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Book ; Online: Chapter L'esperienza formativa di Anton Domenico Gabbiani a Venezia. Disegni e dipinti inediti

Morelli, Laura

(Studi e saggi)

2020

Series title	Studi e saggi
Keywords	Anton Domenico Gabbiani ; Titian ; Florentine baroque painting ; Francesco Saverio Baldinucci ; Ignazio Enrico Hugford
Language	0\|e
Size	1 electronic resource (39 pages)
Publisher	Firenze University Press
Publishing place	Florence
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021609809
ISBN	9788855181815 ; 8855181815
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: A critical evaluation of the factors affecting the survival and persistence of beneficial bacteria in healthy adults.

Morelli, L / Pellegrino, P

Beneficial microbes

2021 Volume 12, Issue 4, Page(s) 15–25

Abstract: The efficacy of a probiotic depends on its ability to survive and persist in the digestive tract. Regulatory agencies around the world recommend minimum dosages in order for a product to be termed a probiotic. However, the effect of dosage on the ... ...

Abstract	The efficacy of a probiotic depends on its ability to survive and persist in the digestive tract. Regulatory agencies around the world recommend minimum dosages in order for a product to be termed a probiotic. However, the effect of dosage on the survival of the bacteria in the gut - the primary objective of probiotic administration - has not been critically evaluated. We performed a systematic literature review to assess the available data on the survival rate, during gastrointestinal transit, of probiotic bacteria that were orally administered to healthy adults. We also evaluated the persistence of the administered strain(s) after discontinuation of treatment and the potential role played by the food matrix in which probiotics have been administered. From a regulatory perspective, the profile of the target population is key to establishing the efficacy of probiotics. Therefore, we focussed on subjects without disease conditions. We evaluated 17 studies of single strains and 13 studies of multi-strain products, which reported survival and persistence outcomes. Persistence in the gut and recovery from stool were strain dependent. When the administered dose was higher than 10
MeSH term(s)	Administration, Oral ; Adult ; Bacteria ; Feces/microbiology ; Gastrointestinal Transit ; Humans ; Probiotics
Language	English
Publishing date	2021-07-29
Publishing country	Netherlands
Document type	Journal Article ; Systematic Review
ZDB-ID	2561259-1
ISSN	1876-2891 ; 1876-2883
ISSN (online)	1876-2891
ISSN	1876-2883
DOI	10.3920/BM2021.0017
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficacy and safety of Lactobacillus plantarum P 17630 strain soft vaginal capsule in vaginal candidiasis: a randomized non-inferiority clinical trial.

Bertarello, C / Savio, D / Morelli, L / Bouzalov, S / Davidova, D / Bonetti, A

European review for medical and pharmacological sciences

2024 Volume 28, Issue 1, Page(s) 384–391

Abstract: Objective: To investigate the non-inferiority of efficacy and tolerability of Lactobacillus plantarum P 17630 soft vaginal capsules compared to the antifungal therapy with miconazole nitrate 400 mg soft vaginal capsules in patients with symptomatic ... ...

Abstract	Objective: To investigate the non-inferiority of efficacy and tolerability of Lactobacillus plantarum P 17630 soft vaginal capsules compared to the antifungal therapy with miconazole nitrate 400 mg soft vaginal capsules in patients with symptomatic vulvovaginal infection due to Candida. Patients and methods: Adult women with vulvovaginal candidiasis were randomized to either L. plantarum P17630 100,000,000 CFU soft vaginal capsules by vaginal route each day for 3 or 6 consecutive days or miconazole nitrate 400 mg soft vaginal capsule. Visual Analog Scale (VAS) scores for vaginitis symptoms were used, and vaginal fluid interleukin 6 (IL6) was dosed. The study was registered in EudraCT database (code LPP17630-C-018; number: 2018-003095-12). Results: 200 patients were included in the study. The mean VAS scores for vaginitis symptoms were progressively reduced in both treatment groups at each visit, without significant difference between groups (p>0.05 for each symptom, at each time point). The efficacy of L. plantarum and the reference medicinal product was maintained at follow-up (day 21). The mean concentration of IL-6 decreased from visit 1 to visit 3 in both groups without a significant difference (p>0.05). No adverse events were reported. Conclusions: L. plantarum P17630 100,000,000 CFU soft vaginal capsules are effective and safe for treating vaginal candidiasis without the concomitant use of an antifungal product, which rules out the risk of antimicrobic resistance. The long-term effect on vaginal microflora may add the possibility of reducing the risk of recurrences.
MeSH term(s)	Adult ; Female ; Humans ; Antifungal Agents/adverse effects ; Candidiasis, Vulvovaginal/drug therapy ; Lactobacillus plantarum ; Miconazole/adverse effects ; Vagina/microbiology ; Vulvovaginitis/drug therapy
Chemical Substances	Antifungal Agents ; Miconazole (7NNO0D7S5M)
Language	English
Publishing date	2024-01-18
Publishing country	Italy
Document type	Equivalence Trial ; Journal Article ; Randomized Controlled Trial
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202401_34927
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Article: A critical evaluation of the factors affecting the survival and persistence of beneficial bacteria in healthy adults

