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Article ; Online: The Second Edition of the Integrative Levels Classification

Park Ziyoung / Gnoli Claudio / Morelli Daniele P.

Journal of Data and Information Science, Vol 5, Iss 1, Pp 39-

Evolution of a KOS

2020 Volume 50

Abstract: This paper informs about the publication of the second edition of the Integrative Levels Classification (ILC2), a freely-faceted knowledge organization system (KOS), and reviews the main changes that have been introduced as compared to its first edition ( ...

Abstract	This paper informs about the publication of the second edition of the Integrative Levels Classification (ILC2), a freely-faceted knowledge organization system (KOS), and reviews the main changes that have been introduced as compared to its first edition (ILC1).
Keywords	freely faceted classification ; fundamental categories ; knowledge organization system ; phenomenon-based classification ; Information technology ; T58.5-58.64 ; Electronic computers. Computer science ; QA75.5-76.95
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Application of morphological characteristics of radiofrequency lesions to individual parameters of thermal rhizolysis for trigeminal neuralgia.

Massager, Nicolas / Pouleau, Henri-Benjamin / Jodaïtis, Alexandre / Morelli, Daniele

European journal of pain (London, England)

2022 Volume 26, Issue 6, Page(s) 1292–1303

Abstract: Background: Thermic rhizolysis is a reliable therapy for pharmaco-resistant trigeminal neuralgia (TN). Temperature, duration of electrocautery and needle location can influence the efficacy and complications of the therapy.: Methods: We performed ... ...

Abstract	Background: Thermic rhizolysis is a reliable therapy for pharmaco-resistant trigeminal neuralgia (TN). Temperature, duration of electrocautery and needle location can influence the efficacy and complications of the therapy. Methods: We performed experimental thermocautery on egg white with increasing parameters of time (30-120 s) and temperature (60-95°C); we analysed the shape, size and volume of the thermic lesions produced. We developed a surgical procedure to assess peroperatively the probable thermocoagulation field and its geometric relations with the trigeminal roots and other anatomical structures of Meckel's cave, and we individually adapted the parameters of rhizolysis to optimize the results. This procedure was applied on 22 patients with TN. Results: The volume of the lesions produced by rhizolysis on egg white had a spheroidal shape and increased linearly with the level of temperature and the time of electrocautery from 1.595 mm Conclusion: We conclude that geometric analysis of the position of the electrode before trigeminal thermocoagulation with morphometric-related individual adaptation of treatment parameters could avoid serious injuries and optimize pain control. Significance: We have adapted the technique of radiofrequency rhizolysis for TN. Our procedure allows individual peroperative adaptation of the parameters of thermocoagulation, according to the specific position of the electrode during rhizolysis. Preliminary results on a series of 22 patients have shown promising results.
MeSH term(s)	Electrocoagulation/methods ; Humans ; Pain ; Pain Management/methods ; Treatment Outcome ; Trigeminal Neuralgia/surgery
Language	English
Publishing date	2022-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1390424-3
ISSN	1532-2149 ; 1090-3801
ISSN (online)	1532-2149
ISSN	1090-3801
DOI	10.1002/ejp.1950
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Zs.A 5194: Show issues

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Article ; Online: Deviation of DBS Recording Microelectrodes during Insertion Assessed by Intraoperative CT.

Massager, Nicolas / Nguyen, Anthony / Pouleau, Henri-Benjamin / Dethy, Sophie / Morelli, Daniele

Stereotactic and functional neurosurgery

2023 Volume 101, Issue 3, Page(s) 161–169

Abstract: Introduction: Intraoperative microelectrodes recording with the Ben Gun microdrive system are often used during DBS surgery. An accurate location of these microelectrodes will directly influence the interest of this recording. We have studied the ... ...

