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  1. Article ; Online: Seasonal and circadian variation of non-volatile metabolites in Lippia alba leaves.

    Gomes, Angélica Ferraz / Rocha, Girlane Oliveira / Scabini, Caroline / da Silva Oliveira, Jayne Ferreira / Oliveira, Déborah Neres / Mota, Luise Carvalho / Almeida Neves, Brenda Novais / Dos Santos, Amanda Menezes / Araújo, Urias Santos / Moreira, Bruno Oliveira / de Souza, Flávio Mendes / de Almeida, Maiara Prates / Amaral, Juliano Geraldo / David, Jorge Maurício

    Chemistry & biodiversity

    2024  , Page(s) e202400594

    Abstract: The present study describes the seasonal and circadian variations of the major compounds from Lippia alba leaves. SPSS was used to identify, quantify, and associate the variations in the secondary metabolites of this species through HPLC/DAD analysis of ... ...

    Abstract The present study describes the seasonal and circadian variations of the major compounds from Lippia alba leaves. SPSS was used to identify, quantify, and associate the variations in the secondary metabolites of this species through HPLC/DAD analysis of the leaves hydroethanolic extracts of six selected L. alba specimens. For the circadian study, the samples were collected at four different daily hours in each year's season. For the seasonal study, the samples were collected monthly from the same individuals for two consecutive years (2018 and 2019). These samples were analyzed and quantified using a validated HPLC method for flavonoids, iridoids, and phenyl ethanoid glycoside. Mussaenoside, acteoside, and tricin-7-O-diglucuronide showed a moderate positive correlation between their biosynthesis and the precipitation index, while epi-loganin had a moderate negative correlation. Acteoside showed a moderate positive correlation between the minimum registered temperature and its production. Compared with previous studies, a drastic reduction (about 95%) in the production of tricin-7-O-diglucuronide compared with previous study and this difference could be attributed to the plant's aging. Thus, the data demonstrated that lower temperatures and high rainfall could favor the production of the major L. alba active compounds (acteoside and tricin-7-O-diglucuronide) and that older plants harm their production.
    Language English
    Publishing date 2024-04-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202400594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: New dimer and trimer of chalcone derivatives from anti-inflammatory and antinociceptive extracts of Schinopsis brasiliensis roots

    Moreira, Bruno Oliveira / Vilar, Vanessa Lima Souza / de Almeida, Ramine Nascimento Santos / Morbeck, Lorena Lôbo Brito / Andrade, Bruno Silva / Barros, Rafael Gomes Moreno / Neves, Breno Magalhães / de Carvalho, Anaildes Lago / Cruz, Mariluze Peixoto / Yatsuda, Regiane / David, Jorge Mauricio

    Journal of ethnopharmacology. 2022 May 10, v. 289

    2022  

    Abstract: Schinopsis brasiliensis Engl. is an endemic tree of the Brazilian semi-arid regions belonging to the Anacardiaceae family. It is the main representative of the genus Schinopsis, mostly native to Brazil and popularly known as "braúna" or "baraúna". ... ...

    Abstract Schinopsis brasiliensis Engl. is an endemic tree of the Brazilian semi-arid regions belonging to the Anacardiaceae family. It is the main representative of the genus Schinopsis, mostly native to Brazil and popularly known as "braúna" or "baraúna". Different parts of this plant are employed in Brazilian folk medicines to treat inflammation in general, sexual impotence, cough, and influenza. This work describes the antinociceptive (acetic acid-induced writhing and formalin-induced nociception) and anti-inflammatory (paw edema and neutrophil migration) activities of the extract of the root of S. brasiliensis. Besides, the evaluation of total phenolic compounds and antioxidant, antimicrobial (including MRSA bacteria), and acetylcholinesterase inhibition activities were also determined. The pure compounds were isolated by different chromatographic techniques and their chemical structures have been unambiguously elucidated based on extensive spectroscopic methods, including 1D (¹H, ¹³C, DEPT, and NOEdiff) and 2D (HSQC, HMBC, and NOESY) NMR experiments, MS data, and comparison with the literature data of similar compounds. The antinociceptive and anti-inflammatory activities were evaluated by acid acetic writhing test, formalin paw edema, and by the investigation of neutrophil migration to the peritoneal cavities of mice. For antimicrobial evaluation were determined MIC and MBC, antioxidant activities were obtained by TPC and DPPH tests, and AChE inhibition by Elmann's methodology. The extracts showed antinociceptive and anti-inflammatory activities and two unusual new compounds, a cyclobutanyl chalcone trimer (schinopsone A) and a cyclohexene-containing chalcone dimer (schinopsone B), with six known compounds were isolated from the active extracts. Additionally, the acetylcholinesterase inhibitory activity for isolated compounds was reported for the first time in this study. Molecular docking studies indicated that the isolated compounds are responsible for the interaction with anti-inflammatory targets (COX 1 and 2 and LOX) with variable binding affinities, indicating a possible mechanism of action of these compounds. These findings indicate for the first time the correlation between the anti-inflammatory activity different enriched polyphenol-organic soluble fractions of S. brasiliensis, and it contributes to the understanding of the anti-inflammatory potential of S. brasiliensis.
    Keywords Schinopsis ; acetylcholinesterase ; anti-inflammatory activity ; antioxidants ; chalcone ; chromatography ; cough ; edema ; formalin ; indigenous species ; inflammation ; influenza ; mechanism of action ; methicillin-resistant Staphylococcus aureus ; neutrophils ; nociception ; traditional medicine ; Brazil
    Language English
    Dates of publication 2022-0510
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115089
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 90/710: Show issues

