion of these visits attributed to recurrent fever diagnoses during the pre-pandemic period (1 March 2019-29 February 2020) and the first year of the COVID-19 pandemic (1 March 2020-28 February 2021) were examined. Data were collected from 27 sites in the United States and Canada. Our results showed an increase in the absolute number of new visits for recurrent fever evaluations in 21 of 27 sites during the COVID-19 pandemic compared to the pre-pandemic period. The increase was observed across different geographic regions in North America. Additionally, the proportion of new visits to these centers for recurrent fever in relation to all new patient evaluations was significantly higher during the first year of the pandemic, increasing from 7.8% before the pandemic to 10.9% during the pandemic year (
Language	English
Publishing date	2023-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1240242
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Article: Corrigendum: Increase in pediatric recurrent fever evaluations during the first year of the COVID-19 pandemic in North America.

Frontiers in pediatrics

2023 Volume 11, Page(s) 1323946

Abstract: This corrects the article DOI: 10.3389/fped.2023.1240242.]. ...

Abstract	[This corrects the article DOI: 10.3389/fped.2023.1240242.].
Language	English
Publishing date	2023-11-06
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1323946
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Article ; Online: Case 1: Alopecia in a Healthy 9-year-old Girl.

Magrini, Danielle / Li, Suzanne C / Bhise, Vikram / Weiss, Pamela F / Moorthy, Lakshmi N

Pediatrics in review

2015 Volume 36, Issue 11, Page(s) 503–505

MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Alopecia/etiology ; Child ; Dermatologic Agents/therapeutic use ; Diagnosis, Differential ; Female ; Humans ; Methotrexate/therapeutic use ; Scleroderma, Localized/complications ; Scleroderma, Localized/diagnosis ; Scleroderma, Localized/drug therapy
Chemical Substances	Adrenal Cortex Hormones ; Dermatologic Agents ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2015-11
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	774515-1
ISSN	1526-3347 ; 0191-9601
ISSN (online)	1526-3347
ISSN	0191-9601
DOI	10.1542/pir.36-11-503
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Article ; Online: Abdominal pain, rash, and arthritis.

Parlow, Brittany / Mohiuddin, Adil / Chou, Theodore / Cato-Varlack, Janice / Boneparth, Alexis / Moorthy, Lakshmi N

Clinical pediatrics

2015 Volume 54, Issue 5, Page(s) 498–500

MeSH term(s)	Abdominal Pain/etiology ; Adolescent ; Anti-Inflammatory Agents/therapeutic use ; Antirheumatic Agents/therapeutic use ; Arthritis/etiology ; Azathioprine/therapeutic use ; Cyclophosphamide/therapeutic use ; Diagnosis, Differential ; Exanthema/etiology ; Female ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnosis ; Granulomatosis with Polyangiitis/therapy ; Hemoptysis/etiology ; Humans ; Immunosuppressive Agents/therapeutic use ; Methylprednisolone Hemisuccinate/therapeutic use ; Plasmapheresis ; Prednisone/therapeutic use ; Rituximab/therapeutic use
Chemical Substances	Anti-Inflammatory Agents ; Antirheumatic Agents ; Immunosuppressive Agents ; Rituximab (4F4X42SYQ6) ; Methylprednisolone Hemisuccinate (5GMR90S4KN) ; Cyclophosphamide (8N3DW7272P) ; Azathioprine (MRK240IY2L) ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Clinical Conference ; Journal Article
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/0009922814554502
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Article: Quality of life measures and psychiatric symptoms in adolescents with systemic lupus erythematosus and familial Mediterranean fever.

Düzçeker, Yasemin / Kanbur, Nuray Ö / Demirkaya, Erkan / Derman, Orhan / Moorthy, Lakshmi N / Ozen, Seza

International journal of adolescent medicine and health

2014 Volume 26, Issue 4, Page(s) 541–549

Abstract: Purpose: To describe the relation between global Quality of Life (QL) and psychiatric symptoms in adolescents with systemic lupus erythematosus (SLE) and familial Mediterranean fever (FMF), and to analyze the perceptions of parents and adolescents.: ... ...

