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  1. Article: Challenges in familial chylomicronemia syndrome diagnosis and management across Latin American countries: An expert panel discussion.

    Santos, Raul D / Lorenzatti, Alberto / Corral, Pablo / Nogueira, Juan Patricio / Cafferata, Alberto M / Aimone, Daniel / Lourenço, Charles M / Izar, Maria Cristina / Lima, Josivan G / Lottenberg, Ana Maria / Alonso, Rodrigo / Garay, Karla / Morales, Alvaro Ruiz / Vargas-Uricoechea, Hernando / Peña, Christian A Colón / Roman-González, Alejandro

    Journal of clinical lipidology

    2021  Volume 15, Issue 5, Page(s) 620–624

    Abstract: Familial chylomicronemia syndrome (FCS) is a rare genetic disorder characterized by extremely high triglyceride levels due to impaired clearance of chylomicrons from plasma. This paper is the result of a panel discussion with Latin American specialists ... ...

    Abstract Familial chylomicronemia syndrome (FCS) is a rare genetic disorder characterized by extremely high triglyceride levels due to impaired clearance of chylomicrons from plasma. This paper is the result of a panel discussion with Latin American specialists who raised the main issues on diagnosis and management of FCS in their countries. Overall FCS is diagnosed late on the course of the disease, is characterized by heterogeneity on the occurrence of pancreatitis, and remains a long time in care of different specialists until reaching a lipidologist. Pancreatitis and secondary diabetes are frequently seen, often due to late diagnosis and inadequate care. Molecular diagnosis is unusual; however, loss of function variants on the lipoprotein lipase gene are apparently the most frequent etiology. A founder effect of the glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 gene has been described in the northeast of Brazil. Low awareness of the disease amongst health professionals contributes to inadequate care and an inadequate patient journey.
    MeSH term(s) Chylomicrons/blood ; Diabetes Mellitus/etiology ; Female ; Glycosylphosphatidylinositols/metabolism ; Humans ; Hyperlipoproteinemia Type I/blood ; Hyperlipoproteinemia Type I/diagnosis ; Hyperlipoproteinemia Type I/etiology ; Hyperlipoproteinemia Type I/therapy ; Latin America ; Lipoprotein Lipase/genetics ; Loss of Function Mutation ; Male ; Pancreatitis/etiology ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Triglycerides/blood
    Chemical Substances Chylomicrons ; Glycosylphosphatidylinositols ; RNA-Binding Proteins ; Triglycerides ; high density lipoprotein binding protein (147605-06-9) ; Lipoprotein Lipase (EC 3.1.1.34)
    Language English
    Publishing date 2021-12-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2365061-8
    ISSN 1876-4789 ; 1933-2874
    ISSN (online) 1876-4789
    ISSN 1933-2874
    DOI 10.1016/j.jacl.2021.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Relation between ultra-sensitive C-reactive protein, diabetes and periodontal disease in patients with and without myocardial infarction.

    Arregoces, Francina Escobar / Uriza, Catalina Latorre / Porras, Juliana Velosa / Camargo, Maria Beatriz Ferro / Morales, Alvaro Ruiz

    Arquivos brasileiros de endocrinologia e metabologia

    2014  Volume 58, Issue 4, Page(s) 362–368

    Abstract: Objective: The purpose of this study was to evaluate the impact of diabetes and periodontal disease in us-CRP, an inflammatory marker in patients with and without acute myocardial infarction (AMI).: Subjects and methods: A case-control study was ... ...