Abstract	Introduction: Intraoperative microelectrodes recording with the Ben Gun microdrive system are often used during DBS surgery. An accurate location of these microelectrodes will directly influence the interest of this recording. We have studied the imprecision of implantation of these microelectrodes. Methods: We have analyzed the stereotactic position of 135 microelectrodes implanted with the Ben Gun microdrive during DBS surgery of 16 patients with advanced Parkinson's disease. An intracranial CT was obtained and integrated to a stereotactic planification system. We recorded the stereotactic coordinates of the 5 microelectrodes inserted simultaneously in a cross-shape. The coordinates of each microelectrode were compared with coordinates of the other 4 electrodes inserted simultaneously with the Ben Gun and visible on the same iCT image. Thus, this procedure avoids errors from image fusion and from brain shift. We calculate (1) the three-dimensional Euclidian deviation of microelectrodes, (2) the deviation in X- and Y-axes on reconstructed probe's eye view MR images, and (3) the deviation from the 2-mm theoretical distance between the central electrode and 4 satellite microelectrodes. Results: The median deviation was 0.64 mm in 3-D and 0.58 mm in 2-D probe's eye view. Satellite electrodes were located from the central electrode theoretically at 2.0 mm and practically within the range 1.9-2.1 mm, 1.5-2.5 mm, 1.0-3.0 mm, and 0.5-3.5 mm for, respectively, 9.3%, 53.7%, 88.0%, and 98.1%, thus highlighting the significant deviation from the theoretical distance. Position imprecisions were similar for the 4 satellite microelectrodes. The imprecision was similar in X-axis and Y-axes and statistically less in Z-axis. For bilateral implantation, the second implantation of the same patient was not associated with a greater risk of deviation of the microelectrodes than for the first side implanted. Conclusion: A significant percentage of microelectrodes for MER can deviate substantially from their theoretical target during DBS procedures. An iCT can be used to estimate the potential deviation of microelectrodes and improve the interpretation of MER during the procedure.
MeSH term(s)	Humans ; Microelectrodes ; Deep Brain Stimulation/methods ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/surgery ; Subthalamic Nucleus/surgery ; Tomography, X-Ray Computed/methods ; Electrodes, Implanted ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	645069-6
ISSN	1423-0372 ; 1011-6125
ISSN (online)	1423-0372
ISSN	1011-6125
DOI	10.1159/000528202
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Article ; Online: Routine perioperative blood tests predict survival of resectable lung cancer.

Morelli, Daniele / Cantarutti, Anna / Valsecchi, Camilla / Sabia, Federica / Rolli, Luigi / Leuzzi, Giovanni / Bogani, Giorgio / Pastorino, Ugo

Scientific reports

2023 Volume 13, Issue 1, Page(s) 17072

Abstract: There is growing evidence that inflammatory, immunologic, and metabolic status is associated with cancer patients survival. Here, we built a simple algorithm to predict lung cancer outcome. Perioperative routine blood tests (RBT) of a cohort of patients ... ...

Abstract	There is growing evidence that inflammatory, immunologic, and metabolic status is associated with cancer patients survival. Here, we built a simple algorithm to predict lung cancer outcome. Perioperative routine blood tests (RBT) of a cohort of patients with resectable primary lung cancer (LC) were analysed. Inflammatory, immunologic, and metabolic profiles were used to create a single algorithm (RBT index) predicting LC survival. A concurrent cohort of patients with resectable lung metastases (LM) was used to validate the RBT index. Charts of 2088 consecutive LC and 1129 LM patients undergoing lung resection were evaluated. Among RBT parameters, C-reactive protein (CRP), lymphocytes, neutrophils, hemoglobin, albumin and glycemia independently correlated with survival, and were used to build the RBT index. Patients with a high RBT index had a higher 5-year mortality than low RBT patients (adjusted HR 1.93, 95% CI 1.62-2.31). High RBT patients also showed a fourfold higher risk of 30-day postoperative mortality (2.3% vs. 0.5%, p 0.0019). The LM analysis validated the results of the LC cohort. We developed a simple and easily available multifunctional tool predicting short-term and long-term survival of curatively resected LC and LM. Prospective external validation of RBT index is warranted.
MeSH term(s)	Humans ; Prospective Studies ; Lung Neoplasms/surgery ; Hematologic Tests ; C-Reactive Protein/metabolism ; Lymphocytes/metabolism ; Retrospective Studies ; Prognosis
Chemical Substances	C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2023-10-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-44308-y
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Article ; Online: Preoperative Neutrophil-to-Lymphocyte Ratio and a New Inflammatory Biomarkers Prognostic Index for Primary Retroperitoneal Sarcomas: Retrospective Monocentric Study.

