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  1. Article ; Online: The next step: how sleep and physical activity can act together in the post-COVID-19 scenario.

    Dokkedal-Silva, Vinícius / Morelhão, Priscila K / Moreira, Gustavo A / Tufik, Sergio / Andersen, Monica L

    Sleep & breathing = Schlaf & Atmung

    2022  Volume 27, Issue 2, Page(s) 689–690

    MeSH term(s) Humans ; COVID-19 ; Exercise ; Sleep
    Language English
    Publishing date 2022-06-17
    Publishing country Germany
    Document type Letter
    ZDB-ID 1500381-4
    ISSN 1522-1709 ; 1520-9512
    ISSN (online) 1522-1709
    ISSN 1520-9512
    DOI 10.1007/s11325-022-02657-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Obstructive sleep apnea in asthmatic children: a cross-sectional study about prevalence and risk factors.

    Fumo-Dos-Santos, Cristiane / Smith, Anna K / Togeiro, Sonia M G P / Tufik, Sergio / Moreira, Gustavo A

    Jornal de pediatria

    2023  Volume 99, Issue 5, Page(s) 443–448

    Abstract: Objectives: Primary objectives were to analyze the prevalence of obstructive sleep apnea in (1) boys and girls, and (2) severe asthma versus moderate and mild cases. The authors hypothesized that girls and severe asthma would have a higher prevalence of ...

    Abstract Objectives: Primary objectives were to analyze the prevalence of obstructive sleep apnea in (1) boys and girls, and (2) severe asthma versus moderate and mild cases. The authors hypothesized that girls and severe asthma would have a higher prevalence of obstructive sleep apnea.
    Methods: Cross-sectional evaluation of asthmatic children attending a tertiary Pediatric Pulmonology clinic. The authors performed a history, physical examination, pulmonary function test, and home sleep apnea test.
    Results: The authors studied 80 consecutive patients, 7-18 years old, mean age of 11.6 years (standard deviation 2.7), 51.3% female, and 18.5% obese. Pulmonary function tests were obtained from 80 volunteers, 45% with obstruction pattern. Home sleep apnea tests were available from 76 volunteers, with a mean obstructive respiratory index of 1.8 events/h. Obstructive sleep apnea was found in 49 volunteers (61.2%). The authors did not find associations between obstructive sleep apnea and sex or asthma severity.
    Conclusions: Obstructive sleep apnea was frequent among these asthmatic children. Sex and asthma severity were not risk factors. Considering the interrelationship of both diseases, it is worth keeping in mind the possibility of obstructive sleep apnea among children and teenagers with asthma.
    MeSH term(s) Male ; Adolescent ; Humans ; Child ; Female ; Cross-Sectional Studies ; Prevalence ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/epidemiology ; Sleep Apnea, Obstructive/diagnosis ; Asthma/complications ; Asthma/epidemiology ; Sleep Apnea Syndromes ; Risk Factors
    Language English
    Publishing date 2023-05-03
    Publishing country Brazil
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 731324-x
    ISSN 1678-4782 ; 0021-7557
    ISSN (online) 1678-4782
    ISSN 0021-7557
    DOI 10.1016/j.jped.2023.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Treatment Approaches to Myasthenia Gravis and Obstructive Sleep Apnea: Case Report

    Iafigliola, Sergio Giamas / Guimarães, Thais Moura / D'Almeida, Vânia / Poyares, Dalva / Dal-Fabbro, Cibele / Tufik, Sergio / Moreira, Gustavo A.

    Sleep Science

    2024  

    Abstract: Myasthenia gravis (MG) is a chronic autoimmune disease characterized by progressive weakness and skeletal muscle fatigue due to the destruction of acetylcholine receptors, causing an abnormality in the synaptic junction between innervation and muscle ... ...

