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Article ; Online: No optic pit serous maculopathy associated with an intraorbital optic nerve sheath lesion.

Georgiadis, Odysseas / Pappelis, Konstantinos / McHugh, James A / Moraitis, Alexandros / Theodossiadis, Panagiotis G / Grabowska, Anna

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2024

Language	English
Publishing date	2024-03-16
Publishing country	England
Document type	Letter
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2024.02.015
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Article: Instrumentierung in der präklinischen PET- und SPECT-Bildgebung

Moraitis, Alexandros / Fragoso Costa, Pedro

Angewandte Nuklearmedizin

2022 Volume 45, Issue 03, Page(s) 189–197

Abstract: Translationale Forschung greift heute mehr denn je in die Praktiken moderner Medizin ein. Im Bereich der tierexperimentellen Forschung, die sich als Brücke zwischen biomedizinischer Grundlagenforschung und klinischer Forschung versteht, stellt die ... ...

Abstract	Translationale Forschung greift heute mehr denn je in die Praktiken moderner Medizin ein. Im Bereich der tierexperimentellen Forschung, die sich als Brücke zwischen biomedizinischer Grundlagenforschung und klinischer Forschung versteht, stellt die Kleintierbildgebung eines der wichtigsten Forschungsinstrumente dar. Unter den verwendeten bildgebenden Verfahren genießen die PET- und SPECT-Bildgebung das höchste Ansehen, da sie quantitative Informationen über metabolische Prozesse liefern, dynamische Aufnahmen erlauben und geeignet für Längsschnittstudien sind. Hierdurch entstehen vielfältige Perspektiven bei der Entwicklung von Tiermodellen für die Erforschung von Erkrankungen des Menschen; sei es zur Überwachung von Krankheitsverläufen, der Validierung theranostischer Ansätze oder der Erprobung neuer Radiopharmaka. Das stetig steigende Interesse an nicht invasiver Kleintierbildgebung fördert insbesondere auch die Entwicklung dedizierter Bildgebungssysteme. Allen Systemen zur präklinischen Bildgebung ist das Ziel gemein, die Auflösung und Sensitivität auf die Dimensionen der Tiere anzupassen. Dieser Übersichtsartikel bietet Einsicht in die konzeptionellen Grundlagen und technischen Eigenschaften präklinischer PET- und SPECT-Systeme, mit Fokus auf die eingesetzten Detektormaterialien und -technologien, sowie die Detektorkonfiguration. Darüber hinaus werden wichtige Aspekte der Qualitätskontrolle genannt.
Keywords	Translationale Forschung ; Kleintierbildgebung ; Gestaltung ; Performance ; Positronenemissionstomografie ; Einzelphotonenemissionscomputertomografie ; Translational research ; small animal imaging ; design ; performance ; positron emission tomography ; single-photon emission tomography
Language	German
Publishing date	2022-08-16
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	3093190-3
ISSN	2749-7453 ; 2749-7445
ISSN (online)	2749-7453
ISSN	2749-7445
DOI	10.1055/a-1715-5254
Database	Thieme publisher's database

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Article ; Online: Routine Third Trimester Sonogram: Friend or Foe.

Stephens, Katie / Moraitis, Alexandros / Smith, Gordon C S

Obstetrics and gynecology clinics of North America

2021 Volume 48, Issue 2, Page(s) 359–369

Abstract: Several risk factors for adverse pregnancy outcomes can be identified by a routine third trimester ultrasound scan. However, there is also potential for harm, anxiety, and additional health care costs through unnecessary intervention due to false ... ...

Abstract	Several risk factors for adverse pregnancy outcomes can be identified by a routine third trimester ultrasound scan. However, there is also potential for harm, anxiety, and additional health care costs through unnecessary intervention due to false positive results. The evidence base informing the balance of risks and benefits of universal screening is inadequate to fully inform decision making. However, data on the diagnostic effectiveness of universal ultrasound suggest that better methods are required to result in net benefit, with the exception of screening for presentation near term, where a clinical and economic case can be made for its implementation.
MeSH term(s)	Amniotic Fluid/diagnostic imaging ; Anxiety/epidemiology ; Biomarkers/blood ; Breech Presentation/diagnostic imaging ; False Positive Reactions ; Female ; Fetal Development ; Fetal Growth Retardation/diagnostic imaging ; Fetal Macrosomia/diagnostic imaging ; Humans ; Pregnancy ; Pregnancy Outcome ; Pregnancy Trimester, Third ; Prenatal Diagnosis/methods ; Risk Factors ; Stillbirth ; Ultrasonography, Doppler/methods ; Ultrasonography, Prenatal/economics ; Ultrasonography, Prenatal/methods
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-05-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1004315-9
ISSN	1558-0474 ; 0889-8545
ISSN (online)	1558-0474
ISSN	0889-8545
DOI	10.1016/j.ogc.2021.02.006
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Article: Biodistribution and radiation dosimetry of

