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  1. Article ; Online: Deceased donor organ retrieval: impact on cardiovascular research.

    Afonso Mendes, Patrícia / Macedo, Cristiane Pais / Moreira, Sónia / Ferreira, Rogério

    European heart journal

    2024  

    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehae033
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    Zs.A 1563: Show issues Location:
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    Zs.MO 640: Show issues

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  2. Article: Deep Vein Thrombosis in the Humeral Vein After Implantable Cardioverter-Defibrillator Implantation: A Family Physician's Perspective.

    Alves, Pedro / Silva, João / Ribeiro, João / Moreira, Sónia

    Cureus

    2023  Volume 15, Issue 12, Page(s) e50827

    Abstract: Upper extremity deep vein thrombosis (DVT) is an uncommon, under-reported, and difficult-to-diagnose condition. Although the strong provoking risk factors of venous thromboembolism are well described in the literature, the majority of cases are provoked ... ...

    Abstract Upper extremity deep vein thrombosis (DVT) is an uncommon, under-reported, and difficult-to-diagnose condition. Although the strong provoking risk factors of venous thromboembolism are well described in the literature, the majority of cases are provoked by weak risk factors or are even considered unprovoked. In this case report, we describe a rare case of a brachial DVT in a woman in her 40s following implantable cardioverter-defibrillator (ICD) implantation. In her first evaluation, slight left arm edema and brachialgia were noted, and physiotherapy was prescribed. One month later, the patient was reevaluated because her complaints did not resolve, and an upper extremity venous ultrasound was done to exclude complications due to ICD implantation. The ultrasound identified an old DVT, which had been completely recanalized. The patient was then referred to a vascular surgery specialty consultation, which confirmed the diagnosis, and an anticoagulant was prescribed for three months. The symptoms resolved, and the patient did not report any more pain.
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.50827
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  3. Article ; Online: Rare manifestations of refractory extrapulmonary sarcoidosis.

    Teles, Catarina / Teles, Carolina / Moreira, Sónia / Santos, Lèlita

    BMJ case reports

    2023  Volume 16, Issue 4

    Abstract: Sarcoidosis is a multisystemic disease, characterised by histopathologic presence of non-necrotising granulomas, primarily affecting the lungs (>90%). We present three cases predominantly characterised by uncommon extrapulmonary manifestations of ... ...

    Abstract Sarcoidosis is a multisystemic disease, characterised by histopathologic presence of non-necrotising granulomas, primarily affecting the lungs (>90%). We present three cases predominantly characterised by uncommon extrapulmonary manifestations of sarcoidosis, where only one had pulmonary involvement. We describe three female patients, between the second and third decades of life, whose sarcoidosis was a diagnostic challenge due to their atypical extrapulmonary manifestations, from which we highlight: livedo reticularis and painful subcutaneous nodules with uncommon localisation, size and histology, being the first reported case of extensive subcutaneous nodules triggered by intramuscular penicillin; extensive symptomatic and refractory osseous involvement; and dispersed erythema nodosum affecting the entire body surface. All three patients required third-line treatment (antitumour necrosis factor agents) to achieve significant clinical and imagiological improvement. Through this case series, we highlight the importance of considering the rare and atypical presentations of sarcoidosis to avoid diagnostic delays and serious repercussions on the patient's prognosis.
    MeSH term(s) Humans ; Female ; Sarcoidosis/complications ; Sarcoidosis/diagnosis ; Sarcoidosis/drug therapy ; Granuloma/drug therapy ; Granuloma/pathology ; Lung/pathology ; Prognosis ; Erythema Nodosum/diagnosis ; Erythema Nodosum/drug therapy ; Erythema Nodosum/pathology
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-254829
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  4. Article: Solvent-Induced Raynaud's Phenomenon.

    Rodrigues, Helena / Reigota, Catarina / Teles, Carolina / Moreira, Sónia / Santos, Lèlita

    Cureus

    2023  Volume 15, Issue 9, Page(s) e45004

    Abstract: Raynaud's phenomenon (RP) is a vasospastic disorder characterized by an exaggerated vasoconstrictive response to cold or emotional stress. It can be classified as primary (PRP) or secondary (SRP) depending on its association with an underlying condition. ...

    Abstract Raynaud's phenomenon (RP) is a vasospastic disorder characterized by an exaggerated vasoconstrictive response to cold or emotional stress. It can be classified as primary (PRP) or secondary (SRP) depending on its association with an underlying condition. We present a case of a young female with severe RP, with trophic changes and abnormal capillaroscopy. After a detailed investigation, a diagnosis of secondary RP due to solvent exposure was made. The patient was treated with calcium channel blocker in low doses, due to hypotension, without improvement of symptoms. Vitamin C and pentoxifylline were added with an unsatisfactory response. Given the progressive worsening of RP and the appearance of trophic lesions, the patient's treatment was reviewed, and continuous intravenous iloprost infusion through an elastomeric pump was started. This resulted in significant symptom improvement and normalization on the capillaroscopic examination.
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.45004
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  5. Article ; Online: Valuing Mundane Manifestations of Rare, but Underdiagnosed, Diseases in Portugal: The Example of McArdle Disease.