Fiore, Marco / Ljevar, Silva / Pasquali, Sandro / Morelli, Daniele / Callegaro, Dario / Sanfilippo, Roberta / Barisella, Marta / Sangalli, Claudia / Miceli, Rosalba / Gronchi, Alessandro

Clinical cancer research : an official journal of the American Association for Cancer Research

2023 Volume 29, Issue 3, Page(s) 614–620

Abstract: Purpose: Inflammatory biomarkers and neutrophil-to-lymphocyte ratio (NLR) are associated with prognosis in several tumors. Data on sarcomas are limited, and insufficient on retroperitoneal sarcoma (RPS).: Experimental design: Patients with primary ... ...

Abstract	Purpose: Inflammatory biomarkers and neutrophil-to-lymphocyte ratio (NLR) are associated with prognosis in several tumors. Data on sarcomas are limited, and insufficient on retroperitoneal sarcoma (RPS). Experimental design: Patients with primary RPS operated between 2002 and 2016 were included. Hemoglobin, monocytes, NLR, platelet-to-lymphocyte ratio (PLR) were retrieved and analyzed both individually and combined into a prognostic index (IBPI). Correlation with clinicopathologic variables was studied, as well as postoperative morbidity according to NLR and IBPI risk categories. The association between overall survival (OS) and biomarkers and, in addition, the 7-year Sarculator-predicted OS probability (pOS) was analyzed using univariable and multivariable Cox models. Results: 423/463 patients had complete data. The median follow-up was 84 months. The median NLR was 3.3 (IQR, 2.4-4.7), with significant variation across histologies. NLR was the only biomarker that independently predicted OS (HR, 1.2; 95% CI, 1.03-1.40; P = 0.02). The IBPI showed good discrimination for subgroups at different OS (log-rank test P < 0.0001). The Cox model for pOS alone showed a 7-year index of prediction accuracy of 26.9, which increased to 29.5 when IBPI was added to pOS as a complementary prognostic tool. IBPI was also associated with the risk of serious infectious postoperative complications (P = 0.0094; noninfectious complications, P = 0.6463). Conclusions: NLR was an independent prognostic factor for OS in RPS. When combined into a prognostic index with hemoglobin, monocytes, and PLR, it serves as a readily available prognostic tool addressing tumor-related inflammation and helps in classifying RPS risk in addition to the Sarculator nomogram.
MeSH term(s)	Humans ; Biomarkers ; Blood Platelets ; Hemoglobins ; Lymphocytes/pathology ; Neutrophils/pathology ; Prognosis ; Retroperitoneal Neoplasms/diagnosis ; Retroperitoneal Neoplasms/pathology ; Retroperitoneal Neoplasms/surgery ; Retrospective Studies ; Sarcoma/diagnosis ; Sarcoma/surgery ; Sarcoma/pathology ; Soft Tissue Neoplasms/diagnosis ; Soft Tissue Neoplasms/pathology ; Leukocyte Count
Chemical Substances	Biomarkers ; Hemoglobins
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-22-2897
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Zs.A 4223: Show issues

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Article ; Online: Invisible hemolysis in serum samples interferes in NSE measurement.

Mastroianni, Antonio / Panella, Rossella / Morelli, Daniele

Tumori

2019 Volume 106, Issue 1, Page(s) 79–81

Abstract: Introduction: The accuracy of serum neuron-specific enolase (NSE) measurements is critical, particularly in neurologic diseases and cancer. NSE measurements are compromised by slight, even invisible, hemolysis, which can produce apparently higher NSE ... ...

Abstract	Introduction: The accuracy of serum neuron-specific enolase (NSE) measurements is critical, particularly in neurologic diseases and cancer. NSE measurements are compromised by slight, even invisible, hemolysis, which can produce apparently higher NSE levels, leading to inappropriate clinical decisions. In this article, we describe this issue and propose a solution for avoiding incorrect results. Methods: Twenty blood samples from donors with NSE values that were within the reference interval were considered. Experimental hemolysis was induced in vitro to examine the relationship between the degree of hemolysis and the increase in serum NSE. The data were then subjected to statistical analysis. Results: There was excellent correlation ( Conclusion: The hemolysis index must be measured in every sample with no evident hemolysis before assaying it for NSE. Moreover, if the degree of hemolysis is between 5 and 30 units, the increase in NSE (from 1.5 to 9.0 ng/mL) must be calculated, and the laboratory results should be appended with comments that suggest the approximate rise in NSE.
MeSH term(s)	Biomarkers ; Hemolysis ; Humans ; Neoplasms/blood ; Nervous System Diseases/blood ; Phosphopyruvate Hydratase/blood ; Reproducibility of Results
Chemical Substances	Biomarkers ; Phosphopyruvate Hydratase (EC 4.2.1.11)
Language	English
Publishing date	2019-08-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	280962-x
ISSN	2038-2529 ; 0300-8916
ISSN (online)	2038-2529
ISSN	0300-8916
DOI	10.1177/0300891619867836
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Ud II Zs.43: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 287: Show issues

