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  1. Article: Effects of "Bacuri" Seed Butter (

    Lindoso, Jéssica Vanessa Dos Santos / Alencar, Salmon Rocha / Santos, Andressa Amorim Dos / Mello Neto, Renato Sampaio / Mendes, Ana Victória da Silva / Furtado, Mariely Mendes / Silva, Maisa Gomes da / Brito, Ana Karolinne da Silva / Batista, Emanuelle Karine Frota / Baêta, Silvia de Araújo França / Moreira Nunes, Paulo Humberto / Lucarini, Massimo / Durazzo, Alessandra / Arcanjo, Daniel Dias Rufino / Martins, Maria do Carmo de Carvalho E

    Biology

    2022  Volume 11, Issue 4

    Abstract: This study aimed to investigate the effects of oral administration ... ...

    Abstract This study aimed to investigate the effects of oral administration of
    Language English
    Publishing date 2022-04-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11040562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Antifungal and anti-inflammatory potential of eschweilenol C-rich fraction derived from Terminalia fagifolia Mart

    Rodrigues de Araújo, Alyne / Iles, Bruno / de Melo Nogueira, Kerolayne / Dias, Jhones do Nascimento / Plácido, Alexandra / Rodrigues, Artur / Albuquerque, Patrícia / Silva-Pereira, Ildinete / Socodatto, Renato / Portugal, Camila C / Relvas, João B / Costa Véras, Leiz Maria / Dalmatti Alves Lima, Filipe Camargo / Batagin-Neto, Augusto / Rolim Medeiros, Jand-Venes / Moreira Nunes, Paulo Humberto / Eaton, Peter / de Souza de Almeida Leite, José Roberto

    Journal of ethnopharmacology. 2019 Aug. 10, v. 240

    2019  

    Abstract: Folk knowledge transmitted between generations allows traditional populations to maintain the use of medicinal plants for the treatment of several diseases. In this context, the species Terminalia fagifolia Mart., native to Brazil, is used for the ... ...

    Abstract Folk knowledge transmitted between generations allows traditional populations to maintain the use of medicinal plants for the treatment of several diseases. In this context, the species Terminalia fagifolia Mart., native to Brazil, is used for the treatment of chronic and infectious diseases. Plants rich in secondary metabolites, such as this species and their derivatives, may represent therapeutic alternatives for the treatment of diseases that reduce the quality of life of people.The aim of this study was to evaluate the antifungal and anti-inflammatory potential of aqueous fraction from ethanolic extract of T. fagifolia, with in silico study of the major compound of the fraction.The phytochemical study of the aqueous fraction was performed by HPLC, LC/MS and NMR. The antifungal activity was evaluated against yeasts, by determination of the minimum inhibitory concentration and minimum fungicidal concentration. The effect on Candida albicans was analyzed by AFM. The antibiofilm potential against biofilms of C. albicans was also tested. The anti-inflammatory potential of the aqueous fraction was evaluated in vivo by the carrageenan-induced paw edema and peritonitis. A microglial model of LPS-induced neuroinflammation was also studied. Further insights on the activation mechanism were studied using quantum chemistry computer simulations. Toxicity was evaluated in the Galleria mellonella and human erythrocytes models.Eschweilenol C was identified as the major constituent of the aqueous fraction of the ethanolic extract of T. fagifolia. The aqueous fraction was active against all Candida strains used (sensitive and resistant to Fluconazole) with MICs ranging from 1000 to 0.4 μg/mL. By AFM it was possible to observe morphological alterations in treated Candida cells. The fraction significantly (p < 0.05) inhibited paw edema and decreased levels of malondialdehyde induced by carrageenan. In a microglial cell model, aqueous fraction demonstrated the ability to inhibit NF-κB after induction with lipopolysaccharide. The theoretical studies showed structural similarity between eschweilenol C and indomethacin and an excellent antioxidant potential. The aqueous fraction did not present toxicity in the studied models.The results indicate that the aqueous fraction of T. fagifolia has potential for biomedical applications with low toxicity. This finding can be attributed to the predominance of eschweilenol C in the aqueous fraction.
    Keywords Candida albicans ; Galleria mellonella ; Terminalia ; anti-inflammatory activity ; antifungal properties ; antioxidant activity ; biofilm ; carrageenan ; computer simulation ; edema ; erythrocytes ; fluconazole ; high performance liquid chromatography ; humans ; indomethacin ; infectious diseases ; lipopolysaccharides ; malondialdehyde ; medicinal plants ; minimum inhibitory concentration ; models ; neuroglia ; nuclear magnetic resonance spectroscopy ; peritonitis ; phytochemicals ; quality of life ; secondary metabolites ; therapeutics ; toxicity ; traditional medicine ; transcription factor NF-kappa B ; yeasts ; Brazil
    Language English
    Dates of publication 2019-0810
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2019.111941
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 90/710: Show issues