Moraitis, Alexandros / Jentzen, Walter / Reiter, Gloria / Schmitz, Jochen / Pöppel, Thorsten Dirk / Weber, Manuel / Herrmann, Ken / Fendler, Wolfgang Peter / Fragoso Costa, Pedro / Bockisch, Andreas / Kersting, David

EJNMMI physics

2024 Volume 11, Issue 1, Page(s) 3

Abstract: Aim: Positron emission tomography (PET) using : Methods: Adult patients with neural crest tumours who underwent sequential : Results: Twenty-one patients (11 females, 10 males) were evaluated. For adults, the organs exposed to the highest dose per ...

Abstract	Aim: Positron emission tomography (PET) using Methods: Adult patients with neural crest tumours who underwent sequential Results: Twenty-one patients (11 females, 10 males) were evaluated. For adults, the organs exposed to the highest dose per unit administered activity were urinary bladder (1.54 ± 0.40 mGy/MBq), salivary glands (0.77 ± 0.28 mGy/MBq) and liver (0.65 ± 0.22 mGy/MBq). Mean effective dose coefficient for adults was 0.25 ± 0.04 mSv/MBq (male: 0.24 ± 0.03 mSv/MBq, female: 0.26 ± 0.06 mSv/MBq), and increased gradually to 0.29, 0.44, 0.69, 1.21, and 2.94 mSv/MBq for the 15-, 10-, 5-, 1-years-old, and newborn paediatric reference patients. Projected mean effective dose coefficients for Conclusion: PET-based derived radiation dosimetry data for
Language	English
Publishing date	2024-01-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2768912-8
ISSN	2197-7364
ISSN	2197-7364
DOI	10.1186/s40658-023-00604-0
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Article ; Online: Safety and Efficacy of

Moraitis, Alexandros / Jentzen, Walter / Costa, Pedro Fragoso / Kersting, David / Himmen, Stephan / Coelho, Marta / Meckel, Marian / van Echteld, Cees J A / Fendler, Wolfgang P / Herrmann, Ken / Sraieb, Miriam

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2024

Abstract: ... ...

Abstract	Para
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.123.266619
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Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Late Pregnancy Ultrasound to Screen for and Manage Potential Birth Complications in Nulliparous Women: A Cost-Effectiveness and Value of Information Analysis.

Wilson, Edward C F / Wastlund, David / Moraitis, Alexandros A / Smith, Gordon C S

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

2021 Volume 24, Issue 4, Page(s) 513–521

Abstract: Background: Fetal growth restriction is a major risk factor for stillbirth. A routine late-pregnancy ultrasound scan could help detect this, allowing intervention to reduce the risk of stillbirth. Such a scan could also detect fetal presentation and ... ...

Abstract	Background: Fetal growth restriction is a major risk factor for stillbirth. A routine late-pregnancy ultrasound scan could help detect this, allowing intervention to reduce the risk of stillbirth. Such a scan could also detect fetal presentation and predict macrosomia. A trial powered to detect stillbirth differences would be extremely large and expensive. Objectives: It is therefore critical to know whether this would be a good investment of public research funds. The aim of this study is to estimate the cost-effectiveness of various late-pregnancy screening and management strategies based on current information and predict the return on investment from further research. Methods: Synthesis of current evidence structured into a decision model reporting expected costs, quality-adjusted life-years, and net benefit over 20 years and value-of-information analysis reporting predicted return on investment from future clinical trials. Results: Given a willingness to pay of £20 000 per quality-adjusted life-year gained, the most cost-effective strategy is a routine presentation-only scan for all women. Universal ultrasound screening for fetal size is unlikely to be cost-effective. Research exploring the cost implications of induction of labor has the greatest predicted return on investment. A randomized, controlled trial with an endpoint of stillbirth is extremely unlikely to be a value for money investment. Conclusion: Given current value-for-money thresholds in the United Kingdom, the most cost-effective strategy is to offer all pregnant women a presentation-only scan in late pregnancy. A randomized, controlled trial of screening and intervention to reduce the risk of stillbirth following universal ultrasound to detect macrosomia or fetal growth restriction is unlikely to represent a value for money investment.
MeSH term(s)	Cost-Benefit Analysis ; Female ; Gestational Age ; Humans ; Monte Carlo Method ; Parity ; Pregnancy ; Pregnancy Complications/diagnostic imaging ; Pregnancy Complications/economics ; Pregnancy Trimester, Third ; Quality-Adjusted Life Years ; Randomized Controlled Trials as Topic/economics ; Randomized Controlled Trials as Topic/methods ; Ultrasonography/economics ; Ultrasonography/methods ; United Kingdom
Language	English
Publishing date	2021-01-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1471745-1
ISSN	1524-4733 ; 1098-3015
ISSN (online)	1524-4733
ISSN	1098-3015
DOI	10.1016/j.jval.2020.11.005
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Zs.A 5904: Show issues

