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Article ; Online: Evaluation of screening practices for primary hyperaldosteronism by specialists and general practitioners: an observational, cross-sectional study.

Fernandes Taboada, Giselle / Barbosa Moraes, Aline / Vieira, Leonardo

Archives of endocrinology and metabolism

2024 Volume 68, Page(s) e230211

Abstract: Objective: Despite its recognized importance, primary hyperaldosteronism (PHA) remains an underdiagnosed condition in clinical practice. The objective of the present study was to evaluate PHA screening practices by general practitioners and specialists ... ...

Abstract	Objective: Despite its recognized importance, primary hyperaldosteronism (PHA) remains an underdiagnosed condition in clinical practice. The objective of the present study was to evaluate PHA screening practices by general practitioners and specialists in endocrinology and cardiology. Subjects and methods: This cross-sectional, observational study invited physicians to respond voluntarily to an online survey. The survey collected the respondents' sociodemographic data and answers to five hypothetical clinical cases meeting Endocrine Society criteria for PHA screening. Results: In all, 126 physicians responded to the online survey. Endocrinologists were the specialists who most often chose PHA screening, although the screening rates were overall low, ranging from 36.5% to 92.9%, depending on the case and the respondents' specialty. The survey also assessed the reasons for not choosing PHA screening, which included limited availability of tests within the public health services, interference of antihypertensive medications on hormone levels, and failure to identify the screening indication. Being an endocrinologist was an independent predictor for choosing PHA screening for the patients in Cases #1 and #5 (p = 0.001 and p = 0.002, respectively). Conclusion: Endocrinologists were the specialists who most often chose PHA screening, although the screening rates were overall low among all specialists. These findings highlight a need for continuing medical education programs addressing PHA screening and making the diagnosis of PHA more present in the daily clinical practice of physicians treating patients with hypertension.
MeSH term(s)	Humans ; Cross-Sectional Studies ; General Practitioners ; Hypertension ; Antihypertensive Agents ; Hyperaldosteronism/diagnosis ; Hyperaldosteronism/drug therapy
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2024-03-25
Publishing country	Brazil
Document type	Observational Study ; Journal Article
ISSN	2359-4292
ISSN (online)	2359-4292
DOI	10.20945/2359-4292-2023-0211
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Population-based surveillance for birth defects potentially related to Zika virus infection including 3-year mortality and developmental outcomes, and Early Intervention Program service use-New York City, 2016 birth cohort.

McVeigh, Katharine H / Tseyang, Tenzin / Vachon, Mary-Elizabeth / Moraes, Aurora

Birth defects research

2024 Volume 116, Issue 3, Page(s) e2320

Abstract: Background: In response to the 2015-2017 Zika virus outbreak, New York City (NYC) identified and monitored infants with birth defects potentially related to congenital Zika virus.: Methods: Administrative data matches were used to describe the birth ... ...

Abstract	Background: In response to the 2015-2017 Zika virus outbreak, New York City (NYC) identified and monitored infants with birth defects potentially related to congenital Zika virus. Methods: Administrative data matches were used to describe the birth characteristics of children born in 2016 meeting screening criteria for birth defects potentially related to congenital Zika virus infection relative to other NYC births and to monitor mortality and Early Intervention Program use through age 2. Results: Among 120,367 children born in NYC in 2016, 463 met screening criteria and 155 met the Centers for Disease Control and Prevention's case definition for birth defects potentially related to congenital Zika virus infection (1.3 per 1000; 95% confidence interval [CI], 1.1-1.5). Post-neonatal deaths occurred among 7.7% of cases (12) and 5.2% of non-cases (8). Odds of referral to the Early intervention Program among children who met screening criteria were lower among children of mothers who were married (OR, 0.60; 95% CI, 0.37-0.97) and among children not classified as cases whose mothers were born in Latin America and the Caribbean (OR, 0.59; 95% CI, 0.37-1.09). Discussion: Prevalence of birth defects potentially related to congenital Zika virus infection was similar to that seen in other jurisdictions without local transmission. Birth defects attributable to congenital Zika virus infection may also have been present among screened children who did not meet the case definition.
MeSH term(s)	Infant, Newborn ; Infant ; Pregnancy ; Female ; Child ; Humans ; Child, Preschool ; Zika Virus Infection/epidemiology ; Zika Virus ; New York City ; Birth Cohort ; Early Medical Intervention ; Pregnancy Complications, Infectious ; Microcephaly/epidemiology
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2104792-3
ISSN	2472-1727
ISSN (online)	2472-1727
DOI	10.1002/bdr2.2320
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Article ; Online: Cirrhosis Management in the Intensive Care Unit.

