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Article ; Online: Photobiomodulation Therapy and Dexamethasone in the Management of Oral Acute Graft-Versus-Host Disease: Case Report.

Ramos, Gabriela de Assis / Moreira, Maria Cláudia Rodrigues / Costa, Ana Maria Dias da / Antunes, Héliton Spíndola

Photobiomodulation, photomedicine, and laser surgery

2020 Volume 38, Issue 11, Page(s) 683–686

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Dexamethasone/therapeutic use ; Female ; Graft vs Host Disease/drug therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Low-Level Light Therapy ; Middle Aged ; Wound Healing
Chemical Substances	Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2020-10-23
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	2578-5478
ISSN (online)	2578-5478
DOI	10.1089/photob.2020.4878
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Article ; Online: The multiple presentation of oral actinomycosis in post-hematopoietic stem cell transplantation patients: case series.

Menezes, Ana Carolina Dos Santos / Alves, Lísia Daltro Borges / Ramos, Gabriela de Assis / Schirmer, Marcelo Ribeiro / Moreira, Maria Claudia Rodrigues / Piragibe, Maria Midori Miura / de Melo, Andréia Cristina / Antunes, Héliton Spíndola

Hematology, transfusion and cell therapy

2023

Language	English
Publishing date	2023-12-20
Publishing country	Brazil
Document type	Case Reports
ISSN	2531-1387
ISSN (online)	2531-1387
DOI	10.1016/j.htct.2023.11.003
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Article ; Online: Treatment of oral chronic graft-versus-host disease: a retrospective cohort study.

Ramos, Gabriela de Assis / Leite, Taísa Domingues Boehmer / Lobo, Camila Brandão / Santos, Paulo Sérgio da Silva / Moreira, Maria Claudia Rodrigues / Antunes, Héliton Spindola

Einstein (Sao Paulo, Brazil)

2021 Volume 19, Page(s) eAO6177

Abstract: Objective: The aim of this study was to evaluate patients with complete response of oral chronic graft-versus-host disease to immunosuppressive treatment.: Methods: A total of 29 patients submitted to allogeneic hematopoietic stem cell ... ...

Abstract	Objective: The aim of this study was to evaluate patients with complete response of oral chronic graft-versus-host disease to immunosuppressive treatment. Methods: A total of 29 patients submitted to allogeneic hematopoietic stem cell transplantation, with oral chronic graft-versus-host disease, were enrolled in this retrospective study, from September 2012 to February 2018. Patients were treated with combined topical dexamethasone solution and topical tacrolimus ointment, combined topical dexamethasone and topical tacrolimus, systemic immunosuppressive medication, and topical dexamethasone only. Results: The mean time of complete response of lichenoid lesions, erythema, and ulcers using dexamethasone and systemic immunosuppressive medication was of 105, 42 and 42 days, respectively (p=0.013).When we associated dexamethasone, tacrolimus and systemic immunosuppressive medication, the mean time of complete response of lichenoid lesions, erythema and ulcers was of 91,84 and 77 days (p=0.011). When dexamethasone was used alone, the mean time of complete response of lichenoid lesions, erythema and ulcers was 182, 140, 21 days, respectively (p=0.042). Conclusion: Our study shows that lichenoid lesions require more time to heal. Notably, lichenoid lesions tend to respond better to dexamethasone combined with tacrolimus and systemic immunosuppressive medication, whereas erythema and ulcers respond better to dexamethasone combined with systemic immunosuppressive medication and dexamethasone only, respectively.
MeSH term(s)	Chronic Disease ; Graft vs Host Disease/drug therapy ; Humans ; Immunosuppressive Agents ; Mouth Diseases ; Retrospective Studies ; Tacrolimus
Chemical Substances	Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM)
Language	Portuguese
Publishing date	2021-10-29
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2418293-X
ISSN	2317-6385 ; 1679-4508
ISSN (online)	2317-6385
ISSN	1679-4508
DOI	10.31744/einstein_journal/2021AO6177
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Article ; Online: Polymicrobial infection of the oral mucosa after hematopoietic stem cell transplantation. Case report.

