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Article: Sphenopalatine Ganglion Block for Headache Treatment After an Incidental Durotomy: A Case Report.

Marques, Ana / Morais, Inês / Costa, Vânia / Romão, Hugo

Turkish journal of anaesthesiology and reanimation

2023 Volume 51, Issue 1, Page(s) 72–74

Abstract: Incidental durotomy is the most common intraoperative complication of spine surgeries. Our main goal is to report a case of a postoperative postdural puncture headache following an incidental durotomy successfully managed with a sphenopalatine ganglion ... ...

Abstract	Incidental durotomy is the most common intraoperative complication of spine surgeries. Our main goal is to report a case of a postoperative postdural puncture headache following an incidental durotomy successfully managed with a sphenopalatine ganglion block. A 75-year-old woman, American Society of Anesthesiologists physical status II, proposed for a lumbar interbody fusion. During surgery, an incidental durotomy with cerebrospinal fluid leak occurred, being repaired with muscle and DuraSeal® Dural Sealant System. In the recovery room, 1 hour after the end of the surgery, the patient developed a severe headache associated with nausea and photophobia. A bilateral transnasal sphenopalatine ganglion block with 0.75% ropivacaine was performed. Immediate pain relief was verified. The patient reported only mild headaches on the first postoperative day, feeling progressively better until discharge. The sphenopalatine ganglion block may be an effective alternative treatment for postdural puncture headache following an incidental durotomy during neurosurgeries. Sphenopalatine ganglion block may be a safe, lowrisk alternative in the treatment of postdural puncture headache after an incidental durotomy that can be used in the immediate postoperative period to enable early recovery and return to day-to-day activities, which will hopefully lead to better surgical outcomes and patient satisfaction.
Language	English
Publishing date	2023-02-27
Publishing country	Turkey
Document type	Journal Article
ISSN	2667-677X
ISSN	2667-677X
DOI	10.5152/TJAR.2023.21634
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Article ; Online: Lombalgia crônica: devemos adotar as novas técnicas de analgesia?

Morais, Inês Gonçalves / Martin, Ana

Brazilian journal of anesthesiology (Elsevier)

2020 Volume 70, Issue 5, Page(s) 565

Title translation	Chronic low back pain: should we be adopting novel analgesic techniques?
MeSH term(s)	Analgesics ; Humans ; Low Back Pain/drug therapy
Chemical Substances	Analgesics
Language	Portuguese
Publishing date	2020-09-16
Publishing country	Brazil
Document type	Letter ; Comment
ISSN	2352-2291
ISSN (online)	2352-2291
DOI	10.1016/j.bjan.2020.09.003
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Article ; Online: EXTRAORAL AND CBCT DENTAL EXPOSURES IN PORTUGAL.

Trindade, Hugo / Morais, Inês / Moreira, Abigail

Radiation protection dosimetry

2020 Volume 190, Issue 3, Page(s) 283–288

Abstract: Data from dental extraoral and cone beam computed tomography (CBCT) exposures in Portugal (2019) were gathered, and patient doses for standard adult exams were evaluated. In panoramic X-rays, 442 units (34% of the existing licensed units) were tested, ... ...

Abstract	Data from dental extraoral and cone beam computed tomography (CBCT) exposures in Portugal (2019) were gathered, and patient doses for standard adult exams were evaluated. In panoramic X-rays, 442 units (34% of the existing licensed units) were tested, with a third quartile value (PKA) of 82 mGy.cm2. For cephalometric radiography (88 units), the third quartile value (Ki) was 0.3 mGy for the posteroanterior projection and 0.2 mGy for lateral projection. In CBCT (69 units), the doses for the placement of an upper first molar implant were evaluated with a third quartile value (PKA) of 820 mGy.cm2. Due to the wide range of values (74-3687 mGy.cm2), the CBCT data were divided by FOV dimensions: for small FOV (average FOV of 7 ×8 cm), a value of 580 mGy.cm2 was obtained and for medium FOV (average FOV of 13 × 12 cm) a value of 1167 mGy.cm2. The number of annual panoramic X-rays made in Portugal was 208 per 1000 inhabitants, which is higher than the value for other countries.
MeSH term(s)	Adult ; Cone-Beam Computed Tomography ; Humans ; Portugal/epidemiology ; Radiation Dosage ; Radiography, Panoramic ; Spiral Cone-Beam Computed Tomography
Language	English
Publishing date	2020-09-27
Publishing country	England
Document type	Journal Article
ZDB-ID	225912-6
ISSN	1742-3406 ; 0144-8420
ISSN (online)	1742-3406
ISSN	0144-8420
DOI	10.1093/rpd/ncaa102
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Article ; Online: 2,3-Diphosphoglycerate and the Protective Effect of Pyruvate Kinase Deficiency against Malaria Infection-Exploring the Role of the Red Blood Cell Membrane.