Morelli, L. / Pellegrino, P.

Beneficial microbes. 2021 Aug. 30, v. 12, no. 4

2021

Abstract	The efficacy of a probiotic depends on its ability to survive and persist in the digestive tract. Regulatory agencies around the world recommend minimum dosages in order for a product to be termed a probiotic. However, the effect of dosage on the survival of the bacteria in the gut – the primary objective of probiotic administration – has not been critically evaluated. We performed a systematic literature review to assess the available data on the survival rate, during gastrointestinal transit, of probiotic bacteria that were orally administered to healthy adults. We also evaluated the persistence of the administered strain(s) after discontinuation of treatment and the potential role played by the food matrix in which probiotics have been administered. From a regulatory perspective, the profile of the target population is key to establishing the efficacy of probiotics. Therefore, we focussed on subjects without disease conditions. We evaluated 17 studies of single strains and 13 studies of multi-strain products, which reported survival and persistence outcomes. Persistence in the gut and recovery from stool were strain dependent. When the administered dose was higher than 10¹⁰ cfu/day, the probiotic could be recovered from stool regardless of the strain used. Treatment duration did not affect faecal recovery. Thus, dosage recommendations for probiotics by regulatory agencies are lower than that required for a strain to survive, persist and be efficacious in the gut.
Keywords	administered dose ; digestive tract ; food matrix ; gastrointestinal transit ; probiotics ; survival rate
Language	English
Dates of publication	2021-0830
Size	p. 321-331.
Publishing place	Wageningen Academic Publishers
Document type	Article
ZDB-ID	2561259-1
ISSN	1876-2891 ; 1876-2883
ISSN (online)	1876-2891
ISSN	1876-2883
DOI	10.3920/BM2021.0017
Database	NAL-Catalogue (AGRICOLA)

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Article: Reuterin, Phenyllactic Acid, and Exopolysaccharides as Main Antifungal Molecules Produced by Lactic Acid Bacteria: A Scoping Review.

Ponzio, Andrea / Rebecchi, Annalisa / Zivoli, Rosanna / Morelli, Lorenzo

Foods (Basel, Switzerland)

2024 Volume 13, Issue 5

Abstract: The primary goal of this scoping review is to collect, analyze, and critically describe information regarding the role of the main compounds (reuterin, phenyllactic acid, and exopolysaccharides) produced by LAB that possess antifungal properties and ... ...

Abstract	The primary goal of this scoping review is to collect, analyze, and critically describe information regarding the role of the main compounds (reuterin, phenyllactic acid, and exopolysaccharides) produced by LAB that possess antifungal properties and provide some suggestions for further research. The use of lactic acid bacteria (LAB) to mitigate spoilage and extend the shelf life of foodstuffs has a long history. Recently, there has been a growing interest in the unique properties of these additions to the foodstuffs in which they are applied. In recent studies regarding biopreservation, significant attention has been given to the role of these microorganisms and their metabolites. This fascinating recent discipline aims not only to replace traditional preservation systems, but also to improve the overall quality of the final product. The biologically active by-products produced by lactic acid bacteria are synthesized under certain conditions (time, temperature, aerobiosis, acidity, water activity, etc.), which can be enacted through one of the oldest approaches to food processing: fermentation (commonly used in the dairy and bakery sectors). This study also delves into the biosynthetic pathways through which they are synthesized, with a particular emphasis on what is known about the mechanisms of action against molds in relation to the type of food.
Language	English
Publishing date	2024-02-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods13050752
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Article ; Online: Open avenues for carotenoid biofortification of plant tissues.

Morelli, Luca / Rodriguez-Concepcion, Manuel

Plant communications

2022 Volume 4, Issue 1, Page(s) 100466

Abstract: Plant carotenoids are plastidial isoprenoids that function as photoprotectants, pigments, and precursors of apocarotenoids such as the hormones abscisic acid and strigolactones. Humans do not produce carotenoids but need to obtain them from their diet as ...