Smith, Thomas N / Gallo de Moraes, Alice / Simonetto, Douglas A

Seminars in liver disease

2023 Volume 43, Issue 1, Page(s) 117–132

Abstract: Patients with cirrhosis frequently require admission to the intensive care unit as complications arise in the course of their disease. These admissions are associated with high short- and long-term morbidity and mortality. Thus, understanding and ... ...

Abstract	Patients with cirrhosis frequently require admission to the intensive care unit as complications arise in the course of their disease. These admissions are associated with high short- and long-term morbidity and mortality. Thus, understanding and characterizing complications and unique needs of patients with cirrhosis and acute-on-chronic liver failure helps providers identify appropriate level of care and evidence-based treatments. While there is no widely accepted critical care admission criteria for patients with cirrhosis, the presence of organ failure and primary or nosocomial infections are associated with particularly high in-hospital mortality. Optimal management of patients with cirrhosis in the critical care setting requires a system-based approach that acknowledges deviations from canonical pathophysiology. In this review, we discuss appropriate considerations and evidence-based practices for the general care of patients with cirrhosis and critical illness.
MeSH term(s)	Humans ; Liver Cirrhosis/complications ; Intensive Care Units ; Critical Care ; Hospitalization ; Hospital Mortality ; Prognosis
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	603177-8
ISSN	1098-8971 ; 0272-8087
ISSN (online)	1098-8971
ISSN	0272-8087
DOI	10.1055/a-2015-1290
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Article ; Online: 43-Year-Old Woman With Painful Jaundice.

James, Amy / Gary, Phillip / Gallo De Moraes, Alice

Mayo Clinic proceedings

2022 Volume 97, Issue 7, Page(s) 1369–1374

MeSH term(s)	Female ; Humans ; Jaundice/diagnosis ; Jaundice/etiology ; Pain
Language	English
Publishing date	2022-07-04
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.1016/j.mayocp.2022.01.017
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Article ; Online: Effect of application rate of sodium nitrite and hexamine on the fermentation and the chemical composition of guinea grass silage harvested at different stages of maturity

Moraes, A. / Auerbach, H.U. / Bragatto, J.M. / Piran Filho, F.A. / Silva, S.M.S. / Nussio, L.G. / Jobim, C.C. / Daniel, J.L.P.

Animal Feed Science and Technology. 2023 Aug., v. 302 p.115667-

2023

Abstract: Grass ensilability varies with maturity stage, mainly due to changing concentrations of dry matter and soluble carbohydrates with progressing forage maturity. Consequently, the required dose of silage additive to prevent the development of undesirable ... ...

Abstract	Grass ensilability varies with maturity stage, mainly due to changing concentrations of dry matter and soluble carbohydrates with progressing forage maturity. Consequently, the required dose of silage additive to prevent the development of undesirable microorganisms may change with maturity stage. The objective of this study was to verify whether the application rate of an additive containing sodium nitrite and hexamine interacts with guinea grass maturity to alter silage fermentation and chemical composition. Four fields of guinea grass (0.5–0.7 ha each field) were mowed and divided into two plots per field. After 5 wk, one plot of each field was mowed again to establish differences in stage of maturity. Ten weeks after the first mowing, the grass plots with 5- and 10-wk regrowth were manually harvested and used for the trial. The grass from each plot (approx. 30 kg) was chopped and divided into 3 piles, totaling to 24 piles, as result of four fields, two maturities, and three additive treatments: control (without additive), low dose of sodium nitrite (0.5 g/kg) + hexamine (0.325 g/kg) (NHL), and high dose of sodium nitrite (1 g/kg) + hexamine (0.65 g/kg) (NHH). After 90 d of storage, the silos were opened and silages sampled to determine dry matter (DM) loss, microbial counts, fermentation end-products, aerobic stability, chemical composition, and in vitro DM digestibility. Guinea grass harvested at 10-wk regrowth had a lower content of crude protein (P < 0.001) and a greater content of cell wall components (P < 0.001), resulting in a more lignified (P < 0.001) and less digestible (P < 0.001) forage than that harvested at 5 wk. There were interactions between plant maturity and additive dose for several silage traits (P < 0.05), likely due to the slightly greater fermentability coefficient (+5.1 points) for the more mature grass (P < 0.001). Within each maturity stage, silage pH and fermentation end-products associated with clostridia metabolism (i.e., n-butyric acid, propionic acid, i-butyric acid, i-valeric acid, n-valeric acid, ammonia, and 2,3-butanediol) linearly decreased (P < 0.001) with additive application rate, but the magnitude of improvement was slightly greater for 5-wk than 10-wk regrowth. Application of additive linearly decreased silage DM loss at both 5-wk (95.2, 46.7, and 20.6 g/kg DM, P < 0.001) and 10-wk (66.5, 31.7, and 13.6 g/kg DM, P < 0.001) regrowth stages, but only silages treated with NHH had n-butyric acid concentration < 3 g/kg DM. The proportion of rumen undegradable protein (P < 0.001), soluble carbohydrates concentration (P < 0.001), and in vitro DM digestibility (P < 0.001) were linearly increased with additive dose within each maturity stage. As treated silages were better conserved, silage aerobic stability was linearly reduced (P < 0.001) with additive dose, although all silages were aerobically stable for ≥ 4.7 d. In conclusion, the additive based on sodium nitrite and hexamine, applied at a regular dose, was able to largely restrict Clostridium development and DM losses during fermentation of guinea grass silage at both maturity stages. However, harvesting more mature grass markedly impaired its chemical composition and digestibility, rendering it no feasible strategy to reduce the additive application rate by half.
Keywords	Clostridium ; Megathyrsus maximus ; ammonia ; application rate ; cell walls ; crude protein ; digestibility ; forage ; grass silage ; grasses ; maturity stage ; pH ; propionic acid ; regrowth ; silage additives ; silage fermentation ; sodium nitrite ; valeric acid ; ADF ; aNDF ; BC ; CFU ; CONN ; CP ; DM ; FC ; FM ; HEX ; iNDF ; IVDMD ; LAB ; NH3-Ncorr ; NHH ; NHL ; NIT ; RDP ; RUP ; SC ; SEM ; Sum BVA ; undVFA ; undVFA/SC+lactic acid ; VFA ; Chemical additive ; Fermentation ; Tropical grass
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	196563-3
ISSN	0377-8401
ISSN	0377-8401
DOI	10.1016/j.anifeedsci.2023.115667
Database	NAL-Catalogue (AGRICOLA)