Abstract	Purpose: To describe the relation between global Quality of Life (QL) and psychiatric symptoms in adolescents with systemic lupus erythematosus (SLE) and familial Mediterranean fever (FMF), and to analyze the perceptions of parents and adolescents. Methods: This study included 51 adolescents diagnosed with SLE (n=25) and FMF (n=26), and 51 healthy adolescents. The Health Related QL (HRQL) of SLE patients was rated by parents and adolescents using the Simple Measurement of Impact of Lupus Erythematosus in Youngsters© (SMILEY©). The global QL of FMF patients and healthy adolescents was rated by the response given to the first question of the SMILEY© by each parent and adolescent. All participants completed the Brief Symptom Inventory (BSI), which measures psychiatric symptoms. Results: In total, 92.3% with FMF, 56% with SLE and 76.5% of healthy adolescents reported their global QL as good and very good using the first question of the SMILEY©. The global QL perceptions of adolescents and their parents did not correlate (FMF, p=0.94; SLE, p=0.16). SLE patients had the highest rate of depression (54.2%), whereas hostility was detected among 54.9% of healthy adolescents. Significant relations were detected between BSI and SMILEY© scores. Conclusion: The global QL perceptions of adolescents with FMF were better than those of healthy adolescents, which may be explained by their perceived relief of anguish they suffer during their short-lived attacks. The global QL perceptions of adolescents with SLE were the worst, most probably due to the chronic course resulting in an awareness of limitations and intense treatment. Adolescents with SLE had similar psychopathological symptom scores when compared with FMF patients and healthy adolescents. This could be explained by developing resilience. Differences in the perception of adolescents versus their parents regarding global QL emphasized the importance of adolescent-specific interviews for chronic illnesses and multidisciplinary follow-up with adolescent medicine.
MeSH term(s)	Adolescent ; Familial Mediterranean Fever/psychology ; Female ; Humans ; Lupus Erythematosus, Systemic/psychology ; Male ; Mental Health ; Parents ; Quality of Life ; Severity of Illness Index
Language	English
Publishing date	2014
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639287-8
ISSN	2191-0278 ; 0334-0139
ISSN (online)	2191-0278
ISSN	0334-0139
DOI	10.1515/ijamh-2013-0332
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Article ; Online: Burden of childhood-onset arthritis.

Moorthy, Lakshmi N / Peterson, Margaret Ge / Hassett, Afton L / Lehman, Thomas Ja

Pediatric rheumatology online journal

2010 Volume 8, Page(s) 20

Abstract: Juvenile arthritis comprises a variety of chronic inflammatory diseases causing erosive arthritis in children, often progressing to disability. These children experience functional impairment due to joint and back pain, heel pain, swelling of joints and ... ...

Abstract	Juvenile arthritis comprises a variety of chronic inflammatory diseases causing erosive arthritis in children, often progressing to disability. These children experience functional impairment due to joint and back pain, heel pain, swelling of joints and morning stiffness, contractures, pain, and anterior uveitis leading to blindness. As children who have juvenile arthritis reach adulthood, they face possible continuing disease activity, medication-associated morbidity, and life-long disability and risk for emotional and social dysfunction. In this article we will review the burden of juvenile arthritis for the patient and society and focus on the following areas: patient disability; visual outcome; other medical complications; physical activity; impact on HRQOL; emotional impact; pain and coping; ambulatory visits, hospitalizations and mortality; economic impact; burden on caregivers; transition issues; educational occupational outcomes, and sexuality.The extent of impact on the various aspects of the patients', families' and society's functioning is clear from the existing literature. Juvenile arthritis imposes a significant burden on different spheres of the patients', caregivers' and family's life. In addition, it imposes a societal burden of significant health care costs and utilization. Juvenile arthritis affects health-related quality of life, physical function and visual outcome of children and impacts functioning in school and home. Effective, well-designed and appropriately tailored interventions are required to improve transitioning to adult care, encourage future vocation/occupation, enhance school function and minimize burden on costs.
Language	English
Publishing date	2010-07-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2279468-2
ISSN	1546-0096 ; 1546-0096
ISSN (online)	1546-0096
ISSN	1546-0096
DOI	10.1186/1546-0096-8-20
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Article ; Online: Successful Treatment of Henoch-Schönlein Purpura With Recurrent Gastrointestinal Involvement With Mycophenolate Mofetil: A Brief Report.

Chou, Theodore / Louissant, Valerie R / Adams, Alexa / Gurkan, Sevgi / Chefitz, Dalya / Weller, Alan S / Moorthy, Lakshmi N

Clinical pediatrics

2015 Volume 54, Issue 9, Page(s) 900–903

MeSH term(s)	Abdominal Pain/etiology ; Child ; Diarrhea/etiology ; Humans ; Immunosuppressive Agents/therapeutic use ; Male ; Mycophenolic Acid/analogs & derivatives ; Mycophenolic Acid/therapeutic use ; Purpura, Schoenlein-Henoch/complications ; Purpura, Schoenlein-Henoch/drug therapy ; Recurrence ; Treatment Outcome
Chemical Substances	Immunosuppressive Agents ; Mycophenolic Acid (HU9DX48N0T)
Language	English
Publishing date	2015-08
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/0009922814568288
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Article ; Online: Burden of childhood-onset arthritis

Hassett Afton L / Peterson Margaret GE / Moorthy Lakshmi N / Lehman Thomas JA

Pediatric Rheumatology, Vol 8, Iss 1, p

2010 Volume 20

Abstract: Abstract Juvenile arthritis comprises a variety of chronic inflammatory diseases causing erosive arthritis in children, often progressing to disability. These children experience functional impairment due to joint and back pain, heel pain, swelling of ... ...