Abstract	Plant carotenoids are plastidial isoprenoids that function as photoprotectants, pigments, and precursors of apocarotenoids such as the hormones abscisic acid and strigolactones. Humans do not produce carotenoids but need to obtain them from their diet as precursors of retinoids, including vitamin A. Carotenoids also provide numerous other health benefits. Multiple attempts to improve the carotenoid profile of different crops have been carried out by manipulating carotenoid biosynthesis, degradation, and/or storage. Here, we will focus on open questions and emerging subjects related to the use of biotechnology for carotenoid biofortification. After impressive achievements, new efforts should be directed to extend the use of genome-editing technologies to overcome regulatory constraints and improve consumer acceptance of the carotenoid-enriched products. Another challenge is to prevent off-target effects like those resulting from altered hormone levels and metabolic homeostasis. Research on biofortification of green tissues should also look for new ways to deal with the negative impact that altered carotenoid contents may have on photosynthesis. Once a carotenoid-enriched product has been obtained, additional effort should be devoted to confirming that carotenoid intake from the engineered food is also improved. This work involves ensuring post-harvest stability and assessing bioaccessibility of the biofortified product to confirm that release of carotenoids from the food matrix has not been negatively affected. Successfully addressing these challenges will ensure new milestones in carotenoid biotechnology and biofortification.
MeSH term(s)	Humans ; Biofortification ; Carotenoids/metabolism ; Vitamin A/metabolism ; Terpenes ; Crops, Agricultural/metabolism
Chemical Substances	Carotenoids (36-88-4) ; Vitamin A (11103-57-4) ; Terpenes
Language	English
Publishing date	2022-10-27
Publishing country	China
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ISSN	2590-3462
ISSN (online)	2590-3462
DOI	10.1016/j.xplc.2022.100466
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cochlear implantation in single-sided deafness: a single-center experience of 138 cases.

Morelli, L / Fancello, Virginia / Gaino, F / Cagliero, G / Caruso, A / Sanna, M

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2023 Volume 280, Issue 10, Page(s) 4427–4432

Abstract: Objectives: Assess the outcomes in patients who underwent cochlear implant (CI) for single-sided deafness (SSD).: Methods: All patients affected by SSD who underwent CI at Gruppo Otologico, Piacenza, from October 2012 to May 2022 with at least 6 ... ...

Abstract	Objectives: Assess the outcomes in patients who underwent cochlear implant (CI) for single-sided deafness (SSD). Methods: All patients affected by SSD who underwent CI at Gruppo Otologico, Piacenza, from October 2012 to May 2022 with at least 6 months of follow-up were selected in the study group. The analysis included subjective and objective measures performed pre-operative and up to 24 months after surgery. Hearing threshold on both sides was evaluated with a weighted four-frequency average (PTA [0.5 kHz + 1 kHz + 2 kHz + 4 kHz]/4) on pure tone audiometry and speech audiometry (Speech Discrimination Score, SDS). The Speech Spatial and Qualities of Hearing scale (SSQ Questionnaire) for binaural hearing benefits and sound localization, the Tinnitus Handicap Inventory Questionnaire (THI) and Dizziness Handicap Inventory Questionnaire (DHI) were used for subjective assessment. Results: Data from 138 patients, 69 males and 69 females, (mean age 49 years, range 17-77 years) underwent CI for SSD were examined. Single-sided hearing deprivation average before undergoing CI surgery was 2.5 years (range 3 months-35 years). There was a significant reduction of THI and DHI scores compared to pre-operative scores alongside a referred improvement in social, physical, and emotional well-being through the SSQ questionnaire. Conclusions: To the best of our knowledge, this paper descried the largest cohort of SSD who underwent CI in a single institution. According to our findings CI in patients affected by SSD represents a valuable tool for an overall improvement of tinnitus and dizziness but also quality of life, after at least 6 months of follow-up. Further studies are desirable to improve rehabilitation pathways and possibly set new standards of care of this condition.
MeSH term(s)	Male ; Female ; Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Cochlear Implantation ; Tinnitus/surgery ; Quality of Life ; Dizziness ; Audiometry, Pure-Tone ; Vertigo ; Deafness/surgery ; Deafness/rehabilitation
Language	English
Publishing date	2023-04-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-023-07959-1
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Article ; Online: Replacement of nitrates and nitrites in meat-derived foods through the utilization of coagulase-negative staphylococci

Premi, Lara / Rocchetti, Gabriele / Lucini, Luigi / Morelli, Lorenzo / Rebecchi, Annalisa

Current research in food science

2024 Volume 8, Page(s) 100731

Abstract: Nitrates and nitrites, which are synthetic additives, are traditionally used as curing agents in meat-based products. These synthetic additives are employed in the preparation of fermented meat foods to improve quality characteristics and microbiological ...