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Article ; Conference proceedings: Neurodevelopmental disorder associated with the DOCK7 gene

Lopes, Icaro Bertechini Soler / Lopes, Nadia Bertechini Soler / Moraes, Aluana

Arquivos de Neuro-Psiquiatria

2023 Volume 81, Issue S 01

Event/congress	SBN Conference 2022, Expo United Curitiba, 2022-11-09
Language	English
Publishing date	2023-09-01
Publisher	Thieme Revinter Publicações Ltda.
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	418916-4
ISSN	1678-4227 ; 0004-282X
ISSN (online)	1678-4227
ISSN	0004-282X
DOI	10.1055/s-0043-1774589
Database	Thieme publisher's database

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Article ; Online: New Decade, Old Debate: Blocking the Cytokine Pathways in Infection-Induced Cytokine Cascade.

Rizvi, Mahrukh S / Gallo De Moraes, Alice

Critical care explorations

2021 Volume 3, Issue 3, Page(s) e0364

Abstract: Objectives: Our understanding of the immunopathogenesis of coronavirus disease 2019 is evolving; however, a "cytokine storm" has been implicated. Ongoing clinical trials are evaluating the value of anticytokine therapies to treat patients with ... ...

Abstract	Objectives: Our understanding of the immunopathogenesis of coronavirus disease 2019 is evolving; however, a "cytokine storm" has been implicated. Ongoing clinical trials are evaluating the value of anticytokine therapies to treat patients with coronavirus disease 2019. This review summarizes the existing literature evaluating the efficacy and safety of anticytokine therapy to tackle the dysregulated immune response to infectious pathogens, discusses potential reasons for failure, applicability to coronavirus disease 2019, and future direction. Data sources: Medline, PubMed, ClinicalTrials.gov, and media reports. Study selection: The studies were included by author consensus. Data extraction: Data were selected for inclusion after reviewing each study by author consensus. Data synthesis: "Cytokine storm" is a nonspecific term, encompassing systemic inflammatory response to infectious pathogens, autoimmune conditions, cancers, trauma, and various chemotherapies. Like bacterial sepsis, viral pathogens may fuel immunopathogenesis by inducing a dysregulated autoamplifying cytokine cascade, ultimately leading to organ injury. This narrative review discusses what we know of the immune milieu of coronavirus disease 2019 versus noncoronavirus disease 2019 sepsis and/or acute respiratory distress syndrome, summarizes the existing literature on cytokine inhibitors in patients with sepsis and/or acute respiratory distress syndrome, and discusses possible reasons for recurrent failure. In doing so, it aims to assist decisions regarding the use of anticytokine therapy in patients with coronavirus disease 2019, as many regions of the world confront the second wave of the pandemic. Conclusions: As ongoing clinical trials determine the efficacy and safety of anticytokine therapy in patients with coronavirus disease 2019, clinicians should uphold caution when incorporating it into treatment protocols, while maintaining focus on established evidence-based practices and the mantra of "less is more."
Language	English
Publishing date	2021-03-23
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2639-8028
ISSN (online)	2639-8028
DOI	10.1097/CCE.0000000000000364
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Family Members of Transferred Critically Ill Patients Also Need Care.

