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  1. Article ; Online: Stereotactic Radiosurgery vs Conventional Radiotherapy for Spine Metastases.

    Yan, Michael / Moraes, Fabio Ynoe

    JAMA oncology

    2023  Volume 10, Issue 2, Page(s) 258–259

    MeSH term(s) Humans ; Radiosurgery ; Spinal Neoplasms/pathology ; Brain Neoplasms/secondary
    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2023.6060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A Precise Approach for Radiotherapy of Breast Cancer.

    Sigurdson, Samantha / Thibodeau, Stephane / Korzeniowski, Martin / Moraes, Fabio Ynoe

    Cancer treatment and research

    2024  Volume 188, Page(s) 175–198

    Abstract: Radiotherapy is an integral part of the multidisciplinary management of breast cancer (BC). There have been multiple recent advances in the delivery of radiotherapy, reviewed with a critical discussion of the evidence from trials investigating adjuvant ... ...

    Abstract Radiotherapy is an integral part of the multidisciplinary management of breast cancer (BC). There have been multiple recent advances in the delivery of radiotherapy, reviewed with a critical discussion of the evidence from trials investigating adjuvant ultra-hypofractionation and partial breast irradiation for early-stage BC, and the locoregional management of lymph nodes in locally advanced BC. Multiple precision medicine-based approaches have been developed as prognostic and/or predictive for BC patients and identifying biomarkers of radioresistance could help identify patients that may benefit from dose-escalated radiotherapy or radiosensitizers. Radiotherapy after breast reconstruction is an area of current controversy in the field, and we evaluated the decision-making considerations in this situation. The oligometastatic state is an emerging field for many cancer sites based on recent trials investigating ablative radiotherapy for oligometastatic BC. This chapter is an overview of radiotherapy for BC, with a focus on recent advances in early-stage, locally advanced, and oligometastatic disease.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/radiotherapy ; Lymph Nodes ; Precision Medicine
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ISSN 0927-3042
    ISSN 0927-3042
    DOI 10.1007/978-3-031-33602-7_7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Artificial intelligence in the medical profession: ready or not, here AI comes.

    Pucchio, Aidan / Papa, Joshua Del / de Moraes, Fabio Ynoe

    Clinics (Sao Paulo, Brazil)

    2022  Volume 77, Page(s) 100010

    MeSH term(s) Artificial Intelligence ; Medicine ; Surveys and Questionnaires
    Language English
    Publishing date 2022-02-14
    Publishing country United States
    Document type Letter
    ZDB-ID 2182801-5
    ISSN 1980-5322 ; 1807-5932
    ISSN (online) 1980-5322
    ISSN 1807-5932
    DOI 10.1016/j.clinsp.2022.100010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Oncology training in Latin America: are we ready for 2040?

    Duma, Narjust / Moraes, Fabio Ynoe

    The Lancet. Oncology

    2020  Volume 21, Issue 10, Page(s) 1267–1268

    MeSH term(s) Education, Medical, Graduate ; Fellowships and Scholarships ; Humans ; International Cooperation ; Interviews as Topic ; Latin America/epidemiology ; Medical Oncology/education ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Neoplasms/therapy
    Language English
    Publishing date 2020-09-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(20)30158-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Meta-Analysis of STereotactic body radiothERapy in non-spine BONE metastaseS (MASTER-BONES).

    Moraes, Fabio Ynoe / Gouveia, Andre Guimaraes / Marta, Gustavo Nader / da Silva, Mauricio Fraga / Hamamura, Ana Carolina / Tsakiridis, Theodoros / Yan, Michael / Viani, Gustavo Arruda

    International journal of radiation oncology, biology, physics

    2024  

    Abstract: Purpose: The efficacy and safety of stereotactic body radiation (SBRT) for patients with non-spine bone metastases (NSBM) remains in question. A systematic review and meta-analysis was performed to evaluate SBRT treatment outcomes in NSBM.: Methods ... ...