Ramos, Gabriela de Assis / Piragibe, Maria Midori Miura / Moreira, Maria Cláudia Rodrigues / Antunes, Héliton Spíndola

Hematology, transfusion and cell therapy

2019 Volume 41, Issue 4, Page(s) 360–364

Language	English
Publishing date	2019-05-12
Publishing country	Brazil
Document type	Journal Article
ISSN	2531-1387
ISSN (online)	2531-1387
DOI	10.1016/j.htct.2019.02.003
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Article ; Online: Acute and chronic Graft-versus-host disease after hematopoietic stem cell transplantation.

Funke, Vaneuza A M / Moreira, Maria Claudia Rodrigues / Vigorito, Afonso Celso

Revista da Associacao Medica Brasileira (1992)

2016 Volume 62 Suppl 1, Page(s) 44–50

Abstract: graft-versus-host disease (GVHD) is one of the main complications of hematopoietic stem cell transplantation, affecting about 50% to 80% of the patients. Acute GVHD and its clinical manifestations are discussed in this article, as well as the new NIH ... ...

Abstract	graft-versus-host disease (GVHD) is one of the main complications of hematopoietic stem cell transplantation, affecting about 50% to 80% of the patients. Acute GVHD and its clinical manifestations are discussed in this article, as well as the new NIH criteria for the diagnosis and classification of chronic GVHD. Therapy for both chronic and acute GVHD is an important field of discussion, as there is no proven superiority for the majority of therapies used after primary treatment has failed. Hence, this review is meant to be a useful consultation tool for hematologists dealing with this complex transplantation procedure complication.
MeSH term(s)	Acute Disease ; Chronic Disease ; Female ; Graft vs Host Disease/classification ; Graft vs Host Disease/etiology ; Graft vs Host Disease/therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Male ; Risk Factors ; Severity of Illness Index
Language	English
Publishing date	2016-10
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2027973-5
ISSN	1806-9282 ; 0104-4230
ISSN (online)	1806-9282
ISSN	0104-4230
DOI	10.1590/1806-9282.62.suppl1.44
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Article ; Online: Chronic graft-versus-host-disease treatment in Brazil: analyses of failure-free survival.

Vigorito, Afonso Celso / Miranda, Eliana Cristina Martins / Colturato, Vergilio Antonio Rensi / Funke, Vaneuza Araujo Moreira / Fatobene, Giancarlo / Mariano, Livia / Macedo, Maria Cristina Martins de Almeida / Ribeiro, Lorena Bedotti / Daudt, Liane Esteves / Moreira, Maria Cláudia Rodrigues / Bonfim, Carmem / Colella, Marcos Paulo / Seber, Adriana / Rodrigues, Morgani / Duarte, Fernando Barroso / Martin, Paul J / Flowers, Mary E D

Transplantation and cellular therapy

2023 Volume 29, Issue 4, Page(s) 276.e1–276.e7

Abstract: Failure-free survival (FFS), defined as the absence of new systemic treatment, recurrence of original malignancy and mortality not associated with recurrence after allogeneic hematopoietic stem cell transplantation (HCT), is a robust clinical measure to ... ...