Abstract	Nitrates and nitrites, which are synthetic additives, are traditionally used as curing agents in meat-based products. These synthetic additives are employed in the preparation of fermented meat foods to improve quality characteristics and microbiological safety, develop distinct flavours and red-colour stability, and counteract lipid oxidation. Nitrites also display significant bacteriostatic and bactericidal action against spoilage microorganisms and foodborne pathogens (such as
Language	English
Publishing date	2024-04-05
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2665-9271
ISSN (online)	2665-9271
DOI	10.1016/j.crfs.2024.100731
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Application of flow cytometry for rapid bacterial enumeration and cells physiological state detection to predict acidification capacity of natural whey starters.

Bellassi, Paolo / Fontana, Alessandra / Morelli, Lorenzo

Heliyon

2023 Volume 9, Issue 8, Page(s) e19146

Abstract: Natural whey starter cultures are undefined microbial communities mainly consisting of thermophilic lactic acid bacteria (LAB). The technological pressure that shapes the natural whey starter community before and during the back-slopping procedure can ... ...

Abstract	Natural whey starter cultures are undefined microbial communities mainly consisting of thermophilic lactic acid bacteria (LAB). The technological pressure that shapes the natural whey starter community before and during the back-slopping procedure can impact the amount and viability of the different thermophilic LAB. Traditional culture-dependent analytical methods are useful for evaluating natural whey cultures based on plate enumeration with various culture media and are commonly used as self-control procedures in dairy items. These methods have high variability and require days to obtain results. As the dairy industry has been searching for a solution to this problem for a long time, researchers must explore alternative methods for the technological evaluation of natural whey and assessment of the health status of the thermophilic acidifying bacteria community in the cheesemaking process. The flow cytometry approach has been considered an alternative to classical methods in this work sector. This study compared bacterial enumeration by plate counting and flow cytometry on natural whey samples. Flow cytometry results showed positive agreement with a tendency to overestimate, linearity, and correlation with plate counting. Other parameters have also been introduced for evaluating a natural whey starter, measuring the physiological state of the cells. Specifically, cell-wall damage and metabolic activity were also evaluated, allowing us to quantify the number of cells even in sub-optimal physiological conditions.
Language	English
Publishing date	2023-08-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e19146
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: ACTION CAMS AND LOW-COST MULTI-FREQUENCY ANTENNAS FOR GNSS ASSISTED PHOTOGRAMMETRIC APPLICATIONS WITHOUT GROUND CONTROL POINTS

Morelli, L. / Menna, F. / Vitti, A. / Remondino, F.

eISSN: 2194-9034

2022

Abstract: In civil, architectural and environmental fields photogrammetry is one of the most common solutions for deriving geometric information about many kind of objects of interest. Photogrammetric surveys suffer for the need of ground control points (GCPs), ... ...

Abstract	In civil, architectural and environmental fields photogrammetry is one of the most common solutions for deriving geometric information about many kind of objects of interest. Photogrammetric surveys suffer for the need of ground control points (GCPs), well distributed over the survey area, to scale and georeference the produced 3D data. The placement of GCPs is both time-consuming and sometimes infeasible because of environmental constraints, such as vegetation on river sides. For aerial surveys with unmanned aerial vehicles (UAV), several studies have been proposed to use the UAV GNSS antenna to reduce or eliminate the need of GCPs. This technique, called GNSS-aided photogrammetry, has been little explored for terrestrial applications despite its potential in reducing surveying time, or for integrating terrestrial and aerial surveying. This gap has been partly caused by the high cost of topographic-grade GNSS, but in recent years the market has offered receivers, such as the ublox ZED-F9P, which can achieve high accuracy at low cost. In this work we propose a simple and fast GNSS-aided methodology for terrestrial photogrammetric surveys using low-cost GNSS and image sensors. The final aim is to create a general procedure to minimize survey costs and time, and derive a scaled and georeferenced 3D information without GCPs.
Subject code	710
Language	English
Publishing date	2022-12-08
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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