    Abstract Purpose: The efficacy and safety of stereotactic body radiation (SBRT) for patients with non-spine bone metastases (NSBM) remains in question. A systematic review and meta-analysis was performed to evaluate SBRT treatment outcomes in NSBM.
    Methods and materials: Eligible studies were retrieved from Medline, Embase, Scielo, the Cochrane Library, and annual meeting proceedings until July 6, 2023. We adhered to the PRISMA and MOOSE guideline recommendations. Quantitative synthesis was performed using a random effects model.
    Results: Seven retrospective studies, with a total of 807 patients (1048 lesions) treated with stereotactic body radiation were included, with median follow-up ranging from 7.6-26.5 months. The most common stereotactic body radiation sites were pelvis (39.2%), ribs (25.8%), femur (16.7%), and humerus/shoulder region (8.7%). At 1-year, the LF and FR were 7% (95%CI 5.5-8.5%; I2=0, n= 75/1048), and 5.3% (95%CI 3-7.5%;I2=0, n= 65/1010). The 2-year cumulative LF incidence was 12.1% (95% CI: 10-15.5%). The OS and PFS at 1-year were 82% (95%CI 75-88%;I2=82%, n= 746/867), and 33.5%(95%CI 26-41%;I2=0%, n= 51/152), with a median of 20.2 months (95%CI: 10.9-49.1 months) and 8.3 months (95% CI: 6.3-10.3%) for OS and PFS, respectively. Meta-regression analysis revealed a significant relationship between planning target volume and fracture rate (p<0.05). Ribs 2.5% followed by the femur 1.9% (95%CI:0-6.1%) were the most common fracture sites. The occurrence of pain flare, fatigue and dermatitis were 7 %, 5.4 %, and 0.65 %, respectively.
    Conclusions: Stereotactic body radiation proves both safety and efficacy for non-spine bone metastases and serious complications (grade 3) are infrequent. Careful consideration of target volume is crucial due to its link with a higher fracture risk.
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2023.12.045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Sequential or concomitant chemotherapy with hypofractionated radiotherapy for locally advanced non-small cell lung cancer: a meta-analysis of randomized trials.

    Viani, Gustavo Arruda / Gouveia, Andre Guimaraes / Moraes, Fabio Ynoe

    Journal of thoracic disease

    2021  Volume 13, Issue 11, Page(s) 6272–6282

    Abstract: Background: For patients with locally advanced non-small cell lung cancer (NSCLC), the standard treatment is concurrent or sequential chemotherapy with radiotherapy. Most treatment schedules use radiotherapy with conventional fractionation; however, the ...

    Abstract Background: For patients with locally advanced non-small cell lung cancer (NSCLC), the standard treatment is concurrent or sequential chemotherapy with radiotherapy. Most treatment schedules use radiotherapy with conventional fractionation; however, the application of hypofractionated radiotherapy (HYPO-RT) regimens is rising. A meta-analysis was performed to assess the efficacy and safety of chemotherapy combined with HYPO-RT and indirectly compare with the outcomes from previous studies employing concomitant conventional radiotherapy (CONV-RT).
    Methods: Randomized controlled trials (RCTs) were identified on the electronic database sources through June 2020. Following the PRISMA guidelines, a meta-analysis was performed to assess if there were significant differences in the overall mortality (OM), local failure (LF), and disease progression (DP), comparing HYPO-RT-C
    Results: Two RCTs with a total of 288 patients were included. The RR for the OM, DP and LF at 3 year comparing HYPO-RT-C
    Discussion: HYPO-RT given with chemotherapy provides satisfactory OM, LF, and DP in locally advanced NSCLC with similar rates to the CONV-RT. These findings support HYPO-RT inclusion in future clinical trials as an experimental arm in addition to the incorporation of new strategies, such as immunotherapy.
    Language English
    Publishing date 2021-12-17
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-21-573
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  7. Article ; Online: Medical students need artificial intelligence and machine learning training.