    Abstract Myasthenia gravis (MG) is a chronic autoimmune disease characterized by progressive weakness and skeletal muscle fatigue due to the destruction of acetylcholine receptors, causing an abnormality in the synaptic junction between innervation and muscle fibers. The treatment of patients with MG and obstructive sleep apnea (OSA) is positive pressure in the airway; however, the lack of adherence to the protocol can lead to increased morbidity. A known alternative treatment for OSA is the mandibular advancement device (MAD). The objective of the present report is to describe an emblematic case of a 50-year-old male patient with MG with sleep complaints and documented OSA, and his response to different treatment approaches.
    Keywords mandibular advancement device ; myasthenia gravis ; obstructive sleep apnea
    Language English
    Publishing date 2024-05-15
    Publisher Thieme Revinter Publicações Ltda.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2697016-8
    ISSN 1984-0063 ; 1984-0659 ; 1984-0063
    ISSN (online) 1984-0063
    ISSN 1984-0659 ; 1984-0063
    DOI 10.1055/s-0044-1780502
    Database Thieme publisher's database

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  4. Article: Quality of life related to residual snoring after adenotonsillectomy: a pilot study.

    Bariani, Rita Catia Brás / Guimaraes, Thais Moura / Moura, Wilana / Cappellette Junior, Mario / Tufik, Sergio / Moreira, Gustavo A / Fujita, Reginaldo Raimundo

    Sleep science (Sao Paulo, Brazil)

    2022  Volume 14, Issue 4, Page(s) 330–336

    Abstract: Introduction: Few studies have addressed long-term quality of life related to residual snoring after adenotonsillectomy. The aim of this study was to compare scores from the OSA-18 questionnaire between children with residual snoring and non-snoring ... ...

    Abstract Introduction: Few studies have addressed long-term quality of life related to residual snoring after adenotonsillectomy. The aim of this study was to compare scores from the OSA-18 questionnaire between children with residual snoring and non-snoring children two or more years after adenotonsillectomy.
    Material and methods: The sample comprised 25 children divided into two groups, a group of 14 snoring children, and a control group of 11 non-snoring children. The OSA-18 questionnaire was applied to the volunteers. In the control group, it was completed by the caregivers of the children, while in individuals with residual snoring it was completed by the caregivers of children in the presence of a doctor or dentist. A statistical comparison was made using a generalized linear model.
    Results: The snorer group had a higher total OSA-18 score, and a higher score in all five domains compared to the control group.
    Conclusion: Children with residual snoring two or more years after adenotonsillectomy may have a worse quality of life compared to the control group.
    Language English
    Publishing date 2022-01-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2697016-8
    ISSN 1984-0063 ; 1984-0659
    ISSN (online) 1984-0063
    ISSN 1984-0659
    DOI 10.5935/1984-0063.20200093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Genetic basis of sleep phenotypes and rare neurodevelopmental syndromes reveal shared molecular pathways.

    Moysés-Oliveira, Mariana / Paschalidis, Mayara / Souza-Cunha, Lais A / Esteves-Guerreiro, Pedro A / Adami, Luana Nayara Gallego / Kloster, Anna K / Mosini, Amanda C / Moreira, Gustavo A / Doria, Sandra / Tempaku, Priscila F / Pires, Gabriel N / Andersen, Monica L / Tufik, Sergio

    Journal of neuroscience research

    2023  Volume 101, Issue 7, Page(s) 1058–1067

    Abstract: Sleep-related phenotypes have been frequently reported in early on-set epileptic encephalopathies and in developmental delay syndromes, in particular in syndromes related to autism spectrum disorder. Yet the convergent pathogenetic mechanisms between ... ...