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Article ; Online: Voxel-Based Dosimetry Predicts Hepatotoxicity in Hepatocellular Carcinoma Patients Undergoing Radioembolization with

Watanabe, Masao / Grafe, Hong / Theysohn, Jens / Schaarschmidt, Benedikt / Ludwig, Johannes / Jochheim, Leonie / Jeschke, Matthias / Schmidt, Hartmut / Fendler, Wolfgang P / Moraitis, Alexandros / Herrmann, Ken / Pomykala, Kelsey L / Weber, Manuel

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2023 Volume 64, Issue 7, Page(s) 1102–1108

Abstract: Personalized dosimetry holds promise to improve radioembolization treatment outcomes in hepatocellular carcinoma (HCC) patients. To this end, tolerance absorbed doses for nontumor liver tissue are assessed by calculating the mean absorbed dose to the ... ...

Abstract	Personalized dosimetry holds promise to improve radioembolization treatment outcomes in hepatocellular carcinoma (HCC) patients. To this end, tolerance absorbed doses for nontumor liver tissue are assessed by calculating the mean absorbed dose to the whole nontumor liver tissue (AD-WNTLT), which may be limited by its neglect of nonuniform dose distribution. Thus, we analyzed whether voxel-based dosimetry could be more accurate in predicting hepatotoxicity in HCC patients undergoing radioembolization.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/radiotherapy ; Carcinoma, Hepatocellular/drug therapy ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/radiotherapy ; Liver Neoplasms/drug therapy ; Microspheres ; Retrospective Studies ; Embolization, Therapeutic/adverse effects ; Embolization, Therapeutic/methods ; Tomography, Emission-Computed, Single-Photon ; Chemical and Drug Induced Liver Injury ; Yttrium Radioisotopes/adverse effects
Chemical Substances	Yttrium Radioisotopes
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.122.264996
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Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Quantification performance of silicon photomultiplier-based PET for small

Kersting, David / Moraitis, Alexandros / Sraieb, Miriam / Zarrad, Fadi / Umutlu, Lale / Rischpler, Christoph / Fendler, Wolfgang Peter / Herrmann, Ken / Weber, Manuel / Conti, Maurizio / Fragoso Costa, Pedro / Jentzen, Walter

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

2023 Volume 114, Page(s) 103149

Abstract: Purpose: The aim of this study was to investigate conditions for reliable quantification of sub-centimeter lesions with low: Methods: A small tumor phantom was investigated under challenging but clinically realistic conditions resembling prostate and ...

Abstract	Purpose: The aim of this study was to investigate conditions for reliable quantification of sub-centimeter lesions with low Methods: A small tumor phantom was investigated under challenging but clinically realistic conditions resembling prostate and thyroid cancer lymph node metastases (6 spheres with 3.7-9.7 mm in diameter, 9 different activity concentrations ranging from about 0.25-25 kBq/mL, and a signal-to-background ratio of 20). Radionuclides with different positron branching ratios and prompt gamma coincidence contributions were investigated. Maximum-, contour-, and oversize-based partial volume effect (PVE) correction approaches were applied. Detection and quantification performance were estimated, considering a ±30 % deviation between imaged-derived and true activity concentrations as acceptable. A standard and a prolonged acquisition time and two image reconstruction algorithms (time-of-flight with/without point spread function modelling) were analyzed. Clinical data were evaluated to assess agreement of PVE-correction approaches indicating lesion quantification validity. Results: The smallest 3.7-mm sphere was not visible. If the lesions were clearly observed, quantification was, except for a few cases, acceptable using contour- or oversized-based PVE-corrections. Quantification accuracy did not substantially differ between Conclusions: At the lower end of size (<10 mm) and activity concentration ranges of lymph-node metastases, quantification with reasonable accuracy is possible for
MeSH term(s)	Male ; Humans ; Positron Emission Tomography Computed Tomography/methods ; Gallium Radioisotopes ; Iodine Radioisotopes/therapeutic use ; Radiometry ; Positron-Emission Tomography
Chemical Substances	Iodine-124 ; Gallium Radioisotopes ; Iodine Radioisotopes
Language	English
Publishing date	2023-09-30
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1122650-x
ISSN	1724-191X ; 1120-1797
ISSN (online)	1724-191X
ISSN	1120-1797
DOI	10.1016/j.ejmp.2023.103149
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Article ; Online: Is There a Role of Artificial Intelligence in Preclinical Imaging?