    Mateus-Pinheiro, António / Costa, Tiago / Esperto, Hélder / Moreira, Sónia

    Acta medica portuguesa

    2023  Volume 36, Issue 3, Page(s) 220–222

    MeSH term(s) Humans ; Glycogen Storage Disease Type V ; Portugal ; Acute Kidney Injury
    Language English
    Publishing date 2023-03-01
    Publishing country Portugal
    Document type Letter ; Comment
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    DOI 10.20344/amp.19315
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    Zs.B 2343: Show issues Location:
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  6. Article ; Online: Effects of the COVID-19 pandemic on nurses' psychological well being in an emergency room.

    Moreira, Sónia Marisa da Rocha / Novais, Rui Manuel Freitas / Martins, Maria de Fátima da Silva Vieira

    Revista brasileira de enfermagem

    2022  Volume 76Suppl 1, Issue Suppl 1, Page(s) e20220171

    Abstract: Objectives: to assess the level of anxiety of nurses in an emergency room in view of the new Coronavirus and describe the relationship between the degrees of anxiety and their sociodemographic variables.: Methods: quantitative descriptive- ... ...

    Abstract Objectives: to assess the level of anxiety of nurses in an emergency room in view of the new Coronavirus and describe the relationship between the degrees of anxiety and their sociodemographic variables.
    Methods: quantitative descriptive-correlational study with a sample of 60 nurses. A questionnaire was used as a data collection instrument based on the Hamilton Anxiety Assessment Scale.
    Results: the nurses' average anxiety is mild. A statistically significant relationship was found between anxiety and the variables "sex" and "children", with women having higher levels of anxiety than men, and nurses who do not have children showing mild, moderate, or severe anxiety.
    Conclusions: COVID-19 triggers anxiety in nurses, sometimes at pathological levels. Being female and not having children increase the anxiety experienced. Sex can be considered the determining factor for the level of anxiety experienced.
    MeSH term(s) Male ; Female ; Humans ; COVID-19/epidemiology ; Pandemics ; Emergency Service, Hospital ; Anxiety/epidemiology ; Anxiety/etiology ; Nurses
    Language English
    Publishing date 2022-11-28
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 731983-6
    ISSN 1984-0446 ; 0034-7167
    ISSN (online) 1984-0446
    ISSN 0034-7167
    DOI 10.1590/0034-7167-2022-0171
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    Zs.A 3392: Show issues Location:
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  7. Article ; Online: Beyond the typical signs: dermatomyositis in a different tone.

    Calado, Rebeca / Soares, João N / Moreira, Sónia / Cardoso, José C / Coutinho, Inês

    Rheumatology (Oxford, England)

    2022  Volume 61, Issue 10, Page(s) e325

    MeSH term(s) Dermatomyositis/diagnosis ; Humans ; Niacinamide ; Paraneoplastic Syndromes
    Chemical Substances Niacinamide (25X51I8RD4)
    Language English
    Publishing date 2022-10-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keac164
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    Zs.B 240: Show issues Location:
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    Zs.MO 497: Show issues

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  8. Article: Influence of contextual factors and reliability of ultrasound skin measures in persons with systemic sclerosis and healthy controls.

    Santiago, Tânia / Santiago, Mariana / Moreira, Sónia / Santos, Lèlita / Salvador, Maria João / da Silva, José António Pereira

    Clinical and experimental rheumatology

    2023  Volume 41, Issue 8, Page(s) 1599–1604

    Abstract: Objectives: To examine the influence of contextual factors upon the evaluation of skin thickness and stiffness by ultrasound and to assess the reliability of these parameters.: Methods: Ultrasound dermal thickness (by B-mode, 18MHz) and skin ... ...

