Article ; Online: Vitamin D status in active and inactive noninfectious uveitis - data from a reference university hospital in Rio de Janeiro, Brazil.
Arquivos brasileiros de oftalmologia
2024 Volume 87, Issue 4, Page(s) e2023
Abstract: Purpose: This study aimed to investigate the correlation between serum vitamin D levels and disease activity in patients with noninfectious uveitis.: Methods: We conducted a prospective case-control study, assessing 51 patients with noninfectious ... ...
| Abstract | Purpose: This study aimed to investigate the correlation between serum vitamin D levels and disease activity in patients with noninfectious uveitis. Methods: We conducted a prospective case-control study, assessing 51 patients with noninfectious uveitis, categorized into active (n=22) and inactive (n=29) groups, along with 51 healthy controls. Serum 25-hydroxy vitamin D [25(OH)D] levels were measured. The uveitis group also completed a questionnaire regarding sunlight exposure habits and vitamin D supplementation. Results: Patients with inflammation-related uveitis exhibited low serum 25(OH)D levels in 68% of cases. The median 25(OH)D level in patients with active uveitis was 17.8 ng/mL (interquartile range [IQR], 15-21 ng/mL), significantly lower compared to the 31.7 ng/mL (IQR, 25-39 ng/mL) in patients with inactive uveitis (p<0.001) and the 27 ng/mL (IQR, 23-31 ng/mL) in the Control Group (p<0.001). Significantly, nearly all patients with uveitis taking vitamin D supplementation were in the Inactive Group (p<0.005). Moreover, reduced sunlight exposure was associated with active uveitis (p<0.003). Furthermore, patients with 25(OH)D levels below 20 ng/mL had ten times higher odds of developing active uveitis (p=0.001). Conclusions: This study revealed a prevalent 25(OH)D deficiency among patients with noninfectious uveitis and suggested a link between low 25(OH)D levels and disease activity. To prevent future episodes of intraocular inflammation, vitamin D supplementation and controlled sunlight exposure could be viable options. |
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| MeSH term(s) | Humans ; Vitamin D/blood ; Vitamin D/analogs & derivatives ; Male ; Uveitis/blood ; Female ; Adult ; Case-Control Studies ; Brazil/epidemiology ; Middle Aged ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Prospective Studies ; Sunlight ; Hospitals, University ; Young Adult ; Surveys and Questionnaires |
| Chemical Substances | Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H) |
| Language | English |
| Publishing date | 2024-04-19 |
| Publishing country | Brazil |
| Document type | Journal Article |
| ZDB-ID | 603915-7 |
| ISSN | 1678-2925 ; 0004-2749 |
| ISSN (online) | 1678-2925 |
| ISSN | 0004-2749 |
| DOI | 10.5935/0004-2749.2023-0141 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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