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  1. Article ; Online: Adhesive small bowel obstruction: predictive factors of laparoscopic failure.

    Morelli, Marta / Strambi, Silvia / Cremonini, Camilla / Musetti, Serena / Tonerini, Michele / Coccolini, Federico / Chiarugi, Massimo / Tartaglia, Dario

    Updates in surgery

    2023  Volume 76, Issue 2, Page(s) 705–712

    Abstract: The adoption of laparoscopy for the management of adhesive small bowel obstruction (ASBO) patients is debated. The laparoscopic approach has been associated with a considerable conversion-to-open rate. Nonetheless, reliable predictors of conversion are ... ...

    Abstract The adoption of laparoscopy for the management of adhesive small bowel obstruction (ASBO) patients is debated. The laparoscopic approach has been associated with a considerable conversion-to-open rate. Nonetheless, reliable predictors of conversion are still unclear. The present study aimed to identify factors associated with conversion to open in ASBO patients who underwent laparoscopic surgery. Patients who underwent laparoscopic surgery for ASBO and were admitted to our unit between December 2014 and October 2022 were retrospectively evaluated. The patients were categorized into two groups: patients who underwent complete laparoscopy approach (Group 1) and patients converted to open technique (Group 2). Demographic, clinical, and radiological features, intraoperative findings, and postoperative outcomes were compared. A total of 168 patients were enrolled: 100 patients (59.5%) were included in Group 1, and 68 patients (40.5%) were included in Group 2. The rate of ischemia (p = 0.023), surgical complications (p = 0.001), operative time (p < 0.0001), days of nasogastric tube maintenance (p < 0.0001), time to canalization (p < 0.0001), and length of hospital stay (p < 0.0001) were significantly higher in Group 2 than Group 1. Following univariate analysis, the presence of feces signs (p = 0.044) and high mean radiodensity of intraperitoneal free fluid (p = 0.031) were significantly associated with Group 2 compared with Group 1. Following multivariate analysis, the feces sign was a significant predictive factor of conversion (OR 1.965 [IC 95%]; p = 0.046). Laparoscopic treatment is a safe and effective approach in patients affected by ASBO. The feces sign may be a predictive factor of conversion and could guide the surgeon in selecting the appropriate management of patients affected by ASBO.
    MeSH term(s) Humans ; Tissue Adhesions/complications ; Tissue Adhesions/surgery ; Retrospective Studies ; Postoperative Complications/epidemiology ; Postoperative Complications/surgery ; Intestinal Obstruction/diagnostic imaging ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Laparoscopy/methods ; Treatment Outcome
    Language English
    Publishing date 2023-12-27
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-023-01725-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Abdominal compartment syndrome as unusual presentation of a fast-growing solid tumor.

    Tartaglia, Dario / Arces, Francesco / Morelli, Marta / Coccolini, Federico / Chiarugi, Massimo

    The journal of trauma and acute care surgery

    2020  Volume 89, Issue 4, Page(s) e125–e127

    MeSH term(s) Abdominal Cavity/diagnostic imaging ; Abdominal Cavity/pathology ; Abdominal Neoplasms/diagnostic imaging ; Abdominal Neoplasms/pathology ; Abdominal Neoplasms/surgery ; Adult ; Compartment Syndromes/etiology ; Humans ; Male ; Neurofibrosarcoma/diagnostic imaging ; Neurofibrosarcoma/pathology ; Neurofibrosarcoma/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    DOI 10.1097/TA.0000000000002883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The impact of hepatitis C virus direct acting agents in liver transplant using very old donor grafts: a real-world single-center analysis.

    Ghinolfi, Davide / Lai, Quirino / Carrai, Paola / Petruccelli, Stefania / Morelli, Marta / Melandro, Fabio / Biancofiore, Giandomenico / De Simone, Paolo

    Updates in surgery

    2021  Volume 74, Issue 2, Page(s) 557–570

    Abstract: The correct timing of use of direct acting agents (DAAs) among transplanted patients remains unknown. The aim of this paperwork is to evaluate the impact of DAAs treatment in pre- or peri-operative period in liver transplantation when grafts ≥ 70 years ... ...

    Abstract The correct timing of use of direct acting agents (DAAs) among transplanted patients remains unknown. The aim of this paperwork is to evaluate the impact of DAAs treatment in pre- or peri-operative period in liver transplantation when grafts ≥ 70 years are used. This is a retrospective analysis comparing adult liver transplant performed for HCV-related cirrhosis and/or hepatocarcinoma using a graft ≥ 70 in the period 2015-2018 (Group DAA-HCV-OLD, study group) to three different groups: (a) anti-HCV-Ab-negative patients receiving graft ≥ 70 (no-HCV-OLD), (b) anti-HCV-Ab-negative patients receiving a graft aged 18-69 years (no-HCV-YOUNG), and (c) anti-HCV-Ab-positive patients receiving a donor graft ≥ 70 in the period 2007-2011 (no-DAA-HCV-OLD). Totally, 528 liver transplants were considered: 164 in DAA-HCV-OLD, 143 in no-HCV-OLD, 120 in no-HCV-YOUNG and 101 in no-DAA-HCV-OLD Group. Graft survival rates at 1 and 3 years were 88% and 81% in DAA-HCV-OLD Group, 82% and 68% in no-DAA-HCV-OLD (p = 0.007), 89% and 84% in no-HCV-OLD (p = 0.76), and 94% and 92% in no-HCV-YOUNG (p = 0.02). No differences were observed among groups in the incidence of primary non-function, primary dysfunction, vascular or biliary complications. DAAs were able to zero HCV-related graft loss, with a 3-year graft survival > 80%. The outcomes of older graft recipients became equal irrespectively of their HCV serological status.
    MeSH term(s) Antiviral Agents/therapeutic use ; Hepacivirus ; Hepatitis C/complications ; Hepatitis C/drug therapy ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/surgery ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/surgery ; Liver Transplantation ; Retrospective Studies
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2021-11-22
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-021-01204-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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