    Abstract Sleep-related phenotypes have been frequently reported in early on-set epileptic encephalopathies and in developmental delay syndromes, in particular in syndromes related to autism spectrum disorder. Yet the convergent pathogenetic mechanisms between these comorbidities are largely unknown. We first performed a gene enrichment study that identified shared risk genes among rare epileptic encephalopathies/neurodevelopmental disorders, rare developmental delay genetic syndromes and sleep disturbances. We then determined cellular and molecular pathways enriched among genes shared between sleep phenotypes and those two early onset mental illnesses, aiming to identify genetic disparities and commonalities among these phenotypic groups. The sleep gene set was observed as significantly overlapped with the two gene lists associated to rare genetic syndromes (i.e., epileptic encephalopathies/neurodevelopmental disorders and developmental delay gene sets), suggesting shared genetic contribution. Similarities across significantly enriched pathways between the two intersect lists comprehended mostly synapse-related pathways, such as retrograde endocannabinoid signaling, serotonergic, and GABAergic synapse. Network analysis indicates epileptic encephalopathies/neurodevelopmental disorders versus sleep-specific clusters and developmental delay versus sleep-specific clusters related to synaptic and transcriptional regulation, respectively. Longstanding functional patterns previously described in epileptic encephalopathies and neurodevelopmental disorders genetic architecture were recaptured after dissecting the overlap between the genes associated to those developmental phenotypes and sleep disturbances, suggesting that during neurodevelopment different molecular and functional mechanisms are related to alterations on circadian rhythm. The overlapping gene set and biological pathways highlighted by this study may serve as a primer for new functional investigations of shared molecular mechanisms between sleep disturbances and rare developmental syndromes.
    MeSH term(s) Humans ; Syndrome ; Autism Spectrum Disorder/genetics ; Phenotype ; Sleep Wake Disorders/genetics ; Brain Diseases ; Sleep/genetics
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/jnr.25180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Rapid maxillary expansion in patient with obstructive sleep apnea: case report.

    Bariani, Rita Catia / Badreddine, Fauze Ramez / Yamamoto, Lucia Hatsue / Shido, Flavio Toshiki / Hoppe, Daniela Pimentel Machado Renofio / Tufik, Sergio / Moreira, Gustavo A / Cappellette, Mario / Fujita, Reginaldo Raimundo

    Sleep science (Sao Paulo, Brazil)

    2022  Volume 15, Issue Spec 1, Page(s) 293–299

    Abstract: The aim of this case report was to evaluate the polysomnography indices, air space in the oropharyngeal region and quality of life scores using the OSA-18 questionnaire in a patient diagnosed with obstructive sleep apnea before and after rapid maxillary ... ...

    Abstract The aim of this case report was to evaluate the polysomnography indices, air space in the oropharyngeal region and quality of life scores using the OSA-18 questionnaire in a patient diagnosed with obstructive sleep apnea before and after rapid maxillary expansion (RME). It is a case report with a male patient, seven years old, with maxillary hypoplasia, who underwent adenotonsillectomy surgery two years ago, had restless sleep, snore more than five times a week. Pre- and post-treatment diagnostic tests were performed, including nasofibroscopy, polysomnography, computed tomography, orthodontic records and the OSA-18 quality of life questionnaire. The treatment consisted of RME with Hyrax maxillary expander. After six months, the exams were redone. The polysomnographic record before treatment: IAH 2.8/h, after treatment 0.5/h. We concluded that rapid maxillary expansion (RME) in children with OSA appears to be an effective treatment.
    Language English
    Publishing date 2022-02-04
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 2697016-8
    ISSN 1984-0063 ; 1984-0659
    ISSN (online) 1984-0063
    ISSN 1984-0659
    DOI 10.5935/1984-0063.20220026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Insomnia episodes, new-onset pharmacological treatments, and other sleep disturbances during the COVID-19 pandemic: a nationwide cross-sectional study in Brazilian health care professionals.

    Drager, Luciano F / Pachito, Daniela V / Moreno, Claudia R C / Tavares, Almir R / Conway, Silvia G / Assis, Márcia / Sguillar, Danilo A / Moreira, Gustavo A / Bacelar, Andrea / Genta, Pedro R

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2022  Volume 18, Issue 2, Page(s) 373–382

    Abstract: Study objectives: To evaluate the impact of the coronavirus disease 2019 (COVID-19) pandemic on insomnia and other sleep disturbances in health care professionals.: Methods: A survey was distributed using social media and organizational emails to ... ...