Carvalho, Maria / Medeiros, Márcia M / Morais, Inês / Lopes, Catarina S / Balau, Ana / Santos, Nuno C / Carvalho, Filomena A / Arez, Ana Paula

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: Malaria remains a major world public health problem, contributing to poverty and inequality. It is urgent to find new efficacious tools with few adverse effects. Malaria has selected red blood cell (RBC) alterations linked to resistance against infection, ...

Abstract	Malaria remains a major world public health problem, contributing to poverty and inequality. It is urgent to find new efficacious tools with few adverse effects. Malaria has selected red blood cell (RBC) alterations linked to resistance against infection, and understanding the protective mechanisms involved may be useful for developing host-directed tools to control
MeSH term(s)	Humans ; 2,3-Diphosphoglycerate/metabolism ; Pyruvate Kinase/metabolism ; Erythrocytes/metabolism ; Malaria/metabolism ; Malaria, Falciparum/parasitology ; Plasmodium falciparum ; Diphosphoglyceric Acids/metabolism
Chemical Substances	2,3-Diphosphoglycerate (138-81-8) ; Pyruvate Kinase (EC 2.7.1.40) ; Diphosphoglyceric Acids
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24021336
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Article ; Online: Reading and reading-related skills in adults with dyslexia from different orthographic systems: a review and meta-analysis.

Reis, Alexandra / Araújo, Susana / Morais, Inês Salomé / Faísca, Luís

Annals of dyslexia

2020 Volume 70, Issue 3, Page(s) 339–368

Abstract: An individual diagnosed with dyslexia in childhood typically remains dyslexic throughout his/her life. However, the cognitive profile of adults with dyslexia has been less explored than that of children. This meta-analytic study is intended to clarify ... ...

Abstract	An individual diagnosed with dyslexia in childhood typically remains dyslexic throughout his/her life. However, the cognitive profile of adults with dyslexia has been less explored than that of children. This meta-analytic study is intended to clarify three questions: (1) To what extent, and in what manner, do adults with reading difficulties (dyslexia) differ from typical adult readers in measures of reading and writing competence and related cognitive skills?; (2) To what extent do speed measures pose a greater challenge than accuracy measures in an adult population that has already had years of print exposure?; and (3) To what extent does orthographic transparency modulate the reading profile of adults with dyslexia? A total of 178 studies comparing adults with dyslexia and matched controls were reviewed. The results showed that adults with dyslexia exhibited poor performance on almost all reading and writing tasks expressed by very large effect sizes (range 1.735 ≤ d ≤ 2.034), except for reading comprehension (d = 0.729). Deficits in reading- and writing-related variables are also present but with a lower expression (range 0.591 ≤ d ≤ 1.295). These difficulties are exacerbated for speed measures, especially for word and pseudoword reading, phonological awareness and orthographic knowledge. Orthographic transparency proved to be a significant moderator of dyslexic deficits in word and pseudoword reading, reading comprehension, spelling and phonological awareness, with the expression of the deficits being weaker on transparent-as opposed to intermediate and opaque-orthographies. Overall, the meta-analysis shows that reading and writing difficulties persist in adulthood and are more pronounced in speed measures. Moreover, symptoms are more severe for reading and writing than they are for measures tapping into the cognitive processes underlying reading skills. Orthographic transparency has a significant effect on the manifestation of dyslexia, with dyslexia symptoms being less marked on transparent orthographies. In addition, phonological awareness seems to be a minor problem in adulthood, especially for transparent orthographies.
MeSH term(s)	Adult ; Attention/physiology ; Awareness/physiology ; Child ; Cognition/physiology ; Comprehension/physiology ; Dyslexia/diagnosis ; Dyslexia/psychology ; Female ; Humans ; Language ; Male ; Phonetics ; Reading ; Writing
Language	English
Publishing date	2020-09-12
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	11939-8
ISSN	1934-7243 ; 0736-9387
ISSN (online)	1934-7243
ISSN	0736-9387
DOI	10.1007/s11881-020-00205-x
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Article: Reading Comprehension Predictors in European Portuguese Adults.