Küper, Alina / Blanc-Durand, Paul / Gafita, Andrei / Kersting, David / Fendler, Wolfgang P / Seibold, Constantin / Moraitis, Alexandros / Lückerath, Katharina / James, Michelle L / Seifert, Robert

Seminars in nuclear medicine

2023 Volume 53, Issue 5, Page(s) 687–693

Abstract: This review provides an overview of the current opportunities for integrating artificial intelligence methods into the field of preclinical imaging research in nuclear medicine. The growing demand for imaging agents and therapeutics that are adapted to ... ...

Abstract	This review provides an overview of the current opportunities for integrating artificial intelligence methods into the field of preclinical imaging research in nuclear medicine. The growing demand for imaging agents and therapeutics that are adapted to specific tumor phenotypes can be excellently served by the evolving multiple capabilities of molecular imaging and theranostics. However, the increasing demand for rapid development of novel, specific radioligands with minimal side effects that excel in diagnostic imaging and achieve significant therapeutic effects requires a challenging preclinical pipeline: from target identification through chemical, physical, and biological development to the conduct of clinical trials, coupled with dosimetry and various pre, interim, and post-treatment staging images to create a translational feedback loop for evaluating the efficacy of diagnostic or therapeutic ligands. In virtually all areas of this pipeline, the use of artificial intelligence and in particular deep-learning systems such as neural networks could not only address the above-mentioned challenges, but also provide insights that would not have been possible without their use. In the future, we expect that not only the clinical aspects of nuclear medicine will be supported by artificial intelligence, but that there will also be a general shift toward artificial intelligence-assisted in silico research that will address the increasingly complex nature of identifying targets for cancer patients and developing radioligands.
MeSH term(s)	Humans ; Artificial Intelligence ; Neural Networks, Computer ; Nuclear Medicine ; Molecular Imaging ; Neoplasms/diagnostic imaging
Language	English
Publishing date	2023-04-08
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	120248-0
ISSN	1558-4623 ; 0001-2998
ISSN (online)	1558-4623
ISSN	0001-2998
DOI	10.1053/j.semnuclmed.2023.03.003
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Article ; Online: Intraoperative Molecular Positron Emission Tomography Imaging for Intraoperative Assessment of Radical Prostatectomy Specimens.

Darr, Christopher / Costa, Pedro Fragoso / Kahl, Theresa / Moraitis, Alexandros / Engel, Jenna / Al-Nader, Mulham / Reis, Henning / Köllermann, Jens / Kesch, Claudia / Krafft, Ulrich / Maurer, Tobias / Köhler, Daniel / Klutmann, Susanne / Falkenbach, Fabian / Kleesiek, Jens / Fendler, Wolfgang P / Hadaschik, Boris A / Herrmann, Ken

European urology open science

2023 Volume 54, Page(s) 28–32

Abstract: In this prospective two-center feasibility study, we evaluate the diagnostic value of intraoperative ex vivo specimenPET/CT imaging of radical prostatectomy (RP) and lymphadenectomy specimens. Ten patients with high-risk prostate cancer underwent ... ...

Abstract	In this prospective two-center feasibility study, we evaluate the diagnostic value of intraoperative ex vivo specimenPET/CT imaging of radical prostatectomy (RP) and lymphadenectomy specimens. Ten patients with high-risk prostate cancer underwent clinical prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) preoperatively on the day of surgery. Six patients received Patient summary: In this report, we examined prostatectomy and lymphadenectomy specimens for suspicious positron emission tomography (PET) signals after preoperative tracer injection. It was found that in all cases, a good signal could be visualized, with a promising correlation of surface assessment compared with histopathology. We conclude that specimenPET imaging is feasible and may help improve oncological outcomes in the future.
Language	English
Publishing date	2023-06-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3040546-4
ISSN	2666-1683 ; 2058-4881
ISSN (online)	2666-1683
ISSN	2058-4881
DOI	10.1016/j.euros.2023.05.017
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