    Pucchio, Aidan / Eisenhauer, Elizabeth A / Moraes, Fabio Ynoe

    Nature biotechnology

    2021  Volume 39, Issue 3, Page(s) 388–389

    Language English
    Publishing date 2021-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/s41587-021-00846-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Real-world evidence for oncological outcomes after radiotherapy or surgery for T1a-T1b glottic squamous cell carcinoma: A population-based cohort study.

    Viani, Gustavo Arruda / Moraes, Fabio Ynoe / Marta, Gustavo Nader / Kowalski, Luiz Paulo / Gouveia, Andre Guimaraes

    Head & neck

    2023  Volume 45, Issue 10, Page(s) 2505–2514

    Abstract: Background: Compare outcomes after surgery (S) or radiotherapy (RT) for T1a-T1b glottic squamous cell carcinoma (T1GSCC) in a population-based cohort study.: Methods: Patients diagnosed with T1GSCC from 1999 to 2020 were identified from a public ... ...

    Abstract Background: Compare outcomes after surgery (S) or radiotherapy (RT) for T1a-T1b glottic squamous cell carcinoma (T1GSCC) in a population-based cohort study.
    Methods: Patients diagnosed with T1GSCC from 1999 to 2020 were identified from a public database. Clinical, demographic, and social data were extracted. Treatment and patient groups and subgroups were compared with log-rank test, Cox proportional test, and propensity-score matched (PSM).
    Results: Eight hundred and eighty-eight patients with T1GSCC were included in the study, with a median follow-up of 61 months. The 5- and 10-year overall survival (OS) S versus RT were 76% versus 71% and 60% versus 52% (p = 0.02), respectively. In the subgroup analysis, S was associated with better OS for T1b, male, and public service patients (p < 0.05). In the PSM cohort of S versus RT with 110 patients each, there was no significant difference in the OS, CSS, and LC.
    Conclusions: T1GSCC has favorable outcomes with S or RT.
    MeSH term(s) Humans ; Male ; Treatment Outcome ; Cohort Studies ; Retrospective Studies ; Carcinoma, Squamous Cell/radiotherapy ; Carcinoma, Squamous Cell/surgery ; Neoplasm Staging ; Glottis/surgery ; Glottis/pathology ; Laryngeal Neoplasms/radiotherapy ; Laryngeal Neoplasms/surgery
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27470
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  9. Article ; Online: In Reply to Fiorino et al.

    Leite, Elton Trigo Teixeira / Ramos, Clarissa Cerchi Angotti / Moraes, Fabio Ynoe

    International journal of radiation oncology, biology, physics

    2021  Volume 110, Issue 5, Page(s) 1549–1550

    MeSH term(s) Humans ; Male ; Prostatic Neoplasms ; Radiation Injuries
    Language English
    Publishing date 2021-07-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2021.04.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Barriers to Access: Global Variability in Implementing Treatment Advances in Lung Cancer.

    Febbraro, Michela / Gheware, Atish / Kennedy, Thomas / Jain, Deepali / de Moraes, Fabio Ynoe / Juergens, Rosalyn

    American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

    2022  Volume 42, Page(s) 1–7

    Abstract: Globally, lung cancer is the second most-diagnosed cancer and is the leading cause of cancer death. Advances in science and technology have contributed to improvements in primary cancer prevention, cancer diagnosis, and cancer therapy, leading to an ... ...

    Abstract Globally, lung cancer is the second most-diagnosed cancer and is the leading cause of cancer death. Advances in science and technology have contributed to improvements in primary cancer prevention, cancer diagnosis, and cancer therapy, leading to an increase in survival and improvement in quality of life. Many of these advances have been seen in high-income countries. Accessibility, availability, and affordability are key domains in barriers to access of care between countries and within countries. The impact of these domains, as they relate to molecular testing, radiation therapy, and systemic therapy, are discussed.
    MeSH term(s) Developing Countries ; Health Services Accessibility ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/epidemiology ; Lung Neoplasms/genetics ; Quality of Life
    Language English
    Publishing date 2022-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2431126-1
    ISSN 1548-8756 ; 1548-8748
    ISSN (online) 1548-8756
    ISSN 1548-8748
    DOI 10.1200/EDBK_351021
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