    Abstract Study objectives: To evaluate the impact of the coronavirus disease 2019 (COVID-19) pandemic on insomnia and other sleep disturbances in health care professionals.
    Methods: A survey was distributed using social media and organizational emails to Brazilian active health care professionals during the COVID-19 outbreak. We explored potential associated factors including age, sex, occupation, workplace, work hours, income, previous infection with COVID-19, recent/current contact with COVID-19 patients, regional number of incident deaths, anxiety, and burnout. We evaluated new-onset/previous insomnia worsening episodes (primary outcome), new pharmacological treatments, sleep quality, duration, nightmares, and snoring (secondary outcomes).
    Results: A total of 4,384 health professionals from all regions of the country were included in the analysis (44 ± 12 years, 76% females, 53.8% physicians). Overall, 55.7% were assisting patients with COVID-19, and 9.2% had a previous COVID-19 infection. The primary outcome occurred in 32.9% of respondents in parallel to 13% new pharmacological treatments for insomnia. The sleep quality worsened for 61.4%, while 43.5% and 22.8% reported ≥ 1-hour sleep duration reduction and worsening or new-onset nightmares, respectively. Multivariate analyses showed that age (odds ratio [OR]: 1.008; 95% confidence interval [CI] 1.001-1.015), females (OR: 1.590; 95% CI 1.335-1.900), weight change (decrease: OR: 1.772; 95% CI 1.453-2.161; increase: OR: 1.468; 95% CI 1.249-1.728), prevalent anxiety (OR: 3.414; 95% CI 2.954-3.948), new-onset burnout (OR: 1.761; 95% CI 1.489-2.083), family income reduction > 30% (OR: 1.288; 95% CI 1.069-1.553), and assisting patients with COVID-19 (OR: 1.275; 95% CI 1.081-1.506) were independently associated with new-onset or worsening of previous insomnia episodes.
    Conclusions: We observed a huge burden of insomnia episodes and other sleep disturbances in health care professionals during the COVID-19 pandemic.
    Citation: Drager LF, Pachito DV, Moreno CRC, et al. Insomnia episodes, new-onset pharmacological treatments, and other sleep disturbances during the COVID-19 pandemic: a nationwide cross-sectional study in Brazilian health care professionals.
    MeSH term(s) Anxiety ; COVID-19 ; Cross-Sectional Studies ; Depression ; Female ; Health Personnel ; Humans ; Male ; Pandemics ; SARS-CoV-2 ; Sleep ; Sleep Initiation and Maintenance Disorders/drug therapy ; Sleep Initiation and Maintenance Disorders/epidemiology
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.9570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Quality of life related to residual snoring after adenotonsillectomy: a pilot study

    Bariani, Rita Catia Brás / Guimaraes, Thais Moura / Moura, Wilana / Cappellette Junior, Mario / Tufik, Sergio / Moreira, Gustavo A. / Fujita, Reginaldo Raimundo

    Sleep Science

    2021  Volume 14, Issue 04, Page(s) 330–336

    Abstract: Introduction: Few studies have addressed long-term quality of life related to residual snoring after adenotonsillectomy. The aim of this study was to compare scores from the OSA-18 questionnaire between children with residual snoring and non-snoring ... ...

    Abstract Introduction: Few studies have addressed long-term quality of life related to residual snoring after adenotonsillectomy. The aim of this study was to compare scores from the OSA-18 questionnaire between children with residual snoring and non-snoring children two or more years after adenotonsillectomy.
    Material and Methods: The sample comprised 25 children divided into two groups, a group of 14 snoring children, and a control group of 11 non-snoring children. The OSA-18 questionnaire was applied to the volunteers. In the control group, it was completed by the caregivers of the children, while in individuals with residual snoring it was completed by the caregivers of children in the presence of a doctor or dentist. A statistical comparison was made using a generalized linear model.
    Results: The snorer group had a higher total OSA-18 score, and a higher score in all five domains compared to the control group.
    Conclusion: Children with residual snoring two or more years after adenotonsillectomy may have a worse quality of life compared to the control group.
    Keywords Sleep Apnea ; Obstructive ; Snoring ; Indicators of Quality of Life ; Tonsillectomy
    Language English
    Publishing date 2021-12-01
    Publisher Thieme Revinter Publicações Ltda.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2697016-8
    ISSN 1984-0063 ; 1984-0659 ; 1984-0063
    ISSN (online) 1984-0063
    ISSN 1984-0659 ; 1984-0063
    DOI 10.5935/1984-0063.20200093
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  9. Article: Narcolepsy, Precocious Puberty and Obesity in the Pediatric Population: a Literature Review.