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  3. Article ; Online: Antifungal and anti-inflammatory potential of eschweilenol C-rich fraction derived from Terminalia fagifolia Mart.

    Rodrigues de Araújo, Alyne / Iles, Bruno / de Melo Nogueira, Kerolayne / Dias, Jhones do Nascimento / Plácido, Alexandra / Rodrigues, Artur / Albuquerque, Patrícia / Silva-Pereira, Ildinete / Socodatto, Renato / Portugal, Camila C / Relvas, João B / Costa Véras, Leiz Maria / Dalmatti Alves Lima, Filipe Camargo / Batagin-Neto, Augusto / Rolim Medeiros, Jand-Venes / Moreira Nunes, Paulo Humberto / Eaton, Peter / de Souza de Almeida Leite, José Roberto

    Journal of ethnopharmacology

    2019  Volume 240, Page(s) 111941

    Abstract: Ethnopharmacological relevance: Folk knowledge transmitted between generations allows traditional populations to maintain the use of medicinal plants for the treatment of several diseases. In this context, the species Terminalia fagifolia Mart., native ... ...

    Abstract Ethnopharmacological relevance: Folk knowledge transmitted between generations allows traditional populations to maintain the use of medicinal plants for the treatment of several diseases. In this context, the species Terminalia fagifolia Mart., native to Brazil, is used for the treatment of chronic and infectious diseases. Plants rich in secondary metabolites, such as this species and their derivatives, may represent therapeutic alternatives for the treatment of diseases that reduce the quality of life of people.
    Aim of the study: The aim of this study was to evaluate the antifungal and anti-inflammatory potential of aqueous fraction from ethanolic extract of T. fagifolia, with in silico study of the major compound of the fraction.
    Material and methods: The phytochemical study of the aqueous fraction was performed by HPLC, LC/MS and NMR. The antifungal activity was evaluated against yeasts, by determination of the minimum inhibitory concentration and minimum fungicidal concentration. The effect on Candida albicans was analyzed by AFM. The antibiofilm potential against biofilms of C. albicans was also tested. The anti-inflammatory potential of the aqueous fraction was evaluated in vivo by the carrageenan-induced paw edema and peritonitis. A microglial model of LPS-induced neuroinflammation was also studied. Further insights on the activation mechanism were studied using quantum chemistry computer simulations. Toxicity was evaluated in the Galleria mellonella and human erythrocytes models.
    Results: Eschweilenol C was identified as the major constituent of the aqueous fraction of the ethanolic extract of T. fagifolia. The aqueous fraction was active against all Candida strains used (sensitive and resistant to Fluconazole) with MICs ranging from 1000 to 0.4 μg/mL. By AFM it was possible to observe morphological alterations in treated Candida cells. The fraction significantly (p < 0.05) inhibited paw edema and decreased levels of malondialdehyde induced by carrageenan. In a microglial cell model, aqueous fraction demonstrated the ability to inhibit NF-κB after induction with lipopolysaccharide. The theoretical studies showed structural similarity between eschweilenol C and indomethacin and an excellent antioxidant potential. The aqueous fraction did not present toxicity in the studied models.
    Conclusion: The results indicate that the aqueous fraction of T. fagifolia has potential for biomedical applications with low toxicity. This finding can be attributed to the predominance of eschweilenol C in the aqueous fraction.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candida albicans/drug effects ; Candida albicans/growth & development ; Carrageenan ; Cryptococcus neoformans/drug effects ; Cryptococcus neoformans/growth & development ; Edema/chemically induced ; Edema/drug therapy ; Ellagic Acid/pharmacology ; Ellagic Acid/therapeutic use ; Erythrocytes/drug effects ; Female ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Heterocyclic Compounds, 4 or More Rings/therapeutic use ; Humans ; Male ; Mice ; Microbial Sensitivity Tests ; Microglia/drug effects ; Microglia/metabolism ; NF-kappa B/metabolism ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Terminalia
    Chemical Substances Anti-Inflammatory Agents ; Antifungal Agents ; Heterocyclic Compounds, 4 or More Rings ; NF-kappa B ; Plant Extracts ; eschweilenol C ; Ellagic Acid (19YRN3ZS9P) ; Carrageenan (9000-07-1)
    Language English
    Publishing date 2019-05-15
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2019.111941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: IN VITRO AND IN VIVO ANTIOXIDANT ACTIVITY OF BURITI FRUIT (MAURITIA FLEXUOSA L.F.).

