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  1. Book ; Online: La ricerca nei 400 anni dell'Università degli Studi di Cagliari

    Morelli, Micaela

    2021  

    Keywords Reference, information & interdisciplinary subjects ; Research ; University of Cagliari ; Sardinia
    Language Italian
    Size 1 electronic resource (67 pages)
    Publisher UNICApress
    Publishing place Cagliari
    Document type Book ; Online
    Note Italian
    HBZ-ID HT030376581
    ISBN 9788833120430 ; 8833120430
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Neurobiology of Parkinson's Disease.

    Morelli, Micaela / Pinna, Annalisa

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Parkinson's disease (PD) is one of the most rapidly growing neurological disorders [ ... ]. ...

    Abstract Parkinson's disease (PD) is one of the most rapidly growing neurological disorders [...].
    MeSH term(s) Humans ; Parkinson Disease
    Language English
    Publishing date 2023-06-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24129933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Serotonin 5-HT

    Pinna, Annalisa / Parekh, Pathik / Morelli, Micaela

    Neuropharmacology

    2023  Volume 226, Page(s) 109411

    Abstract: The dopamine neuronal loss that characterizes Parkinson's Disease (PD) is associated to changes in neurotransmitters, such as serotonin and adenosine, which contribute to the symptomatology of PD and to the onset of dyskinetic movements associated to ... ...

    Abstract The dopamine neuronal loss that characterizes Parkinson's Disease (PD) is associated to changes in neurotransmitters, such as serotonin and adenosine, which contribute to the symptomatology of PD and to the onset of dyskinetic movements associated to levodopa treatment. The present review describes the role played by serotonin 5-HT
    MeSH term(s) Humans ; Parkinson Disease/drug therapy ; Levodopa/adverse effects ; Serotonin ; Antiparkinson Agents/adverse effects ; Dyskinesia, Drug-Induced/drug therapy
    Chemical Substances Levodopa (46627O600J) ; Serotonin (333DO1RDJY) ; Antiparkinson Agents
    Language English
    Publishing date 2023-01-04
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2023.109411
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  4. Article ; Online: Brief history of the medical and non-medical use of amphetamine-like psychostimulants.

    Morelli, Micaela / Tognotti, Eugenia

    Experimental neurology

    2021  Volume 342, Page(s) 113754

    Abstract: The alkaloid ephedrine derived from Ephedra vulgaris is at the origin of psychostimulant-drugs as amphetamine. These drugs have been principally utilized for medical treatments in the past, while their utilization has been largely reduced from the 1970s ... ...

    Abstract The alkaloid ephedrine derived from Ephedra vulgaris is at the origin of psychostimulant-drugs as amphetamine. These drugs have been principally utilized for medical treatments in the past, while their utilization has been largely reduced from the 1970s when the high risk of addiction and abuse has been recognized. The first reported treatments were as anti-asthmatics and to contrast narcolepsy until their recreational stimulant and anorexic effects were reported. Benzedrine and Pervitin use were of great importance during the Second World War due to their abundant utilization among military troops. Nowadays the use of selective amphetamine-like drugs is limited to ADHD treatment.
    MeSH term(s) Altitude Sickness/drug therapy ; Altitude Sickness/history ; Amphetamine/administration & dosage ; Amphetamine/history ; Animals ; Armed Conflicts/history ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Attention Deficit Disorder with Hyperactivity/history ; Central Nervous System Stimulants/administration & dosage ; Central Nervous System Stimulants/history ; Fatigue/drug therapy ; Fatigue/history ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Humans
    Chemical Substances Central Nervous System Stimulants ; Amphetamine (CK833KGX7E)
    Language English
    Publishing date 2021-05-15
    Publishing country United States
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2021.113754
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    Zs.A 184: Show issues Location:
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  5. Article ; Online: Why is fake news so fascinating to the brain?

    Grignolio, Andrea / Morelli, Micaela / Tamietto, Marco

    The European journal of neuroscience

    2022  Volume 56, Issue 11, Page(s) 5967–5971

    MeSH term(s) Disinformation ; Brain
    Language English
    Publishing date 2022-10-27
    Publishing country France
    Document type Editorial
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.15844
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    Zs.A 2548: Show issues Location:
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  6. Article ; Online: Pharmacological interactions between adenosine A

    Pinna, Annalisa / Serra, Marcello / Marongiu, Jacopo / Morelli, Micaela

    Parkinsonism & related disorders

    2020  Volume 80 Suppl 1, Page(s) S37–S44

    Abstract: While Parkinson's disease (PD) is traditionally characterized by dopaminergic neuron degeneration, several neurotransmitters and neuromodulators besides dopamine are also involved in the onset and progression of the disease and its symptoms. The other ... ...