    Abstract Objective: The purpose of this study was to evaluate the impact of diabetes and periodontal disease in us-CRP, an inflammatory marker in patients with and without acute myocardial infarction (AMI).
    Subjects and methods: A case-control study was conducted in 401 subjects aged between 30 and 75 years, living in Bogotá D.C. (Colombia). Patients arriving at the emergency room of the San Ignacio University Hospital with AMI were included into the case group. The control group was defined as those subjects without AMI. The following blood tests were performed: complete blood count (CBC), glycemia, total cholesterol, triglycerides, cHDL, cLDL, and us-CRP. Patients with infections or antibiotic treatment within the last three months, who had received periodontal treatment within the six months prior to the study entry, had oral ulcerations, or less than seven teeth were excluded from the study. Periodontal disease was diagnosed based on the 1999 Armitage's classification.
    Results: The mean us-CRP value found in diabetic patients with severe chronic periodontitis was 5.31 mg/L (SD 6.82), and 2.38 mg/L (SD 4.42) in non-diabetic patients, being statistically significant (p = 0.000).
    Conclusion: Diabetes had an impact in periodontal disease and us-CRP. In patients with AMI, DM and PD considerably increased the us-CRP.
    MeSH term(s) Adult ; Aged ; Biomarkers/blood ; Blood Glucose/analysis ; C-Reactive Protein/analysis ; Case-Control Studies ; Cholesterol/blood ; Chronic Periodontitis/blood ; Chronic Periodontitis/diagnosis ; Diabetes Mellitus, Type 2/blood ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/blood ; Periodontal Diseases/blood ; Periodontal Diseases/diagnosis ; Risk Factors ; Triglycerides/blood
    Chemical Substances Biomarkers ; Blood Glucose ; Triglycerides ; C-Reactive Protein (9007-41-4) ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2014-06-07
    Publishing country Brazil
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603919-4
    ISSN 1677-9487 ; 0004-2730
    ISSN (online) 1677-9487
    ISSN 0004-2730
    DOI 10.1590/0004-2730000002899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Ultra-Sensitive C-Reactive Protein (US-CRP) in Patients With Periodontal Disease and Risk of Acute Myocardial Infarction.

    Uriza, Catalina Latorre / Arregoces, Francina Escobar / Porras, Juliana Velosa / Camargo, Maria Beatriz Ferro / Morales, Alvaro Ruiz

    Cardiology research

    2011  Volume 2, Issue 1, Page(s) 27–35

    Abstract: Background: The purpose of this study was to determine if the US-CRP values associated with periodontal disease are risk markers for Acute Myocardial Infarction (AMI) and to determine if the US-CRP levels associated with recent AMI are higher in ... ...

    Abstract Background: The purpose of this study was to determine if the US-CRP values associated with periodontal disease are risk markers for Acute Myocardial Infarction (AMI) and to determine if the US-CRP levels associated with recent AMI are higher in patients with Periodontal disease.
    Methods: In order to meet the goal of the study, a case control study design was conducted. The analysis sample consisted of 401 adults (30 - 75 years old), living in Bogota D.C., Colombia, from the Hospital Universitario San Ignacio, the Faculty of Dentistry at the Pontificia Universidad Javeriana, and the Fundacion Cardio Infantil. Patients with current infections, antibiotic use in the last 3 months, periodontal treatment at least six months before the baseline of this study, mouth ulcerations caused by any type of prosthesis, candidiasis, stomatitis, or less than 7 teeth in mouth were excluded. Periodontal examination for the case group and the control group was conducted by three previously calibrated examiners. Periodontal disease was diagnosed by the presence of bleeding on probing and attachment loss. The Chronic Periodontitis diagnosis was confirmed with these clinical signs, according to the 1999 Armitage classification. The assessment of the US-CRP was performed using the IMMULITE method containing one monoclonal and one polyclonal anti-CRP antibody. This method provides a measurement range of 0.1 - 500 mg/L. Statistical analysis of variables was performed with OR and confidence intervals. A multivariate analysis was performed to determine the association between the US-CRP increase, periodontal disease and acute myocardial infarction, adjusting for smoking and other confounding factors identified in the analysis.
    Results: The study population was constituted by 401 patients, 56.1% (225) males, with a mean age of 52.6. When groups were compared it was observed that, in those patients with AMI and chronic severe or moderate periodontitis, 24.2% had HDL-C values lower than 40 mg/dl, 78.8% had LDL-C values higher than 100 mg/dl, 55.2% had triglycerides over 150 mg/dl, and US-CRP over 2 mg/L in 53.3%.
    Conclusions: Periodontal disease (moderate, severe, and chronic periodontal disease) may increase the risk of Acute Myocardial Infarction (AMI) by increasing the US-CRP levels.
    Language English
    Publishing date 2011-01-20
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2598593-0
    ISSN 1923-2837 ; 1923-2829
    ISSN (online) 1923-2837
    ISSN 1923-2829
    DOI 10.4021/cr11e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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