Gonçalves, Fábio / Reis, Alexandra / Inácio, Filomena / Morais, Inês Salomé / Faísca, Luís

Frontiers in psychology

2021 Volume 12, Page(s) 789413

Abstract: Research on the predictors of reading comprehension has been largely focused on school-aged children and mainly in opaque orthographies, hindering the generalization of the results to adult populations and more transparent orthographies. In the present ... ...

Abstract	Research on the predictors of reading comprehension has been largely focused on school-aged children and mainly in opaque orthographies, hindering the generalization of the results to adult populations and more transparent orthographies. In the present study, we aim to test two versions of the Simple View of Reading (SVR): the original model and an extended version, including reading fluency and vocabulary. Additional mediation models were analyzed to verify if other reading comprehension predictors (rapid automatized naming, phonological decoding, phonological awareness, morphological awareness, and working memory) have direct effects or if they are mediated through word reading and reading fluency. A sample of 67 typical adult Portuguese readers participated in this study. The SVR model accounted for 27% of the variance in reading comprehension, with oral language comprehension displaying a larger contribution than word reading. In the extended SVR model, reading fluency and vocabulary provided an additional and significant contribution of 7% to the explained variance. Moreover, vocabulary influenced reading comprehension directly and indirectly,
Language	English
Publishing date	2021-12-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2021.789413
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Article ; Online: What is the sodium and trans-fat content in popular street and takeaway food in Bosnia and Herzegovina?

Albuquerque, Gabriela / Sousa, Sofia / Lança de Morais, Inês / Gelormini, Marcello / Santos, Mariana / Moreira, Pedro / Damasceno, Albertino / Breda, João / Lunet, Nuno / Padrão, Patrícia

Journal of Food Composition and Analysis. 2022 Dec., v. 114 p.104815-

2022

Abstract: Street food is part of the Eastern European gastronomy, but there is a knowledge gap on food availability and nutritional composition. The aim was to investigate the street and takeaway food availability and nutritional composition in Sarajevo and Banja ... ...

Abstract	Street food is part of the Eastern European gastronomy, but there is a knowledge gap on food availability and nutritional composition. The aim was to investigate the street and takeaway food availability and nutritional composition in Sarajevo and Banja Luka, Bosnia and Herzegovina. Street food and takeaway food vending sites were included. Information on vending sites’ characteristics and food availability, and samples of the most commonly available foods were collected (Sarajevo: 80 homemade; 39 industrial, Banja Luka: 80 homemade; 40 industrial), for chemical analysis (total fat, lipid profile, sodium and potassium). Among the vending sites selling food other than fruit (98.3 %), 40.9 % were selling only industrial foods (snacks, biscuits and sweet pastries, ice-cream, chocolate), while 52.7 % were selling only homemade foods (savoury pastries, main dishes, cakes, biscuits and sweet pastries, sandwiches, bread, snacks) and 6.3 %, both. Homemade foods presented higher total fat (16.6 vs. 10.1 g/serving, p < 0.001), sodium (603 vs. 187 mg/serving, p < 0.001) and potassium content (168 vs. 110 mg/serving, p < 0.001), compared to industrial foods. Homemade cake presented the highest mean trans-fat content (2.32 g/serving), whereas homemade beefburger presented the highest mean sodium content (3838 mg/serving). In sum, in urban Bosnia and Herzegovina, commonly available street and takeaway foods, particularly homemade, were high in total fat, saturated, trans-fat and sodium. These findings call for the design of healthier urban food environments.
Keywords	breads ; cakes ; chemical analysis ; chocolate ; food availability ; food composition ; fruits ; gastronomy ; ice cream ; lipid composition ; nutrient content ; potassium ; sodium ; street foods ; takeout foods ; trans fatty acids ; Bosnia-Herzegovina ; Nutritional value ; Sodium content ; Street food ; Bosnia and Herzegovina
Language	English
Dates of publication	2022-12
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	743572-1
ISSN	0889-1575 ; 1096-0481
ISSN	0889-1575 ; 1096-0481
DOI	10.1016/j.jfca.2022.104815
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Article ; Online: Discovery of new piperaquine hybrid analogs linked by triazolopyrimidine and pyrazolopyrimidine scaffolds with antiplasmodial and transmission blocking activities.