    Maia Palhano, Ana Clara / Kim, Lenise Jihe / Moreira, Gustavo A / Santos Coelho, Fernando Morgadinho / Tufik, Sergio / Levy Andersen, Monica

    Pediatric endocrinology reviews : PER

    2019  Volume 16, Issue 2, Page(s) 266–274

    Abstract: Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, sleep paralysis and hypnagogic and hypnopompic hallucinations. The onset of the symptoms usually occurs in childhood, and previous studies have reported an ... ...

    Abstract Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, sleep paralysis and hypnagogic and hypnopompic hallucinations. The onset of the symptoms usually occurs in childhood, and previous studies have reported an association between narcolepsy and other endocrine diseases in the pediatric population, such as obesity and precocious puberty. The incidence of overweight or obesity ranges from 25% to 74% in patients with narcolepsy type I, while precocious puberty is present in 17% of children with narcolepsy with cataplexy. However, the mechanisms involved in the association of narcolepsy with obesity and precocious puberty have not been fully elucidated yet. In this review, we aimed to discuss narcolepsy in pediatric populations, highlighting the diagnostic difficulties and the complexity of the possible mechanisms that can relate narcolepsy to precocious puberty and obesity. We also emphasized the fact that endocrine diseases must be taken into consideration in children diagnosed with narcolepsy.
    MeSH term(s) Cataplexy ; Child ; Humans ; Narcolepsy ; Obesity ; Puberty, Precocious
    Language English
    Publishing date 2019-02-18
    Publishing country Israel
    Document type Journal Article ; Review
    ZDB-ID 2434390-0
    ISSN 1565-4753
    ISSN 1565-4753
    DOI 10.17458/per.vol16.2018.Narcolepsypubertyobesity
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Rapid maxillary expansion in patient with obstructive sleep apnea: case report

    Bariani, Rita Catia / Badreddine, Fauze Ramez / Yamamoto, Lucia Hatsue / Shido, Flavio Toshiki / Hoppe, Daniela Pimentel Machado Renofio / Tufik, Sergio / Moreira, Gustavo A. / Cappellette, Mario / Fujita, Reginaldo Raimundo

    Sleep Science

    2022  Volume 15, Issue S 01, Page(s) 293–299

    Abstract: The aim of this case report was to evaluate the polysomnography indices, air space in the oropharyngeal region and quality of life scores using the OSA-18 questionnaire in a patient diagnosed with obstructive sleep apnea before and after rapid maxillary ... ...

    Abstract The aim of this case report was to evaluate the polysomnography indices, air space in the oropharyngeal region and quality of life scores using the OSA-18 questionnaire in a patient diagnosed with obstructive sleep apnea before and after rapid maxillary expansion (RME). It is a case report with a male patient, seven years old, with maxillary hypoplasia, who underwent adenotonsillectomy surgery two years ago, had restless sleep, snore more than five times a week. Pre- and post-treatment diagnostic tests were performed, including nasofibroscopy, polysomnography, computed tomography, orthodontic records and the OSA-18 quality of life questionnaire. The treatment consisted of RME with Hyrax maxillary expander. After six months, the exams were redone. The polysomnographic record before treatment: IAH 2.8/h, after treatment 0.5/h. We concluded that rapid maxillary expansion (RME) in children with OSA appears to be an effective treatment.
    Keywords Sleep Apnea ; Obstructive ; Palatal Expansion Technique ; Sleep Apnea Syndromes ; Craniofacial Abnormalities ; Snoring. Child
    Language English
    Publishing date 2022-03-01
    Publisher Thieme Revinter Publicações Ltda.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2697016-8
    ISSN 1984-0063 ; 1984-0659 ; 1984-0063
    ISSN (online) 1984-0063
    ISSN 1984-0659 ; 1984-0063
    DOI 10.5935/1984-0063.20220026
    Database Thieme publisher's database

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