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Article ; Online: Differential diagnosis between bone relapse of breast cancer and lambda light chain multiple myeloma: role of the clinical biochemist.

Mastroianni, Antonio / Panella, Rossella / Morelli, Daniele

Tumori

2019 Volume 105, Issue 6, Page(s) NP17–NP19

Abstract: Purpose: The integration of expertise between oncologist and clinical biochemist for the monitoring and diagnosis of plasma cell dyscrasia is crucial. In some cases, medical laboratory scientists can provide an original contribution using the ... ...

Abstract	Purpose: The integration of expertise between oncologist and clinical biochemist for the monitoring and diagnosis of plasma cell dyscrasia is crucial. In some cases, medical laboratory scientists can provide an original contribution using the appropriate techniques to arrive at a diagnosis. Methods: We report a case of 67-year-old woman who was admitted to our hospital for bone pain. Imaging studies showed multiple diffuse bone lytic lesions, and a laboratory screen revealed anemia and altered creatinemia; serum capillary zone electrophoresis confirmed a monoclonal peak in the γ-zone that had been known since 2011, typed as immunoglobulin G kappa by immunosubtraction electrophoresis. The patient had undergone surgery for breast cancer in 2013, and based on her clinical history, the oncologist suspected the presence of bone metastases from the breast cancer and opted for relative therapy. Immunosubtraction, however, showed a very small reduction in lambda free light chains in the beta zone, but it was difficult to establish if was a monoclonal component, and consequently additional tests were performed. Discussion: A monoclonal component composed of only lambda free light chains was evidenced. This result in association with multiple diffuse bone lytic lesions observed led us to suspect multiple myeloma and not bone metastases from the breast cancer. Based on these observations, we encouraged the oncologist to conduct an osteomedullary biopsy, allowing us to make a diagnosis of low-grade stage II lambda light chain multiple myeloma. Conclusion: In this report, we show how the expertise of the clinical biochemist was instrumental in solving this case.
MeSH term(s)	Aged ; Biomarkers, Tumor ; Biopsy ; Bone Marrow/pathology ; Bone Neoplasms/diagnosis ; Bone Neoplasms/secondary ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Diagnosis, Differential ; Female ; Humans ; Immunoglobulin lambda-Chains/blood ; Immunoglobulin lambda-Chains/metabolism ; Multiple Myeloma/blood ; Multiple Myeloma/diagnosis ; Multiple Myeloma/metabolism ; Recurrence
Chemical Substances	Biomarkers, Tumor ; Immunoglobulin lambda-Chains
Language	English
Publishing date	2019-02-24
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	280962-x
ISSN	2038-2529 ; 0300-8916
ISSN (online)	2038-2529
ISSN	0300-8916
DOI	10.1177/0300891619832521
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Article: COVID-19 Vaccination in Health Care Workers in Italy: A Literature Review and a Report from a Comprehensive Cancer Center.

Ciniselli, Chiara Maura / Lecchi, Mara / Figini, Mariangela / Melani, Cecilia C / Daidone, Maria Grazia / Morelli, Daniele / Zito, Emanuela / Apolone, Giovanni / Verderio, Paolo

Vaccines

2022 Volume 10, Issue 5

Abstract: The coronavirus disease 2019 pandemic still represents a global public health emergency, despite the availability of different types of vaccines that reduced the number of severe cases, the hospitalization rate and mortality. The Italian Vaccine ... ...