Abstract	Abstract Juvenile arthritis comprises a variety of chronic inflammatory diseases causing erosive arthritis in children, often progressing to disability. These children experience functional impairment due to joint and back pain, heel pain, swelling of joints and morning stiffness, contractures, pain, and anterior uveitis leading to blindness. As children who have juvenile arthritis reach adulthood, they face possible continuing disease activity, medication-associated morbidity, and life-long disability and risk for emotional and social dysfunction. In this article we will review the burden of juvenile arthritis for the patient and society and focus on the following areas: patient disability; visual outcome; other medical complications; physical activity; impact on HRQOL; emotional impact; pain and coping; ambulatory visits, hospitalizations and mortality; economic impact; burden on caregivers; transition issues; educational occupational outcomes, and sexuality. The extent of impact on the various aspects of the patients', families' and society's functioning is clear from the existing literature. Juvenile arthritis imposes a significant burden on different spheres of the patients', caregivers' and family's life. In addition, it imposes a societal burden of significant health care costs and utilization. Juvenile arthritis affects health-related quality of life, physical function and visual outcome of children and impacts functioning in school and home. Effective, well-designed and appropriately tailored interventions are required to improve transitioning to adult care, encourage future vocation/occupation, enhance school function and minimize burden on costs.
Keywords	Diseases of the musculoskeletal system ; RC925-935 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Pediatrics ; RJ1-570 ; DOAJ:Pediatrics
Subject code	360
Language	English
Publishing date	2010-07-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus

Walters Heather M / Pan Nancy / Moorthy Lakshmi N / Ward Mary J / Peterson Margaret G / Lehman Thomas J

Pediatric Rheumatology, Vol 10, Iss 1, p

2012 Volume 22

Abstract: Abstract Background A high prevalence of autoimmune disease (AD) has been documented in relatives of adult patients with systemic lupus erythematosus (SLE). However, data on familial inheritance patterns in pediatric SLE patients is scarce. Findings The ... ...

Abstract	Abstract Background A high prevalence of autoimmune disease (AD) has been documented in relatives of adult patients with systemic lupus erythematosus (SLE). However, data on familial inheritance patterns in pediatric SLE patients is scarce. Findings The charts of 69 patients with pediatric-onset SLE were reviewed retrospectively. The primary aim was to describe the prevalence and types of AD in relatives of children with SLE. The secondary aims were: 1) to compare severity of SLE in children with and without relatives affected by AD, and 2) to evaluate the impact of baseline demographics on severity of SLE in subjects. At diagnosis, 42% of subjects had one or more first, second, or third degree relative(s) with AD; and 32% of subjects had one or more first degree relative(s) with AD. The most common diseases in relatives of children with SLE were SLE (21%) and thyroid disease (15%). Subjects with no family history of AD were more likely to have severe SLE. SLE severity in subjects did not differ by gender. Children presenting with SLE at an earlier age were found to have more severe disease. Conclusions This study demonstrated a high prevalence of AD in families of children with SLE, although a family history of AD did not correlate with more severe SLE in subjects. Future larger studies are necessary to elucidate patterns of familial inheritance and baseline patient characteristics that may affect severity of disease in pediatric SLE.
Keywords	Pediatric systemic lupus erythematosus ; Severity ; Inheritance patterns ; Diseases of the musculoskeletal system ; RC925-935 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Pediatrics ; RJ1-570 ; DOAJ:Pediatrics
Subject code	610
Language	English
Publishing date	2012-08-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Improving transition readiness and quality of life (QOL) with a pediatric lupus health passport

Von Scheven Emily / Tucker Lori B / Moorthy Lakshmi N / Lawson Erica F / Neville Carolyn / DaCosta Deborah / Fortin Paul R

Pediatric Rheumatology, Vol 10, Iss Suppl 1, p A

2012 Volume 23

Keywords	Diseases of the musculoskeletal system ; RC925-935 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Pediatrics ; RJ1-570 ; DOAJ:Pediatrics
Language	English
Publishing date	2012-07-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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