Gallo de Moraes, Alice / Clain, Jeremy

Chest

2021 Volume 160, Issue 3, Page(s) 793–794

MeSH term(s)	Critical Illness ; Family ; Humans ; Intensive Care Units
Language	English
Publishing date	2021-09-06
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2021.04.052
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Ui III Zs.45: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Video versus direct laryngoscopy in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials.

Araújo, Beatriz / Rivera, André / Martins, Suzany / Abreu, Renatha / Cassa, Paula / Silva, Maicon / Gallo de Moraes, Alice

Critical care (London, England)

2024 Volume 28, Issue 1, Page(s) 1

Abstract: Background: The utilization of video laryngoscopy (VL) has demonstrated superiority over direct laryngoscopy (DL) for intubation in surgical settings. However, its effectiveness in the intensive care unit and emergency department settings remains ... ...

Abstract	Background: The utilization of video laryngoscopy (VL) has demonstrated superiority over direct laryngoscopy (DL) for intubation in surgical settings. However, its effectiveness in the intensive care unit and emergency department settings remains uncertain. Methods: We systematically searched PubMed, Embase, Cochrane, and ClinicalTrials.gov databases for randomized controlled trials (RCTs) comparing VL versus DL in critically ill patients. Critical setting was defined as emergency department and intensive care unit. This systematic review and meta-analysis followed Cochrane and PRISMA recommendations. R version 4.3.1 was used for statistical analysis and heterogeneity was examined with I Results: Our meta-analysis of 14 RCTs, compromising 3981 patients assigned to VL (n = 2002) or DL (n = 1979). Compared with DL, VL significantly increased successful intubations on the first attempt (RR 1.12; 95% CI 1.04-1.20; p < 0.01; I Conclusion: VL is a more effective and safer strategy compared with DL for increasing successful intubations on the first attempt and reducing esophageal intubations in critically ill patients. Our findings support the routine use of VL in critically ill patients. Registration CRD42023439685 https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023439685 . Registered 6 July 2023.
MeSH term(s)	Humans ; Laryngoscopy ; Intubation, Intratracheal ; Critical Illness/therapy ; Randomized Controlled Trials as Topic ; Laryngoscopes ; Video Recording
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-023-04727-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cylindrospermopsin impairs zebrafish (Danio rerio) embryo development.

Moraes, A C N / Shah, S / Magalhães, V F / Habibi, H R

Marine environmental research

2022 Volume 175, Page(s) 105567

Abstract: Cyanotoxins are among common contaminants that can impair human, animal, and environmental health. Cylindrospermopsin (CYN) is an abundant form of cyanotoxins elevated following algal bloom in the water worldwide. Previous studies have described CYN ... ...

Abstract	Cyanotoxins are among common contaminants that can impair human, animal, and environmental health. Cylindrospermopsin (CYN) is an abundant form of cyanotoxins elevated following algal bloom in the water worldwide. Previous studies have described CYN effects on several organs in mammals. However, little is known about its toxicity mechanisms in other vertebrates. This study aims to characterize the developmental effects of CYN using zebrafish larvae as an aquatic model organism. A wide range of CYN concentrations (0-2000 μg/L) was tested using a morphometric approach for survival, hatching, various growth and developmental abnormalities. We also investigated the expression of genes related to oxidative stress, osmoregulation, and thyroid function. Exposure to CYN resulted in decreased growth, increased developmental abnormalities such as pericardial and yolk sac edema as well as swim bladder absence. In addition, CYN increased tr1a, and decreased dio1 and dio3 transcript levels which are involved in thyroid-mediated function. It also increased transcript levels related to oxidative stress, including hsp70, ahr1a, cyp1a, gpx and cat. Lastly, CYN exposure increased aqp3a and decreased dab2, which are involved in osmoregulation with a threshold of 10 μg/L. The present study demonstrates multiple effects of exposure to environmentally relevant CYN concentrations in zebrafish embryos.
MeSH term(s)	Alkaloids/metabolism ; Alkaloids/toxicity ; Animals ; Cyanobacteria Toxins ; Embryo, Nonmammalian ; Embryonic Development ; Zebrafish/metabolism
Chemical Substances	Alkaloids ; Cyanobacteria Toxins ; cylindrospermopsin (2JIZ556BA3)
Language	English
Publishing date	2022-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1502505-6
ISSN	1879-0291 ; 0141-1136
ISSN (online)	1879-0291
ISSN	0141-1136
DOI	10.1016/j.marenvres.2022.105567
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