    Abstract While Parkinson's disease (PD) is traditionally characterized by dopaminergic neuron degeneration, several neurotransmitters and neuromodulators besides dopamine are also involved in the onset and progression of the disease and its symptoms. The other principal neurotransmitters/neuromodulators known to control basal ganglia functions and, in particular, motor functions, are GABA, glutamate, serotonin (5-HT), noradrenaline, acetylcholine, adenosine and endocannabinoids. Among these, adenosine is the most relevant, acting through its adenosine A
    MeSH term(s) Adenosine A2 Receptor Antagonists/therapeutic use ; Animals ; Antiparkinson Agents/therapeutic use ; Disease Models, Animal ; Dyskinesia, Drug-Induced/drug therapy ; Humans ; Parkinson Disease/drug therapy ; Receptor, Adenosine A2A/drug effects ; Receptor, Adenosine A2A/metabolism
    Chemical Substances Adenosine A2 Receptor Antagonists ; Antiparkinson Agents ; Receptor, Adenosine A2A
    Language English
    Publishing date 2020-12-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2020.10.023
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    Zs.MO 420: Show issues

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  7. Article ; Online: Neuroinflammation and L-dopa-induced abnormal involuntary movements in 6-hydroxydopamine-lesioned rat model of Parkinson's disease are counteracted by combined administration of a 5-HT

    Pinna, Annalisa / Costa, Giulia / Serra, Marcello / Contu, Liliana / Morelli, Micaela

    Neuropharmacology

    2021  Volume 196, Page(s) 108693

    Abstract: Several lines of evidence have strongly implicated neuroinflammation in Parkinson's disease (PD) progression and l-dopa-induced dyskinesia. The present study investigated whether early subchronic pretreatment with the serotonin 5- ... ...

    Abstract Several lines of evidence have strongly implicated neuroinflammation in Parkinson's disease (PD) progression and l-dopa-induced dyskinesia. The present study investigated whether early subchronic pretreatment with the serotonin 5-HT
    MeSH term(s) Adenosine A2 Receptor Antagonists/pharmacology ; Animals ; Antiparkinson Agents/adverse effects ; Calcium-Binding Proteins/drug effects ; Calcium-Binding Proteins/metabolism ; Caudate Nucleus/drug effects ; Caudate Nucleus/metabolism ; Dyskinesia, Drug-Induced/etiology ; Dyskinesia, Drug-Induced/metabolism ; Dyskinesia, Drug-Induced/physiopathology ; Glial Fibrillary Acidic Protein/drug effects ; Glial Fibrillary Acidic Protein/metabolism ; Interleukin-10/metabolism ; Interleukin-1beta/drug effects ; Interleukin-1beta/metabolism ; Levodopa/adverse effects ; Microfilament Proteins/drug effects ; Microfilament Proteins/metabolism ; Neuroinflammatory Diseases/metabolism ; Oxidopamine/toxicity ; Parkinsonian Disorders/chemically induced ; Parkinsonian Disorders/drug therapy ; Parkinsonian Disorders/metabolism ; Parkinsonian Disorders/physiopathology ; Pars Compacta/drug effects ; Pars Compacta/metabolism ; Piperazines/pharmacology ; Putamen/drug effects ; Putamen/metabolism ; Pyrimidines/pharmacology ; Rats ; Receptor, Serotonin, 5-HT1A ; Receptor, Serotonin, 5-HT1B ; Serotonin 5-HT1 Receptor Agonists/pharmacology ; Triazoles/pharmacology ; Tumor Necrosis Factor-alpha/drug effects ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Adenosine A2 Receptor Antagonists ; Aif1 protein, rat ; Antiparkinson Agents ; Calcium-Binding Proteins ; GFAP protein, rat ; Glial Fibrillary Acidic Protein ; IL1B protein, rat ; Interleukin-1beta ; Microfilament Proteins ; Piperazines ; Pyrimidines ; Receptor, Serotonin, 5-HT1B ; Serotonin 5-HT1 Receptor Agonists ; Triazoles ; Tumor Necrosis Factor-alpha ; Receptor, Serotonin, 5-HT1A (112692-38-3) ; Interleukin-10 (130068-27-8) ; Levodopa (46627O600J) ; eltoprazine (510M006KO6) ; Oxidopamine (8HW4YBZ748) ; 2-(2-furanyl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)-1-piperazinyl)ethyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidine-5-amine (950O97NUPO)
    Language English
    Publishing date 2021-07-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2021.108693
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  8. Article ; Online: Withania somnifera influences MDMA-induced hyperthermic, cognitive, neurotoxic and neuroinflammatory effects in mice.

