Article ; Online: Primary de novo malignant peripheral nerve sheath tumor of the breast mimicking mastitis. Report of a case and review of the literature.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
2023 Volume 64, Issue 1, Page(s) 73–82
Abstract: Malignant peripheral nerve sheath tumor (MPNST) is a rare tumor representing <0.1% of malignant breast tumors. Here, we report a case of sporadic MPNST of the breast in a 45-year-old woman with a fast-evolving painful mass in the right breast associated ... ...
| Abstract | Malignant peripheral nerve sheath tumor (MPNST) is a rare tumor representing <0.1% of malignant breast tumors. Here, we report a case of sporadic MPNST of the breast in a 45-year-old woman with a fast-evolving painful mass in the right breast associated with edema, redness, and increased local temperature, simulating mastitis. This presentation has not been reported. A review of the literature since 1992 has revealed 15 MPNST cases, including the present one with sufficient data for analysis. All the cases were women. The ages ranged from 16-60 years (mean 40.5 years). Duration of symptoms varied from four days to 15 years (mean 2.7 years). Tumor size ranged from 2.5-30 cm (mean 10.9 cm). 64.3% of tumors were well-circumscribed. Tumors were graded as grade 1 (7.7%), grade 2 (38.5%), and grade 3 (53.8%). Three (20%) cases showed histopathological peculiarities. Simple mastectomy was performed in four (26.7%) cases, radical mastectomy in six (40%) cases, and simple excision in five (33.3%) cases. There were no metastases in the six cases where axillary dissection was performed. Seven (53.8%) patients received adjuvant therapy, including chemotherapy and∕or radiotherapy. Local recurrence was observed in two (16.7%) patients. Distant metastasis was detected in one patient (7.7%) affecting the lung 11 months after radical mastectomy. The follow-up was available for 10 patients (mean 2.2 years, median 1 year). One patient (10%) died of the disease. At the last follow-up, 80% of patients were still alive. The main differential diagnosis includes nonpleomorphic spindle cell tumors. |
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| MeSH term(s) | Humans ; Female ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Male ; Breast Neoplasms/pathology ; Neurofibrosarcoma/surgery ; Mastectomy ; Follow-Up Studies ; Mastitis/surgery ; Neoplasm Recurrence, Local/pathology |
| Language | English |
| Publishing date | 2023-05-02 |
| Publishing country | Romania |
| Document type | Review ; Case Reports ; Journal Article |
| ZDB-ID | 1062519-7 |
| ISSN | 2066-8279 ; 1220-0522 ; 0035-4007 |
| ISSN (online) | 2066-8279 |
| ISSN | 1220-0522 ; 0035-4007 |
| DOI | 10.47162/RJME.64.1.09 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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