    da Rocha Romero, Amanda Batista / de Carvalho e Martins, Maria do Carmo / Moreira Nunes, Paulo Humberto / Ravenna Trindade Ferreira, Nayara / da Silva Brito, Ana Karolinne / Marinho da Cunha, Polliana Farias / de Lima, Alessandro / de Assis, Regina Célia / Moreira Araújo, Eva

    Nutricion hospitalaria

    2015  Volume 32, Issue 5, Page(s) 2153–2161

    Abstract: Introduction: studies have shown high concentration of monounsaturated fatty acids, carotenoids, polyphenols and ascorbic acid in Buriti fruit (Mauritia flexuosa L.f.). This study evaluated the in vitro and in vivo antioxidant activities of buriti fruit ...

    Abstract Introduction: studies have shown high concentration of monounsaturated fatty acids, carotenoids, polyphenols and ascorbic acid in Buriti fruit (Mauritia flexuosa L.f.). This study evaluated the in vitro and in vivo antioxidant activities of buriti fruit (Mauritia flexuosa L.f.).
    Methods: the chemical composition and total phenolic and carotenoid contents of the buriti pulp and the feed rations were determined, and the in vitro antioxidant activity was analyzed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical assay. Wistar rats (21 days old) were randomly allocated (n=10) into a control groups and experimental groups (feed enriched with buriti pulp). After 60 days, the in vivo antioxidant activity was evaluated through the determination of the catalase activity and non-protein sulfhydryl (NPSH) groups in the liver and quantification of malondialdehyde (MDA) in the plasma and tissues.
    Results: high contents of oleic fatty acids (73.3%), phenolic compounds (192 ± 0.3 mg/100 g) and carotenoids (23.9 ± 0.5 mg/100 g) as well as elevated in vitro antioxidant activity were found in the buriti pulp. The enriched diet had higher contents of phenols and carotenoids as well as higher antioxidant activity compared with the standard feed (p < 0.05). There were no differences between the groups regarding catalase activity in the liver and MDA concentrations in the plasma, liver and kidneys. The male rats of the experimental group had higher liver concentrations of NPSH compounds (p < 0.05).
    Conclusion: these results may corroborate the claim that buriti fruit is an antioxidant functional food and support its utilization in a nutritionally balanced diet.
    MeSH term(s) Animals ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Arecaceae/chemistry ; Carotenoids/pharmacology ; Diet ; Female ; Fruit/chemistry ; Lipid Peroxidation/drug effects ; Male ; Oleic Acids/pharmacology ; Phenols/pharmacology ; Rats ; Rats, Wistar
    Chemical Substances Antioxidants ; Oleic Acids ; Phenols ; Carotenoids (36-88-4)
    Language English
    Publishing date 2015-11-01
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1481223-x
    ISSN 1699-5198 ; 0212-1611
    ISSN (online) 1699-5198
    ISSN 0212-1611
    DOI 10.3305/nh.2015.32.5.9603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5078: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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