Feitosa, Livia M / Franca, Rodolfo Rodrigo F / Ferreira, Maria de Lourdes G / Aguiar, Anna C C / de Souza, Guilherme E / Maluf, Sarah El Chamy / de Souza, Juliana O / Zapata, Luana / Duarte, Denise / Morais, Ines / Nogueira, Fatima / Nonato, M Cristina / Pinheiro, Luiz C S / Guido, Rafael V C / Boechat, Nubia

European journal of medicinal chemistry

2024 Volume 267, Page(s) 116163

Abstract: The World Health Organization (WHO) estimated that there were 247 million malaria cases in 2021 worldwide, representing an increase in 2 million cases compared to 2020. The urgent need for the development of new antimalarials is underscored by specific ... ...

Abstract	The World Health Organization (WHO) estimated that there were 247 million malaria cases in 2021 worldwide, representing an increase in 2 million cases compared to 2020. The urgent need for the development of new antimalarials is underscored by specific criteria, including the requirement of new modes of action that avoid cross-drug resistance, the ability to provide single-dose cures, and efficacy against both assexual and sexual blood stages. Motivated by the promising results obtained from our research group with [1,2,4]triazolo[1,5-a]pyrimidine and pyrazolo[1,5-a]pyrimidine derivatives, we selected these molecular scaffolds as the foundation for designing two new series of piperaquine analogs as potential antimalarial candidates. The initial series of hybrids was designed by substituting one quinolinic ring of piperaquine with the 1,2,4-triazolo[1,5-a]pyrimidine or pyrazolo[1,5-a]pyrimidine nucleus. To connect the heterocyclic systems, spacers with 3, 4, or 7 methylene carbons were introduced at the 4 position of the quinoline. In the second series, we used piperazine as a spacer to link the 1,2,4-triazolo[1,5-a]pyrimidine or pyrazolo[1,5-a]pyrimidine group to the quinoline core, effectively merging both pharmacophoric groups via a rigid spacer. Our research efforts yielded promising compounds characterized by low cytotoxicity and selectivity indices exceeding 1570. These compounds displayed potent in vitro inhibitory activity in the low nanomolar range against the erythrocytic form of the parasite, encompassing both susceptible and resistant strains. Notably, these compounds did not show cross-resistance with either chloroquine or established P. falciparum inhibitors. Even though they share a pyrazolo- or triazolo-pyrimidine core, enzymatic inhibition assays revealed that these compounds had minimal inhibitory effects on PfDHODH, indicating a distinct mode of action unrelated to targeting this enzyme. We further assessed the compounds' potential to interfere with gametocyte and ookinete infectivity using mature P. falciparum gametocytes cultured in vitro. Four compounds demonstrated significant gametocyte inhibition ranging from 58 % to 86 %, suggesting potential transmission blocking activity. Finally, we evaluated the druggability of these new compounds using in silico methods, and the results indicated that these analogs had favorable physicochemical and ADME (absorption, distribution, metabolism, and excretion) properties. In summary, our research has successfully identified and characterized new piperaquine analogs based on [1,2,4]triazolo[1,5-a]pyrimidine and pyrazolo[1,5-a]pyrimidine scaffolds and has demonstrated their potential as promising candidates for the development of antimalarial drugs with distinct mechanisms of action, considerable selectivity, and P. falciparum transmission blocking activity.
MeSH term(s)	Humans ; Antimalarials/pharmacology ; Antimalarials/chemistry ; Plasmodium falciparum ; Quinolines/chemistry ; Malaria, Falciparum/drug therapy ; Pyrimidines/chemistry ; Piperazines
Chemical Substances	Antimalarials ; piperaquine (A0HV2Q956Y) ; Quinolines ; Pyrimidines ; Piperazines
Language	English
Publishing date	2024-01-25
Publishing country	France
Document type	Journal Article
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2024.116163
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Article ; Online: Degree of processing and nutritional value of children's food products.