    Abstract Objectives: To examine the influence of contextual factors upon the evaluation of skin thickness and stiffness by ultrasound and to assess the reliability of these parameters.
    Methods: Ultrasound dermal thickness (by B-mode, 18MHz) and skin stiffness (by shear-wave elastography, 9MHz) were assessed in persons with systemic sclerosis (SSc) and in healthy controls. The influence of contextual factors upon repeated measures was evaluated: (i) room temperature (16-17ºC vs. 22-24ºC); (ii) time of day (morning vs. afternoon), and (iii) menstrual cycle phase (menstrual vs. ovulatory). Differences were analysed using the related-samples Wilcoxon signed-rank test. Inter- and intra-rater reliability of ultrasound skin thickness and stiffness were evaluated in the 17 skin Rodnan sites of 20 persons with SSc and 20 healthy controls, under stable contextual conditions.
    Results: A significant increase in ultrasound dermal thickness was observed at the leg in the afternoon vs morning, in both patients and controls. Similar observations were made for skin stiffness at the leg (in SSc) and at the foot (in SSc and controls) in the afternoon. No significant changes were observed in association with room temperature and menstrual cycle. Intra- and inter-rater-reliability was good to excellent for ultrasound dermal thickness and stiffness, both in SSc and healthy controls.
    Conclusions: The timing of the ultrasound procedure within each day seems to influence the ultrasound measures at the legs and feet. Our study corroborates that ultrasound dermal thickness and skin stiffness are reliable domains to quantify skin involvement in SSc.
    MeSH term(s) Female ; Humans ; Reproducibility of Results ; Skin/diagnostic imaging ; Scleroderma, Systemic/diagnostic imaging ; Ultrasonography ; Elasticity Imaging Techniques/methods
    Language English
    Publishing date 2023-03-20
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/setd1z
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    Zs.A 2002: Show issues Location:
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  9. Article ; Online: Plasma lipidomics analysis reveals altered profile of triglycerides and phospholipids in children with Medium-Chain Acyl-CoA dehydrogenase deficiency.

    Guerra, Inês M S / Ferreira, Helena B / Maurício, Tatiana / Pinho, Marisa / Diogo, Luísa / Moreira, Sónia / Goracci, Laura / Bonciarelli, Stefano / Melo, Tânia / Domingues, Pedro / Domingues, M Rosário / Moreira, Ana S P

    Journal of inherited metabolic disease

    2024  

    Abstract: Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is the most prevalent mitochondrial fatty acid β-oxidation disorder. In this study, we assessed the variability of the lipid profile in MCADD by analysing plasma samples obtained from 25 children ... ...

    Abstract Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is the most prevalent mitochondrial fatty acid β-oxidation disorder. In this study, we assessed the variability of the lipid profile in MCADD by analysing plasma samples obtained from 25 children with metabolically controlled MCADD (following a normal diet with frequent feeding and under l-carnitine supplementation) and 21 paediatric control subjects (CT). Gas chromatography-mass spectrometry was employed for the analysis of esterified fatty acids, while high-resolution C18-liquid chromatography-mass spectrometry was used to analyse lipid species. We identified a total of 251 lipid species belonging to 15 distinct lipid classes. Principal component analysis revealed a clear distinction between the MCADD and CT groups. Univariate analysis demonstrated that 126 lipid species exhibited significant differences between the two groups. The lipid species that displayed the most pronounced variations included triacylglycerols and phosphatidylcholines containing saturated and monounsaturated fatty acids, specifically C14:0 and C16:0, which were found to be more abundant in MCADD. The observed changes in the plasma lipidome of children with non-decompensated MCADD suggest an underlying alteration in lipid metabolism. Therefore, longitudinal monitoring and further in-depth investigations are warranted to better understand whether such alterations are specific to MCADD children and their potential long-term impacts.
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 438341-2
    ISSN 1573-2665 ; 0141-8955
    ISSN (online) 1573-2665
    ISSN 0141-8955
    DOI 10.1002/jimd.12718
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    Zs.A 1508: Show issues Location:
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  10. Article ; Online: Lymphedema secondary to limited cutaneous systemic sclerosis.

    Moreira, Sónia / Crespo, Jorge / Santos, Lèlita

    BMJ case reports

    2018  Volume 2018

    Abstract: Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterised by vascular abnormalities, immune system activation and fibrosis. Lymphatic involvement in SSc was described more recently and starts in early stages. This report describes ...

    Abstract Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterised by vascular abnormalities, immune system activation and fibrosis. Lymphatic involvement in SSc was described more recently and starts in early stages. This report describes a 46-year-old patient who developed over the last 2 years asymmetric lymphedema in lower extremities. Compromise in lymphatic drainage was confirmed by lymphoscintigraphy. She also presented Raynaud's phenomenon, a scleroderma pattern in nailfold capillaroscopy, cutaneous thickening and anticentromere antibodies, which together resulted in a new diagnosis of limited cutaneous SSc. Treatment with methotrexate, prednisolone and lymphatic drainage resulted in lymphedema improvement. To our knowledge, this is the first case of grade 2 lymphedema in the setting of anticentromere-positive limited cutaneous SSc. We highlight the importance of considering rheumatic diseases in the differential diagnosis of lymphedema.
    MeSH term(s) Female ; Humans ; Lymphedema/diagnostic imaging ; Lymphedema/drug therapy ; Lymphedema/etiology ; Lymphoscintigraphy ; Methotrexate/therapeutic use ; Microscopic Angioscopy ; Middle Aged ; Prednisolone/therapeutic use ; Raynaud Disease/diagnostic imaging ; Raynaud Disease/drug therapy ; Raynaud Disease/etiology ; Scleroderma, Limited/diagnosis ; Scleroderma, Limited/drug therapy ; Treatment Outcome
    Chemical Substances Prednisolone (9PHQ9Y1OLM) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2018-06-15
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2017-224148
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