Abstract	Failure-free survival (FFS), defined as the absence of new systemic treatment, recurrence of original malignancy and mortality not associated with recurrence after allogeneic hematopoietic stem cell transplantation (HCT), is a robust clinical measure to interpret results of initial systemic treatment of chronic graft-versus-host disease (cGVHD). We evaluate FFS after initial treatment of cGVHD in a mixed-race cohort from a resource-constrained country. This retrospective study included 354 consecutive patients after their first HCT between January 2014 and August 2020, who received initial systemic treatment for moderate or severe cGVHD at 13 Brazilian centers. Cox regression models were used to identify risk factors for treatment failure. The overall median follow-up among survivors was 28 months (range 1-71) after initial treatment. FFS was 89% at 6 months, 71% at 1 year and 52% at 2 years. New systemic treatment was the major cause of failure. In multivariable models, prior grades II-IV acute GVHD, a National Institutes of Health severity score of 3 in liver, gastrointestinal tract or lung involvement, and onset of initial treatment of cGVHD within 12 months after transplantation were all associated with an increased risk of treatment failure. Our results could serve as a benchmark for the design of future clinical trials evaluating initial treatment of cGVHD in resource-constrained locations.
MeSH term(s)	United States ; Humans ; Brazil/epidemiology ; Retrospective Studies ; Bronchiolitis Obliterans Syndrome ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Graft vs Host Disease/drug therapy
Language	English
Publishing date	2023-01-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	3062231-1
ISSN	2666-6367
ISSN (online)	2666-6367
DOI	10.1016/j.jtct.2023.01.007
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Article ; Online: Impact of Anti-CMV IgG Titers and CD34 Count Prior to Hematopoietic Stem Cell Transplantation from Alternative Donors on CMV reactivation.

Arcuri, Leonardo Javier / Schirmer, Marcelo / Colares, Marta / Maradei, Simone / Tavares, Rita / Moreira, Maria Claudia Rodrigues / Araujo, Renato de Castro / Lerner, Decio / Pacheco, Antonio Guilherme Fonseca

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

2020 Volume 26, Issue 11, Page(s) e275–e279

Abstract: Cytomegalovirus (CMV) reactivation remains one of the main infectious complications following hematopoietic stem cell transplantation (HSCT). In this study, we explored the role of anti-CMV antibody titers in HSCT from alternative donors and to compare ... ...

Abstract	Cytomegalovirus (CMV) reactivation remains one of the main infectious complications following hematopoietic stem cell transplantation (HSCT). In this study, we explored the role of anti-CMV antibody titers in HSCT from alternative donors and to compare the risk of CMV reactivation between posttransplant cyclophosphamide-based haploidentical HSCT and antithymocyte globulin-based unrelated donor (URD) HSCT. We included 98 CMV-positive patients, 30 undergoing haploidentical HSCT and 68 undergoing URD HSCT. The majority of patients had a malignant disease (84%), received a myeloablative conditioning regimen (78%), and received a bone marrow graft (90%). The median pretransplantation anti-CMV IgG level was 109 U/mL. With median follow-up of 2.2 years, a total of 72 CMV reactivations occurred in 50 patients. There was no difference in CMV reactivation pattern between haploidentical HSCT recipients and URD HSCT recipients. In multivariable analysis until the first event, the incidence of CMV reactivation was higher in patients with anti-CMV IgG levels >100 U/mL (hazard ratio [HR], 2.38; P = .005) and in patients diagnosed with grade II-IV acute graft-versus-host disease (GVHD) (HR, 10.8; P = .003) after day +50 and lower in patients who received higher doses of CD34 cells (HR, .44; P = .006). In multivariable analysis for recurring events, the incidence of CMV reactivation was higher in patients receiving reduced-intensity conditioning (HR, 1.69: P = .04) and in patients with acute GVHD (HR, 1.88; P = .02), and lower in those who received higher doses of CD34 cells (HR, .55; P = .01). In summary, we have shown that pretransplantation anti-CMV IgG titers are correlated with CMV reactivation risk. More studies are needed to assess how this information can be incorporated in HSCT. The use of high-dose cellular grafts, a modifiable risk factor, also protects against CMV reactivation.
MeSH term(s)	Cytomegalovirus Infections ; Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Immunoglobulin G ; Transplantation Conditioning ; Unrelated Donors
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2020-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1474865-4
ISSN	1523-6536 ; 1083-8791
ISSN (online)	1523-6536
ISSN	1083-8791
DOI	10.1016/j.bbmt.2020.07.034
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Zs.A 5082: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 462: Show issues

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Article ; Online: Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Graft- versus -host disease.