    Costa, Giulia / Serra, Marcello / Maccioni, Riccardo / Casu, Maria Antonietta / Kasture, Sanjay B / Acquas, Elio / Morelli, Micaela

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 161, Page(s) 114475

    Abstract: Withania somnifera (WS) is utilized in Ayurvedic medicine owing to its central and peripheral beneficial properties. Several studies have accrued indicating that the recreational amphetamine-related drug (+/-)- 3,4-methylenedioxymethamphetamine (MDMA; ... ...

    Abstract Withania somnifera (WS) is utilized in Ayurvedic medicine owing to its central and peripheral beneficial properties. Several studies have accrued indicating that the recreational amphetamine-related drug (+/-)- 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy) targets the nigrostriatal dopaminergic system in mice, inducing neurodegeneration and gliosis, causing acute hyperthermia and cognitive impairment. This study aimed to investigate the effect of a standardized extract of W. somnifera (WSE) on MDMA-induced neurotoxicity, neuroinflammation, memory impairment and hyperthermia. Mice received a 3-day pretreatment with vehicle or WSE. Thereafter, vehicle- and WSE-pretreated mice were randomly divided into four groups: saline, WSE, MDMA alone, WSE plus MDMA. Body temperature was recorded throughout treatment, and memory performance was assessed by a novel object recognition (NOR) task at the end of treatment. Thereafter, immunohistochemistry was performed to evaluate in the substantia nigra pars compacta (SNc) and striatum the levels of tyrosine hydroxylase (TH), as marker of dopaminergic degeneration, and of glial fibrillary acidic protein (GFAP) and TMEM119, as markers of astrogliosis or microgliosis, respectively. MDMA-treated mice showed a decrease in TH-positive neurons and fibers in the SNc and striatum respectively, an increase in gliosis and body temperature, and a decrease in NOR performance, irrespective of vehicle or WSE pretreatment. Acute WSE plus MDMA counteracted the modifications in TH-positive cells in SNc, GFAP-positive cells in striatum, TMEM in both areas and NOR performance, as compared to MDMA alone, while no differences were observed as compared to saline. Results indicate that WSE acutely administered in combination with MDMA, but not as pretreatment, protects mice against the noxious central effects of MDMA.
    MeSH term(s) Animals ; Mice ; N-Methyl-3,4-methylenedioxyamphetamine/toxicity ; Withania ; Neuroinflammatory Diseases ; Gliosis ; Neurotoxicity Syndromes/drug therapy ; Neurotoxicity Syndromes/etiology ; Neurotoxicity Syndromes/prevention & control ; Hyperthermia, Induced ; Cognition
    Chemical Substances N-Methyl-3,4-methylenedioxyamphetamine (KE1SEN21RM)
    Language English
    Publishing date 2023-03-09
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114475
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  9. Article ; Online: Corrigendum to "In utero exposure to dexamethasone causes a persistent and age-dependent exacerbation of the neurotoxic effects and glia activation induced by MDMA in dopaminergic brain regions of C57BL/6J mice" NeuroToxicology 83 (2021) 1-13.

    Costa, Giulia / Spulber, Stefan / Paci, Elena / Antonietta Casu, Maria / Ceccatelli, Sandra / Simola, Nicola / Morelli, Micaela

    Neurotoxicology

    2023  

    Language English
    Publishing date 2023-12-23
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 800820-6
    ISSN 1872-9711 ; 0161-813X
    ISSN (online) 1872-9711
    ISSN 0161-813X
    DOI 10.1016/j.neuro.2023.12.014
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  10. Article ; Online: Corrigendum to "In utero exposure to dexamethasone causes a persistent and age-dependent exacerbation of the neurotoxic effects and glia activation induced by MDMA in dopaminergic brain regions of C57BL/6J mice" [NeuroToxicology, 83 (2021), 1-13].

    Costa, Giulia / Spulber, Stefan / Paci, Elena / Casu, Maria Antonietta / Ceccatelli, Sandra / Simola, Nicola / Morelli, Micaela

    Neurotoxicology

    2023  Volume 101, Page(s) 128–130

    Language English
    Publishing date 2023-12-21
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 800820-6
    ISSN 1872-9711 ; 0161-813X
    ISSN (online) 1872-9711
    ISSN 0161-813X
    DOI 10.1016/j.neuro.2023.12.010
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