Abstract	The coronavirus disease 2019 pandemic still represents a global public health emergency, despite the availability of different types of vaccines that reduced the number of severe cases, the hospitalization rate and mortality. The Italian Vaccine Distribution Plan identified healthcare workers (HCWs) as the top-priority category to receive access to a vaccine and different studies on HCWs have been implemented to clarify the duration and kinetics of antibody response. The aim of this paper is to perform a literature review across a total of 44 studies of the serologic response to COVID-19 vaccines in HCWs in Italy and to report the results obtained in a prospective longitudinal study implemented at the Fondazione IRCCS Istituto Nazionale Tumori (INT) of Milan on 1565 HCWs. At INT we found that 99.81% of the HCWs developed an antibody response one month after the second dose. About six months after the first serology evaluation, 100% of the HCWs were still positive to the antibody, although we observed a significant decrease in its levels. Overall, our literature review results highlight a robust antibody response in most of the HCWs after the second vaccination dose. These figures are also confirmed in our institutional setting seven months after the completion of the cycle of second doses of vaccination.
Language	English
Publishing date	2022-05-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10050734
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Article ; Online: Evaluation of Simplified Diet Scores Related to

Sabia, Federica / Borgo, Alessandra / Lugo, Alessandra / Suatoni, Paola / Morelli, Daniele / Gallus, Silvano / Villarini, Anna / Pastorino, Ugo

Nutrients

2022 Volume 14, Issue 20

Abstract: The aim of this study was to assess the relationship between adherence to a healthy diet, such as the Mediterranean diet (MedDiet), ... ...

Abstract	The aim of this study was to assess the relationship between adherence to a healthy diet, such as the Mediterranean diet (MedDiet), and
MeSH term(s)	Humans ; C-Reactive Protein/metabolism ; Early Detection of Cancer ; Smokers ; Lung Neoplasms/diagnosis ; Lung Neoplasms/prevention & control ; Diet, Mediterranean
Chemical Substances	C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2022-10-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14204312
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Article ; Online: Modulation of faecal miRNAs highlights the preventive effects of a Mediterranean low-inflammatory dietary intervention.

Clinical nutrition (Edinburgh, Scotland)

2024 Volume 43, Issue 4, Page(s) 951–959

Abstract: Background: Dietary interventions have been proposed as therapeutic approaches for several diseases, including cancer. A low-inflammatory Mediterranean dietary intervention, conducted as a pilot study in subjects with Familial Adenomatous Polyposis (FAP) ...

Abstract	Background: Dietary interventions have been proposed as therapeutic approaches for several diseases, including cancer. A low-inflammatory Mediterranean dietary intervention, conducted as a pilot study in subjects with Familial Adenomatous Polyposis (FAP), reduced markers of local and systemic inflammation. We aim to determine whether this diet may modulate faecal microRNA (miRNA) and gene expression in the gut. Methods: Changes in the faecal miRNome were evaluated by small RNA sequencing at baseline (T0), after the three-month intervention (T1), and after an additional three months (T2). Changes in the transcriptome of healthy rectal mucosa and adenomas were evaluated by RNA sequencing at T0 and T2. The identification of validated miRNA-gene interactions and functional analysis of miRNA targets were performed using in silico approaches. Results: Twenty-seven subjects were included in this study. It was observed that the diet modulated 29 faecal miRNAs (p < 0.01; \|log2 Fold Change\|>1), and this modulation persisted for three months after the intervention. Levels of miR-3612-3p and miR-941 correlated with the adherence to the diet, miR-3670 and miR-4252-5p with faecal calprotectin, and miR-3670 and miR-6867 with serum calprotectin. Seventy genes were differentially expressed between adenoma and normal tissue, and most were different before the dietary intervention but reached similar levels after the diet. Functional enrichment analysis identified the proinflammatory ERK1/2, cell cycle regulation, and nutrient response pathways as commonly regulated by the modulated miRNAs and genes. Conclusions: Faecal miRNAs modulated by the dietary intervention target genes that participate in inflammation. Changes in levels of miRNAs and genes with oncogenic and tumour suppressor functions further support the potential cancer-preventive effect of the low-inflammatory Mediterranean diet. Clinical trial number registration: NCT04552405, Registered in ClinicalTrials.gov.
MeSH term(s)	Humans ; Inflammation/genetics ; Inflammation/prevention & control ; Leukocyte L1 Antigen Complex ; MicroRNAs/genetics ; Neoplasms ; Pilot Projects
Chemical Substances	Leukocyte L1 Antigen Complex ; MicroRNAs
Language	English
Publishing date	2024-02-26
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2024.02.023
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