Pereira, Andréa Z / Vigorito, Afonso Celso / Almeida, Alessandro de Moura / Candolo, Alexandre de Almeida / Silva, Ana Carolina Leão / Brandão-Anjos, Ana Elisa de Paula / Sá, Bianca Laselva de / Souza, Catarina Lôbo Santos de / Castro Junior, Cláudio Galvão de / Oliveira, José Salvador Rodrigues de / Barban, Juliana Bernardo / Mancilha, Elaine Maria Borges / Todaro, Juliana / Lopes, Lilian Pinheiro / Macedo, Maria Cristina Martins de Almeida / Rodrigues, Morgani / Ribeiro, Paulo Cesar / Silva, Roberto Luiz da / Roberto, Telma Sigolo /

Rodrigues, Thays de Cássia Ruiz / Colturato, Vergilio Antonio Rensi / Paton, Eduardo José de Alencar / Barros, George Maurício Navarro / Almeida, Rosana Ducatti Souza / Moreira, Maria Claudia Rodrigues / Flowers, Mary Evelyn

Einstein (Sao Paulo, Brazil)

2020 Volume 18, Page(s) eAE4799

Abstract: The Brazilian Consensus on Nutrition in Hematopoietic Stem Cell Transplantation: Graft- versus -host disease was approved by Sociedade Brasileira de Transplante de Medula Óssea , with the participation of 26 Brazilian hematopoietic stem cell ... ...

Abstract	The Brazilian Consensus on Nutrition in Hematopoietic Stem Cell Transplantation: Graft- versus -host disease was approved by Sociedade Brasileira de Transplante de Medula Óssea , with the participation of 26 Brazilian hematopoietic stem cell transplantation centers. It describes the main nutritional protocols in cases of Graft- versus -host disease, the main complication of hematopoietic stem cell transplantation.
MeSH term(s)	Brazil ; Congresses as Topic ; Consensus Development Conferences as Topic ; Gastrointestinal Diseases/diet therapy ; Gastrointestinal Diseases/etiology ; Gastrointestinal Diseases/physiopathology ; Graft vs Host Disease/diet therapy ; Graft vs Host Disease/etiology ; Graft vs Host Disease/physiopathology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Nutrition Therapy/methods ; Nutrition Therapy/standards ; Nutritional Requirements ; Severity of Illness Index
Language	Portuguese
Publishing date	2020-03-23
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2418293-X
ISSN	2317-6385 ; 1679-4508
ISSN (online)	2317-6385
ISSN	1679-4508
DOI	10.31744/einstein_journal/2020AE4799
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Article ; Online: Impact of Treatment Prior to Allogeneic Transplantation of Hematopoietic Stem Cells in Patients with Myelodysplastic Syndrome: Results of the Latin American Bone Marrow Transplant Registry.

Duarte, Fernando Barroso / Moura, Anna Thawanny Gadelha / Funke, Vaneuza Araújo Moreira / Colturato, Virgílio Antônio Rensi / Hamerschlak, Nelson / Vilela, Neysimélia Costa / Lopes, Luiz Fernando / de Almeida Macedo, Maria Cristina Martins / Vigorito, Afonso Celso / de Almeida Soares, Rodolfo Daniel / Paz, Alessandra / Stevenazzi, Mariana / Diaz, Lilián / Neto, Abrahao Elias Hallack / Bettarello, Gustavo / de Gusmão, Breno Moreno / Salvino, Marco Aurélio / Calixto, Rodolfo Froes / Moreira, Maria Cláudia Rodrigues /

Teixeira, Gustavo Machado / da Silva, Cinthya Corrêa / Simioni, Anderson João / Lemes, Romélia Pinheiro Gonçalves

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

2020 Volume 26, Issue 5, Page(s) 1021–1024

Abstract: It has been suggested that bridging therapy with intensive chemotherapy and/or hypomethylating agents followed by hematopoietic stem cell transplantation (HSCT) can be valuable in the treatment of patients with myelodysplastic syndromes (MDS). However, ... ...