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  3. Article ; Online: New dimer and trimer of chalcone derivatives from anti-inflammatory and antinociceptive extracts of Schinopsis brasiliensis roots.

    Moreira, Bruno Oliveira / Vilar, Vanessa Lima Souza / de Almeida, Ramine Nascimento Santos / Morbeck, Lorena Lôbo Brito / Andrade, Bruno Silva / Barros, Rafael Gomes Moreno / Neves, Breno Magalhães / de Carvalho, Anaildes Lago / Cruz, Mariluze Peixoto / Yatsuda, Regiane / David, Jorge Mauricio

    Journal of ethnopharmacology

    2022  Volume 289, Page(s) 115089

    Abstract: Ethnopharmacology relevance: Schinopsis brasiliensis Engl. is an endemic tree of the Brazilian semi-arid regions belonging to the Anacardiaceae family. It is the main representative of the genus Schinopsis, mostly native to Brazil and popularly known as ...

    Abstract Ethnopharmacology relevance: Schinopsis brasiliensis Engl. is an endemic tree of the Brazilian semi-arid regions belonging to the Anacardiaceae family. It is the main representative of the genus Schinopsis, mostly native to Brazil and popularly known as "braúna" or "baraúna". Different parts of this plant are employed in Brazilian folk medicines to treat inflammation in general, sexual impotence, cough, and influenza.
    Aim of the study: This work describes the antinociceptive (acetic acid-induced writhing and formalin-induced nociception) and anti-inflammatory (paw edema and neutrophil migration) activities of the extract of the root of S. brasiliensis. Besides, the evaluation of total phenolic compounds and antioxidant, antimicrobial (including MRSA bacteria), and acetylcholinesterase inhibition activities were also determined.
    Material and methods: The pure compounds were isolated by different chromatographic techniques and their chemical structures have been unambiguously elucidated based on extensive spectroscopic methods, including 1D (
    Results: The extracts showed antinociceptive and anti-inflammatory activities and two unusual new compounds, a cyclobutanyl chalcone trimer (schinopsone A) and a cyclohexene-containing chalcone dimer (schinopsone B), with six known compounds were isolated from the active extracts. Additionally, the acetylcholinesterase inhibitory activity for isolated compounds was reported for the first time in this study. Molecular docking studies indicated that the isolated compounds are responsible for the interaction with anti-inflammatory targets (COX 1 and 2 and LOX) with variable binding affinities, indicating a possible mechanism of action of these compounds.
    Conclusions: These findings indicate for the first time the correlation between the anti-inflammatory activity different enriched polyphenol-organic soluble fractions of S. brasiliensis, and it contributes to the understanding of the anti-inflammatory potential of S. brasiliensis.
    MeSH term(s) Anacardiaceae/chemistry ; Analgesics/isolation & purification ; Analgesics/pharmacology ; Animals ; Anti-Inflammatory Agents/isolation & purification ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Brazil ; Chalcones/chemistry ; Chalcones/isolation & purification ; Chalcones/pharmacology ; Disease Models, Animal ; Inflammation/drug therapy ; Male ; Mice ; Mice, Inbred BALB C ; Molecular Docking Simulation ; Plant Extracts/chemistry ; Plant Extracts/pharmacology
    Chemical Substances Analgesics ; Anti-Inflammatory Agents ; Antioxidants ; Chalcones ; Plant Extracts
    Language English
    Publishing date 2022-02-07
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Evaluation of anti-inflammatory, antinociceptive and biological activities of

    Moreira, Bruno Oliveira / de Carvalho, Anaildes Lago / Alves, Clayton Queiroz / Morbeck, Lorena Lôbo Brito / Cruz, Mariluze Peixoto / Yatsuda, Regiane / David, Juceni Pereira / David, Jorge Mauricio

    RSC advances

    2019  Volume 9, Issue 70, Page(s) 41256–41268

    Abstract: The stem barks and leaves ... ...

    Abstract The stem barks and leaves of
    Language English
    Publishing date 2019-12-13
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/c9ra05985g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

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