Araújo, Célia Regina Barbosa de / Ribeiro, Karla Danielly da S / Oliveira, Amanda Freitas de / Morais, Inês Lança de / Breda, João / Padrão, Patrícia / Moreira, Pedro

Public health nutrition

2021 Volume 24, Issue 18, Page(s) 5977–5984

Abstract: Objective: This study aimed to characterise the availability, the nutritional composition and the processing degree of industrial foods for 0-36-month-old children according to the neighbourhoods affluence.: Design: A cross-sectional exploratory ... ...

Abstract	Objective: This study aimed to characterise the availability, the nutritional composition and the processing degree of industrial foods for 0-36-month-old children according to the neighbourhoods affluence. Design: A cross-sectional exploratory study. Setting: All food products available in retail stores for children aged 0-36 months were analysed. Data collection took place in two neighbourhoods, comparing two different sociodemographic districts (high v. low per capita income), Campanhã and Foz do Douro in Porto, Portugal. Participants: A total of 431 commercially processed food products for children aged 0-36 months which are sold in 23 retail stores were identified. Food products were classified according to their processing degree using the NOVA Food Classification System. Results: For NOVA analysis, of the 244 food products that were included 82 (33·6 %) were minimally processed, 25 (10·2 %) processed and 137 (56·1 %) ultra processed. No food product was classified as a culinary ingredient. The products included mostly cereals, yogurts, prevailed in high-income neighbourhoods for the 0-6-month-old group. It was observed that some categories of ultra-processed food (UPF) presented higher amounts of energy, sugars, saturated fat and salt than unprocessed/minimally processed products. Conclusions: The high availability of UPF offered for 0-36-month-old children should be considered when designing interventions to promote a healthy diet in infancy.
MeSH term(s)	Child ; Child, Preschool ; Cross-Sectional Studies ; Diet ; Energy Intake ; Fast Foods ; Food Handling ; Humans ; Infant ; Infant, Newborn ; Nutritive Value
Language	English
Publishing date	2021-09-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1436024-x
ISSN	1475-2727 ; 1368-9800
ISSN (online)	1475-2727
ISSN	1368-9800
DOI	10.1017/S1368980021003876
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Article ; Online: Commercial foods for infants under the age of 36 months: an assessment of the availability and nutrient profile of ultra-processed foods.

da Rocha, Karini F / de Araújo, Célia Rb / de Morais, Inês L / Padrão, Patrícia / Moreira, Pedro / Ribeiro, Karla Danielly da S

Public health nutrition

2021 Volume 24, Issue 11, Page(s) 3179–3186

Abstract: Objective: Considering the negative impact of the consumption of ultra-processed foods on health, the current study assessed the availability and nutritional profile of commercial ultra-processed foods for infants in Natal, Brazil.: Design: A cross- ... ...

Abstract	Objective: Considering the negative impact of the consumption of ultra-processed foods on health, the current study assessed the availability and nutritional profile of commercial ultra-processed foods for infants in Natal, Brazil. Design: A cross-sectional exploratory study. Setting: Foods targeted at children under the age of 36 months sold in retail establishments located in high- and low-income areas of the one capital city of Brazil. Participants: 1645 food products consisting of ninety-five different types of food were available. The foods were assessed according to the NOVA classification: minimally processed, processed and ultra-processed. The nutritional content per 100 g was assessed according to processing classification. Results: Half of foods founded were breast milk substitutes and cereal foods (31·6 and 26·3 %, respectively). The foods were predominantly ultra-processed (79 %) and only 4·2 % were minimally processed, with similar proportions of ultra-processed foods being found in both high- and low-income areas. After excluding breast milk substitutes and follow-up formulas, all cereals, food supplements and some of the fruit or vegetable purees were ultra-processed, higher in energy density, fat, carbohydrate and protein and low in fibre (P < 0·05). Conclusions: The findings reveal that ultra-processed foods for infants are widely available in Brazil, reaffirming the need to strengthen the regulation of foods for infants and young children by introducing complementary measures designed to promote the production and marketing of foods manufactured using lower levels of processing.
MeSH term(s)	Brazil ; Child ; Child, Preschool ; Cross-Sectional Studies ; Diet ; Energy Intake ; Fast Foods ; Female ; Food Handling ; Humans ; Infant ; Nutrients
Language	English
Publishing date	2021-04-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1436024-x
ISSN	1475-2727 ; 1368-9800
ISSN (online)	1475-2727
ISSN	1368-9800
DOI	10.1017/S1368980021001555
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