Abstract	It has been suggested that bridging therapy with intensive chemotherapy and/or hypomethylating agents followed by hematopoietic stem cell transplantation (HSCT) can be valuable in the treatment of patients with myelodysplastic syndromes (MDS). However, the influence of this approach on HSCT outcomes remains poorly defined. Therefore, our objective was to investigate the influence of treatment before HSCT in patients with MDS. We retrospectively analyzed data from the Latin American registry of 258 patients from 17 Latin American centers who underwent HSCT from 1988 to 2019. Our data showed that there was pre-HSCT. We detected no significant difference regarding the impact on overall survival of treated and untreated patients before HSCT. Despite these data, the type of previous treatment among treated patients showed a significant difference in overall survival. Treatment with hypomethylating agents together with pre-HSCT chemotherapy seems to result in better survival of the studied population. These data correspond to the first results obtained through cooperative work between various centers in Latin America comparing the different approaches to patients and reflecting their reality and challenges. Therefore, the selection of pretransplant bridge therapy should be analyzed and focus given primarily to those approaches that result in better survival of patients with MDS.
MeSH term(s)	Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells ; Humans ; Latin America ; Myelodysplastic Syndromes/therapy ; Registries ; Retrospective Studies ; Transplantation, Homologous
Language	English
Publishing date	2020-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1474865-4
ISSN	1523-6536 ; 1083-8791
ISSN (online)	1523-6536
ISSN	1083-8791
DOI	10.1016/j.bbmt.2020.01.030
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Zs.A 5082: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Early and late oral features of chronic graft-versus-host disease.

Gomes, Alessandra Oliveira Ferrari / Torres, Sandra Regina / Maiolino, Angelo / Dos Santos, Cesar Werneck Noce / Silva Junior, Arley / Correa, Maria Elvira Pizzigatti / Moreira, Maria Cláudia Rodrigues / Gonçalves, Lucio de Souza

Revista brasileira de hematologia e hemoterapia

2014 Volume 36, Issue 1, Page(s) 43–49

Abstract: Background: Chronic graft-versus-host disease is a serious complication of allogeneic hematopoietic cell transplantation, and the mouth is one of the affected sites.: Objective: The aim of this study was to evaluate the oral features of this disease ... ...

Abstract	Background: Chronic graft-versus-host disease is a serious complication of allogeneic hematopoietic cell transplantation, and the mouth is one of the affected sites. Objective: The aim of this study was to evaluate the oral features of this disease after hematopoietic cell transplantation. Methods: This was a cross-sectional multicenter study that enrolled patients submitted to transplantation. Oral evaluations used the National Institutes of Health criteria, salivary flow rates, and the range of mouth opening. Pain and xerostomia were evaluated through a visual analogue scale. Patients were divided into two groups based on the transplantation time (up to one year and more than one year). Results: Of the 57 evaluated recipients, 44 had chronic graft-versus-host disease: ten (22.72%) in the group with less than one year after transplantation, and 34 (77.27%) in the group with more than one year after transplantation. Lichenoid/hyperkeratotic plaques, erythematous lesions, xerostomia, and hyposalivation were the most commonly reported oral features. Lichenoid/hyperkeratotic plaques were significantly more common in patients within the first year after the transplant. The labial mucosa was affected more in the first year. No significant changes occurred in the frequency of xerostomia, hyposalivation, and reduced mouth opening regarding time after transplantation. Conclusion: Oral chronic graft-versus-host disease lesions were identified early in the course of the disease. The changes observed in salivary gland function and in the range of mouth opening were not correlated with the time after transplantation.
Language	English
Publishing date	2014-02-28
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2105177-X
ISSN	1806-0870 ; 1516-8484
ISSN (online)	1806-0870
ISSN	1516-8484
DOI	10.5581/1516-8484.20140012
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