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  1. AU="More, Jessica"
  2. AU="Eliot, George"
  3. AU="Choi, Kati"
  4. AU="Wiese, Lothar"
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  11. AU="Manes, K"
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  13. AU="Qu, C"
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  17. AU=Butler Taylor
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  1. Artikel: Validation of proteins associated with pathological damage in human tuberculosis granulomas: study protocol.

    Mpotje, Thabo / More, Jessica / Rajkumar-Bhugeloo, Kerishka / Moodley, Denelle / Marakalala, Mohlopheni J

    Wellcome open research

    2023  Band 8, Seite(n) 139

    Abstract: The presence of the Tuberculosis (TB) disease-causing pathogen, ...

    Abstract The presence of the Tuberculosis (TB) disease-causing pathogen,
    Sprache Englisch
    Erscheinungsdatum 2023-03-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.19226.1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Cell type-specific gene expression dynamics during human brain maturation.

    Steyn, Christina / Mishi, Ruvimbo / Fillmore, Stephanie / Verhoog, Matthijs B / More, Jessica / Rohlwink, Ursula K / Melvill, Roger / Butler, James / Enslin, Johannes M N / Jacobs, Muazzam / Sauka-Spengler, Tatjana / Greco, Maria / Quiñones, Sadi / Dulla, Chris G / Raimondo, Joseph V / Figaji, Anthony / Hockman, Dorit

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The human brain undergoes protracted post-natal maturation, guided by dynamic changes in gene expression. To date, studies exploring these processes have used bulk tissue analyses, which mask cell type-specific gene expression dynamics. Here, using ... ...

    Abstract The human brain undergoes protracted post-natal maturation, guided by dynamic changes in gene expression. To date, studies exploring these processes have used bulk tissue analyses, which mask cell type-specific gene expression dynamics. Here, using single nucleus (sn)RNA-seq on temporal lobe tissue, including samples of African ancestry, we build a joint paediatric and adult atlas of 54 cell subtypes, which we verify with spatial transcriptomics. We explore the differences in cell states between paediatric and adult cell types, revealing the genes and pathways that change during brain maturation. Our results highlight excitatory neuron subtypes, including the LTK and FREM subtypes, that show elevated expression of genes associated with cognition and synaptic plasticity in paediatric tissue. The new resources we present here improve our understanding of the brain during a critical period of its development and contribute to global efforts to build an inclusive cell map of the brain.
    Sprache Englisch
    Erscheinungsdatum 2024-05-17
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.09.29.560114
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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